CA2831465C - Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly - Google Patents
Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly Download PDFInfo
- Publication number
- CA2831465C CA2831465C CA2831465A CA2831465A CA2831465C CA 2831465 C CA2831465 C CA 2831465C CA 2831465 A CA2831465 A CA 2831465A CA 2831465 A CA2831465 A CA 2831465A CA 2831465 C CA2831465 C CA 2831465C
- Authority
- CA
- Canada
- Prior art keywords
- oxygen
- gas
- carbon dioxide
- rbcs
- sensor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 title claims abstract description 188
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title claims abstract description 131
- 239000001301 oxygen Substances 0.000 title claims abstract description 131
- 229910052760 oxygen Inorganic materials 0.000 title claims abstract description 131
- 229910002092 carbon dioxide Inorganic materials 0.000 title claims abstract description 94
- 239000001569 carbon dioxide Substances 0.000 title claims abstract description 81
- 239000008280 blood Substances 0.000 title claims abstract description 54
- 210000004369 blood Anatomy 0.000 title claims abstract description 53
- 238000012545 processing Methods 0.000 title claims abstract description 15
- 238000000034 method Methods 0.000 title claims description 37
- 239000012159 carrier gas Substances 0.000 title description 3
- 239000007789 gas Substances 0.000 claims abstract description 123
- 210000003743 erythrocyte Anatomy 0.000 claims abstract description 97
- 238000011010 flushing procedure Methods 0.000 claims abstract description 34
- 238000004891 communication Methods 0.000 claims abstract description 16
- 239000012530 fluid Substances 0.000 claims abstract description 9
- 238000000429 assembly Methods 0.000 claims description 19
- 230000000712 assembly Effects 0.000 claims description 19
- 239000002594 sorbent Substances 0.000 claims description 16
- 230000001954 sterilising effect Effects 0.000 claims description 15
- 238000004659 sterilization and disinfection Methods 0.000 claims description 15
- 239000000654 additive Substances 0.000 claims description 11
- 230000000996 additive effect Effects 0.000 claims description 10
- 210000004027 cell Anatomy 0.000 claims description 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 4
- 102000001554 Hemoglobins Human genes 0.000 claims description 2
- 108010054147 Hemoglobins Proteins 0.000 claims description 2
- 238000000151 deposition Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 description 14
- 239000011261 inert gas Substances 0.000 description 13
- 239000003570 air Substances 0.000 description 12
- 239000012510 hollow fiber Substances 0.000 description 11
- 210000000265 leukocyte Anatomy 0.000 description 10
- 238000002360 preparation method Methods 0.000 description 8
- 239000000835 fiber Substances 0.000 description 6
- 238000000926 separation method Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 4
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 3
- 229930024421 Adenine Natural products 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 229960000643 adenine Drugs 0.000 description 3
- UBAZGMLMVVQSCD-UHFFFAOYSA-N carbon dioxide;molecular oxygen Chemical compound O=O.O=C=O UBAZGMLMVVQSCD-UHFFFAOYSA-N 0.000 description 3
- 239000000306 component Substances 0.000 description 3
- 239000008121 dextrose Substances 0.000 description 3
- 235000019799 monosodium phosphate Nutrition 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 3
- 229910000162 sodium phosphate Inorganic materials 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical group [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 239000012080 ambient air Substances 0.000 description 2
- 210000000601 blood cell Anatomy 0.000 description 2
- 238000004555 blood preservation Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 150000002484 inorganic compounds Chemical class 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 150000002894 organic compounds Chemical class 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 1
- 208000003441 Transfusion reaction Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000010836 blood and blood product Substances 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 229940125691 blood product Drugs 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 230000000779 depleting effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 210000004180 plasmocyte Anatomy 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0209—Multiple bag systems for separating or storing blood components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0209—Multiple bag systems for separating or storing blood components
- A61M1/0218—Multiple bag systems for separating or storing blood components with filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0429—Red blood cells; Erythrocytes
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161468377P | 2011-03-28 | 2011-03-28 | |
| US61/468,377 | 2011-03-28 | ||
| PCT/US2012/030930 WO2013022491A1 (en) | 2011-03-28 | 2012-03-28 | Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2831465A1 CA2831465A1 (en) | 2013-02-14 |
| CA2831465C true CA2831465C (en) | 2018-02-27 |
Family
ID=47668769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2831465A Active CA2831465C (en) | 2011-03-28 | 2012-03-28 | Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP2691160A4 (enExample) |
| JP (2) | JP6034362B2 (enExample) |
| CN (2) | CN103492041B (enExample) |
| AU (1) | AU2012294890B2 (enExample) |
| CA (1) | CA2831465C (enExample) |
| WO (1) | WO2013022491A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12089589B2 (en) | 2009-10-12 | 2024-09-17 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
| US11284616B2 (en) | 2010-05-05 | 2022-03-29 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
| US9199016B2 (en) | 2009-10-12 | 2015-12-01 | New Health Sciences, Inc. | System for extended storage of red blood cells and methods of use |
| EP2608816B1 (en) | 2010-08-25 | 2023-07-05 | Hemanext Inc. | Method for enhancing red blood cell quality and survival during storage |
| PT2635114T (pt) | 2010-11-05 | 2020-06-16 | New Health Sciences Inc | Irradiação de glóbulos vermelhos e armazenamento anaeróbico |
| US9067004B2 (en) | 2011-03-28 | 2015-06-30 | New Health Sciences, Inc. | Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly |
| PT3533507T (pt) | 2011-08-10 | 2022-07-25 | Hemanext Inc | Dispositivo de filtragem integrado para depleção de leucócitos, oxigénio e/ou co2 e separação de plasma |
| JP2016517395A (ja) | 2013-02-28 | 2016-06-16 | ニュー・ヘルス・サイエンシーズ・インコーポレイテッドＮｅｗ Ｈｅａｌｔｈ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． | 血液処理のためのガス枯渇化およびガス添加デバイス |
| US10159778B2 (en) | 2014-03-24 | 2018-12-25 | Fenwal, Inc. | Biological fluid filters having flexible walls and methods for making such filters |
| US9968738B2 (en) | 2014-03-24 | 2018-05-15 | Fenwal, Inc. | Biological fluid filters with molded frame and methods for making such filters |
| US9782707B2 (en) | 2014-03-24 | 2017-10-10 | Fenwal, Inc. | Biological fluid filters having flexible walls and methods for making such filters |
| US9796166B2 (en) | 2014-03-24 | 2017-10-24 | Fenwal, Inc. | Flexible biological fluid filters |
| US10376627B2 (en) | 2014-03-24 | 2019-08-13 | Fenwal, Inc. | Flexible biological fluid filters |
| IL299978B2 (en) | 2015-03-10 | 2024-08-01 | Hemanext Inc | Single-use oxygen reduction kits, devices and methods for their use |
| JP7175611B2 (ja) | 2015-04-23 | 2022-11-21 | ヘマネクスト インコーポレイテッド | 嫌気性血液保存容器 |
| ES3042959T3 (en) | 2015-05-18 | 2025-11-24 | Hemanext Inc | Methods for the storage of whole blood, and compositions thereof |
| CA3025619A1 (en) | 2016-05-27 | 2017-11-30 | New Health Sciences, Inc. | Anaerobic blood storage and pathogen inactivation method |
| CN108114334B (zh) * | 2016-11-28 | 2024-01-12 | 健帆生物科技集团股份有限公司 | 血液净化器、血液净化系统及其预冲方法 |
| CN110982665A (zh) * | 2019-11-22 | 2020-04-10 | 上海理工大学 | 循环肿瘤细胞分选及检测用的多通道进样装置及进样方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4831012A (en) * | 1984-03-23 | 1989-05-16 | Baxter International Inc. | Purified hemoglobin solutions and method for making same |
| US4568328A (en) * | 1984-10-29 | 1986-02-04 | Extracorporeal Medical Specialties, Inc. | Automated photophoresis blood portion control methods and apparatus |
| US5102407A (en) * | 1990-03-13 | 1992-04-07 | Miles Inc. | Blood separation system |
| US5624794A (en) * | 1995-06-05 | 1997-04-29 | The Regents Of The University Of California | Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas |
| US6162396A (en) * | 1997-04-26 | 2000-12-19 | The Regents Of The University Of California | Blood storage device and method for oxygen removal |
| DE69837541T2 (de) * | 1997-05-20 | 2007-12-13 | Zymequest, Inc., Beverly | Drehdichtung für Zellbehandlungssysteme |
| WO2000023140A1 (en) * | 1998-10-16 | 2000-04-27 | Mission Medical, Inc. | Blood processing system |
| WO2002026286A2 (en) * | 2000-09-27 | 2002-04-04 | Cobe Cardiovascular, Inc. | Blood perfusion system |
| US20080027368A1 (en) * | 2000-09-27 | 2008-01-31 | Sorin Group Usa, Inc. | Disposable cartridge for a blood perfusion system |
| JP2002173433A (ja) * | 2000-12-04 | 2002-06-21 | Terumo Corp | 白血球除去血液製剤の調製方法および血液セット |
| JP4564260B2 (ja) * | 2001-11-16 | 2010-10-20 | ヒーマネクスト・エルエルシー | 血液保存のための添加溶液 |
| GB0210022D0 (en) * | 2002-05-01 | 2002-06-12 | Air Prod & Chem | Gas dispenser and recovery apparatus |
| US20060081524A1 (en) * | 2004-10-15 | 2006-04-20 | Amitava Sengupta | Membrane contactor and method of making the same |
| US20100221697A1 (en) * | 2005-01-12 | 2010-09-02 | BioVec Transfusions, LLC | Composition for preserving platelets and method of using and storing the same |
| MX2007013196A (es) * | 2005-04-20 | 2008-01-18 | Hutchinson Fred Cancer Res | Metodos, composiciones y articulos de fabricacion para mejorar la supervivencia de celulas, tejidos, organos y organismos. |
| US20120129149A1 (en) * | 2009-07-31 | 2012-05-24 | Federspiel William J | Removal of oxygen from biological fluids |
-
2012
- 2012-03-28 CN CN201280020712.9A patent/CN103492041B/zh active Active
- 2012-03-28 AU AU2012294890A patent/AU2012294890B2/en active Active
- 2012-03-28 EP EP12821624.9A patent/EP2691160A4/en not_active Withdrawn
- 2012-03-28 JP JP2014502746A patent/JP6034362B2/ja active Active
- 2012-03-28 CA CA2831465A patent/CA2831465C/en active Active
- 2012-03-28 WO PCT/US2012/030930 patent/WO2013022491A1/en not_active Ceased
- 2012-03-28 CN CN201611127102.5A patent/CN107096081B/zh active Active
-
2016
- 2016-10-27 JP JP2016210712A patent/JP2017074381A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014516285A (ja) | 2014-07-10 |
| EP2691160A1 (en) | 2014-02-05 |
| CN103492041A (zh) | 2014-01-01 |
| JP6034362B2 (ja) | 2016-11-30 |
| CA2831465A1 (en) | 2013-02-14 |
| CN107096081A (zh) | 2017-08-29 |
| CN103492041B (zh) | 2017-02-08 |
| WO2013022491A1 (en) | 2013-02-14 |
| EP2691160A4 (en) | 2015-04-08 |
| AU2012294890A1 (en) | 2013-10-31 |
| CN107096081B (zh) | 2019-09-06 |
| JP2017074381A (ja) | 2017-04-20 |
| AU2012294890B2 (en) | 2017-05-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20170321 |