CA2847204A1 - Adjuvanted formulations of staphylococcus aureus antigens - Google Patents
Adjuvanted formulations of staphylococcus aureus antigens Download PDFInfo
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- CA2847204A1 CA2847204A1 CA2847204A CA2847204A CA2847204A1 CA 2847204 A1 CA2847204 A1 CA 2847204A1 CA 2847204 A CA2847204 A CA 2847204A CA 2847204 A CA2847204 A CA 2847204A CA 2847204 A1 CA2847204 A1 CA 2847204A1
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- antigen
- tlr agonist
- polypeptide
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- A—HUMAN NECESSITIES
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- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
Landscapes
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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- Peptides Or Proteins (AREA)
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| US201261607999P | 2012-03-07 | 2012-03-07 | |
| US61/607,999 | 2012-03-07 | ||
| PCT/EP2012/067032 WO2013030378A1 (en) | 2011-09-01 | 2012-08-31 | Adjuvanted formulations of staphylococcus aureus antigens |
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| US8859489B2 (en) * | 2009-04-03 | 2014-10-14 | Momenta Pharmaceuticals, Inc. | Water-mediated control of depolymerization step of glatiramer acetate synthesis |
| BR112012004806B8 (pt) | 2009-09-02 | 2022-10-04 | Novartis Ag | composições imunogênicas que incluem moduladores da atividade de tlr, método para aumento da eficácia da referida composição e uso |
| ES2458355T3 (es) | 2010-09-01 | 2014-05-05 | Novartis Ag | Adsorción de inmunopotenciadores sobre sales metálicas insolubles |
| WO2012109167A1 (en) | 2011-02-08 | 2012-08-16 | Integrated Biotherapeutics, Inc. | Immunogenic composition comprising alpha-hemolysin oligopeptides |
| US20140112950A1 (en) | 2011-03-02 | 2014-04-24 | Manmohan Singh | Combination vaccines with lower doses of antigen and/or adjuvant |
| RU2014112343A (ru) * | 2011-09-01 | 2015-10-10 | Новартис Аг | Оставы антигенов staphylococcus aureus, содержащие адъюванты |
| HUE030175T2 (en) * | 2012-03-07 | 2017-04-28 | Glaxosmithkline Biologicals Sa | Arginine salt of TLR7 agonist |
| CN104159602B (zh) | 2012-03-08 | 2017-10-24 | 葛兰素史密丝克莱恩生物有限公司 | 加强疫苗的含佐剂制剂 |
| US20150191513A1 (en) * | 2012-08-31 | 2015-07-09 | Novartis Ag | Stabilised proteins for immunising against staphylococcus aureus |
| EP2890387A1 (en) * | 2012-08-31 | 2015-07-08 | Novartis AG | Stabilised proteins for immunising against staphylococcus aureus |
| HRP20191166T1 (hr) * | 2012-08-31 | 2019-10-04 | Glaxosmithkline Biologicals Sa | Stabilizirani proteini, namijenjeni imuniziranju protiv bakterije staphylococcus aureus |
| BE1022359B1 (fr) * | 2014-03-17 | 2016-03-25 | Glaxosmithkline Biologicals Sa | Immunisation contre des infections staphylococciques des os et des articulations |
| WO2015144691A1 (en) * | 2014-03-26 | 2015-10-01 | Glaxosmithkline Biologicals Sa | Compositions for immunising against staphylococcus aureus |
| ES2769647T3 (es) * | 2014-03-26 | 2020-06-26 | Glaxosmithkline Biologicals Sa | Antígenos estafilocócicos mutantes |
| CN105646681B (zh) * | 2016-01-21 | 2021-07-16 | 浙江海隆生物科技有限公司 | 一种奶牛金黄色葡萄球菌α-溶血素亚单位疫苗的制备方法及应用 |
| ES2990113T3 (es) | 2016-07-07 | 2024-11-28 | The Board Of Trustees Of The Leland Stanfordjunior Univ | Conjugados de adyuvantes de anticuerpos |
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| CN113993549A (zh) | 2019-03-15 | 2022-01-28 | 博尔特生物治疗药物有限公司 | 靶向her2的免疫缀合物 |
Family Cites Families (52)
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| ATE67769T1 (de) | 1983-01-25 | 1991-10-15 | Ciba Geigy Ag | Neue peptidderivate. |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| SK117395A3 (en) | 1993-03-23 | 1996-11-06 | Smithkline Beecham Biolog | Vaccine composition and manufacturing process thereof |
| KR20060065643A (ko) | 2003-07-24 | 2006-06-14 | 머크 앤드 캄파니 인코포레이티드 | 스타필로코쿠스 아우레우스에 대한 방어 면역 반응을유도하는 폴리펩타이드 |
| US20060188515A1 (en) | 2003-07-24 | 2006-08-24 | Anderson Annaliesa S | Polypeptides for inducing a protective immune response against staphylococcus aureus |
| JP2007528217A (ja) | 2004-02-18 | 2007-10-11 | メルク エンド カムパニー インコーポレーテッド | スタヒロコッカス・アウレウスに対する防御免疫応答を誘導するためのポリペプチド |
| TWI382019B (zh) | 2005-08-19 | 2013-01-11 | Array Biopharma Inc | 作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之胺基二氮雜呯 |
| TW200801003A (en) | 2005-09-16 | 2008-01-01 | Astrazeneca Ab | Novel compounds |
| US20090192153A1 (en) | 2005-09-22 | 2009-07-30 | Dainippon Sumitomo Pharma Co., Ltd. a corporation of Japan | Novel adenine compound |
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| EP1939202A4 (en) | 2005-09-22 | 2010-06-16 | Dainippon Sumitomo Pharma Co | NEW COMPOUND OF ADENINE |
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| WO2007093901A1 (en) | 2006-02-17 | 2007-08-23 | Pfizer Limited | 3 -deazapurine derivatives as tlr7 modulators |
| KR20090019007A (ko) | 2006-06-12 | 2009-02-24 | 나비 바이오파마슈티컬즈 | 스타필로코쿠스 감염증을 치료 및 예방하기 위한 알파-독소의 용도 |
| WO2008004948A1 (en) | 2006-07-05 | 2008-01-10 | Astrazeneca Ab | 8-oxoadenine derivatives acting as modulators of tlr7 |
| AR061839A1 (es) | 2006-07-07 | 2008-09-24 | Gilead Sciences Inc | Compuestos y composiciones farmaceuticas que activan selectivamente a receptores tipo toll 7(tlr7), y uso de los mismos como agentes antivirales |
| WO2008152447A2 (en) | 2006-10-30 | 2008-12-18 | The University Of Western Ontario | Staphylococcus aureus specific anti-infectives |
| HRP20110115T1 (hr) | 2007-02-19 | 2011-03-31 | Glaxosmithkline Llc | Derivati purina kao imunomodulatori |
| PE20081887A1 (es) | 2007-03-20 | 2009-01-16 | Dainippon Sumitomo Pharma Co | Nuevo compuesto de adenina |
| JP5400763B2 (ja) | 2007-05-08 | 2014-01-29 | アストラゼネカ・アクチエボラーグ | 免疫調節特性を有するイミダゾキノリン類 |
| JP2010535755A (ja) | 2007-08-03 | 2010-11-25 | ファイザー・リミテッド | イミダゾピリジノン |
| WO2009029831A1 (en) | 2007-08-31 | 2009-03-05 | University Of Chicago | Methods and compositions related to immunizing against staphylococcal lung diseases and conditions |
| PE20091236A1 (es) | 2007-11-22 | 2009-09-16 | Astrazeneca Ab | Derivados de pirimidina como immunomoduladores de tlr7 |
| SI2268618T1 (sl) | 2008-03-03 | 2015-09-30 | Novartis Ag | Spojine in sestavki kot modulatorji aktivnosti TLR |
| NZ588183A (en) | 2008-03-24 | 2012-05-25 | 4Sc Discovery Gmbh | Novel substituted imidazoquinolines |
| CA2732437C (en) | 2008-08-01 | 2017-11-21 | Ventirx Pharmaceuticals, Inc. | Toll-like receptor agonist formulations and their use |
| BRPI0923305B1 (pt) | 2008-12-09 | 2019-01-22 | Gilead Sciences Inc | moduladores de receptores toll-like, seu uso e composição farmacêutica que os compreende |
| US8679505B2 (en) * | 2009-04-14 | 2014-03-25 | Novartis Ag | Compositions for immunising against Staphylococcus aureus |
| HUE036372T2 (hu) * | 2009-06-22 | 2018-07-30 | Wyeth Llc | Staphylococcus aureus antigének immunogén készítményei |
| EP2453915B1 (en) | 2009-07-16 | 2017-04-19 | The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin | Treatment of infections |
| GB0913681D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| GB0913680D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| BR112012004806B8 (pt) * | 2009-09-02 | 2022-10-04 | Novartis Ag | composições imunogênicas que incluem moduladores da atividade de tlr, método para aumento da eficácia da referida composição e uso |
| TWI445708B (zh) * | 2009-09-02 | 2014-07-21 | Irm Llc | 作為ｔｌｒ活性調節劑之化合物及組合物 |
| CA2792938C (en) | 2010-03-23 | 2018-07-31 | Irm Llc | Compounds (cystein based lipopeptides) and compositions as tlr2 agonists used for treating infections, inflammations, respiratory diseases etc. |
| ES2458355T3 (es) | 2010-09-01 | 2014-05-05 | Novartis Ag | Adsorción de inmunopotenciadores sobre sales metálicas insolubles |
| US20140112950A1 (en) * | 2011-03-02 | 2014-04-24 | Manmohan Singh | Combination vaccines with lower doses of antigen and/or adjuvant |
| RU2014112343A (ru) * | 2011-09-01 | 2015-10-10 | Новартис Аг | Оставы антигенов staphylococcus aureus, содержащие адъюванты |
| US20150132339A1 (en) * | 2012-03-07 | 2015-05-14 | Novartis Ag | Adjuvanted formulations of streptococcus pneumoniae antigens |
| CN104159602B (zh) * | 2012-03-08 | 2017-10-24 | 葛兰素史密丝克莱恩生物有限公司 | 加强疫苗的含佐剂制剂 |
| WO2013132043A1 (en) * | 2012-03-08 | 2013-09-12 | Novartis Ag | Combination vaccines with tlr4 agonists |
| EP2890395A1 (en) * | 2012-08-31 | 2015-07-08 | Novartis AG | Stabilised proteins for immunising against staphylococcus aureus |
| EP2890387A1 (en) * | 2012-08-31 | 2015-07-08 | Novartis AG | Stabilised proteins for immunising against staphylococcus aureus |
| HRP20191166T1 (hr) * | 2012-08-31 | 2019-10-04 | Glaxosmithkline Biologicals Sa | Stabilizirani proteini, namijenjeni imuniziranju protiv bakterije staphylococcus aureus |
| US20150191513A1 (en) * | 2012-08-31 | 2015-07-09 | Novartis Ag | Stabilised proteins for immunising against staphylococcus aureus |
| BR112015005056A2 (pt) * | 2012-09-06 | 2017-11-21 | Novartis Ag | vacinas de combinação com sorogrupo b meningococcus e d/t/p |
| GB201219420D0 (en) * | 2012-10-29 | 2012-12-12 | Novartis Ag | Staphyloccal immunogens |
| EP2950819B1 (en) * | 2013-02-01 | 2018-03-28 | GlaxoSmithKline Biologicals SA | Intradermal delivery of immunological compositions comprising toll-like receptor agonists |
| BE1022359B1 (fr) * | 2014-03-17 | 2016-03-25 | Glaxosmithkline Biologicals Sa | Immunisation contre des infections staphylococciques des os et des articulations |
| WO2015144691A1 (en) * | 2014-03-26 | 2015-10-01 | Glaxosmithkline Biologicals Sa | Compositions for immunising against staphylococcus aureus |
| ES2769647T3 (es) * | 2014-03-26 | 2020-06-26 | Glaxosmithkline Biologicals Sa | Antígenos estafilocócicos mutantes |
-
2012
- 2012-08-31 RU RU2014112343/10A patent/RU2014112343A/ru not_active Application Discontinuation
- 2012-08-31 CN CN201280053918.1A patent/CN104093418A/zh active Pending
- 2012-08-31 MX MX2014002363A patent/MX2014002363A/es unknown
- 2012-08-31 EP EP12753488.1A patent/EP2763695A1/en not_active Withdrawn
- 2012-08-31 IN IN2152CHN2014 patent/IN2014CN02152A/en unknown
- 2012-08-31 US US14/240,616 patent/US20140363461A1/en not_active Abandoned
- 2012-08-31 SG SG11201400210RA patent/SG11201400210RA/en unknown
- 2012-08-31 KR KR1020147008622A patent/KR20140066212A/ko not_active Withdrawn
- 2012-08-31 CA CA2847204A patent/CA2847204A1/en not_active Abandoned
- 2012-08-31 BR BR112014004782A patent/BR112014004782A2/pt not_active IP Right Cessation
- 2012-08-31 AU AU2012300765A patent/AU2012300765A1/en not_active Abandoned
- 2012-08-31 WO PCT/EP2012/067032 patent/WO2013030378A1/en not_active Ceased
- 2012-08-31 JP JP2014527686A patent/JP2014525429A/ja active Pending
-
2014
- 2014-02-24 IL IL231104A patent/IL231104A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG11201400210RA (en) | 2014-03-28 |
| CN104093418A (zh) | 2014-10-08 |
| RU2014112343A (ru) | 2015-10-10 |
| KR20140066212A (ko) | 2014-05-30 |
| EP2763695A1 (en) | 2014-08-13 |
| US20140363461A1 (en) | 2014-12-11 |
| IN2014CN02152A (enExample) | 2015-09-04 |
| MX2014002363A (es) | 2014-04-14 |
| AU2012300765A1 (en) | 2014-03-13 |
| BR112014004782A2 (pt) | 2017-03-21 |
| IL231104A0 (en) | 2014-04-30 |
| WO2013030378A1 (en) | 2013-03-07 |
| JP2014525429A (ja) | 2014-09-29 |
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| Date | Code | Title | Description |
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| FZDE | Discontinued |
Effective date: 20170831 |