CA2814371C - Use of malononitrilamides in neuropathic pain - Google Patents

Use of malononitrilamides in neuropathic pain Download PDF

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Publication number
CA2814371C
CA2814371C CA2814371A CA2814371A CA2814371C CA 2814371 C CA2814371 C CA 2814371C CA 2814371 A CA2814371 A CA 2814371A CA 2814371 A CA2814371 A CA 2814371A CA 2814371 C CA2814371 C CA 2814371C
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CA
Canada
Prior art keywords
compound
neuropathic pain
pain
syndrome
use according
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Active
Application number
CA2814371A
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English (en)
French (fr)
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CA2814371A1 (en
Inventor
Birgit Hasse
Guido Koopmans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ALGIAX PHARMACEUTICALS GmbH
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ALGIAX PHARMACEUTICALS GmbH
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Publication of CA2814371A1 publication Critical patent/CA2814371A1/en
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Publication of CA2814371C publication Critical patent/CA2814371C/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2814371A 2010-10-29 2011-10-28 Use of malononitrilamides in neuropathic pain Active CA2814371C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US40819510P 2010-10-29 2010-10-29
EP10014122 2010-10-29
US61/408,195 2010-10-29
EP10014122.5 2010-10-29
PCT/EP2011/005452 WO2012055567A2 (en) 2010-10-29 2011-10-28 Use of malononitrilamides in neuropathic pain

Publications (2)

Publication Number Publication Date
CA2814371A1 CA2814371A1 (en) 2012-05-03
CA2814371C true CA2814371C (en) 2019-03-19

Family

ID=44992853

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2814371A Active CA2814371C (en) 2010-10-29 2011-10-28 Use of malononitrilamides in neuropathic pain

Country Status (16)

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US (2) US20130217737A1 (US20070167479A1-20070719-C00034.png)
EP (1) EP2632451B1 (US20070167479A1-20070719-C00034.png)
JP (1) JP6257326B2 (US20070167479A1-20070719-C00034.png)
CN (1) CN103179962B (US20070167479A1-20070719-C00034.png)
CA (1) CA2814371C (US20070167479A1-20070719-C00034.png)
DK (1) DK2632451T3 (US20070167479A1-20070719-C00034.png)
ES (1) ES2655084T3 (US20070167479A1-20070719-C00034.png)
HR (1) HRP20171848T1 (US20070167479A1-20070719-C00034.png)
HU (1) HUE034890T2 (US20070167479A1-20070719-C00034.png)
LT (1) LT2632451T (US20070167479A1-20070719-C00034.png)
NO (1) NO2632451T3 (US20070167479A1-20070719-C00034.png)
PL (1) PL2632451T3 (US20070167479A1-20070719-C00034.png)
PT (1) PT2632451T (US20070167479A1-20070719-C00034.png)
RS (1) RS56713B1 (US20070167479A1-20070719-C00034.png)
SI (1) SI2632451T1 (US20070167479A1-20070719-C00034.png)
WO (1) WO2012055567A2 (US20070167479A1-20070719-C00034.png)

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WO2013168015A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of asthma and allergy
WO2013167999A2 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of neurologic diseases
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WO2013175376A2 (en) 2012-05-23 2013-11-28 Mahesh Kandula Compositions and methods for the treatment of local pain
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JP2015518854A (ja) 2012-05-23 2015-07-06 セリックスビオ プライヴェート リミテッド 多発性硬化症の治療のための組成物および方法
WO2013175347A2 (en) 2012-05-23 2013-11-28 Mahesh Kandula Compositions and methods for the treatment of respiratory disorders
WO2013175344A2 (en) * 2012-05-23 2013-11-28 Mahesh Kandula Compositions and methods for the treatment of periodontitis and rheumatoid arthritis
US9765020B2 (en) 2012-05-23 2017-09-19 Cellix Bio Private Limited Dichlorophenyl-imino compounds and compositions, and methods for the treatment of mucositis
US9108942B1 (en) 2014-11-05 2015-08-18 Mahesh Kandula Compositions and methods for the treatment of moderate to severe pain
WO2014020480A2 (en) 2012-08-03 2014-02-06 Mahesh Kandula Compositions and methods for the treatment migraine and neurologic diseases
US9624168B2 (en) 2012-09-06 2017-04-18 Cellix Bio Private Limited Compositions and methods for the treatment inflammation and lipid disorders
WO2014037834A2 (en) 2012-09-08 2014-03-13 Mahesh Kandula Compositions and methods for the treatment of inflammation and lipid disorders
US9333187B1 (en) 2013-05-15 2016-05-10 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory bowel disease
CA2914461A1 (en) 2013-06-04 2014-12-11 Cellixbio Private Limited Compositions and methods for the treatment of diabetes and pre-diabetes
US9096537B1 (en) 2014-12-31 2015-08-04 Mahesh Kandula Compositions and methods for the treatment of mucositis
WO2016046835A1 (en) 2014-09-26 2016-03-31 Cellix Bio Private Limited Compositions and methods for the treatment of epilepsy and neurological disorders
CA2967908C (en) 2014-09-29 2020-11-17 Mahesh Kandula Compositions and methods for the treatment of multiple sclerosis
EP3212626B1 (en) 2014-10-27 2018-11-07 Cellix Bio Private Limited Three component salts of fumaric acid monomethyl ester with piperazine or ethylene diamine for the treatment of multiple sclerosis
US10208014B2 (en) 2014-11-05 2019-02-19 Cellix Bio Private Limited Compositions and methods for the treatment of neurological disorders
US9321716B1 (en) 2014-11-05 2016-04-26 Cellix Bio Private Limited Compositions and methods for the treatment of metabolic syndrome
US9150557B1 (en) 2014-11-05 2015-10-06 Cellix Bio Private Limited Compositions and methods for the treatment of hyperglycemia
US9173877B1 (en) 2014-11-05 2015-11-03 Cellix Bio Private Limited Compositions and methods for the treatment of local pain
US9290486B1 (en) 2014-11-05 2016-03-22 Cellix Bio Private Limited Compositions and methods for the treatment of epilepsy
US9284287B1 (en) 2014-11-05 2016-03-15 Cellix Bio Private Limited Compositions and methods for the suppression of carbonic anhydrase activity
US9175008B1 (en) 2014-11-05 2015-11-03 Cellix Bio Private Limited Prodrugs of anti-platelet agents
US9932294B2 (en) 2014-12-01 2018-04-03 Cellix Bio Private Limited Compositions and methods for the treatment of multiple sclerosis
US9206111B1 (en) 2014-12-17 2015-12-08 Cellix Bio Private Limited Compositions and methods for the treatment of neurological diseases
SG11201705524SA (en) 2015-01-06 2017-08-30 Cellix Bio Private Ltd Compositions and methods for the treatment of inflammation and pain
CN109069502B (zh) * 2016-09-24 2021-08-06 山东亨利医药科技有限责任公司 含盐皮质激素受体拮抗剂的药物组合物及其用途
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Also Published As

Publication number Publication date
CN103179962A (zh) 2013-06-26
JP2013545730A (ja) 2013-12-26
US20130217737A1 (en) 2013-08-22
WO2012055567A2 (en) 2012-05-03
EP2632451A2 (en) 2013-09-04
NO2632451T3 (US20070167479A1-20070719-C00034.png) 2018-03-17
DK2632451T3 (en) 2017-12-18
US20140357722A1 (en) 2014-12-04
CA2814371A1 (en) 2012-05-03
EP2632451B1 (en) 2017-10-18
HRP20171848T1 (hr) 2018-02-09
SI2632451T1 (en) 2018-02-28
ES2655084T3 (es) 2018-02-16
JP6257326B2 (ja) 2018-01-10
LT2632451T (lt) 2018-02-12
RS56713B1 (sr) 2018-03-30
HUE034890T2 (hu) 2018-03-28
PL2632451T3 (pl) 2018-04-30
CN103179962B (zh) 2017-03-22
WO2012055567A3 (en) 2012-07-05
US9468615B2 (en) 2016-10-18
PT2632451T (pt) 2017-12-14

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