CA2850391A1 - Methods of therapeutic monitoring of nitrogen scavenging drugs - Google Patents

Methods of therapeutic monitoring of nitrogen scavenging drugs Download PDF

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Publication number
CA2850391A1
CA2850391A1 CA2850391A CA2850391A CA2850391A1 CA 2850391 A1 CA2850391 A1 CA 2850391A1 CA 2850391 A CA2850391 A CA 2850391A CA 2850391 A CA2850391 A CA 2850391A CA 2850391 A1 CA2850391 A1 CA 2850391A1
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CA
Canada
Prior art keywords
ammonia
subject
ammonia level
blood ammonia
dosage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CA2850391A
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English (en)
French (fr)
Inventor
Bruce Scharschmidt
Masoud MOKHTARANI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Horizon Therapeutics LLC
Original Assignee
Horizon Therapeutics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47892277&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2850391(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Horizon Therapeutics LLC filed Critical Horizon Therapeutics LLC
Publication of CA2850391A1 publication Critical patent/CA2850391A1/en
Withdrawn legal-status Critical Current

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G01N31/22Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
    • G01N31/221Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating pH value
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/49Blood
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/49Blood
    • G01N33/4925Blood measuring blood gas content, e.g. O2, CO2, HCO3
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/04Endocrine or metabolic disorders
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/08Hepato-biliairy disorders other than hepatitis
    • G01N2800/085Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/17Nitrogen containing
    • Y10T436/173845Amine and quaternary ammonium
    • Y10T436/175383Ammonia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Emergency Medicine (AREA)
  • Biophysics (AREA)
  • Ecology (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Inorganic Chemistry (AREA)
  • Cell Biology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
CA2850391A 2011-09-30 2012-03-09 Methods of therapeutic monitoring of nitrogen scavenging drugs Withdrawn CA2850391A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161542100P 2011-09-30 2011-09-30
US61/542,100 2011-09-30
US201161564668P 2011-11-29 2011-11-29
US61/564,668 2011-11-29
PCT/US2012/028620 WO2013048558A2 (en) 2011-09-30 2012-03-09 Methods of therapeutic monitoring of nitrogen scavenging drugs

Publications (1)

Publication Number Publication Date
CA2850391A1 true CA2850391A1 (en) 2013-04-04

Family

ID=47892277

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2850391A Withdrawn CA2850391A1 (en) 2011-09-30 2012-03-09 Methods of therapeutic monitoring of nitrogen scavenging drugs

Country Status (25)

Country Link
US (21) US8404215B1 (enExample)
EP (2) EP2760479B1 (enExample)
JP (2) JP6073898B2 (enExample)
KR (2) KR20140094517A (enExample)
CN (2) CN107271696A (enExample)
AU (2) AU2012316750B2 (enExample)
BR (1) BR112014007357B1 (enExample)
CA (1) CA2850391A1 (enExample)
CL (1) CL2014000783A1 (enExample)
CY (1) CY1119028T1 (enExample)
DK (1) DK2760479T3 (enExample)
ES (1) ES2629859T3 (enExample)
HR (1) HRP20171063T1 (enExample)
HU (1) HUE035220T2 (enExample)
IL (2) IL231732A (enExample)
LT (1) LT2760479T (enExample)
MX (2) MX366197B (enExample)
PL (1) PL2760479T3 (enExample)
PT (1) PT2760479T (enExample)
RS (1) RS56196B1 (enExample)
SG (1) SG11201400781TA (enExample)
SI (1) SI2760479T1 (enExample)
SM (1) SMT201700321T1 (enExample)
WO (1) WO2013048558A2 (enExample)
ZA (1) ZA201401851B (enExample)

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Publication number Publication date
PL2760479T3 (pl) 2017-09-29
US20180221325A1 (en) 2018-08-09
US20180263949A1 (en) 2018-09-20
US20180021291A1 (en) 2018-01-25
AU2012316750B2 (en) 2017-08-31
EP3263102A1 (en) 2018-01-03
US10183002B2 (en) 2019-01-22
DK2760479T3 (en) 2017-07-17
IL231732A (en) 2017-09-28
US10183003B2 (en) 2019-01-22
MX366197B (es) 2019-06-25
ES2629859T3 (es) 2017-08-16
JP2017067791A (ja) 2017-04-06
US8404215B1 (en) 2013-03-26
JP2014532179A (ja) 2014-12-04
CN107271696A (zh) 2017-10-20
MX2019006900A (es) 2019-09-04
US20180221327A1 (en) 2018-08-09
US10183006B2 (en) 2019-01-22
US20130210914A1 (en) 2013-08-15
SG11201400781TA (en) 2014-04-28
US9095559B2 (en) 2015-08-04
RS56196B1 (sr) 2017-11-30
US9254278B2 (en) 2016-02-09
US20160202240A1 (en) 2016-07-14
EP2760479A4 (en) 2015-08-26
HRP20171063T1 (hr) 2017-10-06
US9962359B2 (en) 2018-05-08
AU2017251691A1 (en) 2017-11-09
LT2760479T (lt) 2017-07-10
US20160199333A1 (en) 2016-07-14
MX2014003854A (es) 2014-10-17
BR112014007357B1 (pt) 2022-12-06
US10183004B2 (en) 2019-01-22
US20160081969A1 (en) 2016-03-24
US10617665B2 (en) 2020-04-14
ZA201401851B (en) 2018-05-30
US20190125713A1 (en) 2019-05-02
KR102019000B1 (ko) 2019-09-05
PT2760479T (pt) 2017-07-21
US20160199332A1 (en) 2016-07-14
US20180221326A1 (en) 2018-08-09
JP6073898B2 (ja) 2017-02-01
CY1119028T1 (el) 2018-01-10
EP2760479B1 (en) 2017-05-03
CL2014000783A1 (es) 2015-01-16
US20210000784A1 (en) 2021-01-07
US9326966B2 (en) 2016-05-03
US10045958B1 (en) 2018-08-14
US9999608B2 (en) 2018-06-19
WO2013048558A3 (en) 2014-04-03
US20160199334A1 (en) 2016-07-14
BR112014007357A2 (pt) 2017-04-04
KR20180085823A (ko) 2018-07-27
US20180021293A1 (en) 2018-01-25
JP6425746B2 (ja) 2018-11-21
US20180221324A1 (en) 2018-08-09
US20130085179A1 (en) 2013-04-04
SI2760479T1 (sl) 2017-07-31
US20180235920A1 (en) 2018-08-23
US10045959B1 (en) 2018-08-14
US20180263948A1 (en) 2018-09-20
KR20140094517A (ko) 2014-07-30
US20150335605A1 (en) 2015-11-26
EP2760479A2 (en) 2014-08-06
IL231732A0 (en) 2014-05-28
US9962358B2 (en) 2018-05-08
AU2012316750A1 (en) 2014-03-27
US20180055807A1 (en) 2018-03-01
US10183005B2 (en) 2019-01-22
CN104039358A (zh) 2014-09-10
SMT201700321T1 (it) 2017-09-07
US20180015064A1 (en) 2018-01-18
HUE035220T2 (hu) 2018-05-02
WO2013048558A2 (en) 2013-04-04
IL254134A0 (en) 2017-10-31

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US10617665B2 (en) Methods of therapeutic monitoring of nitrogen scavenging drugs

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