CA2796034A1 - Nmn modulator - Google Patents

Nmn modulator Download PDF

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Publication number
CA2796034A1
CA2796034A1 CA2796034A CA2796034A CA2796034A1 CA 2796034 A1 CA2796034 A1 CA 2796034A1 CA 2796034 A CA2796034 A CA 2796034A CA 2796034 A CA2796034 A CA 2796034A CA 2796034 A1 CA2796034 A1 CA 2796034A1
Authority
CA
Canada
Prior art keywords
nmn
modulator
degeneration
biomarker
detecting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2796034A
Other languages
English (en)
French (fr)
Inventor
Michael Coleman
Laura Conforti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Babraham Institute
Original Assignee
Babraham Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Babraham Institute filed Critical Babraham Institute
Publication of CA2796034A1 publication Critical patent/CA2796034A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2796034A 2010-04-27 2011-04-19 Nmn modulator Abandoned CA2796034A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1006961.5A GB201006961D0 (en) 2010-04-27 2010-04-27 NMN modulator
GB1006961.5 2010-04-27
PCT/GB2011/050770 WO2011135332A2 (en) 2010-04-27 2011-04-19 Nmn modulator

Publications (1)

Publication Number Publication Date
CA2796034A1 true CA2796034A1 (en) 2011-11-03

Family

ID=42270852

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2796034A Abandoned CA2796034A1 (en) 2010-04-27 2011-04-19 Nmn modulator

Country Status (7)

Country Link
US (1) US20130131111A1 (enExample)
EP (1) EP2563363A2 (enExample)
JP (1) JP2013525416A (enExample)
AU (1) AU2011247078A1 (enExample)
CA (1) CA2796034A1 (enExample)
GB (1) GB201006961D0 (enExample)
WO (1) WO2011135332A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120328526A1 (en) * 2011-06-27 2012-12-27 University Of Maryland, Baltimore Modulation of Nad+ Activity in Neuropathophysiological Conditions and Uses Thereof
CN103961691A (zh) * 2013-02-03 2014-08-06 复旦大学 尼克酰胺磷酸核糖转移酶在制备神经保护药物中的用途
CN104758307A (zh) * 2015-03-16 2015-07-08 邦泰生物工程(深圳)有限公司 Nadh和nmn在制备帕金森病药物或保健品的应用
EP3897670A4 (en) * 2018-12-19 2022-09-07 Disarm Therapeutics, Inc. MRSA1 INHIBITORS IN COMBINATION WITH NEUROPROTECTIVE AGENTS
WO2020191257A1 (en) * 2019-03-20 2020-09-24 The Johns Hopkins University Inhibition of nampt and/or sarm1 for the treatment of axonal degradation
JP2020156463A (ja) * 2019-03-20 2020-10-01 株式会社リコー インビトロで細胞を評価する方法、細胞基板、及び細胞基板の製造方法
US11754548B2 (en) * 2019-03-20 2023-09-12 Ricoh Company, Ltd. Method of in vitro cellular assay, cell circuit board, and method of manufacturing cell circuit board
CN112569289A (zh) * 2020-12-24 2021-03-30 深圳市旷逸生物科技有限公司 一种含有nmn的帕金森治疗药物及其制备方法
US12364681B2 (en) 2021-01-08 2025-07-22 The Johns Hopkins University Combined MAPK and NAMPT inhibition for treatment of neuron degeneration

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6797478B1 (en) * 1998-03-05 2004-09-28 University Of Cincinnati Method of detecting axonal damage, from associated disease states using tau monoclonal antibodies
EP1446014A4 (en) * 2001-10-01 2004-12-08 Univ Emory INTRODUCTION OF THE WLDS GENE TO PREVENT AXON DEGENERATION IN NEUROLOGICAL DISEASES
WO2003082187A2 (en) * 2002-03-26 2003-10-09 Indiana University Purification and cloning of nmn adenylyltranserase and its therapeutic use
AU2003294696A1 (en) * 2002-10-17 2004-05-04 Evotec Neurosciences Gmbh Diagnostic and therapeutic use of the nicotinamide mononucleotide adenylytransferase 2 (nmnat-2) gene and protein for neurodegenerative diseases
ES2663226T3 (es) * 2004-06-04 2018-04-11 Washington University Procedimientos y composiciones para tratar neuropatías
WO2007136744A1 (en) * 2006-05-19 2007-11-29 The Johns Hopkins University Crystal structure of a substrate complex of nampt/pbef/visfatin
WO2008026018A1 (en) * 2006-09-01 2008-03-06 Topotarget Switzerland Sa New method for the treatment of inflammatory diseases
EP2098231A1 (en) * 2008-03-05 2009-09-09 Topotarget Switzerland SA Use of NAD formation inhibitors for the treatment of ischemia-reperfusion injury
AU2009286604B2 (en) * 2008-08-29 2015-05-28 Onxeo Dk, Branch Of Onxeo S.A., France Novel urea and thiourea derivatives
GB0902147D0 (en) * 2009-02-10 2009-03-25 Babraham Inst NMNAT2 modulator

Also Published As

Publication number Publication date
US20130131111A1 (en) 2013-05-23
AU2011247078A1 (en) 2012-11-08
GB201006961D0 (en) 2010-06-09
WO2011135332A4 (en) 2012-02-23
WO2011135332A3 (en) 2011-12-22
WO2011135332A2 (en) 2011-11-03
JP2013525416A (ja) 2013-06-20
EP2563363A2 (en) 2013-03-06

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20160420