CA2788669C - Bismuth-thiols comme antiseptiques destines a des utilisations biomedicales, comprenant le traitement de biofilms bacteriens et d'autres utilisations - Google Patents
Bismuth-thiols comme antiseptiques destines a des utilisations biomedicales, comprenant le traitement de biofilms bacteriens et d'autres utilisations Download PDFInfo
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- CA2788669C CA2788669C CA2788669A CA2788669A CA2788669C CA 2788669 C CA2788669 C CA 2788669C CA 2788669 A CA2788669 A CA 2788669A CA 2788669 A CA2788669 A CA 2788669A CA 2788669 C CA2788669 C CA 2788669C
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- Prior art keywords
- bismuth
- thiol
- composition
- antibiotic
- compound
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- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
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Abstract
La présente invention concerne des compositions et des procédés, comprenant de nouvelles suspensions microparticulaires homogènes, qui sont destinés à traiter des surfaces naturelles contenant des biofilms bactériens, comprenant des effets synergétiques ou amplificateurs insoupçonnés entre des composés bismuth-thiol (BT) et certains antibiotiques, pour fournir des formulations comprenant des formulations antiseptiques. L'invention concerne également les propriétés antibactériennes et anti-biofilm précédemment inattendues des composés BT et des combinaisons composé BT-plus-antibiotique décrites, comprenant les efficacités préférentielles de certaines de telles compositions pour traiter certaines infections par des bactéries gram-positives, et les efficacités préférentielles distinctes de certaines de telles compositions pour traiter certaines infections par des bactéries gram-négatives.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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USPCT/US2010/023108 | 2010-02-03 | ||
PCT/US2010/023108 WO2010091124A2 (fr) | 2009-02-03 | 2010-02-03 | Bismuth-thiols comme antiseptiques pour tissus épithéliaux, plaies aiguës et chroniques, biofilms bactériens et autres indications |
US37318810P | 2010-08-12 | 2010-08-12 | |
US61/373,188 | 2010-08-12 | ||
PCT/US2011/023549 WO2011097347A2 (fr) | 2010-02-03 | 2011-02-03 | Bismuth-thiols comme antiseptiques destinés à des utilisations biomédicales, comprenant le traitement de biofilms bactériens et d'autres utilisations |
Publications (2)
Publication Number | Publication Date |
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CA2788669A1 CA2788669A1 (fr) | 2011-08-11 |
CA2788669C true CA2788669C (fr) | 2021-05-25 |
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ID=51355699
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CA2788669A Active CA2788669C (fr) | 2010-02-03 | 2011-02-03 | Bismuth-thiols comme antiseptiques destines a des utilisations biomedicales, comprenant le traitement de biofilms bacteriens et d'autres utilisations |
Country Status (7)
Country | Link |
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EP (1) | EP2536406A4 (fr) |
JP (1) | JP2013518895A (fr) |
CN (2) | CN103079557A (fr) |
AU (1) | AU2011212941B2 (fr) |
CA (1) | CA2788669C (fr) |
MX (1) | MX346409B (fr) |
WO (1) | WO2011097347A2 (fr) |
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WO2005072710A2 (fr) | 2004-01-28 | 2005-08-11 | Johns Hopkins University | Medicaments et particules de transport de genes se deplaçant rapidement a travers les barrieres muqueuses |
US11596599B2 (en) | 2012-05-03 | 2023-03-07 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
EP2844295A1 (fr) | 2012-05-03 | 2015-03-11 | Kala Pharmaceuticals, Inc. | Nanoparticules pharmaceutiques permettant un transport muqueux amélioré |
WO2013166408A1 (fr) | 2012-05-03 | 2013-11-07 | Kala Pharmaceuticals, Inc. | Nanoparticules pharmaceutiques présentant un transport muqueux amélioré |
US9827191B2 (en) | 2012-05-03 | 2017-11-28 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
WO2014052973A1 (fr) * | 2012-09-28 | 2014-04-03 | Stelo Technologies | Procédés de fabrication de nanoparticules d'argent et leurs applications |
CN103667119B (zh) * | 2013-11-26 | 2015-07-29 | 浙江大学 | 用于降解乙硫醇的菌株及其培养方法和应用 |
US11039621B2 (en) | 2014-02-19 | 2021-06-22 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
US9622483B2 (en) | 2014-02-19 | 2017-04-18 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
US11039620B2 (en) | 2014-02-19 | 2021-06-22 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
AU2014385792B2 (en) | 2014-03-07 | 2021-01-21 | Tuffley, Mark DR | Composition and method for enhancing wound healing |
CN105572126B (zh) * | 2015-04-07 | 2018-10-23 | 湖南华纳大药厂股份有限公司 | 一种胶体果胶铋药物组合物 |
US10045950B2 (en) * | 2015-04-08 | 2018-08-14 | BioMendics, LLC | Formulation and process for modulating wound healing |
WO2017145142A1 (fr) | 2016-02-25 | 2017-08-31 | Nobio Ltd. | Compositions de microparticules et de nanoparticules comprenant des groupes à activité antimicrobienne |
BR112019011660A2 (pt) * | 2016-12-05 | 2019-10-22 | Technophage Investig E Desenvolvimento Em Biotecnologia Sa | composições de bacteriófagos que compreendem fagos antibacterianos respiratórios e métodos de uso das mesmas |
WO2018112511A1 (fr) * | 2016-12-22 | 2018-06-28 | Whiteley Corporation Pty Ltd | Composition de rupture de biofilm |
WO2019043714A1 (fr) | 2017-08-30 | 2019-03-07 | Nobio Ltd. | Particules antimicrobiennes et procédés d'utilisation de celles-ci |
EP3485869B1 (fr) * | 2017-11-16 | 2021-07-21 | DSM IP Assets B.V. | Utilisation de phytantriol comme agent antimicrobien dans la conservation d'une composition |
CN110387416B (zh) * | 2018-04-16 | 2022-06-17 | 华东理工大学 | 可控聚合调控功能的纳米金双探针体系及其应用 |
CN112788950A (zh) * | 2018-07-31 | 2021-05-11 | 微生物公司 | 用于治疗伤口的铋-硫醇组合物和方法 |
US11464749B2 (en) * | 2018-07-31 | 2022-10-11 | Microbion Corporation | Bismuth-thiol compositions and methods of use |
CN110870874A (zh) * | 2018-08-13 | 2020-03-10 | 中山大学 | 具有抗菌效果的药物及其应用 |
KR102054341B1 (ko) * | 2019-06-20 | 2019-12-10 | 한국지질자원연구원 | 비흡수성 항생물질 및 점토광물의 복합체를 포함하는 항생제 내성인 헬리코박터 파일로리 제균을 위한 경구투여용 약학적 조성물 |
SG11202108262VA (en) * | 2019-01-31 | 2021-08-30 | Pulsethera Corp | Bacterialcidal methods and compositions |
WO2020191076A1 (fr) * | 2019-03-18 | 2020-09-24 | Cedars-Sinai Medical Center | Compositions et méthodes pour traiter des maladies et des troubles gastro-intestinaux |
CN112425608B (zh) * | 2019-08-23 | 2023-07-21 | 香港科技大学 | 弹性蛋白酶抑制剂、具有抗生物膜活性的抑菌剂 |
CN111034711B (zh) * | 2019-12-19 | 2022-04-05 | 海南一龄医疗产业发展有限公司 | 高效清除细胞培养过程中微生物污染的组合物及方法 |
CN111175103B (zh) * | 2020-01-16 | 2023-07-04 | 江西业力医疗器械有限公司 | 一种真菌性阴道炎荧光检测的白带样本前处理液及其制备方法 |
US20230124862A1 (en) * | 2020-03-24 | 2023-04-20 | Jeffrey W. MILLARD | Bismuth thiol compounds and compositions and methods of treating microbial co-infections |
CN113712842B (zh) * | 2020-05-25 | 2023-06-13 | 基元美业生物科技(上海)有限公司 | 一种组合物及其在制备化妆品及医疗器械中的应用 |
CN112618716B (zh) * | 2021-01-11 | 2022-04-08 | 福州大学 | 一种光动力联合溶菌酶抗菌方法 |
CN113930462A (zh) * | 2021-10-19 | 2022-01-14 | 江南大学 | 高丝氨酸内酯信号分子促进碳链延长微生物合成己酸的方法 |
CN114984746B (zh) * | 2022-08-05 | 2022-11-01 | 山东建筑大学 | 一种消杀剂及养殖废水池VOCs废气处理系统方法和装置 |
CN115532295B (zh) * | 2022-09-27 | 2023-07-25 | 苏州大学 | 含有Zn-N-C活性中心的纳米材料在去除细菌生物膜中的应用 |
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US6086921A (en) * | 1995-04-25 | 2000-07-11 | Wintrop-University Hospital | Metal/thiol biocides |
US5999828A (en) * | 1997-03-19 | 1999-12-07 | Qualcomm Incorporated | Multi-user wireless telephone having dual echo cancellers |
US6380248B1 (en) * | 1998-02-04 | 2002-04-30 | Winthrop University Hospital | Metal-thiols as immunomodulating agents |
US6682724B2 (en) * | 1999-02-23 | 2004-01-27 | Arch Chemcials, Inc. | Sonic method of enhancing chemical reactions to provide uniform, non-agglomerated particles |
US7381751B2 (en) * | 2003-08-26 | 2008-06-03 | Shantha Sarangapani | Antimicrobial composition for medical articles |
US8343536B2 (en) * | 2007-01-25 | 2013-01-01 | Cook Biotech Incorporated | Biofilm-inhibiting medical products |
EP3695835A1 (fr) * | 2009-02-03 | 2020-08-19 | Microbion Corporation | Bismuth-thiols comme antiseptiques pour tissus épithéliaux, plaies aiguës et chroniques, biofilms bactériens et autres indications |
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CA2788669A1 (fr) | 2011-08-11 |
WO2011097347A3 (fr) | 2011-12-22 |
EP2536406A4 (fr) | 2014-04-09 |
MX346409B (es) | 2017-03-17 |
AU2011212941B2 (en) | 2016-03-03 |
CN107308186A (zh) | 2017-11-03 |
WO2011097347A2 (fr) | 2011-08-11 |
EP2536406A2 (fr) | 2012-12-26 |
JP2013518895A (ja) | 2013-05-23 |
AU2011212941A1 (en) | 2012-09-27 |
CN103079557A (zh) | 2013-05-01 |
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