CA2847057C - Methods and compositions to detect the level of lysosomal exocytosis activity and methods of use - Google Patents

Methods and compositions to detect the level of lysosomal exocytosis activity and methods of use Download PDF

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Publication number
CA2847057C
CA2847057C CA2847057A CA2847057A CA2847057C CA 2847057 C CA2847057 C CA 2847057C CA 2847057 A CA2847057 A CA 2847057A CA 2847057 A CA2847057 A CA 2847057A CA 2847057 C CA2847057 C CA 2847057C
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activity
neu1
lysosomal
level
cancer
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CA2847057A1 (en
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Ida ANNUNZIATA
Alessandra D'azzo
Shai WHITE-GILBERTSON
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St Jude Childrens Research Hospital
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
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    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/40—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4813—Exopeptidases (3.4.11. to 3.4.19)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
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    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01018—Exo-alpha-sialidase (3.2.1.18), i.e. trans-sialidase
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    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/16—Serine-type carboxypeptidases (3.4.16)
    • C12Y304/16005—Carboxypeptidase C (3.4.16.5), i.e. carboxypeptidase Y
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
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    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/57595—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving intracellular compounds
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    • G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)
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  • Animal Behavior & Ethology (AREA)
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CA2847057A 2011-08-31 2012-08-28 Methods and compositions to detect the level of lysosomal exocytosis activity and methods of use Active CA2847057C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161529675P 2011-08-31 2011-08-31
US61/529,675 2011-08-31
US201161544855P 2011-10-07 2011-10-07
US61/544,855 2011-10-07
PCT/US2012/052629 WO2013033074A2 (en) 2011-08-31 2012-08-28 Methods and compositions to detect the level of lysosomal exocytosis activity and methods of use

Publications (2)

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CA2847057A1 CA2847057A1 (en) 2013-03-07
CA2847057C true CA2847057C (en) 2019-06-11

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US (5) US9399791B2 (https=)
EP (1) EP2751279B1 (https=)
JP (1) JP6228121B2 (https=)
AU (1) AU2012300252B2 (https=)
CA (1) CA2847057C (https=)
CY (1) CY1119689T1 (https=)
DK (1) DK2751279T3 (https=)
ES (1) ES2653918T3 (https=)
HR (1) HRP20171909T1 (https=)
HU (1) HUE037829T2 (https=)
LT (1) LT2751279T (https=)
PL (1) PL2751279T3 (https=)
PT (1) PT2751279T (https=)
SI (1) SI2751279T1 (https=)
WO (1) WO2013033074A2 (https=)

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WO2013033074A2 (en) * 2011-08-31 2013-03-07 St. Jude Children's Research Hospital Methods and compositions to detect the level of lysosomal exocytosis activity and methods of use
CA2882730C (en) 2012-08-22 2019-12-31 Arbor Pharmaceuticals, Llc Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof
US10945984B2 (en) 2012-08-22 2021-03-16 Arbor Pharmaceuticals, Llc Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects
US10179118B2 (en) 2013-03-24 2019-01-15 Arbor Pharmaceuticals, Llc Pharmaceutical compositions of dimethyl fumarate
US9302977B2 (en) 2013-06-07 2016-04-05 Xenoport, Inc. Method of making monomethyl fumarate
US9421182B2 (en) 2013-06-21 2016-08-23 Xenoport, Inc. Cocrystals of dimethyl fumarate
US9416096B2 (en) 2013-09-06 2016-08-16 Xenoport, Inc. Crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, methods of synthesis and use
US9999672B2 (en) 2014-03-24 2018-06-19 Xenoport, Inc. Pharmaceutical compositions of fumaric acid esters
US10695338B2 (en) 2015-05-07 2020-06-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Cancer treatment via repositioned tricyclic anti-depressant-like drugs as anti-cancer agents and new combinations of such drugs
WO2017075540A1 (en) * 2015-10-30 2017-05-04 Ultragenyx Pharmaceutical Inc. Methods and compositions for the treatment of amyloidosis
CN109312364A (zh) * 2016-03-18 2019-02-05 河谷细胞有限公司 用于感染树突状细胞的多模式载体
BR112019013843A2 (pt) * 2017-01-04 2020-01-28 Ericsson Telefon Ab L M método e estação base para transmitir informações do sistema, método e equipamento de usuário para receber informações do sistema e meio de armazenagem legível por computador
JP7537762B2 (ja) 2019-07-05 2024-08-21 国立大学法人徳島大学 改変ノイラミニダーゼ
JP2025504704A (ja) * 2022-01-31 2025-02-14 センス リサーチ ファウンデーション 老化細胞表面マーカー

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