CA2829200C - Methods and compositions for treating depression using cyclobenzaprine - Google Patents

Methods and compositions for treating depression using cyclobenzaprine Download PDF

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Publication number
CA2829200C
CA2829200C CA2829200A CA2829200A CA2829200C CA 2829200 C CA2829200 C CA 2829200C CA 2829200 A CA2829200 A CA 2829200A CA 2829200 A CA2829200 A CA 2829200A CA 2829200 C CA2829200 C CA 2829200C
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Prior art keywords
cyclobenzaprine
pharmaceutical composition
depression
day
use according
Prior art date
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CA2829200A
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English (en)
French (fr)
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CA2829200A1 (en
Inventor
Seth Lederman
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Tonix Pharma Holdings Ltd
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Tonix Pharma Holdings Ltd
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Application filed by Tonix Pharma Holdings Ltd filed Critical Tonix Pharma Holdings Ltd
Publication of CA2829200A1 publication Critical patent/CA2829200A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2829200A 2011-03-07 2012-03-06 Methods and compositions for treating depression using cyclobenzaprine Active CA2829200C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161449838P 2011-03-07 2011-03-07
US61/449,838 2011-03-07
PCT/US2012/027926 WO2012122193A1 (en) 2011-03-07 2012-03-06 Methods and compositions for treating depression using cyclobenzaprine

Publications (2)

Publication Number Publication Date
CA2829200A1 CA2829200A1 (en) 2012-09-13
CA2829200C true CA2829200C (en) 2022-05-03

Family

ID=46796107

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2829200A Active CA2829200C (en) 2011-03-07 2012-03-06 Methods and compositions for treating depression using cyclobenzaprine

Country Status (17)

Country Link
US (1) US11998516B2 (US20070167479A1-20070719-C00034.png)
EP (2) EP2683245B2 (US20070167479A1-20070719-C00034.png)
JP (2) JP2014507475A (US20070167479A1-20070719-C00034.png)
AU (4) AU2012225548B2 (US20070167479A1-20070719-C00034.png)
CA (1) CA2829200C (US20070167479A1-20070719-C00034.png)
CY (1) CY1122998T1 (US20070167479A1-20070719-C00034.png)
DK (1) DK2683245T4 (US20070167479A1-20070719-C00034.png)
ES (1) ES2773834T5 (US20070167479A1-20070719-C00034.png)
FI (1) FI2683245T4 (US20070167479A1-20070719-C00034.png)
HR (1) HRP20200142T4 (US20070167479A1-20070719-C00034.png)
HU (1) HUE048596T2 (US20070167479A1-20070719-C00034.png)
LT (1) LT2683245T (US20070167479A1-20070719-C00034.png)
PL (1) PL2683245T5 (US20070167479A1-20070719-C00034.png)
PT (1) PT2683245T (US20070167479A1-20070719-C00034.png)
RS (1) RS60240B2 (US20070167479A1-20070719-C00034.png)
SI (1) SI2683245T2 (US20070167479A1-20070719-C00034.png)
WO (1) WO2012122193A1 (US20070167479A1-20070719-C00034.png)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2501234B1 (en) * 2009-11-20 2017-09-13 Tonix Pharma Holdings Limited Methods and compositions for treating symptoms associated with post-traumatic stress disorder using cyclobenzaprine
US20110319389A1 (en) 2010-06-24 2011-12-29 Tonix Pharmaceuticals, Inc. Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine
US11998516B2 (en) 2011-03-07 2024-06-04 Tonix Pharma Holdings Limited Methods and compositions for treating depression using cyclobenzaprine
EP2968992B8 (en) 2013-03-15 2020-01-15 Tonix Pharma Holdings Limited Eutectic formulations of cyclobenzaprine hydrochloride and mannitol
WO2015150948A1 (en) * 2014-03-29 2015-10-08 Wockhardt Limited Modified release solid oral pharmaceutical compositions of cyclobenzaprine or a salt thereof
CN107072968B (zh) 2014-09-18 2021-01-12 通尼克斯制药控股有限公司 环苯扎林盐酸盐的低共熔混合物配制剂
CN106890129A (zh) * 2015-12-18 2017-06-27 健乔信元医药生技股份有限公司 环苄普林之延释剂型
EP3723860A1 (en) * 2017-12-11 2020-10-21 Tonix Pharma Holdings Limited Cyclobenzaprine treatment for agitation, psychosis and cognitive decline in dementia and neurodegenerative conditions

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Also Published As

Publication number Publication date
AU2018204633A1 (en) 2018-07-12
EP3682885A1 (en) 2020-07-22
CA2829200A1 (en) 2012-09-13
EP2683245B1 (en) 2019-12-25
AU2016222412B2 (en) 2018-03-29
PL2683245T3 (pl) 2020-10-05
DK2683245T4 (da) 2023-01-09
SI2683245T1 (sl) 2020-07-31
AU2012225548B2 (en) 2016-06-02
AU2018204633B2 (en) 2020-03-12
AU2016222412A1 (en) 2016-09-22
US11998516B2 (en) 2024-06-04
ES2773834T3 (es) 2020-07-15
DK2683245T3 (da) 2020-02-24
AU2012225548A1 (en) 2013-09-19
EP2683245B2 (en) 2022-12-07
ES2773834T5 (es) 2023-03-16
JP2014507475A (ja) 2014-03-27
AU2020203874B2 (en) 2021-09-09
CY1122998T1 (el) 2021-10-29
NZ714294A (en) 2017-06-30
PL2683245T5 (pl) 2023-03-20
PT2683245T (pt) 2020-02-21
NZ614725A (en) 2016-07-29
SI2683245T2 (sl) 2023-04-28
WO2012122193A1 (en) 2012-09-13
EP2683245A1 (en) 2014-01-15
AU2020203874A1 (en) 2020-07-02
AU2018204633C1 (en) 2020-09-10
JP2016053095A (ja) 2016-04-14
LT2683245T (lt) 2020-03-25
EP2683245A4 (en) 2014-08-27
HRP20200142T1 (hr) 2020-06-26
RS60240B2 (sr) 2023-05-31
US20120232159A1 (en) 2012-09-13
HRP20200142T4 (hr) 2023-02-17
HUE048596T2 (hu) 2020-08-28
RS60240B1 (sr) 2020-06-30
FI2683245T4 (fi) 2023-01-13

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