WO2017126995A1 - Composition pour le traitement et la prévention d'une infection, d'ulcérations et de boutons causés par le papillomavirus humain hpv - Google Patents

Composition pour le traitement et la prévention d'une infection, d'ulcérations et de boutons causés par le papillomavirus humain hpv Download PDF

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Publication number
WO2017126995A1
WO2017126995A1 PCT/SA2016/000001 SA2016000001W WO2017126995A1 WO 2017126995 A1 WO2017126995 A1 WO 2017126995A1 SA 2016000001 W SA2016000001 W SA 2016000001W WO 2017126995 A1 WO2017126995 A1 WO 2017126995A1
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WO
WIPO (PCT)
Prior art keywords
virus
composition based
herbal composition
protection factor
myrrh
Prior art date
Application number
PCT/SA2016/000001
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English (en)
Inventor
Nadiah Abdulkarim A. Alessa
Original Assignee
Alessa Nadiah Abdulkarim A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Alessa Nadiah Abdulkarim A filed Critical Alessa Nadiah Abdulkarim A
Priority to PCT/SA2016/000001 priority Critical patent/WO2017126995A1/fr
Priority to CA2967506A priority patent/CA2967506A1/fr
Publication of WO2017126995A1 publication Critical patent/WO2017126995A1/fr

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • A61K35/08Mineral waters; Sea water
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/328Commiphora, e.g. mecca myrrh or balm of Gilead
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/886Aloeaceae (Aloe family), e.g. aloe vera
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962Allium, e.g. garden onion, leek, garlic or chives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/02Suppositories; Bougies; Bases therefor; Ovules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents

Definitions

  • HPV Human Papilloma Virus
  • HPV human papilloma virus
  • myrrh gum is used for bedsore. It is also known that resin and oil is used in treatment of Schistosomiasis according to an American Patent No. 6077513, and myrrh is also used as food or food supplements according to an American Patent Application No. 5248503. It is also used for treatment of vagina atrophy according to an international Patent Application No. 2012/123539 dated 20/152012. It is worth mentioning that myrrh is considered a kind of natural resins and it is safe for human usage.
  • Aloe Vera leaves which serve as an microbial agents according to an American Patent No. 7169414 dated 2007. It discovered a gelatinous fluid which include an antagonist to germs. Aloe Vera can also be used with other combinations to serve as an antivirus, and treatment of Aids, according to an international Patent Application No. 2012/012513 dated 26/01/2012.
  • garlic cream is used as topical treatment for skin infections, according to an international Patent Application No. 2002089826 dated 14/11/2002.
  • Garlic extract can also be used as an antibiotic according to an international Patent Application No. 2011012855 dated 30/06/2011.
  • Citrullus colocynthis plant as an anti-factor for infections. This is published in the International Journal of Current Research Vol. 2, pp. 067 - 069, 2010 - Rajamanickam, et al "Evaluation of anti - Inflammatory Activity of Citrullus colocynthis"
  • This invention compared to previous inventions has good advantages: no need for using ancient methods such as electric cauterization, laser or removal by surgery. This new method is safe and easy to use.
  • This herbal composition is used as lotion for a short period of time. It works to eliminate the existing virus and can also be used as protective procedure. Detailed Description
  • this composition is a herbal mixture of five main and effective materials with water addition:
  • Citrullus colocynthis plant is also used with a mixture of medical herbs as a safe composition to treat diabetes according to the American Patent No. 8993008 dated
  • Aloe Vera 50 grams are to be grind .Myrrh, Aloe Vera and hard sea salt are to be mixed together, and to be dissolved in 750 grams of water. Then it is put in a tight container, and placed on fire for 20 minutes and left until it cools. The Citrullus colocynthis and garlic are added. All these are to be well mixed together. It should remain in the container for 72 hours, until it is ferment. Finally it is refined and kept in a container ready for use.
  • the best way is to be used as a daily lotion after each visit to the bathroom.
  • the infected area is to be washed with mild soap first and then with the solution. This will help fast cure from the virus.
  • Example 1 Lotion for the infected area:
  • Example 3 - suppositories for vagina:

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Organic Chemistry (AREA)
  • Reproductive Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

La présente invention concerne le traitement du papillomavirus humain, qui appartient à un groupe de virus variants, appelés (DAN). Il est infectieux pour la peau et les membranes muqueuses. Il est transmissible de personne à personne par contact sexuel, ou contact avec des zones infectées. Ce virus peut causer différents types de cancer chez l'homme et la femme, approximativement 90 % des cas de cancers anal chez les hommes et les femmes, environ 70 % des cancers de la bouche et du pharynx, 65 % à 70 % des cancers du col de l'utérus et 50 % des cancers du pénis chez les hommes sont causés par ce virus. De plus, ce virus cause d'autres maladies chez les hommes et les femmes telles que les verrues génitales et différentes verrues cutanées. Il n'existe pas de remède efficace pour ce virus, par conséquent, chacun doit prendre des précautions et prendre les mesures de prévention requises. Sur la base de ces données, j'ai préparé une composition qui contribue à guérir et éliminer ce virus dès qu'il apparaît sur la peau. Par conséquent, il n'est pas nécessaire que le patient utilise les traitements conventionnels tels que la cautérisation électrique et d'autres procédés. Les composants les plus importants de ce remède sont une combinaison à base de plantes, constituée d'Aloe vera, Citrullus colocynthis, sel de mer dur, myrrhe et ail.
PCT/SA2016/000001 2016-01-18 2016-01-18 Composition pour le traitement et la prévention d'une infection, d'ulcérations et de boutons causés par le papillomavirus humain hpv WO2017126995A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/SA2016/000001 WO2017126995A1 (fr) 2016-01-18 2016-01-18 Composition pour le traitement et la prévention d'une infection, d'ulcérations et de boutons causés par le papillomavirus humain hpv
CA2967506A CA2967506A1 (fr) 2016-01-18 2016-01-18 Composition de traitement et de prevention d'infection, ulcerations et furoncles attribuables au virus du papillome humain (vph)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/SA2016/000001 WO2017126995A1 (fr) 2016-01-18 2016-01-18 Composition pour le traitement et la prévention d'une infection, d'ulcérations et de boutons causés par le papillomavirus humain hpv

Publications (1)

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WO2017126995A1 true WO2017126995A1 (fr) 2017-07-27

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CA (1) CA2967506A1 (fr)
WO (1) WO2017126995A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115066250A (zh) * 2019-12-15 2022-09-16 巴诺伊阿玛甘泰伯有限公司 草药化合物和治疗感染、外阴阴道和盆腔器官炎症的方法

Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US471919A (en) 1892-03-29 Drawers
US2602066A (en) 1950-09-05 1952-07-01 Petrolite Corp Process for breaking petroleum emulsions
US5248503A (en) 1992-01-03 1993-09-28 Emanuel King Rosalba Herbal dietary supplement
US5350774A (en) 1990-06-12 1994-09-27 Cathy Palou Therapeutic preparation for topical application to the skin
US6077513A (en) 1996-05-02 2000-06-20 Massoud; Ahmed Mohamed Ali Drug for treatment of bilharziasis (Schistosomiasis)
WO2002089826A1 (fr) 2001-05-04 2002-11-14 Morepen Laboratories Ltd. Procede de preparation d'un onguent a base d'ail et composition d'onguent a base d'ail pour l'utilisation topique en cas d'infection cutanee
US7169414B2 (en) 1998-03-06 2007-01-30 Kathleen Shupe Antimicrobial agents isolated from aloe vera
US20080213410A1 (en) * 2007-02-08 2008-09-04 Michel Serrano Anti-human papillomas virus topical composition
CN101632756A (zh) 2008-07-24 2010-01-27 张国政 一种治疗恶性肿瘤的中药及其制备方法
WO2011012855A2 (fr) 2009-07-28 2011-02-03 Raymond Stanley Steggles Compositions antibactériennes
WO2012012513A1 (fr) 2010-07-23 2012-01-26 North Texas Medical Associates Propriétés antivirales de l'aloès et traitement du syndrome d'immunodéficience acquise (sida)
WO2012123539A1 (fr) 2011-03-17 2012-09-20 Sonia Pharma Gmbh Traitement de l'atrophie vaginale en tant qu'une nouvelle indication de myrrhe
WO2012134520A2 (fr) * 2010-08-31 2012-10-04 Sami Labs Limited Régulation de la réponse immunitaire par la colocynthine et/ou ses dérivés
WO2013103944A1 (fr) * 2012-01-07 2013-07-11 Aloe Baby, Llc Compositions et méthodes de traitement d'affections cutanées
WO2013171607A1 (fr) 2012-05-18 2013-11-21 Labomar S.R.L. Crème vaginale pour le traitement d'une infection au papillome comprenant du docosanol, du curcuma, de l'amla et de l'aloe
US8993008B1 (en) 2013-12-16 2015-03-31 Umm Al-Qura University Herbal composition for treating diabetes

Patent Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US471919A (en) 1892-03-29 Drawers
US2602066A (en) 1950-09-05 1952-07-01 Petrolite Corp Process for breaking petroleum emulsions
US5350774A (en) 1990-06-12 1994-09-27 Cathy Palou Therapeutic preparation for topical application to the skin
US5248503A (en) 1992-01-03 1993-09-28 Emanuel King Rosalba Herbal dietary supplement
US6077513A (en) 1996-05-02 2000-06-20 Massoud; Ahmed Mohamed Ali Drug for treatment of bilharziasis (Schistosomiasis)
US7169414B2 (en) 1998-03-06 2007-01-30 Kathleen Shupe Antimicrobial agents isolated from aloe vera
WO2002089826A1 (fr) 2001-05-04 2002-11-14 Morepen Laboratories Ltd. Procede de preparation d'un onguent a base d'ail et composition d'onguent a base d'ail pour l'utilisation topique en cas d'infection cutanee
US20080213410A1 (en) * 2007-02-08 2008-09-04 Michel Serrano Anti-human papillomas virus topical composition
CN101632756A (zh) 2008-07-24 2010-01-27 张国政 一种治疗恶性肿瘤的中药及其制备方法
WO2011012855A2 (fr) 2009-07-28 2011-02-03 Raymond Stanley Steggles Compositions antibactériennes
WO2012012513A1 (fr) 2010-07-23 2012-01-26 North Texas Medical Associates Propriétés antivirales de l'aloès et traitement du syndrome d'immunodéficience acquise (sida)
WO2012134520A2 (fr) * 2010-08-31 2012-10-04 Sami Labs Limited Régulation de la réponse immunitaire par la colocynthine et/ou ses dérivés
WO2012123539A1 (fr) 2011-03-17 2012-09-20 Sonia Pharma Gmbh Traitement de l'atrophie vaginale en tant qu'une nouvelle indication de myrrhe
WO2013103944A1 (fr) * 2012-01-07 2013-07-11 Aloe Baby, Llc Compositions et méthodes de traitement d'affections cutanées
WO2013171607A1 (fr) 2012-05-18 2013-11-21 Labomar S.R.L. Crème vaginale pour le traitement d'une infection au papillome comprenant du docosanol, du curcuma, de l'amla et de l'aloe
US8993008B1 (en) 2013-12-16 2015-03-31 Umm Al-Qura University Herbal composition for treating diabetes

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
"4719111 Novel composition for treatment of decubitus ulcers - Lynn Wilson", BIOTECHNOLOGY ADVANCES, ELSEVIER PUBLISHING, BARKING, GB, vol. 6, no. 2, 1 January 1988 (1988-01-01), pages 292, XP023927969, ISSN: 0734-9750, [retrieved on 19880101], DOI: 10.1016/0734-9750(88)90333-3 *
ALIMENTARY PHARMACOLOGY AND THERAPEUTIC, vol. 19, no. 7, April 2004 (2004-04-01), pages 739 - 747
ILJAZOVIC ERMINA ET AL: "EFFICACY IN TREATMENT OF CERVICAL HRHPV INFECTION BY COMBINATION OF BETA INTERFERON, AND HERBAL THERAPY IN WOMAN WITH DIFFERENT CERVICAL LESIONS", BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES, SARAJEVO, vol. 6, no. 4, 1 November 2006 (2006-11-01), pages 79 - 84, XP009080091, ISSN: 1512-8601 *
RAJAMANICKAM ET AL.: "Evaluation of anti - Inflammatory Activity of Citrullus colocynthis", INTERNATIONAL JOURNAL OF CURRENT RESEARCH, vol. 2, 2010, pages 067 - 069
RASHAD A.; ABDUL GUNI ET AL.: "Myrrh and trematodoses in Egypt. An overview of safety, efficacy and effectiveness profiles", ELSEVIER MAGAZINE, vol. 58, no. 3, September 2009 (2009-09-01), XP026337967, DOI: doi:10.1016/j.parint.2009.04.006
TABASSUM N; HAMDANI M: "Plants used to treat skin diseases", PHARMACOGNOSY REVIEWS, vol. 8, no. 15, 1 January 2014 (2014-01-01), India, pages 52 - 60, XP055190539, ISSN: 0973-7847, DOI: 10.4103/0973-7847.125531 *
TSOUH FOKOU PATRICK VALERE ET AL: "Ethnopharmacological reports on anti-Buruli ulcer medicinal plants in three West African countries", JOURNAL OF ETHNOPHARMACOLOGY, vol. 172, 20 June 2015 (2015-06-20), pages 297 - 311, XP029252932, ISSN: 0378-8741, DOI: 10.1016/J.JEP.2015.06.024 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115066250A (zh) * 2019-12-15 2022-09-16 巴诺伊阿玛甘泰伯有限公司 草药化合物和治疗感染、外阴阴道和盆腔器官炎症的方法

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