CA2804290A1 - Preparation of (3as,7ar)-hexahydroisobenzofuran-1(3h)-one by catalyzed biological resolution of dimethyl cyclohexane-1,2-dicarboxylate - Google Patents

Preparation of (3as,7ar)-hexahydroisobenzofuran-1(3h)-one by catalyzed biological resolution of dimethyl cyclohexane-1,2-dicarboxylate Download PDF

Info

Publication number
CA2804290A1
CA2804290A1 CA2804290A CA2804290A CA2804290A1 CA 2804290 A1 CA2804290 A1 CA 2804290A1 CA 2804290 A CA2804290 A CA 2804290A CA 2804290 A CA2804290 A CA 2804290A CA 2804290 A1 CA2804290 A1 CA 2804290A1
Authority
CA
Canada
Prior art keywords
enzyme
hexahydroisobenzofuran
dicarboxylate
esterase
methoxycarbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2804290A
Other languages
English (en)
French (fr)
Inventor
Michael Charles Lloyd
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BGP Products Operations GmbH
Original Assignee
Abbott Products Operations AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Products Operations AG filed Critical Abbott Products Operations AG
Publication of CA2804290A1 publication Critical patent/CA2804290A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
CA2804290A 2010-05-24 2011-05-24 Preparation of (3as,7ar)-hexahydroisobenzofuran-1(3h)-one by catalyzed biological resolution of dimethyl cyclohexane-1,2-dicarboxylate Abandoned CA2804290A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34748710P 2010-05-24 2010-05-24
US61/347,487 2010-05-24
PCT/US2011/037745 WO2011149938A2 (en) 2010-05-24 2011-05-24 PREPARATION OF (3aS,7aR)-HEXAHYDROISOBENZOFURAN-1(3H)-ONE BY CATALYZED BIOLOGICAL RESOLUTION OF DIMETHYL CYCLOHEXANE-1,2-DICARBOXYLATE

Publications (1)

Publication Number Publication Date
CA2804290A1 true CA2804290A1 (en) 2011-12-01

Family

ID=45004710

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2804290A Abandoned CA2804290A1 (en) 2010-05-24 2011-05-24 Preparation of (3as,7ar)-hexahydroisobenzofuran-1(3h)-one by catalyzed biological resolution of dimethyl cyclohexane-1,2-dicarboxylate

Country Status (11)

Country Link
US (1) US9080193B2 (https=)
EP (1) EP2576803B1 (https=)
JP (2) JP2013526293A (https=)
CN (1) CN102947461B (https=)
AU (1) AU2011258453B2 (https=)
BR (1) BR112012029562B1 (https=)
CA (1) CA2804290A1 (https=)
CO (1) CO6640245A2 (https=)
MX (1) MX344158B (https=)
RU (1) RU2570635C2 (https=)
WO (1) WO2011149938A2 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107815445B (zh) * 2016-09-12 2021-03-19 弈柯莱生物科技(上海)股份有限公司 一种干粉型固定化脂肪酶及其生产工艺
CN109680016B (zh) * 2018-10-29 2020-10-13 浙江大鹏药业股份有限公司 一种调环酸钙的制备方法
CN111118073B (zh) * 2019-12-27 2022-02-15 宜昌东阳光生化制药有限公司 酶法合成依米他韦中间体的方法
CN111073914B (zh) * 2020-01-03 2023-08-29 江苏威凯尔医药科技有限公司 反式-1,2-环己烷二甲醇的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2605630B1 (fr) * 1986-10-22 1989-06-30 Roussel Uclaf Procede de preparation de derives de l'octahydroindole et intermediaires de preparation
US5262313A (en) 1991-06-14 1993-11-16 Andcare, Inc. Carrageeman-immobilized esterase
GB9714877D0 (en) 1997-07-15 1997-09-17 Chiroscience Ltd Microorganism and its use

Also Published As

Publication number Publication date
WO2011149938A2 (en) 2011-12-01
CN102947461A (zh) 2013-02-27
EP2576803B1 (en) 2019-07-10
BR112012029562A2 (https=) 2021-12-28
CN102947461B (zh) 2015-01-28
EP2576803A4 (en) 2014-08-27
RU2012153213A (ru) 2014-06-27
CO6640245A2 (es) 2013-03-22
AU2011258453A1 (en) 2012-12-06
WO2011149938A3 (en) 2012-03-01
JP2013526293A (ja) 2013-06-24
EP2576803A2 (en) 2013-04-10
US9080193B2 (en) 2015-07-14
AU2011258453B2 (en) 2013-10-24
JP2016182128A (ja) 2016-10-20
US20130273618A1 (en) 2013-10-17
BR112012029562B1 (pt) 2023-05-09
MX344158B (es) 2016-12-06
MX2012013644A (es) 2013-05-01
JP6145538B2 (ja) 2017-06-14
RU2570635C2 (ru) 2015-12-10

Similar Documents

Publication Publication Date Title
IL292194B1 (en) Process for the production of acyloxymethyl esters of (4s)-(4-cyano-2-methoxyphenyl)-5-ethoxy-8,2-dimethyl-4,1-dihydro-6,1-naphthyridine-3-carboxylic acid
AU2011258453B2 (en) Preparation of (3aS,7aR)-hexahydroisobenzofuran-1(3H)-one by catalyzed biological resolution of dimethyl cyclohexane-1,2-dicarboxylate
CN105274027B (zh) 类产碱假单胞菌株及其在制备西他列汀中间体中的应用
Kurokawa et al. Enzyme-catalyzed enantiomeric resolution of N-Boc-proline as the key-step in an expeditious route towards RAMP
Bosetti et al. Enzymatic resolution of 1, 2-diols: comparison between hydrolysis and transesterification reactions
AU2014200205B2 (en) Preparation of (3aS,7aR)-hexahydroisobenzofuran-1(3H)-one by catalyzed biological resolution of dimethyl cyclohexane-1,2-dicarboxylate
Singh et al. Enantioselective transesterification of (RS)-1-chloro-3-(3, 4-difluorophenoxy)-2-propanol using Pseudomonas aeruginosa lipases
CN101821404A (zh) 3,4-环氧丁酸乙酯的微生物动力学拆分
HK1183909A (en) Preparation of (3as,7ar)-hexahydroisobenzofuran-1(3h)-one by catalyzed biological resolution of dimethyl cyclohexane-1,2-dicarboxylate
HK1183909B (en) Preparation of (3as,7ar)-hexahydroisobenzofuran-1(3h)-one by catalyzed biological resolution of dimethyl cyclohexane-1,2-dicarboxylate
Li et al. Highly regioselective enzymatic synthesis of 5′-O-stearate of 1-β-D-arabinofuranosylcytosine in binary organic solvent mixtures
EP2502897B1 (en) Method for producing optically active bicyclo [3.1.0]hexane derivative using enzyme
US7994342B2 (en) Method for producing optically active succinimide compound
US8618312B2 (en) Method of producing bicyclo[3.1.0] hexane derivative using enzyme
JP3732535B2 (ja) 光学活性α−メチルアルカンジカルボン酸−ω−モノエステル及びその対掌体ジエステルを製造する方法
Kato et al. Preparation of optically active trifluoromethylated (3′-indolyl) thiacarboxylic acids, novel plant growth regulators, through lipase-catalyzed enantioselective hydrolysis
WO1999004028A1 (fr) Procede de preparation d'un acide alpha-trifluoromethylacetique optiquement actif et des esters antipodes dudit acide, et methode de purification dudit acide
Çalışkan et al. A Novel Microbial Biotransformation Method has been Developed to resolve 4-oxo-4, 5, 6, 7-tetrahydrobenzofuran Derivatives
JP3970898B2 (ja) 光学活性α−メチルアルカンジカルボン酸−ω−モノエステル及びその対掌体ジエステルを製造する方法
Babich et al. Use of Hydrolases and Related Enzymes for Synthesis
Guo et al. 3.6 Enzyme-Catalyzed Hydrolysis of Bicycloheptane Diester to Monoester
KR20070090833A (ko) 가수분해효소를 이용한 ｓ－ｈｇｂ의 제조방법
JP2007202563A (ja) 光学活性α−トリフルオロメチル乳酸及びその対掌体エステルの製造方法及び精製方法
JP2005323612A (ja) 光学活性β−ヒドロキシカルボン酸及びその対掌体エステルの製造方法
HK1135434A (en) Specific hydrolysis of the n-unprotected (r) -ester of (3) -amin0-3-arylpr0pi0nic acid esters

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20160524

FZDE Discontinued

Effective date: 20200831