CA2822515C - Anti-il-18 antibodies and their uses - Google Patents
Anti-il-18 antibodies and their uses Download PDFInfo
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- CA2822515C CA2822515C CA2822515A CA2822515A CA2822515C CA 2822515 C CA2822515 C CA 2822515C CA 2822515 A CA2822515 A CA 2822515A CA 2822515 A CA2822515 A CA 2822515A CA 2822515 C CA2822515 C CA 2822515C
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- A—HUMAN NECESSITIES
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
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- Engineering & Computer Science (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Biomedical Technology (AREA)
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- Pulmonology (AREA)
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- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Biotechnology (AREA)
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- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
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- General Physics & Mathematics (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061424920P | 2010-12-20 | 2010-12-20 | |
| US61/424,920 | 2010-12-20 | ||
| PCT/EP2011/073496 WO2012085015A1 (en) | 2010-12-20 | 2011-12-20 | Anti-il-18 antibodies and their uses |
Publications (2)
| Publication Number | Publication Date |
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| CA2822515A1 CA2822515A1 (en) | 2012-06-28 |
| CA2822515C true CA2822515C (en) | 2023-04-25 |
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| CA2822515A Active CA2822515C (en) | 2010-12-20 | 2011-12-20 | Anti-il-18 antibodies and their uses |
Country Status (11)
| Country | Link |
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| US (1) | US9255144B2 (OSRAM) |
| EP (1) | EP2655416A1 (OSRAM) |
| JP (1) | JP2014508511A (OSRAM) |
| KR (1) | KR20140003467A (OSRAM) |
| CN (1) | CN103339147A (OSRAM) |
| AU (2) | AU2011347354A1 (OSRAM) |
| BR (1) | BR112013015508B1 (OSRAM) |
| CA (1) | CA2822515C (OSRAM) |
| MX (1) | MX2013007067A (OSRAM) |
| RU (1) | RU2013133846A (OSRAM) |
| WO (1) | WO2012085015A1 (OSRAM) |
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| JOP20200308A1 (ar) * | 2012-09-07 | 2017-06-16 | Novartis Ag | جزيئات إرتباط il-18 |
| ES2742413T3 (es) * | 2012-11-21 | 2020-02-14 | Km Biologics Co Ltd | Nuevo anticuerpo humano contra IL-18 |
| KR102321172B1 (ko) * | 2013-09-05 | 2021-11-05 | 에이비2 바이오 에스에이 | 염증성 질환에서 il-18 결합 단백질(ｉｌ-18ｂｐ) |
| WO2015160795A1 (en) * | 2014-04-14 | 2015-10-22 | The Regents Of The University Of California | Compositions and methods for treating inflammation |
| MX2017010919A (es) * | 2015-03-05 | 2017-12-07 | Ab2 Bio Sa | Proteina de union il-18 (il-18bp) y anticuerpos en enfermedades inflamatorias. |
| ES3042097T3 (en) | 2017-03-09 | 2025-11-18 | Mab Discovery Gmbh | Antibodies specifically binding to human il-1r7 |
| WO2019213686A1 (en) * | 2018-05-10 | 2019-11-14 | The Council Of The Queensland Institute Of Medical Research | Therapeutic compositions and uses therefor |
| EP3892300A4 (en) | 2018-12-03 | 2022-12-14 | Mabprotein Co.,Ltd. | ANTIBODIES RECOGNIZING A NEO-EPITOPE OF ACTIVATED INTERLEUKIN-18 PROTEINS AND ASSOCIATED APPLICATION |
| CN109870570A (zh) * | 2018-12-29 | 2019-06-11 | 广东云天抗体生物科技有限公司 | 一种检测猴il-18的酶联免疫试剂盒 |
| GB202007404D0 (en) * | 2020-05-19 | 2020-07-01 | Nasser Syed Muhammad Tahir | Treatment for viral respiratory infections |
| AU2021283858A1 (en) * | 2020-06-01 | 2023-01-05 | Avalo Therapeutics, Inc. | Methods and treatment involving antibodies to IL-18 |
| CN112415191A (zh) * | 2020-11-06 | 2021-02-26 | 郑州人福博赛生物技术有限责任公司 | 一种白细胞三烯检测试剂盒 |
| EP4371573A4 (en) | 2021-07-13 | 2025-08-20 | National Univ Corporation Tokai National Higher Education And Research System | MEDICINAL COMPOSITION FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE |
| WO2023067348A1 (en) | 2021-10-21 | 2023-04-27 | Biosirius Ltd | Treatment for virally-induced pneumonia |
| MX2024007616A (es) * | 2021-12-20 | 2024-09-04 | Avalo Therapeutics Inc | Métodos y tratamiento para la enfermedad de still de inicio en la edad adulta y la artritis idiopática juvenil de inicio sistemico que implica anticuerpos contra il-18. |
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| CN116236560A (zh) * | 2022-12-13 | 2023-06-09 | 华中科技大学同济医学院附属同济医院 | 人白细胞介素-37b在制备治疗鼻息肉的药品中的应用 |
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| TW202515608A (zh) | 2023-06-26 | 2025-04-16 | 以色列商坎布根有限公司 | Ｉｌ—１８ｂｐ拮抗抗體及其於癌症治療之單一療法及組合療法的用途 |
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| US4479930A (en) | 1982-07-26 | 1984-10-30 | Trustees Of The University Of Massachusetts | Amines coupled wth dicyclic dianhydrides capable of being radiolabeled product |
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| US6225447B1 (en) | 1991-05-15 | 2001-05-01 | Cambridge Antibody Technology Ltd. | Methods for producing members of specific binding pairs |
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-
2011
- 2011-12-20 AU AU2011347354A patent/AU2011347354A1/en not_active Abandoned
- 2011-12-20 JP JP2013545325A patent/JP2014508511A/ja active Pending
- 2011-12-20 CA CA2822515A patent/CA2822515C/en active Active
- 2011-12-20 RU RU2013133846/10A patent/RU2013133846A/ru not_active Application Discontinuation
- 2011-12-20 BR BR112013015508-6A patent/BR112013015508B1/pt active IP Right Grant
- 2011-12-20 MX MX2013007067A patent/MX2013007067A/es not_active Application Discontinuation
- 2011-12-20 CN CN2011800612426A patent/CN103339147A/zh active Pending
- 2011-12-20 EP EP11799104.2A patent/EP2655416A1/en not_active Withdrawn
- 2011-12-20 US US13/993,537 patent/US9255144B2/en active Active
- 2011-12-20 WO PCT/EP2011/073496 patent/WO2012085015A1/en not_active Ceased
- 2011-12-20 KR KR1020137018576A patent/KR20140003467A/ko not_active Withdrawn
-
2017
- 2017-03-06 AU AU2017201512A patent/AU2017201512A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BR112013015508B1 (pt) | 2022-04-05 |
| EP2655416A1 (en) | 2013-10-30 |
| JP2014508511A (ja) | 2014-04-10 |
| AU2017201512A1 (en) | 2017-03-23 |
| BR112013015508A2 (pt) | 2016-10-11 |
| WO2012085015A1 (en) | 2012-06-28 |
| US20140004128A1 (en) | 2014-01-02 |
| MX2013007067A (es) | 2013-11-01 |
| CA2822515A1 (en) | 2012-06-28 |
| KR20140003467A (ko) | 2014-01-09 |
| AU2011347354A1 (en) | 2013-08-01 |
| US9255144B2 (en) | 2016-02-09 |
| RU2013133846A (ru) | 2015-01-27 |
| CN103339147A (zh) | 2013-10-02 |
| WO2012085015A9 (en) | 2013-06-27 |
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