CA2819492C - Therapeutic and diagnostic conjugates for use with multispecific antibodies - Google Patents

Therapeutic and diagnostic conjugates for use with multispecific antibodies Download PDF

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Publication number
CA2819492C
CA2819492C CA2819492A CA2819492A CA2819492C CA 2819492 C CA2819492 C CA 2819492C CA 2819492 A CA2819492 A CA 2819492A CA 2819492 A CA2819492 A CA 2819492A CA 2819492 C CA2819492 C CA 2819492C
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Prior art keywords
peptide
disease
antibody
combinations
lys
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CA2819492A
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English (en)
French (fr)
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CA2819492A1 (en
Inventor
William J. Mcbride
David M. Goldenberg
Carl Noren
Hans J. Hansen
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Immunomedics Inc
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Immunomedics Inc
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    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
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    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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US20050002945A1 (en) 2005-01-06
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JP5084267B2 (ja) 2012-11-28
EP1720575A4 (en) 2011-09-07
AU2005211754B2 (en) 2010-11-11
AU2010249265A1 (en) 2011-01-06
EP1720575A2 (en) 2006-11-15
CA2555666A1 (en) 2005-08-25
WO2005077071A3 (en) 2009-04-09
WO2005077071A2 (en) 2005-08-25
CA2819492A1 (en) 2005-08-25
JP2007528372A (ja) 2007-10-11
AU2010249265C1 (en) 2013-06-27
AU2010249265B2 (en) 2012-12-13
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US20120063993A1 (en) 2012-03-15
US8158573B2 (en) 2012-04-17

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