CA2825066C - Trifunctional crosslinking reagents comprising a succinimide, a hydrazone and an affinity group - Google Patents

Trifunctional crosslinking reagents comprising a succinimide, a hydrazone and an affinity group Download PDF

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Publication number
CA2825066C
CA2825066C CA2825066A CA2825066A CA2825066C CA 2825066 C CA2825066 C CA 2825066C CA 2825066 A CA2825066 A CA 2825066A CA 2825066 A CA2825066 A CA 2825066A CA 2825066 C CA2825066 C CA 2825066C
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Canada
Prior art keywords
ligand
group
receptor
sample
glycoprotein receptor
Prior art date
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Active
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CA2825066A
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English (en)
French (fr)
Other versions
CA2825066A1 (en
Inventor
Andreas Frei
Bernd Wollscheid
Ock-Youm Jeon
Erick Carreira
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eidgenoessische Technische Hochschule Zurich ETHZ
Original Assignee
Eidgenoessische Technische Hochschule Zurich ETHZ
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Publication of CA2825066A1 publication Critical patent/CA2825066A1/en
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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CA2825066A 2011-01-31 2012-01-30 Trifunctional crosslinking reagents comprising a succinimide, a hydrazone and an affinity group Active CA2825066C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11000731 2011-01-31
EP11000731.7 2011-01-31
PCT/EP2012/000392 WO2012104051A1 (en) 2011-01-31 2012-01-30 Trifunctional crosslinking reagents

Publications (2)

Publication Number Publication Date
CA2825066A1 CA2825066A1 (en) 2012-08-09
CA2825066C true CA2825066C (en) 2019-09-03

Family

ID=45569544

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2825066A Active CA2825066C (en) 2011-01-31 2012-01-30 Trifunctional crosslinking reagents comprising a succinimide, a hydrazone and an affinity group

Country Status (8)

Country Link
US (1) US9766235B2 (https=)
EP (2) EP2942351B1 (https=)
JP (1) JP5886324B2 (https=)
KR (1) KR101845581B1 (https=)
CN (1) CN103403011A (https=)
AU (1) AU2012213753B2 (https=)
CA (1) CA2825066C (https=)
WO (1) WO2012104051A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6545960B2 (ja) 2014-02-27 2019-07-17 シスメックス株式会社 標的物質の検出用試薬、検出方法および標的物質を検出するために用いられる担体ならびにその製造方法
JP6893510B2 (ja) * 2015-11-10 2021-06-23 イーティーエイチ・チューリッヒ 三官能性架橋試薬
EP3430769A4 (en) * 2016-03-18 2019-11-20 Coco Communications Corp. SYSTEMS AND METHODS FOR THE COMMON USE OF NETWORK INFORMATION
JP7325243B2 (ja) * 2018-06-27 2023-08-14 東ソー株式会社 アルデヒド捕捉剤
CN110873772B (zh) * 2018-08-30 2023-05-23 南方科技大学 一种探针及其合成方法和应用
CN111220679B (zh) * 2018-11-23 2022-08-02 中国科学院大连化学物理研究所 基于化学交联质谱解析的质膜蛋白质相互作用的鉴定方法
CN110252079B (zh) * 2019-05-08 2022-03-15 天津大学 一种气味远程传输的方法
US11470038B1 (en) 2020-05-19 2022-10-11 Marvell Asia Pte Ltd. Line side multiplexers with protection switching

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1203164A (en) * 1982-03-09 1986-04-15 Thomas J. Mckearn Antibody conjugates
GB9223168D0 (en) * 1992-11-05 1992-12-16 Johnson Matthey Plc Improvements in molecule labelling
WO1999051628A1 (en) * 1998-04-03 1999-10-14 Du Pont Pharmaceuticals Company Radiopharmaceuticals for imaging infection and inflammation and for imaging and treatment of cancer
AU8366398A (en) * 1998-07-07 2000-01-24 Department Of Radiation Oncology University Of Washington Trifunctional reagent for conjugation to a biomolecule
US7879799B2 (en) * 2006-08-10 2011-02-01 Institute For Systems Biology Methods for characterizing glycoproteins and generating antibodies for same
US8546531B2 (en) * 2008-07-16 2013-10-01 The General Hospital Corporation Methods and reagents for preparing multifunctional probes

Also Published As

Publication number Publication date
EP2670755A1 (en) 2013-12-11
WO2012104051A1 (en) 2012-08-09
JP5886324B2 (ja) 2016-03-16
KR101845581B1 (ko) 2018-04-05
JP2014506879A (ja) 2014-03-20
EP2942351A1 (en) 2015-11-11
CA2825066A1 (en) 2012-08-09
CN103403011A (zh) 2013-11-20
EP2942351B1 (en) 2016-10-12
KR20140020893A (ko) 2014-02-19
EP2670755B1 (en) 2016-10-12
US20140011212A1 (en) 2014-01-09
AU2012213753B2 (en) 2016-09-01
US9766235B2 (en) 2017-09-19

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