CA2806639A1 - Microvesicules ciblees remplies de gaz - Google Patents

Info

Publication number

CA2806639A1

CA2806639A1 CA2806639A CA2806639A CA2806639A1 CA 2806639 A1 CA2806639 A1 CA 2806639A1 CA 2806639 A CA2806639 A CA 2806639A CA 2806639 A CA2806639 A CA 2806639A CA 2806639 A1 CA2806639 A1 CA 2806639A1

Authority

CA

Canada

Prior art keywords

aqueous suspension

suspension according

gas

polypeptide

amino acid

Prior art date

2010-08-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 76
• 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 70
• 229920001184 polypeptide Polymers 0.000 claims abstract description 68
• 150000001413 amino acids Chemical class 0.000 claims abstract description 59
• 239000007900 aqueous suspension Substances 0.000 claims abstract description 36
• 239000000725 suspension Substances 0.000 claims abstract description 30
• 125000000539 amino acid group Chemical group 0.000 claims abstract description 11
• 238000012285 ultrasound imaging Methods 0.000 claims abstract description 7
• 239000007789 gas Substances 0.000 claims description 94
• 235000001014 amino acid Nutrition 0.000 claims description 64
• 150000003904 phospholipids Chemical class 0.000 claims description 60
• 239000000463 material Substances 0.000 claims description 29
• 238000000034 method Methods 0.000 claims description 28
• 238000003384 imaging method Methods 0.000 claims description 25
• 239000002243 precursor Substances 0.000 claims description 24
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 18
• 239000004472 Lysine Substances 0.000 claims description 18
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 18
• 238000011282 treatment Methods 0.000 claims description 17
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 16
• 150000004676 glycans Chemical group 0.000 claims description 14
• 229910052757 nitrogen Inorganic materials 0.000 claims description 13
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• 230000000087 stabilizing effect Effects 0.000 claims description 12
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• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims description 10
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 10
• 239000000654 additive Substances 0.000 claims description 9
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• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims description 8
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• NIGUVXFURDGQKZ-UQTBNESHSA-N alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc Chemical group O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](O[C@]3(O[C@H]([C@H](NC(C)=O)[C@@H](O)C3)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](CO)O[C@@H](O)[C@@H]1NC(C)=O NIGUVXFURDGQKZ-UQTBNESHSA-N 0.000 claims description 3
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• SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 description 8
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