CA2802635A1 - Peptides as active agents to stabilize biologic barriers - Google Patents

Peptides as active agents to stabilize biologic barriers Download PDF

Info

Publication number
CA2802635A1
CA2802635A1 CA2802635A CA2802635A CA2802635A1 CA 2802635 A1 CA2802635 A1 CA 2802635A1 CA 2802635 A CA2802635 A CA 2802635A CA 2802635 A CA2802635 A CA 2802635A CA 2802635 A1 CA2802635 A1 CA 2802635A1
Authority
CA
Canada
Prior art keywords
seq
peptide
xib
peptides
lps
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2802635A
Other languages
English (en)
French (fr)
Inventor
Peter Petzelbauer
Sonja Reingruber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
XiberScience GmbH
Original Assignee
XiberScience GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by XiberScience GmbH filed Critical XiberScience GmbH
Publication of CA2802635A1 publication Critical patent/CA2802635A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2802635A 2010-06-18 2011-06-17 Peptides as active agents to stabilize biologic barriers Abandoned CA2802635A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ATA1010/2010(4BA1010 2010-06-18
AT10102010 2010-06-18
PCT/EP2011/060105 WO2011157819A2 (en) 2010-06-18 2011-06-17 Peptides as active agents to stabilize biological barriers

Publications (1)

Publication Number Publication Date
CA2802635A1 true CA2802635A1 (en) 2011-12-22

Family

ID=44628513

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2802635A Abandoned CA2802635A1 (en) 2010-06-18 2011-06-17 Peptides as active agents to stabilize biologic barriers

Country Status (8)

Country Link
US (1) US9012403B2 (enExample)
EP (1) EP2582720B1 (enExample)
JP (1) JP5709985B2 (enExample)
CN (1) CN103038253A (enExample)
CA (1) CA2802635A1 (enExample)
ES (1) ES2486321T3 (enExample)
RU (1) RU2012157399A (enExample)
WO (1) WO2011157819A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103068400A (zh) 2010-06-25 2013-04-24 阿斯顿大学 具有脂类动员性质的糖蛋白及其治疗用途
WO2015022326A1 (en) 2013-08-12 2015-02-19 Xiber Science Gmbh Peptides as active agents for treating primary graft dysfunction
NL2015130B1 (en) * 2015-07-09 2017-02-01 Mimetas B V Barrier function measurements.
US20190112380A1 (en) * 2016-03-29 2019-04-18 University Of Southern California Chimeric antigen receptors targeting cancer
CN112703009B (zh) * 2018-08-17 2024-06-11 宾夕法尼亚大学董事会 治疗急性肺损伤的组合物和方法
EP3911739A1 (en) * 2019-01-16 2021-11-24 University Of Rochester Improvement of epithelial or endothelial barrier function
US20230190869A1 (en) 2020-01-22 2023-06-22 Ucl Business Ltd Peptide inhibitors of guanine nucleotide exchange factor h-1
EP3912679A1 (en) * 2020-05-19 2021-11-24 Johann Wolfgang Goethe-Universität Frankfurt am Main Bbeta-15-42 for the treatment of viral endothelitis

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4263428A (en) 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
DE3169595D1 (en) 1980-11-10 1985-05-02 Gersonde Klaus Method of preparing lipid vesicles by ultrasonic treatment, the use of this method and apparatus for its application
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
JPS58118008A (ja) 1982-01-06 1983-07-13 Nec Corp デ−タ処理装置
EP0088046B1 (de) 1982-02-17 1987-12-09 Ciba-Geigy Ag Lipide in wässriger Phase
DE3218121A1 (de) 1982-05-14 1983-11-17 Leskovar, Peter, Dr.-Ing., 8000 München Arzneimittel zur tumorbehandlung
CA1223831A (en) 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
EP0102324A3 (de) 1982-07-29 1984-11-07 Ciba-Geigy Ag Lipide und Tenside in wässriger Phase
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
HUT35524A (en) 1983-08-02 1985-07-29 Hoechst Ag Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
DE3486459D1 (de) 1983-09-26 1997-12-11 Udo Dr Med Ehrenfeld Mittel und Erzeugnis für die Diagnose und Therapie von Tumoren sowie zur Behandlung von Schwächen der zelligen und humoralen Immunabwehr
EP0143949B1 (en) 1983-11-01 1988-10-12 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Pharmaceutical composition containing urokinase
US5792608A (en) 1991-12-12 1998-08-11 Gilead Sciences, Inc. Nuclease stable and binding competent oligomers and methods for their use
US5525711A (en) 1994-05-18 1996-06-11 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pteridine nucleotide analogs as fluorescent DNA probes
US6372250B1 (en) * 2000-04-25 2002-04-16 The Regents Of The University Of California Non-invasive gene targeting to the brain
US20040053250A1 (en) * 2001-03-05 2004-03-18 Tang Y. Tom Novel arginine-rich protein-like nucleic acids and polypeptides
DE60326453D1 (de) * 2002-07-03 2009-04-16 Ct Cardiologico Monzino S P A Die verwendung von hmgb1 zur behandlung von gewebeverletzungen und/oder zur unterstützung der gewebewiederherstellung
CA2644712C (en) 2006-03-06 2016-09-13 Amunix, Inc. Unstructured recombinant polymers and uses thereof
US8563521B2 (en) 2007-06-21 2013-10-22 Technische Universitat Munchen Biological active proteins having increased in vivo and/or in vitro stability

Also Published As

Publication number Publication date
EP2582720A2 (en) 2013-04-24
US20130143791A1 (en) 2013-06-06
ES2486321T3 (es) 2014-08-18
WO2011157819A3 (en) 2012-02-23
US9012403B2 (en) 2015-04-21
RU2012157399A (ru) 2014-07-27
EP2582720B1 (en) 2014-05-21
CN103038253A (zh) 2013-04-10
JP5709985B2 (ja) 2015-04-30
WO2011157819A2 (en) 2011-12-22
JP2013529916A (ja) 2013-07-25

Similar Documents

Publication Publication Date Title
EP2582720B1 (en) Peptides as active agents to stabilize biological barriers
US7718610B2 (en) Retrocyclins: antiviral and antimicrobial peptides
US11787850B2 (en) Peptidic TGF-beta antagonists
AU2007272578B2 (en) Methods for treating and limiting fibrotic disorders and keloids
AU2020417604A1 (en) Multimerization delivery system for intracellular delivery of molecule
JP2022545554A (ja) Q-erペプチド
US11117930B2 (en) Peptide inhibitors of transcription factor aggregation
US20240197828A1 (en) Chimeric molecule to treat sepsis and other inflammatory conditions
US20230218710A1 (en) Method of treating coronavirus infections
WO2015022326A1 (en) Peptides as active agents for treating primary graft dysfunction
US20140094409A1 (en) Antagonist for (pro)renin receptor for the treatment of hypertension and diabetes
US9683025B2 (en) Methods and compositions for treating cancer and inflammatory diseases
US10335449B2 (en) Rho associated kinase (ROCK) inhibitors and their use in treating disease
WO2016042411A1 (en) Ncx1 peptides and uses thereof
CN103214555B (zh) 介导应激反应的肽抑制剂
HK1184167A (en) Peptides as active agents to stabilize biological barriers
US9573976B2 (en) Antagonist for (pro)renin receptor for the treatment of hypertension and diabetes
WO2022066899A1 (en) Method to improve protein quality control
KR20250138134A (ko) 표적 단백질 분해자 및 세포 투과 펩타이드를 포함하는 융합 분자 및 이의 용도
EP2060581A1 (en) Scaffold proteins for recombinant peptide aptamers
WO2026085280A1 (en) Cell-penetrating peptides with enhanced solubility
JP6320752B2 (ja) 新規ユビキチンリガーゼ及びその利用方法
EA049385B1 (ru) Пептиды bnip3 для лечения реперфузионного повреждения
EP2835135A2 (en) Means and methods for treating pseudomonas infection
WO2013023166A2 (en) Hapivirins and diprovirins

Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20170619