CA2829792C - Traitement de l'atrophie vaginale en tant qu'une nouvelle indication de myrrhe - Google Patents
Traitement de l'atrophie vaginale en tant qu'une nouvelle indication de myrrhe Download PDFInfo
- Publication number
- CA2829792C CA2829792C CA2829792A CA2829792A CA2829792C CA 2829792 C CA2829792 C CA 2829792C CA 2829792 A CA2829792 A CA 2829792A CA 2829792 A CA2829792 A CA 2829792A CA 2829792 C CA2829792 C CA 2829792C
- Authority
- CA
- Canada
- Prior art keywords
- myrrh
- vaginal
- treatment
- extract
- vaginal atrophy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 240000007311 Commiphora myrrha Species 0.000 title abstract description 70
- 235000006965 Commiphora myrrha Nutrition 0.000 title abstract description 70
- 235000007265 Myrrhis odorata Nutrition 0.000 title abstract description 62
- 206010003694 Atrophy Diseases 0.000 title abstract description 22
- 230000037444 atrophy Effects 0.000 title abstract description 22
- 206010027304 Menopausal symptoms Diseases 0.000 abstract description 18
- 239000000825 pharmaceutical preparation Substances 0.000 abstract description 14
- 238000000034 method Methods 0.000 abstract description 12
- 239000002552 dosage form Substances 0.000 abstract description 7
- 239000000203 mixture Substances 0.000 description 18
- 239000000284 extract Substances 0.000 description 17
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- 208000024891 symptom Diseases 0.000 description 12
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 10
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 239000004480 active ingredient Substances 0.000 description 6
- 229940081859 myrrh extract Drugs 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 239000003826 tablet Substances 0.000 description 6
- 239000006216 vaginal suppository Substances 0.000 description 6
- 229940044977 vaginal tablet Drugs 0.000 description 6
- 239000000003 vaginal tablet Substances 0.000 description 6
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- AUSAHAHDEVYCOC-DZGCQCFKSA-N (4as,8as)-3,5,8a-trimethyl-4a,9-dihydro-4h-benzo[f][1]benzofuran Chemical compound C([C@]1(C)C2)=CC=C(C)[C@@H]1CC1=C2OC=C1C AUSAHAHDEVYCOC-DZGCQCFKSA-N 0.000 description 4
- BZQURGSQMBBPRU-DZGCQCFKSA-N (4as,8as)-3,8a-dimethyl-5-methylidene-4,4a,6,9-tetrahydrobenzo[f][1]benzofuran Chemical compound C([C@]1(C)C2)=CCC(=C)[C@@H]1CC1=C2OC=C1C BZQURGSQMBBPRU-DZGCQCFKSA-N 0.000 description 4
- AUSAHAHDEVYCOC-UHFFFAOYSA-N 106001-39-2 Natural products C1C2(C)C=CC=C(C)C2CC2=C1OC=C2C AUSAHAHDEVYCOC-UHFFFAOYSA-N 0.000 description 4
- BZQURGSQMBBPRU-ZFWWWQNUSA-N Lindestrene Natural products C=C1[C@H]2[C@@](C)(C=CC1)Cc1occ(C)c1C2 BZQURGSQMBBPRU-ZFWWWQNUSA-N 0.000 description 4
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- 240000003890 Commiphora wightii Species 0.000 description 3
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- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000159174 Commiphora Species 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 229930008672 Furanosesquiterpene Natural products 0.000 description 2
- 206010060800 Hot flush Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 230000003444 anaesthetic effect Effects 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000000843 anti-fungal effect Effects 0.000 description 2
- 239000003240 coconut oil Substances 0.000 description 2
- 235000019864 coconut oil Nutrition 0.000 description 2
- 230000007691 collagen metabolic process Effects 0.000 description 2
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- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
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- 239000007909 solid dosage form Substances 0.000 description 2
- 238000000194 supercritical-fluid extraction Methods 0.000 description 2
- 239000002511 suppository base Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 210000001215 vagina Anatomy 0.000 description 2
- 229940044959 vaginal cream Drugs 0.000 description 2
- 239000000522 vaginal cream Substances 0.000 description 2
- 229940044952 vaginal foam Drugs 0.000 description 2
- 239000000259 vaginal foam Substances 0.000 description 2
- 229940044950 vaginal gel Drugs 0.000 description 2
- 239000000029 vaginal gel Substances 0.000 description 2
- 229940098946 vaginal ointment Drugs 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 244000205574 Acorus calamus Species 0.000 description 1
- 235000006480 Acorus calamus Nutrition 0.000 description 1
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- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 241000159188 Commiphora habessinica Species 0.000 description 1
- 241001033433 Commiphora schimperi Species 0.000 description 1
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- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 1
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- 235000019482 Palm oil Nutrition 0.000 description 1
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 description 1
- 229920002675 Polyoxyl Polymers 0.000 description 1
- 208000004210 Pressure Ulcer Diseases 0.000 description 1
- CWEZAWNPTYBADX-UHFFFAOYSA-N Procyanidin Natural products OC1C(OC2C(O)C(Oc3c2c(O)cc(O)c3C4C(O)C(Oc5cc(O)cc(O)c45)c6ccc(O)c(O)c6)c7ccc(O)c(O)c7)c8c(O)cc(O)cc8OC1c9ccc(O)c(O)c9 CWEZAWNPTYBADX-UHFFFAOYSA-N 0.000 description 1
- 206010049677 Salpingo-oophoritis Diseases 0.000 description 1
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- 208000006011 Stroke Diseases 0.000 description 1
- 244000299461 Theobroma cacao Species 0.000 description 1
- 206010046798 Uterine leiomyoma Diseases 0.000 description 1
- 206010046914 Vaginal infection Diseases 0.000 description 1
- 201000008100 Vaginitis Diseases 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000002192 cholecystectomy Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000002573 colposcopy Methods 0.000 description 1
- 239000001555 commiphora myrrha gum extract Substances 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
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- 150000004665 fatty acids Chemical class 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 230000003325 follicular Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 208000001130 gallstones Diseases 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
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- 230000007774 longterm Effects 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 230000003821 menstrual periods Effects 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
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- 206010029410 night sweats Diseases 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
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- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
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- 229920002414 procyanidin Polymers 0.000 description 1
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- 229940095055 progestogen systemic hormonal contraceptives Drugs 0.000 description 1
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- 150000003722 vitamin derivatives Chemical class 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Gynecology & Obstetrics (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
Abstract
L'invention porte sur une nouvelle indication médicale de myrrhe, à savoir le traitement de l'atrophie vaginale en tant que symptôme ménopausique. L'invention porte en outre sur une préparation pharmaceutique sous forme de dosage vaginal pour le traitement de l'atrophie vaginale et sur un procédé de préparation d'une préparation pharmaceutique contre l'atrophie vaginale en tant que symptôme ménopausique.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/050,225 US8287924B2 (en) | 2011-03-17 | 2011-03-17 | Treatment of menopausal symptoms as novel indication for myrrh |
| EP11158593.1A EP2500026B1 (fr) | 2011-03-17 | 2011-03-17 | Traitement des symptômes de la ménopause en tant que nouvelle indication pour myrrhe |
| US13/050,225 | 2011-03-17 | ||
| EP11158593.1 | 2011-03-17 | ||
| PCT/EP2012/054548 WO2012123539A1 (fr) | 2011-03-17 | 2012-03-15 | Traitement de l'atrophie vaginale en tant qu'une nouvelle indication de myrrhe |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2829792A1 CA2829792A1 (fr) | 2012-09-20 |
| CA2829792C true CA2829792C (fr) | 2017-04-04 |
Family
ID=45929506
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2829792A Active CA2829792C (fr) | 2011-03-17 | 2012-03-15 | Traitement de l'atrophie vaginale en tant qu'une nouvelle indication de myrrhe |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JP5519879B2 (fr) |
| KR (1) | KR20130130034A (fr) |
| AU (1) | AU2012228213B2 (fr) |
| BR (1) | BR112013023092A2 (fr) |
| CA (1) | CA2829792C (fr) |
| CO (1) | CO6771460A2 (fr) |
| MX (1) | MX352788B (fr) |
| WO (1) | WO2012123539A1 (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017126995A1 (fr) | 2016-01-18 | 2017-07-27 | Alessa Nadiah Abdulkarim A | Composition pour le traitement et la prévention d'une infection, d'ulcérations et de boutons causés par le papillomavirus humain hpv |
| EP3813944A1 (fr) * | 2018-06-29 | 2021-05-05 | The Procter & Gamble Company | Compositions pour soins vaginaux |
| CN115066250B (zh) * | 2019-12-15 | 2025-02-18 | 巴诺伊阿玛甘泰伯有限公司 | 草药化合物和治疗感染、外阴阴道和盆腔器官炎症的方法 |
| KR102714551B1 (ko) * | 2023-07-21 | 2024-10-11 | 주식회사 초이랩 | 몰약 추출물을 포함하는 바이오차 조성물 및 항균 및 항바이러스 바이오차 제조방법 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4592912A (en) | 1983-10-31 | 1986-06-03 | Harriet Nickolaus | Ache and pain relieving and preventing composition |
| US4719111A (en) | 1985-06-14 | 1988-01-12 | Wilson Lynn M | Novel composition for treatment of decubitus ulcers |
| JPS63104924A (ja) * | 1986-10-20 | 1988-05-10 | Kanebo Ltd | 膣坐剤 |
| AU630561B2 (en) | 1990-06-12 | 1992-10-29 | Cathy Palou | A therapeutic preparation containing myrrh for treating skin disorders |
| US6350784B1 (en) * | 1996-02-12 | 2002-02-26 | Meryl J. Squires | Antimicrobial prevention and treatment of human immunedeficiency virus and other infectious diseases |
| US5248503A (en) | 1992-01-03 | 1993-09-28 | Emanuel King Rosalba | Herbal dietary supplement |
| US6077513A (en) | 1996-05-02 | 2000-06-20 | Massoud; Ahmed Mohamed Ali | Drug for treatment of bilharziasis (Schistosomiasis) |
| ZA200000192B (en) * | 1998-10-30 | 2000-08-07 | Jullienne Jacques Roger Jean M | Novel composition. |
| US6893648B2 (en) | 2002-01-04 | 2005-05-17 | Harold Mermelstein | Composition and method for treatment of vaginal dryness |
| CN1559586A (zh) * | 2004-03-04 | 2005-01-05 | 健 曹 | 一种治疗妇科疾病的外用中成药 |
| CN1679687A (zh) | 2005-02-02 | 2005-10-12 | 姚素英 | 一种治疗妇科疾病外用胶囊及制备方法 |
| CN101057892B (zh) * | 2006-04-19 | 2010-11-10 | 河南省宛西制药股份有限公司 | 一种治疗阴道疾病的药物组合物及其制备方法和应用 |
| CN101849981B (zh) * | 2010-06-22 | 2011-11-23 | 南京中医药大学 | 一种具有抗妇科肿瘤作用的没药有效部位及其制备方法和其应用 |
-
2012
- 2012-03-15 WO PCT/EP2012/054548 patent/WO2012123539A1/fr not_active Ceased
- 2012-03-15 AU AU2012228213A patent/AU2012228213B2/en not_active Ceased
- 2012-03-15 KR KR1020137021591A patent/KR20130130034A/ko not_active Ceased
- 2012-03-15 CA CA2829792A patent/CA2829792C/fr active Active
- 2012-03-15 JP JP2013555906A patent/JP5519879B2/ja not_active Expired - Fee Related
- 2012-03-15 MX MX2013010415A patent/MX352788B/es active IP Right Grant
- 2012-03-15 BR BR112013023092A patent/BR112013023092A2/pt not_active Application Discontinuation
-
2013
- 2013-09-30 CO CO13231573A patent/CO6771460A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014508158A (ja) | 2014-04-03 |
| WO2012123539A1 (fr) | 2012-09-20 |
| MX2013010415A (es) | 2013-12-02 |
| BR112013023092A2 (pt) | 2016-12-06 |
| MX352788B (es) | 2017-12-05 |
| JP5519879B2 (ja) | 2014-06-11 |
| KR20130130034A (ko) | 2013-11-29 |
| AU2012228213A1 (en) | 2013-09-12 |
| AU2012228213B2 (en) | 2015-08-06 |
| CO6771460A2 (es) | 2013-10-15 |
| CA2829792A1 (fr) | 2012-09-20 |
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| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20130909 |