WO2013103944A1 - Compositions et méthodes de traitement d'affections cutanées - Google Patents

Compositions et méthodes de traitement d'affections cutanées Download PDF

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Publication number
WO2013103944A1
WO2013103944A1 PCT/US2013/020488 US2013020488W WO2013103944A1 WO 2013103944 A1 WO2013103944 A1 WO 2013103944A1 US 2013020488 W US2013020488 W US 2013020488W WO 2013103944 A1 WO2013103944 A1 WO 2013103944A1
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Prior art keywords
skin
group
composition
gel
aloe vera
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PCT/US2013/020488
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English (en)
Inventor
Melissa J. MERCER-TACHICK
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Aloe Baby, Llc
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Publication of WO2013103944A1 publication Critical patent/WO2013103944A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

Definitions

  • barrier creams/ointments/aerosols directly on the cleansed skin without powder can trap moisture and encourage microbial colonization. Moreover, powders interfere with the adherence of the cream/ointment on the skin. Furthermore, talc has susceptibility of having contaminants, and corn starch is a food source for microbes.
  • Barrier creams have been used for many skin conditions for animals and humans and include such brand names as DesitinTM, A&D OintmentTM, CavilonTM, LansinohTM, CalmoseptineTM, VaselineTM, and Tuf-SkinTM. Such uses include but are not limited to: pressure sores,
  • barrier creams/ointments/aerosols are also used for fly strike, fur lice, and other open wounds.
  • the present invention provides a composition
  • a composition comprising: a.) at least about 50% concentrated Aloe vera juice by weight, as a percentage of total weight; b.) at least about 1% carrier oil by weight, as a percentage of total weight; and c.) at least about 0.05% essential oil by weight, as a percentage of total weight.
  • compositions wherein the Aloe vera is concentrated from about
  • compositions wherein the percentage of concentrated Aloe vera is selected from the group consisting of: from about 50% w/w to about 99% w/w; from about 60% w/w to about 95% w/w; from about 70% w/w to about 95% w/w; from about 80% w/w to about 95% w/w; from about 88% w/w to about 93% w/w; from about 90% w/w to about 95% w/w; from about 90% w/w to about 92% w/w; approximately 91% w/w.
  • compositions wherein the percentage of carrier oil is selected from the group consisting of: from about 1% w/w to about 15% w/w; from about 2% w/w to about 12% w/w; from about 5% w/w to about 10% w/w; from about 5% w/w to 7% w/w; approximately 6% w/w.
  • compositions wherein the percentage of essential oil is selected from the group consisting of: from about 0.05% w/w to about 10% w/w; from about 0.1% w/w to about 8% w/w; from about 0.5% to about 3% w/w; from about 0.8% w/w to about 2% w/w; from about 1% w/w to 1.5% w/w; from about 1% w/w to about 1.3% w/w; approximately 1.2% w/w.
  • compositions which further comprise an ingredient selected from the group consisting of: at least one humectant; at least one nutrient; at least one preservative; at least one gelling agent.
  • compositions which are formulated for use on human or animal skin.
  • compositions wherein the carrier oil is selected from the group consisting of: almond, apricot kernel, argan, avocado, baobab, black cumin, borage, camelina, canola (rapeseed), castor, coconut, cranberry, emu, evening primrose, grapeseed, hazelnut, hemp, jojoba, kukui nut, macadamia nut, meadowfoam, neem, olive, palm, peanut, pecan, plum, pomegranate seed, pumpkin, rosehip seed, safflower, sea buckthorn, sesame, shea, soybean, sunflower, sweet almond, tamanu, walnut, watermelon seed, or wheat germ oils.
  • the carrier oil is selected from the group consisting of: almond, apricot kernel, argan, avocado, baobab, black cumin, borage, camelina, canola (rapeseed), castor, coconut, cranberry, emu, evening primrose, grapes
  • compositions wherein the essential oil is selected from the group consisting of: allspice, ambrette, ammi visnaga, amyris, angelica root, anise seed, balsam, basil, bay laurel, benzoin, bergamot, birch, black pepper, calendula, chamomile, cardamom, carrot seed, cedar, cedarwood, celery seed, chamomile, champaca, chaste berry, cinnamon, cistus, citronella, clary sage, clove bud, coffee bean, coriander, cypress, davana, elemi, eucalyptus, fennel, fir, frangipani, frankincense, galbanum, gardenia, geranium, ginger, grapefruit, helichrysum, hyssop, inula, jasmine, juniper berry, khella, lavender, ledum, lemon
  • compositions which further comprise an additional ingredient selected from the group consisting of: at least one preservative; at least one gelling agent; vitamin A; vitamin C; vitamin D; vitamin E; camphor; at least one botanical extract; at least one sea extract;
  • glycerine at least one plant-based butter; lanolin; at least one mineral; sea salt; at least one pH balancer.
  • compositions which are formulated for delivery from a device selected from the group consisting of: tube; tub; aerosol container; bandage; diaper; polymer strip; spritz container; stick; wipe; and syringe.
  • compositions wherein the formulation has at least one property selected from the group consisting of: antibacterial; antifungal; antiprotozoal; antiviral; antiseptic; antiinflammatory; immunostimulative; analgesic; and antipruritic properties.
  • the present invention provides methods to ameliorate the symptoms of a skin disorder in a subject, comprising administering a composition of claim 1 to the skin of a subject with a skin disorder.
  • composition is administered via several applications during a 24 hour period.
  • the skin disorder is selected from the group consisting of: acne, rosacea, psoriasis, skin blisters, sunburn, dermatitis, eczema, common rashes, allergic reactions (including poison ivy, oak, or sumac), cellulitis, fungal infections, bacterial infections, viral infections, pruritus, physical or chemical burns, hives, bed/pressure sores, skin grafts, chapped lips, biopsy sites, suture sites, tattoos, laser treatments, depilation, transplant sites, catheter sites, injection sites, diabetic ulcers, radiation dermatitis, cuts, abrasions, cryosurgical post-blistering care, and scleroderma.
  • the present invention provides methods to ameliorate the symptoms of diaper rash in a human in need of diaper rash symptom amelioration, comprising: A method to ameliorate the symptoms of diaper rash in a human in need of diaper rash symptom amelioration, comprising: a. cleansing the diaper rash- affected skin of a human with diaper rash, b. applying a nutritive gel to the diaper rash-affected skin wherein the nutritive gel comprises from about 94% w/w to about 96% w/w concentrated Aloe vera, from about 3% w/w to about 4% w/w carrier oils, from about 0.2% w/w to about 0.7% essential oils, and from about 0.2% w/w to about 0.7% w/w other ingredients; c. allowing the nutritive gel to dry or actively dry the gel; and d. applying a barrier cream or ointment to the diaper rash-affected skin.
  • the Aloe vera concentrate is at least about 1.2x compared to natural Aloe vera juice
  • the carrier oils are apricot kernel oil and rosehip seed oil
  • the essential oils are selected from the group consisting of: niaouli; lavender; chamomile; and ginger.
  • the present invention provides methods to ameliorate the symptoms of nipple trauma in a human in need of nipple trauma symptom amelioration, comprising: a. cleansing the nipple trauma- affected skin of a human with nipple trauma; b. applying a nutritive gel to the nipple trauma-affected skin, wherein the nutritive gel comprises from about 90% w/w to about 92% w/w concentrated Aloe vera, from about 5% w/w to about 7% w/w carrier oils, from about 0.5% w/w to about 2% w/w essential oils, and from about 0.2% w/w to about 2.5% w/w other ingredients; c. allowing the nutritive gel to dry or actively dry the gel; and d. applying a barrier cream or ointment to the nipple trauma-affected skin.
  • the Aloe vera concentrate is at least about 1.2x compared to natural Aloe vera juice
  • the carrier oils are apricot kernel oil and rosehip seed oil
  • the essential oils are selected from the group consisting of: rosemary; lavender; chamomile; niaouli; and lemon eucalyptus
  • the other ingredients comprise 0.7% grapefruit seed extract and 0.8% gentian violet.
  • Figure 1 depicts the steps for a method of administering a composition herein.
  • the present invention provides bio-active, nutritive gels.
  • the gels may be massaged into the skin and allowed to dry prior to any application of a barrier cream/ointment/aerosol.
  • the inventors disclose gels containing skin regenerative ingredients such as concentrated Aloe vera (51-99% of the formulation by weight), carrier oils that are appropriate to the skin condition (1-15% of the formulation by weight), essential oils (0.05-10% of the formulation by weight) and miscellaneous emollients, humectants, vitamins, preservatives, and polymers (0.1-35% of the formulation by weight) is applied to the affected area.
  • a.) Aloe vera The current formulation comprises a majority (at least 50% by weight) of the mixture consisting of concentrated (l.Olx to lOx strength) Aloe vera juice.
  • concentrated Aloe vera composition is Aloecorp, 3005 First Avenue, Seattle, WA 98121.
  • Carrier Oil The current formulation comprises at least one, but optionally a combination of, carrier oil.
  • carrier oils include, but are not limited to: almond, apricot kernel, avocado, black cumin, coconut, grapeseed, hemp, jojoba, neem, olive, rosehip seed, sesame, sunflower, or tamanu oils.
  • Essential Oil The current formulation comprises at least one, but optionally a combination of, essential oil.
  • essential oils include, but are not limited to: allspice, ammi visnaga, amyris, angelica root, balsam, basil, bay laurel, bergamot, birch, calendula, chamomile, cardamom, carrot seed, cedar, cinnamon, cistus, citronella, clary sage, clove bud, coriander, cypress, davana, elemi, eucalyptus, fennel, fir, frangipani, frankincense, galbanum, geranium, ginger, grapefruit, helichrysum, hyssop, inula, jasmine, juniper berry, lavender, lemon, lemon verbena, lemongrass, lime, lotus, mandarin, marjoram, melissa, myrrh, myrtle,
  • Optional ingredients of the bio-active, nutritive elements are many, but they make up a minority of the formulation by volume. Preservatives and gelling polymers are expected but may not be necessary.
  • Other bio-active, nutritive ingredients include but are not limited to: Vitamins A, C, D, and E; camphor; botanical (land and sea) extracts; glycerin; plant-based butters; lanolin; natural mineral sources (such as coral reef sea salt).
  • pH balancers and other chemical additives may be necessary for the stabilization and safety of the product.
  • this formulation may be formulated so as to be capable of being aerosolized in order to reduce skin-to-skin contact or otherwise aid application.
  • the present formulations may be made according to the following series of events, although any manufacturing process which results in producing a formulation herein is acceptable.
  • the concentrated aloe base is prepared.
  • Concentrated Aloe vera powder for example,
  • 200x Aloe vera powder is measured and added to measured deionized water to achieve the desired concentration of hydrated aloe.
  • any Aloe vera juice that is within the concentrations useful in the present invention may be used; the formulation does not require the use of re -hydrated powdered Aloe vera.
  • Thickening/gelling agents such as xanthum gum or carbopol are added to the base. The base is vigorously mixed in order to activate the thickening agent.
  • oils and aloe gel are combined and final ingredients, such as buffers, preservatives, and any other ingredients, are added.
  • the present invention provides skin care treatments, optionally in conjunction with barrier creams/ointments/aerosols.
  • the formulations herein may be applied directly to the affected area, optionally after cleansing the skin but before application of barrier creams, ointments, or aerosols. This additional step adds a layer of botanically active gel that is completely absorbed by the skin and air dried prior to use of traditional creams or ointments.
  • the gel may be massaged into the skin to aid in absorption.
  • the massage step may be skipped in instances where touching the skin is exceedingly painful or exposes the patient to new contaminants or others to contracting a contaminant, such as in the case of the treatment of necrotizing fasciitis or new or unknown pathogens.
  • the bio-active, nutritive gel may then be optionally allowed to dry, or active steps to dry the gel to the skin may be taken.
  • the drying step can result in complete or partial drying, and can be accomplished by waiting for a specified drying time or by using an air movement and/or heating device with optional low heat (preferably no more than body temperature for sensitive skins or up to 110 degrees Fahrenheit for less sensitive uses).
  • the skin is completely dried.
  • Barrier creams/ointments/aerosols may then optionally be applied.
  • Figure 1 shows a flowchart: (100)
  • cleanse the affected area (200) Apply a nutritive, bioactive gel comprising concentrated Aloe vera, an appropriate carrier oil, and essential oils to the affected area. In some cases, it may be beneficial to aerosolize the gel and apply without touching the skin; (300) Optionally gently massage the gel into the skin. ; (400) Optionally, allow time for gel to air dry, OR, using a mildly warm (70-100 or 110 degrees Fahrenheit) source of moving air, exsiccate the affected area until it is completely dry. (500) Optionally, apply a barrier cream/ointment/aerosol.
  • the formulations and methods herein provide antibacterial, antifungal, antiprotozoal, antiviral, antiseptic, anti-inflammatory, immunostimulative, analgesic, and antipruritic properties.
  • the present invention stimulates healing in the skin, retards growth of harmful microbes, and, when completely dried as directed, allows barrier creams to adhere to the skin, sealing in biologically active, nutritive elements while sealing out moisture and irritants.
  • This process could be useful to any sort of wound care for humans and animals, particularly those in which barrier creams are an indicated treatment. Applying an intermediate nutritive gel and drying it completely (optionally using some sort of fan, hair dryer, or other air delivery device) prior to use of barrier creams/ointments/aerosols could be useful in the treatment of many issues, including but not limited to: acne, rosacea, psoriasis, skin blisters, sunburn, dermatitis, eczema, common rashes, allergic reactions (including poison ivy, oak, or sumac), cellulitis, fungal infections, bacterial infections, viral infections, pruritus, physical or chemical burns, hives, bed/pressure sores, skin grafts, chapped lips, biopsy sites, suture sites, tattoos, laser treatments, depilation, transplant sites, catheter sites, injection sites, diabetic ulcers, radiation dermatitis, cuts, abrasions, cryosurgical post-blistering care,
  • the steps of the present methods for diaper rash treatment include the following: [0028] 1. Cleanse the affected area;
  • a formula for this purpose may be (by weight): 95% Aloe vera , 4% carrier oils (apricot kernel oil, rosehip seed oil), 0.5% essential oils (such as: niaouli, lavender, chamomile, ginger), and 0.5% preservatives, buffers, and gelling polymers.
  • creams/ointments/aerosols such as lanolin may be used).
  • the present methods include the use of a bio-active, nutritive gel as follows:
  • a gel containing Aloe vera, appropriate food-grade carrier oil(s), and essential oils is applied to the affected area.
  • a formula for this purpose is (by weight): 91.35% Aloe vera , 5.5% carrier oils (Rosehip seed, borage, apricot kernel, olive, and coconut oils), 0.35 % essential oils (such as: labender, geranium, myrrh, niaouli, and fennel), and 2.8% preservatives, buffers and gelling polymers.
  • the gel is gently massaged in and then air dried, optionally completely. For instance, a hair dryer on a "cold” or "warm” setting, with care taken not to burn the sensitive skin, may be used. When the skin is completely dry to the touch, then barrier creams/ointments/aerosols may be applied.
  • any human skin pathology or cosmetic procedure wherein barrier creams are indicated are within the scope of the present invention, including:incontinence, any ostomy site including gastronomy tubes, radiotherapy; difficult to treat human issues— pressure sores, diabetic ulcers, necrotizing fasciitis; eczema, psoriasis, external hemorrhoids; dermabrasion, epilation/waxing.
  • the present invention is not limited to human skin care; the present formulations and methods are useful for the treatment of skin pathologies or cosmetic applications in horses, cats, dogs, and any other animals.
  • Aloe gel base About 93.5% of 1.35 times concentrated Aloe vera barbadensis, from 200 times strength Aloe vera powder mixed with deionized water. The required volume relative to other ingredients will vary slightly based on buffering and neutralizing requirements.
  • 0.5% essential oil blend made up of:
  • Water base Mix the aloe base from 200x aloe powder and deionized water at 40
  • Oil mix Mix the carrier oils and essential oils at 40 degrees C.
  • a gel of the formula of Example 1 was manufactured and applied to moderate diaper rash as such:
  • Aloe gel base About 91.5% of 1.6 times concentrated Aloe vera barbadensis, from 200 times strength Aloe vera gel powder mixed with deionized water. The required volume relative to other ingredients will vary slightly based on buffering and neutralizing requirements.
  • Water base Mix the aloe base from 200x aloe powder and deionized water at 40 degrees C.
  • Oil mix Mix the carrier oils and essential oils at 40 degrees C.
  • EXAMPLE 5 Formulation for eczema
  • Aloe gel base About 92% of 1.65 times concentrated Aloe vera barbadensis, from 200 times strength Aloe vera gel powder mixed with deionized water. The required volume relative to other ingredients will vary slightly based on buffering and neutralizing requirements.
  • Water base Mix the aloe base from 200x aloe powder and deionized water at 40 degrees C.
  • Oil mix Mix the carrier oils and essential oils at 40 degrees C.

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Abstract

La présente invention concerne des gels nutritifs bioactifs. La composition de gel peut comprendre les éléments suivants : a) au moins environ 50 % en poids de gel concentré d'Aloe vera, en pourcentage du poids total; b) au moins environ 1 % en poids d'huile support, en pourcentage du poids total; et c) au moins environ 0,05 % en poids d'huile essentielle, en pourcentage du poids total. Lesdits gels peuvent être appliqués sur la peau par massage et laissés séchés avant l'application d'une crème/un onguent/un aérosol barrière. L'invention porte également sur des compositions et des procédés afférents.
PCT/US2013/020488 2012-01-07 2013-01-07 Compositions et méthodes de traitement d'affections cutanées WO2013103944A1 (fr)

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US201261584234P 2012-01-07 2012-01-07
US61/584,234 2012-01-07

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WO2016049088A1 (fr) * 2014-09-22 2016-03-31 Vama, Inc. Compositions de lutte contre les tiques et les puces comprenant des huiles essentielles végétales et différentes formes pour faciliter l'application
WO2016144196A1 (fr) * 2015-03-07 2016-09-15 Furmaniak Andrzej Karol Composition pharmaceutique et/ou cosmétique pour traiter des lésions et maladies de peau, procédé de préparation de composition pharmaceutique et/ou cosmétique, et son utilisation
FR3037500A1 (fr) * 2015-06-19 2016-12-23 Kala Karite Composition chimique pour dermite
FR3037499A1 (fr) * 2015-06-18 2016-12-23 Kala Karite Composition chimique pour la robe des equides
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WO2017126995A1 (fr) * 2016-01-18 2017-07-27 Alessa Nadiah Abdulkarim A Composition pour le traitement et la prévention d'une infection, d'ulcérations et de boutons causés par le papillomavirus humain hpv
RU2638798C1 (ru) * 2017-03-06 2017-12-15 Александр Владимирович Локарев Гель противогрибкового действия (варианты)
CN108553357A (zh) * 2018-05-19 2018-09-21 邵俊轩 一种天然止痛止痒芦荟水
EP3391879A4 (fr) * 2015-12-16 2019-08-21 Guerrero Gonzalez, Tayde Composition pharmaceutique pour le traitement de blessures, de brûlures et d'ulcères de la peau
WO2019194775A3 (fr) * 2017-12-27 2019-12-26 Montero Gida Sanayi Ve Ticaret Anonim Sirketi Composition de traitement de maladies du mamelon et de l'aréole
CN110623920A (zh) * 2019-11-05 2019-12-31 张伟 一种可长期保存的外泌体修复凝胶及其制备方法
CN114344219A (zh) * 2022-01-27 2022-04-15 山西万龄国际贸易有限公司 一种用于皮肤红肿痒痛的芳香植物组合物及其制备方法
US20230133004A1 (en) * 2021-11-01 2023-05-04 Solaana MD LLC Vitamin d base layer
US11707427B2 (en) 2020-04-29 2023-07-25 Mary Kay Inc. Cosmetic compositions and methods
US11717437B2 (en) 2019-03-22 2023-08-08 Natasha Polster Compress for relief from radiation treatments
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WO2016049088A1 (fr) * 2014-09-22 2016-03-31 Vama, Inc. Compositions de lutte contre les tiques et les puces comprenant des huiles essentielles végétales et différentes formes pour faciliter l'application
WO2016144196A1 (fr) * 2015-03-07 2016-09-15 Furmaniak Andrzej Karol Composition pharmaceutique et/ou cosmétique pour traiter des lésions et maladies de peau, procédé de préparation de composition pharmaceutique et/ou cosmétique, et son utilisation
FR3037499A1 (fr) * 2015-06-18 2016-12-23 Kala Karite Composition chimique pour la robe des equides
FR3037500A1 (fr) * 2015-06-19 2016-12-23 Kala Karite Composition chimique pour dermite
EP3391879A4 (fr) * 2015-12-16 2019-08-21 Guerrero Gonzalez, Tayde Composition pharmaceutique pour le traitement de blessures, de brûlures et d'ulcères de la peau
WO2017126995A1 (fr) * 2016-01-18 2017-07-27 Alessa Nadiah Abdulkarim A Composition pour le traitement et la prévention d'une infection, d'ulcérations et de boutons causés par le papillomavirus humain hpv
US10743543B2 (en) 2016-12-07 2020-08-18 Shuqing Zhang Botanical disinfection composition, disinfectant and preparation method thereof
CN106665700A (zh) * 2016-12-07 2017-05-17 张树清 一种植物源类消毒组合物、消毒剂及其制备方法
CN106665700B (zh) * 2016-12-07 2022-07-26 张树清 一种植物源类消毒组合物、消毒剂及其制备方法
RU2638798C1 (ru) * 2017-03-06 2017-12-15 Александр Владимирович Локарев Гель противогрибкового действия (варианты)
WO2019194775A3 (fr) * 2017-12-27 2019-12-26 Montero Gida Sanayi Ve Ticaret Anonim Sirketi Composition de traitement de maladies du mamelon et de l'aréole
CN108553357A (zh) * 2018-05-19 2018-09-21 邵俊轩 一种天然止痛止痒芦荟水
US11717437B2 (en) 2019-03-22 2023-08-08 Natasha Polster Compress for relief from radiation treatments
CN110623920A (zh) * 2019-11-05 2019-12-31 张伟 一种可长期保存的外泌体修复凝胶及其制备方法
US11707427B2 (en) 2020-04-29 2023-07-25 Mary Kay Inc. Cosmetic compositions and methods
US20230133004A1 (en) * 2021-11-01 2023-05-04 Solaana MD LLC Vitamin d base layer
CN114344219A (zh) * 2022-01-27 2022-04-15 山西万龄国际贸易有限公司 一种用于皮肤红肿痒痛的芳香植物组合物及其制备方法
WO2023200199A1 (fr) * 2022-04-13 2023-10-19 김드보라 Sol fonctionnel de soulagement de problème de peau prurigineuse d'animal avec mélange vieilli de jus de citron et de formulation de crème, et procédé de fabrication

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