CA2822422C - Enzymatic peracid generation for use in oral care products - Google Patents
Enzymatic peracid generation for use in oral care products Download PDFInfo
- Publication number
- CA2822422C CA2822422C CA2822422A CA2822422A CA2822422C CA 2822422 C CA2822422 C CA 2822422C CA 2822422 A CA2822422 A CA 2822422A CA 2822422 A CA2822422 A CA 2822422A CA 2822422 C CA2822422 C CA 2822422C
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- enzyme
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- oral cavity
- peracid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Cosmetics (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061424903P | 2010-12-20 | 2010-12-20 | |
| US61/424,903 | 2010-12-20 | ||
| PCT/US2011/065912 WO2012087970A2 (en) | 2010-12-20 | 2011-12-19 | Enzymatic peracid generation for use in oral care products |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2822422A1 CA2822422A1 (en) | 2012-06-28 |
| CA2822422C true CA2822422C (en) | 2021-02-02 |
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| CA2822422A Active CA2822422C (en) | 2010-12-20 | 2011-12-19 | Enzymatic peracid generation for use in oral care products |
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| EP (1) | EP2654695B8 (OSRAM) |
| JP (2) | JP6359831B2 (OSRAM) |
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| CN (1) | CN103269679B (OSRAM) |
| AU (1) | AU2011349451A1 (OSRAM) |
| BR (1) | BR112013015459B8 (OSRAM) |
| CA (1) | CA2822422C (OSRAM) |
| ES (1) | ES2784495T3 (OSRAM) |
| MX (1) | MX2013006994A (OSRAM) |
| PH (1) | PH12013501285A1 (OSRAM) |
| RU (1) | RU2660373C2 (OSRAM) |
| WO (1) | WO2012087970A2 (OSRAM) |
| ZA (1) | ZA201303372B (OSRAM) |
Families Citing this family (19)
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| DE112008001301T5 (de) | 2007-05-14 | 2010-04-29 | Reserach Foundation Of State University Of New York | Induktion einer physiologischen Dispersions-Antwort in Bakterien-Zellen in einem Biofilm |
| CA2846504C (en) * | 2011-09-14 | 2017-10-10 | Colgate-Palmolive Company | Tooth whitening strip |
| HK1203401A1 (en) * | 2011-12-19 | 2015-10-30 | Colgate-Palmolive Company | System providing enzyme-catalyzed reaction |
| AU2012355355B2 (en) * | 2011-12-19 | 2015-04-16 | Colgate-Palmolive Company | Peracid-generating compositions |
| HK1203400A1 (en) * | 2011-12-19 | 2015-10-30 | Colgate-Palmolive Company | System providing perhydrolase-catalyzed reaction |
| AU2015201460B2 (en) * | 2011-12-19 | 2017-03-16 | Colgate-Palmolive Company | System providing enzyme-catalyzed reaction |
| RU2644336C2 (ru) | 2012-03-30 | 2018-02-08 | Е.И.Дюпон Де Немур Энд Компани | Ферменты, пригодные для получения перкислот |
| JP6335873B2 (ja) | 2012-03-30 | 2018-05-30 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ | 過酸生成に有用な酵素 |
| US8865437B2 (en) | 2012-03-30 | 2014-10-21 | E. I. Du Pont De Nemours And Company | Enzymes useful for peracid production |
| JP6200485B2 (ja) | 2012-03-30 | 2017-09-20 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ | 過酸生成に有用な酵素 |
| EP2831252B1 (en) | 2012-03-30 | 2021-11-24 | DuPont US Holding, LLC | Enzymes useful for peracid production |
| TWI561248B (en) * | 2012-12-22 | 2016-12-11 | Colgate Palmolive Co | Peracid-generating compositions |
| US11304889B2 (en) * | 2016-12-20 | 2022-04-19 | Colgate-Palmolive Company | Oral care compositions and methods for increasing the stability of the same |
| US10413500B2 (en) * | 2016-12-20 | 2019-09-17 | Colgate-Palmolive Company | Oral care compositions and methods for whitening teeth |
| EP3903765A1 (en) * | 2016-12-20 | 2021-11-03 | Colgate-Palmolive Company | Methods for stabilizing enzymes |
| CN113226271B (zh) | 2018-12-27 | 2023-07-25 | 高露洁-棕榄公司 | 口腔护理组合物 |
| AU2021237644A1 (en) * | 2020-03-18 | 2022-10-13 | Sri International | Molecular transport system to the Central Nervous System |
| CN120344550A (zh) * | 2022-12-16 | 2025-07-18 | 东亚合成株式会社 | 合成肽和构建体 |
| WO2025128645A1 (en) | 2023-12-13 | 2025-06-19 | Colgate-Palmolive Company | Oral care compositions and methods for whitening teeth |
Family Cites Families (93)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3974082A (en) | 1972-08-21 | 1976-08-10 | Colgate-Palmolive Company | Bleaching compositions |
| JPS526867B2 (OSRAM) | 1972-09-14 | 1977-02-25 | ||
| US4138476A (en) | 1977-08-03 | 1979-02-06 | The United States Of America As Represented By The Secretary Of The Navy | Plaque dispersing enzymes as oral therapeutic agents by molecular alteration |
| US4444886A (en) | 1982-08-11 | 1984-04-24 | Eastman Kodak Company | Diacetinase from Bacillus subtilis |
| US5116575A (en) | 1986-02-06 | 1992-05-26 | Steris Corporation | Powdered anti-microbial composition |
| US5296161A (en) | 1986-06-09 | 1994-03-22 | The Clorox Company | Enzymatic perhydrolysis system and method of use for bleaching |
| US5364554A (en) | 1986-06-09 | 1994-11-15 | The Clorox Company | Proteolytic perhydrolysis system and method of use for bleaching |
| EP0491782B1 (en) | 1989-09-12 | 1993-12-15 | Novo Nordisk A/S | A process for preparing peroxycarboxylic acids using an enzyme catalyst |
| AU641736B2 (en) | 1990-03-21 | 1993-09-30 | Quest International B.V. | Delivery of agents |
| AU642979B2 (en) | 1990-03-21 | 1993-11-04 | Quest International B.V. | Utilization and delivery of enzymes |
| GB9021671D0 (en) | 1990-10-05 | 1990-11-21 | Unilever Plc | Delivery of agents |
| AU642980B2 (en) | 1990-03-21 | 1993-11-04 | Quest International B.V. | Ultilization of enzymes |
| GB9122048D0 (en) | 1991-10-17 | 1991-11-27 | Interox Chemicals Ltd | Compositions and uses thereof |
| US5279816A (en) | 1991-11-22 | 1994-01-18 | Colgate-Palmolive Co. | Oral composition having improved tooth whitening effect |
| BE1006057A3 (fr) | 1992-07-06 | 1994-05-03 | Solvay Interox | Procede pour la delignification d'une pate a papier chimique. |
| US5302375A (en) | 1992-11-19 | 1994-04-12 | Colgate-Palmolive Company | Oral composition having improved tooth whitening effect |
| US5683724A (en) | 1993-03-17 | 1997-11-04 | Ecolab Inc. | Automated process for inhibition of microbial growth in aqueous food transport or process streams |
| US5398846A (en) | 1993-08-20 | 1995-03-21 | S. C. Johnson & Son, Inc. | Assembly for simultaneous dispensing of multiple fluids |
| GB2297976A (en) | 1995-02-01 | 1996-08-21 | Reckitt & Colmann Prod Ltd | Improvements in or relating to a bleaching process |
| AU4550997A (en) | 1996-10-11 | 1998-05-11 | Novo Nordisk A/S | Cellulose binding domains (cbds) for oral care products |
| US5871714A (en) | 1997-10-16 | 1999-02-16 | Pharmacal Biotechnologies, Inc. | Compositions for controlling bacterial colonization |
| US6830745B1 (en) | 1997-10-16 | 2004-12-14 | Pharmacal Biotechnologies, Llc | Compositions for treating biofilm |
| US6221341B1 (en) | 1997-11-19 | 2001-04-24 | Oraceutical Llc | Tooth whitening compositions |
| FR2774588B1 (fr) | 1998-02-11 | 2000-05-05 | Oreal | Composition cosmetique ou dermatologique contenant au moins une proteine de soie d'arachnides naturelle, recombinante ou un analogue |
| US6010729A (en) | 1998-08-20 | 2000-01-04 | Ecolab Inc. | Treatment of animal carcasses |
| AU758625B2 (en) | 1998-08-20 | 2003-03-27 | Ecolab Inc. | The treatment of meat products |
| US6210639B1 (en) | 1998-10-26 | 2001-04-03 | Novartis Ag | Apparatus, method and composition for cleaning and disinfecting |
| ES2230096T3 (es) | 1999-04-12 | 2005-05-01 | Unilever N.V. | Composiciones blanqueadoras de multiples componentes. |
| EP1202706A1 (en) | 1999-07-22 | 2002-05-08 | Pericor Science, Inc. | Lysine oxidase linkage of agents to tissue |
| US6245729B1 (en) | 1999-07-27 | 2001-06-12 | Ecolab, Inc. | Peracid forming system, peracid forming composition, and methods for making and using |
| PT1360500E (pt) | 2000-04-14 | 2010-04-19 | Genencor Int | Métodos para direccionamento selectivo |
| WO2002092028A2 (en) | 2001-05-15 | 2002-11-21 | The Procter & Gamble Company | Oral care compositions |
| DE60229745D1 (de) | 2001-06-25 | 2008-12-18 | Procter & Gamble | Mundpflegezusammensetzungen |
| US6635286B2 (en) | 2001-06-29 | 2003-10-21 | Ecolab Inc. | Peroxy acid treatment to control pathogenic organisms on growing plants |
| US7448556B2 (en) | 2002-08-16 | 2008-11-11 | Henkel Kgaa | Dispenser bottle for at least two active fluids |
| WO2004048399A2 (en) | 2002-11-25 | 2004-06-10 | Genencor International, Inc. | Skin or hair binding peptides |
| DE10260903A1 (de) * | 2002-12-20 | 2004-07-08 | Henkel Kgaa | Neue Perhydrolasen |
| US20060161121A1 (en) | 2003-02-06 | 2006-07-20 | Dehli-Cleve Collection As | Peroxide compositions |
| ATE394464T1 (de) | 2003-07-08 | 2008-05-15 | Procter & Gamble | Flüssige bleichaktivatorzusamensetzung |
| US20050069501A1 (en) | 2003-08-15 | 2005-03-31 | Sayed Ibrahim | Rapid temporary tooth whitening composition |
| US20050226839A1 (en) | 2003-09-08 | 2005-10-13 | Xueying Huang | Pepetide-based body surface reagents for personal care |
| US7807141B2 (en) | 2003-09-08 | 2010-10-05 | E.I. Du Pont De Nemours And Company | Peptide-based oral care surface reagents for personal care |
| US7220405B2 (en) * | 2003-09-08 | 2007-05-22 | E. I. Du Pont De Nemours And Company | Peptide-based conditioners and colorants for hair, skin, and nails |
| US7285264B2 (en) | 2003-09-08 | 2007-10-23 | E.I. Du Pont De Nemours And Company | Peptide-based body surface coloring reagents |
| US20050054752A1 (en) | 2003-09-08 | 2005-03-10 | O'brien John P. | Peptide-based diblock and triblock dispersants and diblock polymers |
| US8772007B2 (en) | 2003-12-03 | 2014-07-08 | Danisco Us Inc. | Perhydrolase |
| US7754460B2 (en) | 2003-12-03 | 2010-07-13 | Danisco Us Inc. | Enzyme for the production of long chain peracid |
| US20070196305A1 (en) | 2005-03-01 | 2007-08-23 | Hong Wang | Method for identifying hair conditioner-resistant hair-binding peptides and hair benefit agents therefrom |
| EP1877566B1 (en) | 2005-04-29 | 2009-02-18 | E.I. Du Pont De Nemours And Company | Enzymatic production of peracids using perhydrolytic enzymes |
| US7550420B2 (en) | 2005-04-29 | 2009-06-23 | E. I. Dupont De Nemours And Company | Enzymatic production of peracids using perhydrolytic enzymes |
| WO2006133079A2 (en) | 2005-06-06 | 2006-12-14 | Regents Of The University Of Minnesota | Increasing perhydrolase activity in esterases and/or lipases |
| US20070065387A1 (en) | 2005-09-16 | 2007-03-22 | Beck William A | Method for enhancing the effect of particulate benefit agents |
| US20070082832A1 (en) | 2005-10-06 | 2007-04-12 | Dicosimo Robert | Enzymatic production of peracids from carboxylic acid ester substrates using non-heme haloperoxidases |
| US7563758B2 (en) | 2005-10-06 | 2009-07-21 | E. I. Du Pont De Nemours And Company | Enzymatic production of peracids using Lactobacilli having perhydrolysis activity |
| US7964378B2 (en) * | 2005-12-13 | 2011-06-21 | E.I. Du Pont De Nemours And Company | Production of peracids using an enzyme having perhydrolysis activity |
| US8518675B2 (en) | 2005-12-13 | 2013-08-27 | E. I. Du Pont De Nemours And Company | Production of peracids using an enzyme having perhydrolysis activity |
| US7723083B2 (en) | 2005-12-13 | 2010-05-25 | E.I. Du Pont De Nemours And Company | Production of peracids using an enzyme having perhydrolysis activity |
| US7951566B2 (en) * | 2005-12-13 | 2011-05-31 | E.I. Du Pont De Nemours And Company | Production of peracids using an enzyme having perhydrolysis activity |
| US7709601B2 (en) | 2005-12-15 | 2010-05-04 | E. I. Du Pont De Nemours And Company | Nylon binding peptides and methods of use |
| US7632919B2 (en) | 2005-12-15 | 2009-12-15 | E.I. Du Pont De Nemours And Company | Polystyrene binding peptides and methods of use |
| US7858581B2 (en) | 2005-12-15 | 2010-12-28 | E. I. Du Pont De Nemours And Company | PMMA binding peptides and methods of use |
| US7906617B2 (en) | 2005-12-15 | 2011-03-15 | E. I. Du Pont De Nemours And Company | Polyethylene binding peptides and methods of use |
| US7928076B2 (en) | 2005-12-15 | 2011-04-19 | E. I. Du Pont De Nemours And Company | Polypropylene binding peptides and methods of use |
| US7700716B2 (en) | 2005-12-15 | 2010-04-20 | E. I. Du Pont De Nemours And Company | Polytetrafluoroethylene binding peptides and methods of use |
| MX2008011092A (es) * | 2006-03-02 | 2008-09-10 | Genencor Int | Blanqueador activo de superficie y ph dinamico. |
| US20090311198A1 (en) | 2006-03-03 | 2009-12-17 | Concar Edward M | Perhydrolase for Tooth Whitening |
| US20080280810A1 (en) | 2006-10-30 | 2008-11-13 | O'brien John P | Peptides having affinity for body surfaces |
| DE102007036392A1 (de) * | 2007-07-31 | 2009-02-05 | Henkel Ag & Co. Kgaa | Zusammensetzungen enthaltend Perhydrolasen und Alkylenglykoldiacetate |
| EP2331686B1 (en) * | 2008-08-13 | 2012-05-09 | E. I. du Pont de Nemours and Company | Control of enzymatic peracid generation |
| EP2342327B1 (en) | 2008-10-03 | 2016-02-24 | E. I. du Pont de Nemours and Company | Multi-component peracid generation system |
| US20100158846A1 (en) | 2008-12-18 | 2010-06-24 | E. I. Du Pont De Nemours And Company | Hair-binding peptides |
| US8697654B2 (en) | 2008-12-18 | 2014-04-15 | E I Du Pont De Nemours And Company | Peptide linkers for effective multivalent peptide binding |
| US8287845B2 (en) | 2008-12-18 | 2012-10-16 | E I Du Pont De Nemours And Company | Hair-binding peptides |
| US7662587B1 (en) * | 2009-03-05 | 2010-02-16 | E. I. Du Pont De Nemours And Company | Gene knockout mutations that increase peptide production |
| WO2010114638A1 (en) * | 2009-03-30 | 2010-10-07 | E. I. Du Pont De Nemours And Company | Peptide-based tooth whitening reagents |
| US8389675B2 (en) | 2009-05-20 | 2013-03-05 | E I Du Pont De Nemours And Company | PMMA binding peptides |
| US8206693B2 (en) | 2009-05-20 | 2012-06-26 | E I Du Pont De Nemours And Company | PMMA binding peptides |
| US8378065B2 (en) | 2009-05-20 | 2013-02-19 | E I Du Pont De Nemours And Company | PMMA binding peptides |
| US8263737B2 (en) | 2009-05-20 | 2012-09-11 | E I Du Pont De Nemours And Company | PMMA binding peptides |
| US20100298531A1 (en) | 2009-05-20 | 2010-11-25 | E.I. Du Pont De Nemours And Company | Pmma binding peptides |
| US20100298535A1 (en) | 2009-05-20 | 2010-11-25 | E. I. Du Pont De Nemours And Company | Pmma binding peptides |
| US8404214B2 (en) | 2009-05-20 | 2013-03-26 | E I Du Pont De Nemours And Company | PMMA binding peptides |
| US8455614B2 (en) | 2009-05-20 | 2013-06-04 | E.I. Du Pont De Nemours And Company | PMMA binding peptides |
| US20100310495A1 (en) | 2009-06-08 | 2010-12-09 | E. I. Du Pont De Nemours And Company | Peptides having affinity for poly (benzyl methacrylate-co-methacrylic acid) potassium salt copolymers and methods of use |
| US8222012B2 (en) | 2009-10-01 | 2012-07-17 | E. I. Du Pont De Nemours And Company | Perhydrolase for enzymatic peracid production |
| US7923233B1 (en) | 2009-12-07 | 2011-04-12 | E. I. Du Pont De Nemours And Company | Perhydrolase providing improved peracid stability |
| US7932072B1 (en) | 2009-12-07 | 2011-04-26 | E. I. Du Pont De Nemours And Company | Perhydrolase providing improved peracid stability |
| US7960528B1 (en) | 2009-12-07 | 2011-06-14 | E. I. Du Pont De Nemours And Company | Perhydrolase providing improved peracid stability |
| US7910347B1 (en) | 2009-12-07 | 2011-03-22 | E. I. Du Pont De Nemours And Company | Perhydrolase providing improved peracid stability |
| US7927854B1 (en) | 2009-12-07 | 2011-04-19 | E. I. Du Pont De Nemours And Company | Perhydrolase providing improved peracid stability |
| JP2013523914A (ja) * | 2010-03-26 | 2013-06-17 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | ポリアリーレンスルフィド含有ポリマー溶融物 |
| WO2011119706A1 (en) | 2010-03-26 | 2011-09-29 | E.I. Dupont De Nemours And Company | Perhydrolase providing improved specific activity |
| WO2011119703A1 (en) | 2010-03-26 | 2011-09-29 | E.I. Dupont De Nemours And Company | Process for the purification of proteins |
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2011
- 2011-12-19 CA CA2822422A patent/CA2822422C/en active Active
- 2011-12-19 EP EP11850480.2A patent/EP2654695B8/en active Active
- 2011-12-19 MX MX2013006994A patent/MX2013006994A/es unknown
- 2011-12-19 PH PH1/2013/501285A patent/PH12013501285A1/en unknown
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- 2011-12-19 ES ES11850480T patent/ES2784495T3/es active Active
- 2011-12-19 WO PCT/US2011/065912 patent/WO2012087970A2/en not_active Ceased
- 2011-12-19 JP JP2013546292A patent/JP6359831B2/ja active Active
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- 2011-12-19 KR KR20137019091A patent/KR20130132936A/ko not_active Withdrawn
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2013
- 2013-05-09 ZA ZA2013/03372A patent/ZA201303372B/en unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2822422A1 (en) | 2012-06-28 |
| JP6359831B2 (ja) | 2018-07-18 |
| EP2654695B8 (en) | 2020-03-04 |
| AU2011349451A1 (en) | 2013-05-30 |
| JP2017081958A (ja) | 2017-05-18 |
| BR112013015459A2 (pt) | 2017-06-13 |
| BR112013015459B1 (pt) | 2018-04-10 |
| US20120328534A1 (en) | 2012-12-27 |
| JP2014506250A (ja) | 2014-03-13 |
| CN103269679B (zh) | 2019-04-12 |
| EP2654695A4 (en) | 2015-05-27 |
| RU2660373C2 (ru) | 2018-07-05 |
| RU2013133831A (ru) | 2015-01-27 |
| WO2012087970A3 (en) | 2012-11-22 |
| RU2018123151A (ru) | 2019-03-06 |
| JP6410786B2 (ja) | 2018-10-24 |
| MX2013006994A (es) | 2013-07-29 |
| ES2784495T3 (es) | 2020-09-28 |
| US8663616B2 (en) | 2014-03-04 |
| RU2018123151A3 (OSRAM) | 2022-02-08 |
| WO2012087970A2 (en) | 2012-06-28 |
| EP2654695B1 (en) | 2020-01-22 |
| EP2654695A2 (en) | 2013-10-30 |
| KR20130132936A (ko) | 2013-12-05 |
| BR112013015459B8 (pt) | 2018-06-12 |
| PH12013501285A1 (en) | 2013-08-12 |
| CN103269679A (zh) | 2013-08-28 |
| ZA201303372B (en) | 2014-08-27 |
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