CA2850932A1 - Novel imidazole quinoline-based immune system modulators - Google Patents
Novel imidazole quinoline-based immune system modulators Download PDFInfo
- Publication number
- CA2850932A1 CA2850932A1 CA2850932A CA2850932A CA2850932A1 CA 2850932 A1 CA2850932 A1 CA 2850932A1 CA 2850932 A CA2850932 A CA 2850932A CA 2850932 A CA2850932 A CA 2850932A CA 2850932 A1 CA2850932 A1 CA 2850932A1
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- Prior art keywords
- alkyl
- heterocycle
- optionally substituted
- cycloalkyl
- heteroatoms
- Prior art date
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- Abandoned
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| PCT/US2012/058566 WO2013052550A2 (en) | 2011-10-04 | 2012-10-03 | Novel imidazole quinoline-based immune system modulators |
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| US10071079B2 (en) | 2016-06-29 | 2018-09-11 | Bristol-Myers Squibb Company | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds |
| WO2018026620A1 (en) | 2016-07-30 | 2018-02-08 | Bristol-Myers Squibb Company | Dimethoxyphenyl substituted indole compounds as tlr7, tlr8 or tlr9 inhibitors |
| WO2018049089A1 (en) | 2016-09-09 | 2018-03-15 | Bristol-Myers Squibb Company | Pyridyl substituted indole compounds |
| WO2019028301A1 (en) | 2017-08-04 | 2019-02-07 | Bristol-Myers Squibb Company | INDOLE COMPOUNDS SUBSTITUTED WITH [1,2,4] TRIAZOLO [4,3-A] PYRIDINYL |
| WO2019028302A1 (en) | 2017-08-04 | 2019-02-07 | Bristol-Myers Squibb Company | SUBSTITUTED INDOLE COMPOUNDS USEFUL AS TLR7 / 8/9 INHIBITORS |
| EP3710440B1 (en) | 2017-11-14 | 2023-04-05 | Bristol-Myers Squibb Company | Substituted indole compounds |
| CN111527080B (zh) | 2017-12-15 | 2023-09-22 | 百时美施贵宝公司 | 取代的吲哚醚化合物 |
| BR112020011771A2 (pt) | 2017-12-18 | 2020-11-17 | Bristol-Myers Squibb Company | compostos 4-azaindol |
| AU2018390543A1 (en) | 2017-12-19 | 2020-08-06 | Bristol-Myers Squibb Company | 6-azaindole compounds |
| US11878975B2 (en) | 2017-12-19 | 2024-01-23 | Bristol-Myers Squibb Company | Substituted indole compounds useful as TLR inhibitors |
| ES2922174T3 (es) | 2017-12-19 | 2022-09-09 | Bristol Myers Squibb Co | Compuestos de indol sustituidos con amida útiles como inhibidores de TLR |
| SG11202005694RA (en) | 2017-12-20 | 2020-07-29 | Bristol Myers Squibb Co | Amino indole compounds useful as tlr inhibitors |
| EA202091530A1 (ru) | 2017-12-20 | 2020-09-14 | Бристол-Маерс Сквибб Компани | Диазаиндольные соединения |
| MX2020005622A (es) | 2017-12-20 | 2020-08-20 | Bristol Myers Squibb Co | Compuestos de indol sustituidos con arilo y heteroarilo. |
| US11998537B2 (en) | 2018-10-24 | 2024-06-04 | Bristol-Myers Squibb Company | Substituted indole dimer compounds |
| JP7597709B2 (ja) | 2018-10-24 | 2024-12-10 | ブリストル－マイヤーズ スクイブ カンパニー | 置換インドールおよびインダゾール化合物 |
| CN113811299A (zh) * | 2019-03-15 | 2021-12-17 | 博笛生物科技有限公司 | 用于治疗癌症的免疫调控性组合物和方法 |
| JP7621275B2 (ja) | 2019-05-09 | 2025-01-24 | ブリストル－マイヤーズ スクイブ カンパニー | 置換ベンズイミダゾロン化合物 |
| EP4041730A1 (en) | 2019-10-01 | 2022-08-17 | Bristol-Myers Squibb Company | Substituted bicyclic heteroaryl compounds |
| JP7545467B2 (ja) | 2019-10-04 | 2024-09-04 | ブリストル－マイヤーズ スクイブ カンパニー | 置換カルバゾール化合物 |
| US11530218B2 (en) | 2020-01-20 | 2022-12-20 | Incyte Corporation | Spiro compounds as inhibitors of KRAS |
| US11739102B2 (en) | 2020-05-13 | 2023-08-29 | Incyte Corporation | Fused pyrimidine compounds as KRAS inhibitors |
| US11999752B2 (en) | 2020-08-28 | 2024-06-04 | Incyte Corporation | Vinyl imidazole compounds as inhibitors of KRAS |
| US11767320B2 (en) | 2020-10-02 | 2023-09-26 | Incyte Corporation | Bicyclic dione compounds as inhibitors of KRAS |
| WO2022204112A1 (en) | 2021-03-22 | 2022-09-29 | Incyte Corporation | Imidazole and triazole kras inhibitors |
| AU2022257039A1 (en) | 2021-04-16 | 2023-10-05 | Gilead Sciences, Inc. | Thienopyrrole compounds |
| US12441727B2 (en) | 2021-07-07 | 2025-10-14 | Incyte Corporation | Tricyclic compounds as inhibitors of KRAS |
| CA3229855A1 (en) | 2021-08-31 | 2023-03-09 | Incyte Corporation | Naphthyridine compounds as inhibitors of kras |
| WO2023039464A1 (en) | 2021-09-10 | 2023-03-16 | Gilead Sciences, Inc. | Thienopyrrole compounds |
| WO2023049697A1 (en) | 2021-09-21 | 2023-03-30 | Incyte Corporation | Hetero-tricyclic compounds as inhibitors of kras |
| WO2023056421A1 (en) | 2021-10-01 | 2023-04-06 | Incyte Corporation | Pyrazoloquinoline kras inhibitors |
| KR20240101561A (ko) | 2021-10-14 | 2024-07-02 | 인사이트 코포레이션 | Kras의 저해제로서의 퀴놀린 화합물 |
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| WO1998040100A1 (en) | 1997-03-10 | 1998-09-17 | Ottawa Civic Loeb Research Institute | USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE AS AN ADJUVANT |
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| EP1948173B1 (en) * | 2005-11-04 | 2013-07-17 | 3M Innovative Properties Company | Hydroxy and alkoxy substituted 1h-imidazoquinolines and methods |
| US20100010217A1 (en) * | 2006-03-23 | 2010-01-14 | Valiante Nicholas M | Methods for the preparation of imidazole-containing compounds |
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| EP1972629A1 (en) | 2007-03-23 | 2008-09-24 | Mutabilis SA | New imidazolo-heteroaryl derivatives with antibacterial properties |
| MX2011002264A (es) | 2008-09-10 | 2011-05-23 | Kalypsys Inc | Inhibidores heterocíclicos de los receptores de histamina para el tratamiento de una enfermedad. |
| EP2507237A1 (en) * | 2009-12-03 | 2012-10-10 | Dainippon Sumitomo Pharma Co., Ltd. | Imidazoquinolines which act via toll - like receptors (tlr) |
| US8728486B2 (en) * | 2011-05-18 | 2014-05-20 | University Of Kansas | Toll-like receptor-7 and -8 modulatory 1H imidazoquinoline derived compounds |
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| WO2013052550A2 (en) | 2013-04-11 |
| AU2012318694B2 (en) | 2016-12-22 |
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| EP2763677A2 (en) | 2014-08-13 |
| EP2763677A4 (en) | 2015-05-20 |
| JP2014528449A (ja) | 2014-10-27 |
| EP2763677B1 (en) | 2020-02-26 |
| AU2012318694A1 (en) | 2014-05-22 |
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| US20140242121A1 (en) | 2014-08-28 |
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