CA2849409A1 - Anti-tumor necrosis factor-alpha agents and uses thereof - Google Patents
Anti-tumor necrosis factor-alpha agents and uses thereof Download PDFInfo
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- CA2849409A1 CA2849409A1 CA2849409A CA2849409A CA2849409A1 CA 2849409 A1 CA2849409 A1 CA 2849409A1 CA 2849409 A CA2849409 A CA 2849409A CA 2849409 A CA2849409 A CA 2849409A CA 2849409 A1 CA2849409 A1 CA 2849409A1
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/567—Framework region [FR]
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- C07K—PEPTIDES
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/42—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a HA(hemagglutinin)-tag
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
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- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
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- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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| US201161538548P | 2011-09-23 | 2011-09-23 | |
| US61/538,548 | 2011-09-23 | ||
| PCT/PT2012/000035 WO2013043070A2 (en) | 2011-09-23 | 2012-09-19 | Anti-tumor necrosis factor-alpha agents and uses thereof |
Publications (1)
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| CA2849409A1 true CA2849409A1 (en) | 2013-03-28 |
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| CN103906765A (zh) * | 2011-09-23 | 2014-07-02 | 抗菌技术生物技术研究与发展股份有限公司 | 抗肿瘤坏死因子-α试剂及其用途 |
| US9119832B2 (en) | 2014-02-05 | 2015-09-01 | The Regents Of The University Of California | Methods of treating mild brain injury |
| DE102014112212A1 (de) * | 2014-08-26 | 2016-03-03 | Akesion Gmbh | Rekombinante Fusionsproteine zur Vorbeugung oder Behandlung von Adhäsionen bei Geweben oder Organen |
| WO2016144978A1 (en) * | 2015-03-09 | 2016-09-15 | Oxeia Biopharmaceuticals, Inc. | Methods of treating cognitive impairments or dysfunction |
| WO2017136807A1 (en) * | 2016-02-05 | 2017-08-10 | The Board Of Regents Of The University Of Texas System | Egfl6 specific monoclonal antibodies and methods of their use |
| US20200033363A1 (en) * | 2017-03-27 | 2020-01-30 | Garvan Institute Of Medical Research | Screening methods |
| JP2020530453A (ja) | 2017-08-09 | 2020-10-22 | マサチューセッツ インスティテュート オブ テクノロジー | アルブミン結合ペプチド結合体及びその方法 |
| CN110066337B (zh) * | 2019-05-16 | 2022-06-21 | 艾柏森(江苏)生物科技有限公司 | 一种抗TNF-α抗体 |
| US11224858B1 (en) | 2020-10-01 | 2022-01-18 | Immunicom, Inc. | Reduced leaching of a ligand |
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| CN118930648B (zh) * | 2024-08-22 | 2025-02-28 | 武汉爱博泰克生物科技有限公司 | 抗人pax8蛋白的兔单克隆抗体、抗体偶联物及其应用 |
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| DE3378250D1 (en) | 1982-04-22 | 1988-11-24 | Ici Plc | Continuous release formulations |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| US5128326A (en) | 1984-12-06 | 1992-07-07 | Biomatrix, Inc. | Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same |
| US5336603A (en) | 1987-10-02 | 1994-08-09 | Genentech, Inc. | CD4 adheson variants |
| US6267964B1 (en) | 1989-08-01 | 2001-07-31 | Affibody Technology Sweden Ab | Stabilized protein or peptide conjugates able to bond albumin having extended biological half-lives |
| SE509359C2 (sv) | 1989-08-01 | 1999-01-18 | Cemu Bioteknik Ab | Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel |
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| SE9002213D0 (sv) | 1990-06-21 | 1990-06-21 | Hightech Receptor Ab | Albumin binding proteins |
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| DE69110032T2 (de) | 1991-06-08 | 1995-12-21 | Hewlett Packard Gmbh | Verfahren und Gerät zur Feststellung und/oder Konzentrationsbestimmung von Biomolekülen. |
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| EP0983303B1 (en) * | 1997-05-21 | 2006-03-08 | Biovation Limited | Method for the production of non-immunogenic proteins |
| US5989463A (en) | 1997-09-24 | 1999-11-23 | Alkermes Controlled Therapeutics, Inc. | Methods for fabricating polymer-based controlled release devices |
| SE512663C2 (sv) | 1997-10-23 | 2000-04-17 | Biogram Ab | Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer |
| JP2002518663A (ja) | 1998-05-20 | 2002-06-25 | グラッフィニティ ファルマシューティカル デザイン ゲーエムベーハー | 液体状態で存在する多数の試料を同時に測定するためのsprセンサー |
| US6289286B1 (en) | 1998-05-29 | 2001-09-11 | Biacore Ab | Surface regeneration of biosensors and characterization of biomolecules associated therewith |
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| DE05733048T1 (de) | 2004-04-06 | 2007-05-10 | Affibody Ab | Serumalbuminbindende peptidkonjugate zur arzneimittelherstellung |
| CN103254309B (zh) | 2005-05-18 | 2017-09-26 | 埃博灵克斯股份有限公司 | 针对肿瘤坏死因子α的改进的纳米体TM |
| BRPI0707425A2 (pt) | 2006-02-01 | 2011-05-03 | Arana Therapeutics Ltd | construção de anticorpo de domìnio, molécula isolada de ácido nucleico, composição farmacêutica, e, métodos para detectar tnf-alfa humano em uma amostra, e para tratar um distúrbio |
| US20110319597A1 (en) * | 2008-08-14 | 2011-12-29 | Caphalon Australia Pty. Ltd. | Variant domain antibodies |
| US9393304B2 (en) | 2008-10-29 | 2016-07-19 | Ablynx N.V. | Formulations of single domain antigen binding molecules |
| US20110195404A1 (en) | 2010-02-10 | 2011-08-11 | Selinfreund Richard H | Systems and methods for determining calcium levels |
| AU2012237287B2 (en) | 2011-03-30 | 2016-09-08 | Ablynx Nv | Methods of treating immune disorders with single domain antibodies against TNF-alpha |
| CN103906765A (zh) * | 2011-09-23 | 2014-07-02 | 抗菌技术生物技术研究与发展股份有限公司 | 抗肿瘤坏死因子-α试剂及其用途 |
-
2012
- 2012-09-19 CN CN201280053629.1A patent/CN103906765A/zh active Pending
- 2012-09-19 AU AU2012310328A patent/AU2012310328A1/en not_active Abandoned
- 2012-09-19 SG SG10201504605RA patent/SG10201504605RA/en unknown
- 2012-09-19 BR BR112014006929A patent/BR112014006929A2/pt active Search and Examination
- 2012-09-19 JP JP2014531755A patent/JP2014530001A/ja active Pending
- 2012-09-19 CA CA2849409A patent/CA2849409A1/en not_active Abandoned
- 2012-09-19 SG SG11201400879SA patent/SG11201400879SA/en unknown
- 2012-09-19 WO PCT/PT2012/000035 patent/WO2013043070A2/en not_active Ceased
- 2012-09-19 US US14/346,151 patent/US9399678B2/en not_active Expired - Fee Related
- 2012-09-19 EP EP12783676.5A patent/EP2758434A2/en not_active Ceased
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2016
- 2016-07-22 US US15/217,495 patent/US20170137510A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BR112014006929A2 (pt) | 2017-04-04 |
| CN103906765A (zh) | 2014-07-02 |
| EP2758434A2 (en) | 2014-07-30 |
| AU2012310328A2 (en) | 2014-05-22 |
| US9399678B2 (en) | 2016-07-26 |
| SG10201504605RA (en) | 2015-07-30 |
| WO2013043070A3 (en) | 2013-07-25 |
| US20150037349A1 (en) | 2015-02-05 |
| US20170137510A1 (en) | 2017-05-18 |
| JP2014530001A (ja) | 2014-11-17 |
| SG11201400879SA (en) | 2014-04-28 |
| AU2012310328A1 (en) | 2014-04-10 |
| WO2013043070A9 (en) | 2014-05-08 |
| WO2013043070A2 (en) | 2013-03-28 |
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