CN102947461B - 通过环己烷-1,2-二羧酸二甲酯的催化生物拆分制备(3aS,7aR)-六氢异苯并呋喃-1(3H)-酮 - Google Patents

通过环己烷-1,2-二羧酸二甲酯的催化生物拆分制备(3aS,7aR)-六氢异苯并呋喃-1(3H)-酮 Download PDF

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CN102947461B
CN102947461B CN201180025723.1A CN201180025723A CN102947461B CN 102947461 B CN102947461 B CN 102947461B CN 201180025723 A CN201180025723 A CN 201180025723A CN 102947461 B CN102947461 B CN 102947461B
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buffer
enzyme
hydrolase
column
methoxycarbonyl
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CN102947461A (zh
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迈克尔·查尔斯·劳埃德
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Dr Reddys Laboratories Ltd
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
CN201180025723.1A 2010-05-24 2011-05-24 通过环己烷-1,2-二羧酸二甲酯的催化生物拆分制备(3aS,7aR)-六氢异苯并呋喃-1(3H)-酮 Active CN102947461B (zh)

Applications Claiming Priority (3)

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US34748710P 2010-05-24 2010-05-24
US61/347,487 2010-05-24
PCT/US2011/037745 WO2011149938A2 (en) 2010-05-24 2011-05-24 PREPARATION OF (3aS,7aR)-HEXAHYDROISOBENZOFURAN-1(3H)-ONE BY CATALYZED BIOLOGICAL RESOLUTION OF DIMETHYL CYCLOHEXANE-1,2-DICARBOXYLATE

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CN102947461A CN102947461A (zh) 2013-02-27
CN102947461B true CN102947461B (zh) 2015-01-28

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US (1) US9080193B2 (https=)
EP (1) EP2576803B1 (https=)
JP (2) JP2013526293A (https=)
CN (1) CN102947461B (https=)
AU (1) AU2011258453B2 (https=)
BR (1) BR112012029562B1 (https=)
CA (1) CA2804290A1 (https=)
CO (1) CO6640245A2 (https=)
MX (1) MX344158B (https=)
RU (1) RU2570635C2 (https=)
WO (1) WO2011149938A2 (https=)

Families Citing this family (4)

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Publication number Priority date Publication date Assignee Title
CN107815445B (zh) * 2016-09-12 2021-03-19 弈柯莱生物科技(上海)股份有限公司 一种干粉型固定化脂肪酶及其生产工艺
CN109680016B (zh) * 2018-10-29 2020-10-13 浙江大鹏药业股份有限公司 一种调环酸钙的制备方法
CN111118073B (zh) * 2019-12-27 2022-02-15 宜昌东阳光生化制药有限公司 酶法合成依米他韦中间体的方法
CN111073914B (zh) * 2020-01-03 2023-08-29 江苏威凯尔医药科技有限公司 反式-1,2-环己烷二甲醇的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879392A (en) * 1986-10-22 1989-11-07 Roussel Uclaf Process for making perhydroindole-2-carbonxylic acid
US5262313A (en) * 1991-06-14 1993-11-16 Andcare, Inc. Carrageeman-immobilized esterase

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9714877D0 (en) 1997-07-15 1997-09-17 Chiroscience Ltd Microorganism and its use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879392A (en) * 1986-10-22 1989-11-07 Roussel Uclaf Process for making perhydroindole-2-carbonxylic acid
US5262313A (en) * 1991-06-14 1993-11-16 Andcare, Inc. Carrageeman-immobilized esterase

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CALB脂肪酶的固定化及其拆分2-辛醇的研究;高红娟;《精细化工》;20080430;第25卷(第4期);338-341 *

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WO2011149938A2 (en) 2011-12-01
CN102947461A (zh) 2013-02-27
EP2576803B1 (en) 2019-07-10
BR112012029562A2 (https=) 2021-12-28
EP2576803A4 (en) 2014-08-27
RU2012153213A (ru) 2014-06-27
CO6640245A2 (es) 2013-03-22
AU2011258453A1 (en) 2012-12-06
WO2011149938A3 (en) 2012-03-01
JP2013526293A (ja) 2013-06-24
EP2576803A2 (en) 2013-04-10
US9080193B2 (en) 2015-07-14
AU2011258453B2 (en) 2013-10-24
JP2016182128A (ja) 2016-10-20
US20130273618A1 (en) 2013-10-17
CA2804290A1 (en) 2011-12-01
BR112012029562B1 (pt) 2023-05-09
MX344158B (es) 2016-12-06
MX2012013644A (es) 2013-05-01
JP6145538B2 (ja) 2017-06-14
RU2570635C2 (ru) 2015-12-10

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