CA2821721A1 - Extracranial implantable devices, systems and methods for the treatment of medical disorders - Google Patents
Extracranial implantable devices, systems and methods for the treatment of medical disorders Download PDFInfo
- Publication number
- CA2821721A1 CA2821721A1 CA2821721A CA2821721A CA2821721A1 CA 2821721 A1 CA2821721 A1 CA 2821721A1 CA 2821721 A CA2821721 A CA 2821721A CA 2821721 A CA2821721 A CA 2821721A CA 2821721 A1 CA2821721 A1 CA 2821721A1
- Authority
- CA
- Canada
- Prior art keywords
- nerve
- disorders
- disorder
- stimulation
- trigeminal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title claims abstract description 109
- 238000011282 treatment Methods 0.000 title claims abstract description 101
- 210000003901 trigeminal nerve Anatomy 0.000 claims abstract description 354
- 230000000638 stimulation Effects 0.000 claims abstract description 293
- 210000005036 nerve Anatomy 0.000 claims abstract description 257
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 440
- 208000035475 disorder Diseases 0.000 claims description 439
- 210000001186 vagus nerve Anatomy 0.000 claims description 229
- 230000000747 cardiac effect Effects 0.000 claims description 124
- 230000007383 nerve stimulation Effects 0.000 claims description 96
- 210000004556 brain Anatomy 0.000 claims description 95
- 230000033228 biological regulation Effects 0.000 claims description 86
- 206010016256 fatigue Diseases 0.000 claims description 70
- 230000000694 effects Effects 0.000 claims description 68
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims description 67
- 230000011514 reflex Effects 0.000 claims description 59
- 210000004273 ophthalmic nerve Anatomy 0.000 claims description 49
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims description 48
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims description 48
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims description 47
- 206010022437 insomnia Diseases 0.000 claims description 47
- 208000008589 Obesity Diseases 0.000 claims description 46
- 210000000627 locus coeruleus Anatomy 0.000 claims description 46
- 235000020824 obesity Nutrition 0.000 claims description 46
- 208000029560 autism spectrum disease Diseases 0.000 claims description 45
- 230000004054 inflammatory process Effects 0.000 claims description 45
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims description 44
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims description 43
- 208000033830 Hot Flashes Diseases 0.000 claims description 41
- 206010060800 Hot flush Diseases 0.000 claims description 41
- 230000029058 respiratory gaseous exchange Effects 0.000 claims description 41
- 206010061218 Inflammation Diseases 0.000 claims description 40
- 230000002567 autonomic effect Effects 0.000 claims description 40
- 230000007661 gastrointestinal function Effects 0.000 claims description 40
- 208000010125 myocardial infarction Diseases 0.000 claims description 39
- 230000009076 regulation of hemostasis Effects 0.000 claims description 38
- 208000034972 Sudden Infant Death Diseases 0.000 claims description 36
- 206010042440 Sudden infant death syndrome Diseases 0.000 claims description 36
- 230000003213 activating effect Effects 0.000 claims description 35
- 206010015037 epilepsy Diseases 0.000 claims description 33
- 238000007920 subcutaneous administration Methods 0.000 claims description 33
- 206010003119 arrhythmia Diseases 0.000 claims description 31
- 208000009205 Tinnitus Diseases 0.000 claims description 28
- 230000017531 blood circulation Effects 0.000 claims description 28
- 231100000886 tinnitus Toxicity 0.000 claims description 28
- 206010012335 Dependence Diseases 0.000 claims description 27
- 208000028017 Psychotic disease Diseases 0.000 claims description 27
- 230000003542 behavioural effect Effects 0.000 claims description 27
- 206010049418 Sudden Cardiac Death Diseases 0.000 claims description 25
- 208000030814 Eating disease Diseases 0.000 claims description 24
- 208000019454 Feeding and Eating disease Diseases 0.000 claims description 24
- 206010019280 Heart failures Diseases 0.000 claims description 24
- 206010042434 Sudden death Diseases 0.000 claims description 24
- 235000014632 disordered eating Nutrition 0.000 claims description 24
- 230000001771 impaired effect Effects 0.000 claims description 24
- 208000011117 substance-related disease Diseases 0.000 claims description 24
- 206010003658 Atrial Fibrillation Diseases 0.000 claims description 23
- 208000022531 anorexia Diseases 0.000 claims description 23
- 206010061428 decreased appetite Diseases 0.000 claims description 23
- 208000019622 heart disease Diseases 0.000 claims description 23
- 230000007958 sleep Effects 0.000 claims description 23
- 208000020706 Autistic disease Diseases 0.000 claims description 22
- 206010054048 Postoperative ileus Diseases 0.000 claims description 22
- 230000015355 regulation of circadian sleep/wake cycle, sleep Effects 0.000 claims description 22
- 230000004936 stimulating effect Effects 0.000 claims description 22
- 206010003805 Autism Diseases 0.000 claims description 21
- 206010006895 Cachexia Diseases 0.000 claims description 21
- 206010012438 Dermatitis atopic Diseases 0.000 claims description 21
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 21
- 206010040047 Sepsis Diseases 0.000 claims description 21
- 206010047700 Vomiting Diseases 0.000 claims description 21
- 201000008937 atopic dermatitis Diseases 0.000 claims description 21
- 230000008901 benefit Effects 0.000 claims description 21
- 201000006549 dyspepsia Diseases 0.000 claims description 21
- 201000003152 motion sickness Diseases 0.000 claims description 21
- 206010010774 Constipation Diseases 0.000 claims description 20
- 206010012735 Diarrhoea Diseases 0.000 claims description 20
- 208000014540 Functional gastrointestinal disease Diseases 0.000 claims description 20
- 206010021518 Impaired gastric emptying Diseases 0.000 claims description 20
- 206010028813 Nausea Diseases 0.000 claims description 20
- 208000006673 asthma Diseases 0.000 claims description 20
- 210000003710 cerebral cortex Anatomy 0.000 claims description 20
- 238000002512 chemotherapy Methods 0.000 claims description 20
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims description 20
- 208000001288 gastroparesis Diseases 0.000 claims description 20
- 208000006454 hepatitis Diseases 0.000 claims description 20
- 231100000283 hepatitis Toxicity 0.000 claims description 20
- 230000008693 nausea Effects 0.000 claims description 20
- 230000009747 swallowing Effects 0.000 claims description 20
- 208000019505 Deglutition disease Diseases 0.000 claims description 19
- 208000032928 Dyslipidaemia Diseases 0.000 claims description 19
- 208000017170 Lipid metabolism disease Diseases 0.000 claims description 19
- 208000001145 Metabolic Syndrome Diseases 0.000 claims description 19
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims description 19
- 230000004913 activation Effects 0.000 claims description 19
- 206010003246 arthritis Diseases 0.000 claims description 19
- 206010012601 diabetes mellitus Diseases 0.000 claims description 19
- 208000001797 obstructive sleep apnea Diseases 0.000 claims description 19
- 201000006474 Brain Ischemia Diseases 0.000 claims description 18
- 206010008120 Cerebral ischaemia Diseases 0.000 claims description 18
- 206010008118 cerebral infarction Diseases 0.000 claims description 18
- 230000035515 penetration Effects 0.000 claims description 16
- 208000012902 Nervous system disease Diseases 0.000 claims description 14
- 208000025966 Neurological disease Diseases 0.000 claims description 14
- 230000001154 acute effect Effects 0.000 claims description 14
- 238000002513 implantation Methods 0.000 claims description 13
- 238000005259 measurement Methods 0.000 claims description 13
- 230000008859 change Effects 0.000 claims description 11
- 238000004891 communication Methods 0.000 claims description 7
- 230000003044 adaptive effect Effects 0.000 claims description 6
- 230000000977 initiatory effect Effects 0.000 claims description 4
- 210000002216 heart Anatomy 0.000 description 50
- 102100024547 Tensin-1 Human genes 0.000 description 48
- 230000001965 increasing effect Effects 0.000 description 25
- 206010069828 Trigemino-cardiac reflex Diseases 0.000 description 23
- 208000024891 symptom Diseases 0.000 description 22
- 210000003491 skin Anatomy 0.000 description 20
- 210000003952 cochlear nucleus Anatomy 0.000 description 18
- 239000000835 fiber Substances 0.000 description 18
- 230000008035 nerve activity Effects 0.000 description 17
- 230000004044 response Effects 0.000 description 17
- 230000001953 sensory effect Effects 0.000 description 17
- 230000001515 vagal effect Effects 0.000 description 17
- 230000002146 bilateral effect Effects 0.000 description 15
- 210000001679 solitary nucleus Anatomy 0.000 description 14
- 210000000133 brain stem Anatomy 0.000 description 13
- 208000024714 major depressive disease Diseases 0.000 description 13
- 238000002600 positron emission tomography Methods 0.000 description 13
- 230000007012 clinical effect Effects 0.000 description 11
- 210000001061 forehead Anatomy 0.000 description 11
- 230000037361 pathway Effects 0.000 description 11
- 230000009467 reduction Effects 0.000 description 11
- 238000013459 approach Methods 0.000 description 10
- 230000006793 arrhythmia Effects 0.000 description 10
- 230000002093 peripheral effect Effects 0.000 description 10
- 208000019901 Anxiety disease Diseases 0.000 description 9
- 210000003484 anatomy Anatomy 0.000 description 9
- 208000020016 psychiatric disease Diseases 0.000 description 9
- 210000004761 scalp Anatomy 0.000 description 9
- 210000003625 skull Anatomy 0.000 description 9
- 210000001519 tissue Anatomy 0.000 description 9
- 208000002193 Pain Diseases 0.000 description 8
- 230000006399 behavior Effects 0.000 description 8
- 230000003247 decreasing effect Effects 0.000 description 8
- 229940079593 drug Drugs 0.000 description 8
- 239000003814 drug Substances 0.000 description 8
- 238000002610 neuroimaging Methods 0.000 description 8
- 230000036407 pain Effects 0.000 description 8
- 210000002442 prefrontal cortex Anatomy 0.000 description 8
- 230000001225 therapeutic effect Effects 0.000 description 8
- 230000006378 damage Effects 0.000 description 7
- 238000009826 distribution Methods 0.000 description 7
- 230000006870 function Effects 0.000 description 7
- 208000014674 injury Diseases 0.000 description 7
- 238000002483 medication Methods 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 206010010904 Convulsion Diseases 0.000 description 6
- 206010021143 Hypoxia Diseases 0.000 description 6
- 208000027418 Wounds and injury Diseases 0.000 description 6
- 230000004308 accommodation Effects 0.000 description 6
- 230000036506 anxiety Effects 0.000 description 6
- 230000036772 blood pressure Effects 0.000 description 6
- 230000001149 cognitive effect Effects 0.000 description 6
- 230000007423 decrease Effects 0.000 description 6
- 230000007954 hypoxia Effects 0.000 description 6
- 230000001939 inductive effect Effects 0.000 description 6
- 230000005764 inhibitory process Effects 0.000 description 6
- 230000033001 locomotion Effects 0.000 description 6
- 230000007246 mechanism Effects 0.000 description 6
- 230000001404 mediated effect Effects 0.000 description 6
- 230000036651 mood Effects 0.000 description 6
- 230000001936 parietal effect Effects 0.000 description 6
- 208000024827 Alzheimer disease Diseases 0.000 description 5
- 241000700159 Rattus Species 0.000 description 5
- 208000023944 Sudden Unexpected Death in Epilepsy Diseases 0.000 description 5
- 230000004075 alteration Effects 0.000 description 5
- 210000003169 central nervous system Anatomy 0.000 description 5
- 238000010168 coupling process Methods 0.000 description 5
- 238000005859 coupling reaction Methods 0.000 description 5
- 210000003792 cranial nerve Anatomy 0.000 description 5
- 230000006735 deficit Effects 0.000 description 5
- 210000000613 ear canal Anatomy 0.000 description 5
- 238000002635 electroconvulsive therapy Methods 0.000 description 5
- 238000012544 monitoring process Methods 0.000 description 5
- 230000001734 parasympathetic effect Effects 0.000 description 5
- 208000028173 post-traumatic stress disease Diseases 0.000 description 5
- 201000000980 schizophrenia Diseases 0.000 description 5
- 230000035807 sensation Effects 0.000 description 5
- 235000019615 sensations Nutrition 0.000 description 5
- 230000035945 sensitivity Effects 0.000 description 5
- 230000002889 sympathetic effect Effects 0.000 description 5
- 210000001103 thalamus Anatomy 0.000 description 5
- 210000000427 trigeminal ganglion Anatomy 0.000 description 5
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 4
- 206010003840 Autonomic nervous system imbalance Diseases 0.000 description 4
- 208000030886 Traumatic Brain injury Diseases 0.000 description 4
- 230000009471 action Effects 0.000 description 4
- 230000002411 adverse Effects 0.000 description 4
- 210000004727 amygdala Anatomy 0.000 description 4
- 230000003110 anti-inflammatory effect Effects 0.000 description 4
- 230000007177 brain activity Effects 0.000 description 4
- 230000008878 coupling Effects 0.000 description 4
- 230000034994 death Effects 0.000 description 4
- 210000005153 frontal cortex Anatomy 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 208000028867 ischemia Diseases 0.000 description 4
- 231100000518 lethal Toxicity 0.000 description 4
- 230000001665 lethal effect Effects 0.000 description 4
- 210000004165 myocardium Anatomy 0.000 description 4
- 210000000653 nervous system Anatomy 0.000 description 4
- 230000000926 neurological effect Effects 0.000 description 4
- 229960002748 norepinephrine Drugs 0.000 description 4
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 230000033764 rhythmic process Effects 0.000 description 4
- 210000000225 synapse Anatomy 0.000 description 4
- 208000011580 syndromic disease Diseases 0.000 description 4
- 230000009529 traumatic brain injury Effects 0.000 description 4
- 230000002861 ventricular Effects 0.000 description 4
- 102000004127 Cytokines Human genes 0.000 description 3
- 108090000695 Cytokines Proteins 0.000 description 3
- 206010012289 Dementia Diseases 0.000 description 3
- 201000011240 Frontotemporal dementia Diseases 0.000 description 3
- 241000282412 Homo Species 0.000 description 3
- 208000019695 Migraine disease Diseases 0.000 description 3
- 208000009668 Neurobehavioral Manifestations Diseases 0.000 description 3
- 208000001871 Tachycardia Diseases 0.000 description 3
- 230000002159 abnormal effect Effects 0.000 description 3
- 206010000891 acute myocardial infarction Diseases 0.000 description 3
- 230000006978 adaptation Effects 0.000 description 3
- VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 description 3
- 230000037007 arousal Effects 0.000 description 3
- 230000037424 autonomic function Effects 0.000 description 3
- 210000003050 axon Anatomy 0.000 description 3
- 239000003990 capacitor Substances 0.000 description 3
- 230000003727 cerebral blood flow Effects 0.000 description 3
- 230000001713 cholinergic effect Effects 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- 210000000860 cochlear nerve Anatomy 0.000 description 3
- 208000010877 cognitive disease Diseases 0.000 description 3
- 230000001054 cortical effect Effects 0.000 description 3
- 230000003001 depressive effect Effects 0.000 description 3
- 230000004064 dysfunction Effects 0.000 description 3
- 210000005069 ears Anatomy 0.000 description 3
- 210000004709 eyebrow Anatomy 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 210000004326 gyrus cinguli Anatomy 0.000 description 3
- 231100000869 headache Toxicity 0.000 description 3
- 230000004217 heart function Effects 0.000 description 3
- 230000023597 hemostasis Effects 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 3
- 230000001976 improved effect Effects 0.000 description 3
- 238000007917 intracranial administration Methods 0.000 description 3
- 230000009545 invasion Effects 0.000 description 3
- 206010027599 migraine Diseases 0.000 description 3
- 230000000116 mitigating effect Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 208000031225 myocardial ischemia Diseases 0.000 description 3
- 239000002858 neurotransmitter agent Substances 0.000 description 3
- 230000002474 noradrenergic effect Effects 0.000 description 3
- 230000000144 pharmacologic effect Effects 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 210000004189 reticular formation Anatomy 0.000 description 3
- 210000004872 soft tissue Anatomy 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 230000002739 subcortical effect Effects 0.000 description 3
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 241001074130 Cryptotis parva Species 0.000 description 2
- 208000012661 Dyskinesia Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010017999 Gastrointestinal pain Diseases 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 208000010496 Heart Arrest Diseases 0.000 description 2
- 208000019022 Mood disease Diseases 0.000 description 2
- 208000016285 Movement disease Diseases 0.000 description 2
- 208000028389 Nerve injury Diseases 0.000 description 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- 208000006735 Periostitis Diseases 0.000 description 2
- 206010062519 Poor quality sleep Diseases 0.000 description 2
- 208000020114 Schizophrenia and other psychotic disease Diseases 0.000 description 2
- 208000003734 Supraventricular Tachycardia Diseases 0.000 description 2
- 230000001430 anti-depressive effect Effects 0.000 description 2
- 230000003556 anti-epileptic effect Effects 0.000 description 2
- 239000000935 antidepressant agent Substances 0.000 description 2
- 229940005513 antidepressants Drugs 0.000 description 2
- 238000013528 artificial neural network Methods 0.000 description 2
- 230000000712 assembly Effects 0.000 description 2
- 238000000429 assembly Methods 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 210000001992 atrioventricular node Anatomy 0.000 description 2
- 230000003935 attention Effects 0.000 description 2
- 208000013404 behavioral symptom Diseases 0.000 description 2
- 230000023555 blood coagulation Effects 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 208000029028 brain injury Diseases 0.000 description 2
- 210000005013 brain tissue Anatomy 0.000 description 2
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 2
- 210000003477 cochlea Anatomy 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000004020 conductor Substances 0.000 description 2
- 210000002808 connective tissue Anatomy 0.000 description 2
- 230000001351 cycling effect Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000035487 diastolic blood pressure Effects 0.000 description 2
- 230000003292 diminished effect Effects 0.000 description 2
- 208000010118 dystonia Diseases 0.000 description 2
- 210000000883 ear external Anatomy 0.000 description 2
- 235000005686 eating Nutrition 0.000 description 2
- 230000002526 effect on cardiovascular system Effects 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 230000007717 exclusion Effects 0.000 description 2
- 210000000744 eyelid Anatomy 0.000 description 2
- 208000013403 hyperactivity Diseases 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000013507 mapping Methods 0.000 description 2
- 210000004228 maxillary nerve Anatomy 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 230000008764 nerve damage Effects 0.000 description 2
- 210000000944 nerve tissue Anatomy 0.000 description 2
- 210000002569 neuron Anatomy 0.000 description 2
- 230000004112 neuroprotection Effects 0.000 description 2
- 230000000324 neuroprotective effect Effects 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 238000007427 paired t-test Methods 0.000 description 2
- 230000007310 pathophysiology Effects 0.000 description 2
- 210000003460 periosteum Anatomy 0.000 description 2
- 238000001050 pharmacotherapy Methods 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000000770 proinflammatory effect Effects 0.000 description 2
- 230000004224 protection Effects 0.000 description 2
- 238000011552 rat model Methods 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 230000007115 recruitment Effects 0.000 description 2
- 230000004895 regional blood flow Effects 0.000 description 2
- 238000013548 repetitive transcranial magnetic stimulation Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 230000011664 signaling Effects 0.000 description 2
- 201000002859 sleep apnea Diseases 0.000 description 2
- 208000019116 sleep disease Diseases 0.000 description 2
- 208000022925 sleep disturbance Diseases 0.000 description 2
- 230000003238 somatosensory effect Effects 0.000 description 2
- 210000004304 subcutaneous tissue Anatomy 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 230000002123 temporal effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000004797 therapeutic response Effects 0.000 description 2
- 235000019649 trigeminal effects Nutrition 0.000 description 2
- 210000000836 trigeminal nuclei Anatomy 0.000 description 2
- 208000003663 ventricular fibrillation Diseases 0.000 description 2
- 230000009278 visceral effect Effects 0.000 description 2
- YFGHCGITMMYXAQ-UHFFFAOYSA-N 2-[(diphenylmethyl)sulfinyl]acetamide Chemical compound C=1C=CC=CC=1C(S(=O)CC(=O)N)C1=CC=CC=C1 YFGHCGITMMYXAQ-UHFFFAOYSA-N 0.000 description 1
- OJSXICLEROKMBP-FFUDWAICSA-N 869705-22-6 Chemical compound C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 OJSXICLEROKMBP-FFUDWAICSA-N 0.000 description 1
- 208000030507 AIDS Diseases 0.000 description 1
- 102000012440 Acetylcholinesterase Human genes 0.000 description 1
- 108010022752 Acetylcholinesterase Proteins 0.000 description 1
- 208000031091 Amnestic disease Diseases 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 208000000103 Anorexia Nervosa Diseases 0.000 description 1
- 208000036640 Asperger disease Diseases 0.000 description 1
- 201000006062 Asperger syndrome Diseases 0.000 description 1
- 206010003497 Asphyxia Diseases 0.000 description 1
- 206010003671 Atrioventricular Block Diseases 0.000 description 1
- 206010004716 Binge eating Diseases 0.000 description 1
- 208000020925 Bipolar disease Diseases 0.000 description 1
- 208000032841 Bulimia Diseases 0.000 description 1
- 206010006550 Bulimia nervosa Diseases 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 235000012766 Cannabis sativa ssp. sativa var. sativa Nutrition 0.000 description 1
- 235000012765 Cannabis sativa ssp. sativa var. spontanea Nutrition 0.000 description 1
- 208000020446 Cardiac disease Diseases 0.000 description 1
- 206010007556 Cardiac failure acute Diseases 0.000 description 1
- 206010007558 Cardiac failure chronic Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010008748 Chorea Diseases 0.000 description 1
- 208000000532 Chronic Brain Injury Diseases 0.000 description 1
- 208000028698 Cognitive impairment Diseases 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 206010011903 Deafness traumatic Diseases 0.000 description 1
- 206010012218 Delirium Diseases 0.000 description 1
- 206010012239 Delusion Diseases 0.000 description 1
- 206010012374 Depressed mood Diseases 0.000 description 1
- 208000020401 Depressive disease Diseases 0.000 description 1
- 206010013647 Drowning Diseases 0.000 description 1
- 241001269524 Dura Species 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 208000014094 Dystonic disease Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000024658 Epilepsy syndrome Diseases 0.000 description 1
- 208000002877 Epileptic Syndromes Diseases 0.000 description 1
- 206010016059 Facial pain Diseases 0.000 description 1
- 206010016275 Fear Diseases 0.000 description 1
- 208000001613 Gambling Diseases 0.000 description 1
- 102000012004 Ghrelin Human genes 0.000 description 1
- 101800001586 Ghrelin Proteins 0.000 description 1
- 208000004547 Hallucinations Diseases 0.000 description 1
- 208000027109 Headache disease Diseases 0.000 description 1
- 208000010271 Heart Block Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010019663 Hepatic failure Diseases 0.000 description 1
- 102100037907 High mobility group protein B1 Human genes 0.000 description 1
- 101001025337 Homo sapiens High mobility group protein B1 Proteins 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010020850 Hyperthyroidism Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 206010061216 Infarction Diseases 0.000 description 1
- 208000032382 Ischaemic stroke Diseases 0.000 description 1
- 206010023203 Joint destruction Diseases 0.000 description 1
- 102000016267 Leptin Human genes 0.000 description 1
- 108010092277 Leptin Proteins 0.000 description 1
- HBBGRARXTFLTSG-UHFFFAOYSA-N Lithium ion Chemical compound [Li+] HBBGRARXTFLTSG-UHFFFAOYSA-N 0.000 description 1
- 208000016604 Lyme disease Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 102000001796 Melanocortin 4 receptors Human genes 0.000 description 1
- 108010008364 Melanocortins Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- DUGOZIWVEXMGBE-UHFFFAOYSA-N Methylphenidate Chemical compound C=1C=CC=CC=1C(C(=O)OC)C1CCCCN1 DUGOZIWVEXMGBE-UHFFFAOYSA-N 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 206010028347 Muscle twitching Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 208000002946 Noise-Induced Hearing Loss Diseases 0.000 description 1
- 101800000590 Obestatin Proteins 0.000 description 1
- 208000005141 Otitis Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 206010033645 Pancreatitis Diseases 0.000 description 1
- 241000935974 Paralichthys dentatus Species 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 206010034158 Pathological gambling Diseases 0.000 description 1
- 208000000609 Pick Disease of the Brain Diseases 0.000 description 1
- 206010037211 Psychomotor hyperactivity Diseases 0.000 description 1
- 206010038776 Retching Diseases 0.000 description 1
- 208000006289 Rett Syndrome Diseases 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 206010049447 Tachyarrhythmia Diseases 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- NRTOMJZYCJJWKI-UHFFFAOYSA-N Titanium nitride Chemical compound [Ti]#N NRTOMJZYCJJWKI-UHFFFAOYSA-N 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 108010021436 Type 4 Melanocortin Receptor Proteins 0.000 description 1
- 201000004810 Vascular dementia Diseases 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 229940022698 acetylcholinesterase Drugs 0.000 description 1
- 238000001467 acupuncture Methods 0.000 description 1
- 231100000569 acute exposure Toxicity 0.000 description 1
- 210000000593 adipose tissue white Anatomy 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 230000036626 alertness Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 102000047725 alpha7 Nicotinic Acetylcholine Receptor Human genes 0.000 description 1
- 108700006085 alpha7 Nicotinic Acetylcholine Receptor Proteins 0.000 description 1
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 description 1
- 229960003805 amantadine Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000002891 anorexigenic effect Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 230000005735 apoptotic response Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000004872 arterial blood pressure Effects 0.000 description 1
- 230000001746 atrial effect Effects 0.000 description 1
- 210000003926 auditory cortex Anatomy 0.000 description 1
- 210000003984 auditory pathway Anatomy 0.000 description 1
- 230000003416 augmentation Effects 0.000 description 1
- 210000003403 autonomic nervous system Anatomy 0.000 description 1
- 230000003376 axonal effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 108091008698 baroreceptors Proteins 0.000 description 1
- 230000035581 baroreflex Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 208000014679 binge eating disease Diseases 0.000 description 1
- 230000008512 biological response Effects 0.000 description 1
- 208000028683 bipolar I disease Diseases 0.000 description 1
- 208000025307 bipolar depression Diseases 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 208000006218 bradycardia Diseases 0.000 description 1
- 230000003925 brain function Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 210000001715 carotid artery Anatomy 0.000 description 1
- 210000001159 caudate nucleus Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 229960003920 cocaine Drugs 0.000 description 1
- 230000019771 cognition Effects 0.000 description 1
- 231100000867 compulsive behavior Toxicity 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 231100000868 delusion Toxicity 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 238000011833 dog model Methods 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 208000019258 ear infection Diseases 0.000 description 1
- 230000020595 eating behavior Effects 0.000 description 1
- 230000000355 effect on anorexia Effects 0.000 description 1
- 230000002913 effect on cachexia Effects 0.000 description 1
- 230000000062 effect on obesity Effects 0.000 description 1
- 210000002049 efferent pathway Anatomy 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 238000005868 electrolysis reaction Methods 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 210000000105 enteric nervous system Anatomy 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 201000006517 essential tremor Diseases 0.000 description 1
- 230000000763 evoking effect Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 210000000256 facial nerve Anatomy 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000004055 fourth ventricle Anatomy 0.000 description 1
- 238000002599 functional magnetic resonance imaging Methods 0.000 description 1
- 230000030136 gastric emptying Effects 0.000 description 1
- 210000000320 geniculate body Anatomy 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 238000001631 haemodialysis Methods 0.000 description 1
- 230000010370 hearing loss Effects 0.000 description 1
- 231100000888 hearing loss Toxicity 0.000 description 1
- 208000016354 hearing loss disease Diseases 0.000 description 1
- 230000000322 hemodialysis Effects 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 230000013632 homeostatic process Effects 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 230000036543 hypotension Effects 0.000 description 1
- 230000002267 hypothalamic effect Effects 0.000 description 1
- 210000003016 hypothalamus Anatomy 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 210000003552 inferior colliculi Anatomy 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 238000011221 initial treatment Methods 0.000 description 1
- 230000030214 innervation Effects 0.000 description 1
- 230000003914 insulin secretion Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 229910052741 iridium Inorganic materials 0.000 description 1
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 description 1
- 210000004731 jugular vein Anatomy 0.000 description 1
- 230000008140 language development Effects 0.000 description 1
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 description 1
- 229940039781 leptin Drugs 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 229910001416 lithium ion Inorganic materials 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 231100000835 liver failure Toxicity 0.000 description 1
- 208000007903 liver failure Diseases 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 210000000111 lower esophageal sphincter Anatomy 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 210000002698 mandibular nerve Anatomy 0.000 description 1
- 210000001767 medulla oblongata Anatomy 0.000 description 1
- 239000002865 melanocortin Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000009245 menopause Effects 0.000 description 1
- 238000010197 meta-analysis Methods 0.000 description 1
- 230000006371 metabolic abnormality Effects 0.000 description 1
- 230000037323 metabolic rate Effects 0.000 description 1
- 229960001344 methylphenidate Drugs 0.000 description 1
- 244000309715 mini pig Species 0.000 description 1
- 229960001165 modafinil Drugs 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 230000001423 neocortical effect Effects 0.000 description 1
- 210000001577 neostriatum Anatomy 0.000 description 1
- 230000003767 neural control Effects 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 230000007372 neural signaling Effects 0.000 description 1
- 230000001703 neuroimmune Effects 0.000 description 1
- 230000008062 neuronal firing Effects 0.000 description 1
- 229910001120 nichrome Inorganic materials 0.000 description 1
- 229910052758 niobium Inorganic materials 0.000 description 1
- 239000010955 niobium Substances 0.000 description 1
- GUCVJGMIXFAOAE-UHFFFAOYSA-N niobium atom Chemical compound [Nb] GUCVJGMIXFAOAE-UHFFFAOYSA-N 0.000 description 1
- 230000000422 nocturnal effect Effects 0.000 description 1
- 238000011457 non-pharmacological treatment Methods 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 230000002450 orbitofrontal effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 230000008058 pain sensation Effects 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 210000001819 pancreatic juice Anatomy 0.000 description 1
- 230000009958 parasympathetic pathway Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000009543 pathological alteration Effects 0.000 description 1
- 229960000761 pemoline Drugs 0.000 description 1
- NRNCYVBFPDDJNE-UHFFFAOYSA-N pemoline Chemical compound O1C(N)=NC(=O)C1C1=CC=CC=C1 NRNCYVBFPDDJNE-UHFFFAOYSA-N 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 238000011886 postmortem examination Methods 0.000 description 1
- 230000003334 potential effect Effects 0.000 description 1
- 230000002360 prefrontal effect Effects 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 210000001774 pressoreceptor Anatomy 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 210000001176 projection neuron Anatomy 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 210000004129 prosencephalon Anatomy 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000003368 psychostimulant agent Substances 0.000 description 1
- 229940127250 psychostimulant medication Drugs 0.000 description 1
- 238000001671 psychotherapy Methods 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 238000002106 pulse oximetry Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 239000003870 refractory metal Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000010410 reperfusion Effects 0.000 description 1
- 210000001034 respiratory center Anatomy 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000021670 response to stimulus Effects 0.000 description 1
- 230000003938 response to stress Effects 0.000 description 1
- 229910052702 rhenium Inorganic materials 0.000 description 1
- WUAPFZMCVAUBPE-UHFFFAOYSA-N rhenium atom Chemical compound [Re] WUAPFZMCVAUBPE-UHFFFAOYSA-N 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 208000022610 schizoaffective disease Diseases 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000031893 sensory processing Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 210000001013 sinoatrial node Anatomy 0.000 description 1
- 230000003997 social interaction Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 201000009032 substance abuse Diseases 0.000 description 1
- 231100000736 substance abuse Toxicity 0.000 description 1
- 201000006152 substance dependence Diseases 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 238000010408 sweeping Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000035488 systolic blood pressure Effects 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 229910052715 tantalum Inorganic materials 0.000 description 1
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 208000037816 tissue injury Diseases 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 210000000515 tooth Anatomy 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000001927 transneuronal effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 206010044652 trigeminal neuralgia Diseases 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 206010047302 ventricular tachycardia Diseases 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36146—Control systems specified by the stimulation parameters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0551—Spinal or peripheral nerve electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0504—Subcutaneous electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0526—Head electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36053—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for vagal stimulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36064—Epilepsy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
- A61N1/36085—Eating disorders or obesity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
- A61N1/36089—Addiction or withdrawal from substance abuse such as alcohol or drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
- A61N1/36096—Mood disorders, e.g. depression, anxiety or panic disorder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/361—Phantom sensations, e.g. tinnitus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/3611—Respiration control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36114—Cardiac control, e.g. by vagal stimulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36146—Control systems specified by the stimulation parameters
- A61N1/3615—Intensity
- A61N1/3616—Voltage density or current density
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36146—Control systems specified by the stimulation parameters
- A61N1/36167—Timing, e.g. stimulation onset
- A61N1/36171—Frequency
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36146—Control systems specified by the stimulation parameters
- A61N1/36167—Timing, e.g. stimulation onset
- A61N1/36178—Burst or pulse train parameters
Landscapes
- Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Electrotherapy Devices (AREA)
- Electroluminescent Light Sources (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42300810P | 2010-12-14 | 2010-12-14 | |
| US61/423,008 | 2010-12-14 | ||
| US201161440802P | 2011-02-08 | 2011-02-08 | |
| US61/440,802 | 2011-02-08 | ||
| US201161445454P | 2011-02-22 | 2011-02-22 | |
| US61/445,454 | 2011-02-22 | ||
| US201161479779P | 2011-04-27 | 2011-04-27 | |
| US61/479,779 | 2011-04-27 | ||
| PCT/US2011/065003 WO2012082961A2 (en) | 2010-12-14 | 2011-12-14 | Extracranial implantable devices, systems and methods for the treatment of medical disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2821721A1 true CA2821721A1 (en) | 2012-06-21 |
Family
ID=46245360
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2821721A Abandoned CA2821721A1 (en) | 2010-12-14 | 2011-12-14 | Extracranial implantable devices, systems and methods for the treatment of medical disorders |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US20140142669A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2651497B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6559395B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2821721A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012082961A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112012008028A2 (pt) | 2009-10-05 | 2016-03-01 | Univ California | sistema para estimulação do nervo trigêmeo para tratamento de um distúrbio neuropsquiátrico, unidade de eletrodo cutâneo, método para tratar um distúrbio neuropsquiátrico, e, kit para estimulação do nervo trigêmeo para tratamento de um distúrbio neuropsiquiátrico |
| US9364674B2 (en) | 2010-11-30 | 2016-06-14 | Ian A. Cook | Pulse generator for cranial nerve stimulation |
| EP2651496A4 (en) * | 2010-12-14 | 2014-07-09 | Univ California | DEVICES, SYSTEMS AND METHODS OF TREATING MEDICAL DISEASES |
| EP2651497B1 (en) | 2010-12-14 | 2019-02-20 | The Regents of The University of California | Extracranial implantable systems for the treatment of medical disorders |
| US10035013B2 (en) * | 2012-04-05 | 2018-07-31 | The Regents Of The University Of California | Subcutaneous electrodes for cranial nerve stimulation |
| WO2014164435A1 (en) * | 2013-03-11 | 2014-10-09 | Ohio State Innovation Foundation | Systems for treating anxiety and anxiety-associated disorders |
| AU2014257024B2 (en) * | 2013-04-24 | 2019-05-09 | Neurosigma, Inc. | Modulation of autonomic nervous system activity and integrated electrode assemblies for trigeminal neurostimulation |
| US9839777B2 (en) | 2013-08-14 | 2017-12-12 | Syntilla Medical LLC | Implantable neurostimulation lead for head pain |
| US9042991B2 (en) | 2013-08-14 | 2015-05-26 | Syntilla Medical LLC | Implantable head mounted neurostimulation system for head pain |
| US9427566B2 (en) | 2013-08-14 | 2016-08-30 | Syntilla Medical LLC | Implantable neurostimulation lead for head pain |
| US12311114B2 (en) | 2013-08-30 | 2025-05-27 | Neuromod Devices Limited | Method and apparatus for treating a neurological disorder |
| US9498635B2 (en) | 2013-10-16 | 2016-11-22 | Syntilla Medical LLC | Implantable head located radiofrequency coupled neurostimulation system for head pain |
| US10960215B2 (en) | 2013-10-23 | 2021-03-30 | Nuxcel, Inc. | Low profile head-located neurostimulator and method of fabrication |
| US10258805B2 (en) | 2013-10-23 | 2019-04-16 | Syntilla Medical, Llc | Surgical method for implantable head mounted neurostimulation system for head pain |
| WO2016119654A1 (zh) * | 2015-01-26 | 2016-08-04 | 周常安 | 生理反馈系统及发光装置 |
| US20170143972A1 (en) | 2015-11-19 | 2017-05-25 | Boston Scientific Neuromodulation Corporation | Neuromodulation for neuroinflammation treatments with parameters controlled using biomarkers |
| US9717917B2 (en) | 2016-01-06 | 2017-08-01 | Syntilla Medical LLC | Charging system incorporating independent charging and communication with multiple implanted devices |
| US10406360B2 (en) * | 2016-09-13 | 2019-09-10 | Richard Charles Niemtzow | Electrical acupuncture eye treatment |
| US10716951B2 (en) * | 2016-10-17 | 2020-07-21 | Wave Neuroscience, Inc. | High frequency magnetic foot stimulation |
| US10596378B2 (en) * | 2016-10-18 | 2020-03-24 | Joseph Rustick | Method for treatment of depression using synaptic pathway training |
| US11723579B2 (en) | 2017-09-19 | 2023-08-15 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement |
| US11547854B2 (en) * | 2017-09-29 | 2023-01-10 | Cochlear Limited | Hearing prosthesis |
| US12403306B2 (en) | 2017-10-23 | 2025-09-02 | Cardiac Pacemakers, Inc. | Electric field shaping leads for treatment of cancer |
| US11717686B2 (en) | 2017-12-04 | 2023-08-08 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to facilitate learning and performance |
| EP3720552A4 (en) | 2017-12-06 | 2021-08-25 | Technion Research & Development Foundation Limited | Methods of neural inhibition for treating bowel diseases and disorders |
| US11894148B2 (en) * | 2017-12-22 | 2024-02-06 | Electrocore, Inc. | Systems and methods for treating patients with diseases associated with viruses |
| US12280219B2 (en) | 2017-12-31 | 2025-04-22 | NeuroLight, Inc. | Method and apparatus for neuroenhancement to enhance emotional response |
| US11318277B2 (en) | 2017-12-31 | 2022-05-03 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to enhance emotional response |
| TWI667860B (zh) | 2018-02-09 | 2019-08-01 | 鉅旺生技股份有限公司 | 植入式醫材遠距離無線充電強化結構 |
| US11364361B2 (en) | 2018-04-20 | 2022-06-21 | Neuroenhancement Lab, LLC | System and method for inducing sleep by transplanting mental states |
| WO2019239367A1 (en) | 2018-06-14 | 2019-12-19 | Inner Cosmos Llc | Virtual user interface system and methods for use thereof |
| CN109045468B (zh) * | 2018-08-09 | 2022-05-24 | 西安科悦医疗技术有限公司 | 一种耳部迷走神经刺激系统及其装置 |
| EP3849410A4 (en) | 2018-09-14 | 2022-11-02 | Neuroenhancement Lab, LLC | System and method of improving sleep |
| US11623088B2 (en) | 2018-12-10 | 2023-04-11 | Spark Biomedical, Inc. | Devices and methods for the treatment of substance use disorders |
| US10967182B2 (en) | 2018-12-10 | 2021-04-06 | Spark Biomedical, Inc. | Devices and methods for reducing inflammation using electrical stimulation |
| US11351370B2 (en) | 2018-12-10 | 2022-06-07 | Spark Biomedical, Inc. | Devices and methods for treating cognitive dysfunction and depression using electrical stimulation |
| US12502527B2 (en) | 2018-12-10 | 2025-12-23 | Spark Biomedical, Inc. | Devices and methods for treating stress and improving alertness using electrical stimulation |
| US11433237B2 (en) * | 2018-12-13 | 2022-09-06 | Livanova Usa, Inc. | Neuromodulation therapy for auto-immune and inflammatory disorders |
| EP3920793A1 (en) | 2019-02-07 | 2021-12-15 | Inner Cosmos Inc. | Intracalvarial bci systems and methods for their making, implantation and use |
| WO2020219336A1 (en) * | 2019-04-22 | 2020-10-29 | Boston Scientific Scimed, Inc. | Electrical stimulation devices for cancer treatment |
| WO2020219339A1 (en) | 2019-04-22 | 2020-10-29 | Boston Scientific Scimed, Inc. | Combination electrical and chemotherapeutic treatment of cancer |
| WO2020219517A2 (en) | 2019-04-23 | 2020-10-29 | Boston Scientific Scimed, Inc. | Electrical stimulation for cancer treatment with internal and external electrodes |
| JP2022529374A (ja) | 2019-04-23 | 2022-06-21 | ボストン サイエンティフィック サイムド，インコーポレイテッド | がん治療のための電気刺激用電極 |
| JP7476231B2 (ja) | 2019-04-23 | 2024-04-30 | ボストン サイエンティフィック サイムド，インコーポレイテッド | 温熱療法又は熱モニタと共に行われる電気刺激 |
| US11065461B2 (en) | 2019-07-08 | 2021-07-20 | Bioness Inc. | Implantable power adapter |
| CN114423490A (zh) * | 2019-07-14 | 2022-04-29 | 火花生物医学股份有限公司 | 使用耳状刺激设备递送疗法的系统和方法 |
| US11911620B2 (en) | 2019-07-22 | 2024-02-27 | Ismail Mohammed Yousif Musallam | Neuromodulation for treatment of brain and eye strokes and/or acute dysregulated reduced cerebral or ocular blood flow |
| US11241574B2 (en) | 2019-09-11 | 2022-02-08 | Bose Corporation | Systems and methods for providing and coordinating vagus nerve stimulation with audio therapy |
| US11235156B2 (en) | 2019-09-11 | 2022-02-01 | Bose Corporation | Wearable audio device with vagus nerve stimulation |
| US12485277B2 (en) | 2020-01-14 | 2025-12-02 | Inner Cosmos Inc. | Devices, systems and methods for cortical stimulation |
| US11883655B2 (en) | 2020-02-24 | 2024-01-30 | Boston Scientific Scimed, Inc. | Systems and methods for treatment of pancreatic cancer |
| ES2993637T3 (en) | 2020-05-04 | 2025-01-03 | Btl Healthcare Technologies As | Device for unattended treatment of a patient |
| US11878167B2 (en) | 2020-05-04 | 2024-01-23 | Btl Healthcare Technologies A.S. | Device and method for unattended treatment of a patient |
| TWI894280B (zh) * | 2020-05-26 | 2025-08-21 | 南韓商愛思阿爾法數字醫療科技有限公司 | 用以治療癌症惡病質之系統、用以治療癌症惡病質之運算系統及其操作方法、以及非暫態電腦可讀取媒體 |
| US20220184405A1 (en) * | 2020-12-11 | 2022-06-16 | Advanced Neuromodulation Systems, Inc. | Systems and methods for labeling data in active implantable medical device systems |
| US20240149063A1 (en) * | 2021-03-04 | 2024-05-09 | Washington University | Transcutaneous auricular vagal nerve stimulation for subarachnoid hemorrhages |
| WO2023091469A1 (en) * | 2021-11-17 | 2023-05-25 | The Board Of Trustees Of The Leland Stanford Junior University | Targeting periosteal tissue for delivery of therapeutics |
| US12017068B2 (en) | 2022-05-27 | 2024-06-25 | Spark Biomedical, Inc. | Devices and methods for treating motion sickness using electrical stimulation |
| US12029893B1 (en) | 2023-06-14 | 2024-07-09 | Spark Biomedical, Inc. | Wearable auricular neurostimulator and methods of use |
Family Cites Families (113)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3279468A (en) | 1963-05-14 | 1966-10-18 | Vine Sidney Le | Electrotherapeutic facial mask apparatus |
| US3709228A (en) | 1971-01-07 | 1973-01-09 | D Barker | Apparatus for facial stimulation |
| US4233986A (en) | 1978-07-18 | 1980-11-18 | Agar Ginosar Electronics And Metal Products | Apparatus and method for controlling pain by transcutaneous electrical stimulation (TES) |
| US4305402A (en) | 1979-06-29 | 1981-12-15 | Katims Jefferson J | Method for transcutaneous electrical stimulation |
| US4635641A (en) | 1985-10-16 | 1987-01-13 | Murray Electronics Associates Limited | Multi-element electrode |
| SU1718976A1 (ru) | 1989-10-31 | 1992-03-15 | 1-Й Московский Медицинский Институт Им.И.М.Сеченова | Способ купировани болей при невралгии тройничного нерва |
| RU2086227C1 (ru) | 1994-04-05 | 1997-08-10 | Российский научно-исследовательский нейрохирургический институт им.проф.А.Л.Поленова | Способ лечения поражений нервно-сосудистых структур орбиты |
| JPH07289649A (ja) | 1994-04-22 | 1995-11-07 | Hayashibara Takeshi | 眼神経の刺激信号発生装置 |
| US5540734A (en) | 1994-09-28 | 1996-07-30 | Zabara; Jacob | Cranial nerve stimulation treatments using neurocybernetic prosthesis |
| US5514175A (en) | 1994-11-09 | 1996-05-07 | Cerebral Stimulation, Inc. | Auricular electrical stimulator |
| US5549734A (en) | 1995-03-08 | 1996-08-27 | Astec Industries, Inc. | Baghouse cleaning method |
| JPH08299141A (ja) | 1995-05-08 | 1996-11-19 | Mori Mihoko | 枕カバー |
| US5814095A (en) | 1996-09-18 | 1998-09-29 | Implex Gmbh Spezialhorgerate | Implantable microphone and implantable hearing aids utilizing same |
| US6016449A (en) | 1997-10-27 | 2000-01-18 | Neuropace, Inc. | System for treatment of neurological disorders |
| US20070060975A1 (en) | 1999-07-08 | 2007-03-15 | Mannheimer Jeffrey S | Combination electrode-battery and programming assembly for a miniature wireless transcutaneous electrical neuro or muscular-stimulation unit |
| US7200446B2 (en) | 1999-07-21 | 2007-04-03 | Borkan William N | Catheter leads for the intrathecal space and method of use |
| US6567702B1 (en) | 1999-10-15 | 2003-05-20 | The Board Of Trustees Of The Leland Stanford Junior University | Eliciting analgesia by transcranial electrical stimulation |
| US6466822B1 (en) | 2000-04-05 | 2002-10-15 | Neuropace, Inc. | Multimodal neurostimulator and process of using it |
| US6405079B1 (en) * | 2000-09-22 | 2002-06-11 | Mehdi M. Ansarinia | Stimulation method for the dural venous sinuses and adjacent dura for treatment of medical conditions |
| US7158832B2 (en) | 2000-09-27 | 2007-01-02 | Cvrx, Inc. | Electrode designs and methods of use for cardiovascular reflex control devices |
| US6549808B1 (en) | 2000-10-19 | 2003-04-15 | Heinz R. Gisel | Devices and methods for the transcutaneous delivery of ions and the electrical stimulation of tissue and cells at targeted areas in the eye |
| US6950707B2 (en) | 2000-11-21 | 2005-09-27 | Advanced Bionics Corporation | Systems and methods for treatment of obesity and eating disorders by electrical brain stimulation and/or drug infusion |
| RU2185092C1 (ru) | 2000-12-21 | 2002-07-20 | Ремнев Андрей Геннадьевич | Способ диагностики поражения первой и второй ветвей тройничного нерва |
| US6735475B1 (en) | 2001-01-30 | 2004-05-11 | Advanced Bionics Corporation | Fully implantable miniature neurostimulator for stimulation as a therapy for headache and/or facial pain |
| US6788975B1 (en) | 2001-01-30 | 2004-09-07 | Advanced Bionics Corporation | Fully implantable miniature neurostimulator for stimulation as a therapy for epilepsy |
| US20060064140A1 (en) | 2001-01-30 | 2006-03-23 | Whitehurst Todd K | Methods and systems for stimulating a trigeminal nerve to treat a psychiatric disorder |
| US7171276B2 (en) | 2001-06-29 | 2007-01-30 | Abbott Laboratories | Hydrogel and scrim assembly for use with electro-acupuncture device with stimulation electrodes |
| US20030045922A1 (en) | 2001-08-29 | 2003-03-06 | Nancy Northrop | Skin treatment method and apparatus |
| US20140046407A1 (en) | 2001-08-31 | 2014-02-13 | Bio Control Medical (B.C.M.) Ltd. | Nerve stimulation techniques |
| US8565896B2 (en) | 2010-11-22 | 2013-10-22 | Bio Control Medical (B.C.M.) Ltd. | Electrode cuff with recesses |
| US6954668B1 (en) | 2001-10-11 | 2005-10-11 | Cuozzo John W | Apparatus and method for intra-oral stimulation of the trigeminal nerve |
| US7689277B2 (en) | 2002-03-22 | 2010-03-30 | Leptos Biomedical, Inc. | Neural stimulation for treatment of metabolic syndrome and type 2 diabetes |
| US20030195588A1 (en) | 2002-04-16 | 2003-10-16 | Neuropace, Inc. | External ear canal interface for the treatment of neurological disorders |
| US7003352B1 (en) * | 2002-05-24 | 2006-02-21 | Advanced Bionics Corporation | Treatment of epilepsy by brain stimulation |
| JP2003339884A (ja) * | 2002-05-31 | 2003-12-02 | Fes:Kk | 顔面電気刺激装置 |
| US7158834B2 (en) | 2002-06-13 | 2007-01-02 | Atlantic Medical, Inc. | Method and apparatus for performing microcurrent stimulation (MSC) therapy |
| AU2003265509A1 (en) | 2002-08-19 | 2004-03-03 | Arizona Board Regents | Neurostimulator |
| US20040138097A1 (en) | 2002-11-01 | 2004-07-15 | Bahman Guyuron | Method and treatment for treating and preventing pain associated with compression of a nerve |
| WO2005000090A2 (en) | 2003-05-30 | 2005-01-06 | Medi-Screw, Inc. | Medical implant systems |
| US8190248B2 (en) | 2003-10-16 | 2012-05-29 | Louisiana Tech University Foundation, Inc. | Medical devices for the detection, prevention and/or treatment of neurological disorders, and methods related thereto |
| WO2005062829A2 (en) | 2003-12-19 | 2005-07-14 | Advanced Bionics Corporation | Skull-mounted electrical stimulation system and method for treating patients |
| JP4879754B2 (ja) | 2004-01-22 | 2012-02-22 | リハブトロニクス インコーポレーテッド | 移植された非活性導電体を介して、身体組織に電流を搬送する方法 |
| US7844344B2 (en) | 2004-03-30 | 2010-11-30 | Medtronic, Inc. | MRI-safe implantable lead |
| US7565197B2 (en) | 2004-06-18 | 2009-07-21 | Medtronic, Inc. | Conditional requirements for remote medical device programming |
| WO2006019764A2 (en) | 2004-07-15 | 2006-02-23 | Northstar Neuroscience, Inc. | Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy |
| US20060050912A1 (en) | 2004-09-09 | 2006-03-09 | Earcraft, Inc. | Shell and tip for hearing aid |
| WO2006034305A2 (en) | 2004-09-21 | 2006-03-30 | University Of Florida Research Foundation, Inc. | Multiple lead method for deep brain stimulation |
| JP2008516696A (ja) | 2004-10-18 | 2008-05-22 | ルイジアナ テック ユニバーシティ ファウンデーション | 神経障害の検出、予防および／または治療のための医療装置ならびにその医療装置に関連する方法 |
| US7685817B2 (en) | 2004-10-18 | 2010-03-30 | Ceti, Inc. | Method and system for providing a rotational output using a non-combustion heat source |
| EP1827580A1 (en) | 2004-10-21 | 2007-09-05 | Advanced Neuromodulation Systems, Inc. | New stimulation design for neuromodulation |
| FR2877583B1 (fr) | 2004-11-10 | 2007-05-11 | Patrick Cosson | Dispositif d'electrotherapie |
| EP1671670A1 (fr) | 2004-12-14 | 2006-06-21 | STX Sprl | Appareil pour l'electro-inhibition des muscles de la face |
| US8825166B2 (en) | 2005-01-21 | 2014-09-02 | John Sasha John | Multiple-symptom medical treatment with roving-based neurostimulation |
| DE102005003735B4 (de) | 2005-01-26 | 2008-04-03 | Cerbomed Gmbh | Vorrichtung zur transkutanen Stimulation eines Nervs des menschlichen Körpers |
| US8700163B2 (en) | 2005-03-04 | 2014-04-15 | Cyberonics, Inc. | Cranial nerve stimulation for treatment of substance addiction |
| EP2412306B1 (en) | 2005-03-09 | 2017-08-30 | DELTA, Dansk Elektronik, Lys & Akustik | A three-dimensional adhesive device having a microelectronic system embedded therein |
| US7853321B2 (en) | 2005-03-14 | 2010-12-14 | Boston Scientific Neuromodulation Corporation | Stimulation of a stimulation site within the neck or head |
| US7920915B2 (en) | 2005-11-16 | 2011-04-05 | Boston Scientific Neuromodulation Corporation | Implantable stimulator |
| US20060206165A1 (en) * | 2005-03-14 | 2006-09-14 | Jaax Kristen N | Occipital nerve stimulation to treat headaches and other conditions |
| EP1861160B1 (en) | 2005-03-24 | 2011-11-16 | Metacure Limited | Wireless leads for gastrointestinal tract applications |
| US20070027486A1 (en) | 2005-07-29 | 2007-02-01 | Cyberonics, Inc. | Medical devices for enhancing intrinsic neural activity |
| US7499752B2 (en) | 2005-07-29 | 2009-03-03 | Cyberonics, Inc. | Selective nerve stimulation for the treatment of eating disorders |
| JP2007054299A (ja) | 2005-08-24 | 2007-03-08 | Sharp Corp | 電気治療装置、およびそれを構成するためのシステム |
| JP2007061267A (ja) | 2005-08-30 | 2007-03-15 | Nova Medico:Kk | 鼻炎又は結膜炎治療器具 |
| US20070150027A1 (en) * | 2005-12-22 | 2007-06-28 | Rogers Lesco L | Non-invasive device and method for electrical stimulation of neural tissue |
| US8725243B2 (en) | 2005-12-28 | 2014-05-13 | Cyberonics, Inc. | Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders |
| US20070173908A1 (en) * | 2006-01-20 | 2007-07-26 | Cyberonics, Inc. | Transcutaneous trigeminal nerve stimulation to treat motion sickness |
| BRPI0706678A2 (pt) | 2006-01-23 | 2011-04-05 | Koninkl Philips Electronics Nv | conjunto de eletrodo biomédico de uso prolongado, aparelho médico de monitoração e/ou administração de terapia, e, método para aplicar o conjunto de eletrodo biomédico |
| US7801601B2 (en) | 2006-01-27 | 2010-09-21 | Cyberonics, Inc. | Controlling neuromodulation using stimulus modalities |
| GB0603464D0 (en) | 2006-02-21 | 2006-04-05 | Goreszeniuk Teodor | Improvements in & relating to external neurostimulation |
| JP5052596B2 (ja) | 2006-03-29 | 2012-10-17 | ディグニティー ヘルス | 患者の心周期による迷走神経刺激の同期化 |
| WO2007136726A2 (en) | 2006-05-18 | 2007-11-29 | Ndi Medical, Llc | Portable assemblies, systems, and methods for providing functional or therapeutic neurostimulation |
| US20080128215A1 (en) | 2006-05-24 | 2008-06-05 | Gershon Nowitz | Portable Scissor Lift |
| US8909342B2 (en) * | 2006-08-15 | 2014-12-09 | Andres M. Lozano | Method for treating eating disorders |
| US7940933B2 (en) | 2006-08-18 | 2011-05-10 | Medtronic, Inc. | Secure telemetric link |
| US7774072B2 (en) | 2006-11-30 | 2010-08-10 | Medtronic, Inc. | Attached implantable medical elongated members |
| US20080140151A1 (en) | 2006-12-11 | 2008-06-12 | Brodkey Jason A | Nerve stimulation apparatus and method for the treatment of head pain |
| US7890178B2 (en) | 2006-12-15 | 2011-02-15 | Medtronic Xomed, Inc. | Method and apparatus for assisting deglutition |
| US9913593B2 (en) | 2006-12-27 | 2018-03-13 | Cyberonics, Inc. | Low power device with variable scheduling |
| US20080171929A1 (en) | 2007-01-11 | 2008-07-17 | Katims Jefferson J | Method for standardizing spacing between electrodes, and medical tape electrodes |
| US8696724B2 (en) | 2007-01-11 | 2014-04-15 | Scion Neurostim, Llc. | Devices for vestibular or cranial nerve stimulation |
| JP4961558B2 (ja) * | 2007-03-30 | 2012-06-27 | 国立大学法人信州大学 | 三叉神経固有知覚枝刺激装置 |
| EP2136872A4 (en) | 2007-04-13 | 2010-05-12 | Alejandro Covalin | DEVICE AND METHOD FOR THE TREATMENT OF HEADACHE |
| US20080262566A1 (en) | 2007-04-23 | 2008-10-23 | Boston Scientific Neuromodulation Corporation | Methods and systems of treating medication overuse headache |
| US8954162B2 (en) * | 2007-04-25 | 2015-02-10 | Medtronic, Inc. | Medical device implantation |
| EP2164389B1 (en) | 2007-07-06 | 2013-06-19 | Koninklijke Philips Electronics N.V. | Shielded biomedical electrode patch |
| BRPI0817271A2 (pt) | 2007-09-26 | 2015-06-16 | Univ Duke | Método de tratamento da doença de parkinson e outros distúrbios relacionados |
| EP2222370A1 (en) | 2007-10-24 | 2010-09-01 | Medtronic, Inc. | Transmission of power source usage information over a network |
| US8849407B1 (en) | 2008-01-04 | 2014-09-30 | Yuri P. Danilov | Non-invasive neuromodulation (NINM) for rehabilitation of brain function |
| EP2092951A1 (fr) * | 2008-02-20 | 2009-08-26 | Stx-Med Sprl | Appareil pour le traîtement électrothérapeutique des céphalées de tension |
| PL2320997T3 (pl) * | 2008-05-13 | 2016-05-31 | Cerbomed Gmbh | Urządzenie do poprawy działania tkanki nerwowej |
| US20090326602A1 (en) | 2008-06-27 | 2009-12-31 | Arkady Glukhovsky | Treatment of indications using electrical stimulation |
| ES2736276T3 (es) | 2008-07-14 | 2019-12-27 | Arizona Board Of Regents For And On Behalf Of Arizona State Univ | Dispositivos de modulación de la actividad celular utilizando ultrasonido |
| US20100030227A1 (en) | 2008-07-31 | 2010-02-04 | Medtronic, Inc. | Medical lead implantation |
| US8512715B2 (en) | 2008-08-14 | 2013-08-20 | The Cleveland Clinic Foundation | Apparatus and method for treating a neuromuscular defect |
| JP5687627B2 (ja) | 2008-10-21 | 2015-03-18 | メド−エル エレクトロメディジニシェ ゲラテ ゲーエムベーハー | 顔面神経刺激のためのシステムおよび方法 |
| US8666498B2 (en) | 2008-10-27 | 2014-03-04 | Serene Medical, Inc. | Treatment of headache |
| DE102008043973B4 (de) | 2008-11-21 | 2011-12-01 | Burkhard Brocke | Vorrichtung zur transkraniellen Neurostimulation |
| US8494641B2 (en) | 2009-04-22 | 2013-07-23 | Autonomic Technologies, Inc. | Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism |
| BR112012008028A2 (pt) | 2009-10-05 | 2016-03-01 | Univ California | sistema para estimulação do nervo trigêmeo para tratamento de um distúrbio neuropsquiátrico, unidade de eletrodo cutâneo, método para tratar um distúrbio neuropsquiátrico, e, kit para estimulação do nervo trigêmeo para tratamento de um distúrbio neuropsiquiátrico |
| US9101766B2 (en) * | 2009-10-16 | 2015-08-11 | The Board Of Trustees Of The Leland Stanford Junior University | Eliciting analgesia by transcranial electrical stimulation |
| JP2013525069A (ja) | 2010-05-02 | 2013-06-20 | レイク バイオサイエンシーズ リミテッド ライアビリティ カンパニー | 顔面神経系または関連神経構造の耳を介した機能調整方法 |
| US8702584B2 (en) | 2010-05-12 | 2014-04-22 | Cefaly Technology Sprl | Neurostimulation method to induce relaxation or sleep |
| US9364674B2 (en) | 2010-11-30 | 2016-06-14 | Ian A. Cook | Pulse generator for cranial nerve stimulation |
| EP2651497B1 (en) | 2010-12-14 | 2019-02-20 | The Regents of The University of California | Extracranial implantable systems for the treatment of medical disorders |
| EP2651496A4 (en) | 2010-12-14 | 2014-07-09 | Univ California | DEVICES, SYSTEMS AND METHODS OF TREATING MEDICAL DISEASES |
| US20120203301A1 (en) | 2011-02-07 | 2012-08-09 | Advanced Neuromodulation Systems, Inc. | Methods using trigeminal nerve stimulation to treat neurological diseases |
| US20140081369A1 (en) | 2011-05-11 | 2014-03-20 | Alejandro Covalin | Headache-treatment device with gel dispensing kit and method |
| BE1020458A3 (fr) | 2012-01-13 | 2013-10-01 | Stx Med Sprl | Appareil electronique autonome et dipositif de fixation de celui-ci sur une electrode localisee au niveau de la tete pour une utilisation en position couchee du patient. |
| US10035013B2 (en) | 2012-04-05 | 2018-07-31 | The Regents Of The University Of California | Subcutaneous electrodes for cranial nerve stimulation |
| US20140039572A1 (en) | 2012-08-03 | 2014-02-06 | Boston Scientific Neuromodulation Corporation | System and method for treating depression and epilepsy |
| US8903494B2 (en) | 2012-11-26 | 2014-12-02 | Thync, Inc. | Wearable transdermal electrical stimulation devices and methods of using them |
| US10220211B2 (en) | 2013-01-22 | 2019-03-05 | Livanova Usa, Inc. | Methods and systems to diagnose depression |
-
2011
- 2011-12-14 EP EP11849890.6A patent/EP2651497B1/en active Active
- 2011-12-14 US US13/994,512 patent/US20140142669A1/en not_active Abandoned
- 2011-12-14 JP JP2013544760A patent/JP6559395B2/ja active Active
- 2011-12-14 WO PCT/US2011/065003 patent/WO2012082961A2/en not_active Ceased
- 2011-12-14 CA CA2821721A patent/CA2821721A1/en not_active Abandoned
-
2017
- 2017-06-15 US US15/624,640 patent/US20170348521A1/en not_active Abandoned
-
2018
- 2018-04-10 US US15/949,987 patent/US10238862B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014501139A (ja) | 2014-01-20 |
| US10238862B2 (en) | 2019-03-26 |
| US20180229029A1 (en) | 2018-08-16 |
| EP2651497A2 (en) | 2013-10-23 |
| JP6559395B2 (ja) | 2019-08-14 |
| EP2651497A4 (en) | 2014-06-04 |
| WO2012082961A3 (en) | 2012-08-09 |
| WO2012082961A2 (en) | 2012-06-21 |
| US20170348521A1 (en) | 2017-12-07 |
| EP2651497B1 (en) | 2019-02-20 |
| US20140142669A1 (en) | 2014-05-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10238862B2 (en) | Extracranial implantable devices, systems and methods for the treatment of medical disorders | |
| US10639468B2 (en) | Devices, systems and methods for the treatment of medical disorders | |
| US20230093826A1 (en) | Devices, systems and methods for the treatment of neurological disorders and neuropsychiatric disorders | |
| JP2014501139A5 (cg-RX-API-DMAC7.html) | ||
| JP2014501138A5 (cg-RX-API-DMAC7.html) | ||
| AU2015264876A1 (en) | Devices, Systems and Methods for Treatment of Neuropsychiatric Disorders |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20161212 |
|
| FZDE | Dead |
Effective date: 20200225 |