CA2788669C - Bismuth-thiols comme antiseptiques destines a des utilisations biomedicales, comprenant le traitement de biofilms bacteriens et d'autres utilisations - Google Patents

Bismuth-thiols comme antiseptiques destines a des utilisations biomedicales, comprenant le traitement de biofilms bacteriens et d'autres utilisations Download PDF

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CA2788669C
CA2788669C CA2788669A CA2788669A CA2788669C CA 2788669 C CA2788669 C CA 2788669C CA 2788669 A CA2788669 A CA 2788669A CA 2788669 A CA2788669 A CA 2788669A CA 2788669 C CA2788669 C CA 2788669C
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bismuth
thiol
composition
antibiotic
compound
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CA2788669A1 (fr
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Brett Hugh James Baker
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Microbion Corp
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Microbion Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
    • A01N55/02—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing metal atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/29—Antimony or bismuth compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/245—Bismuth; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Inorganic Chemistry (AREA)
  • Plant Pathology (AREA)
  • Environmental Sciences (AREA)
  • Child & Adolescent Psychology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Virology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention concerne des compositions et des procédés, comprenant de nouvelles suspensions microparticulaires homogènes, qui sont destinés à traiter des surfaces naturelles contenant des biofilms bactériens, comprenant des effets synergétiques ou amplificateurs insoupçonnés entre des composés bismuth-thiol (BT) et certains antibiotiques, pour fournir des formulations comprenant des formulations antiseptiques. L'invention concerne également les propriétés antibactériennes et anti-biofilm précédemment inattendues des composés BT et des combinaisons composé BT-plus-antibiotique décrites, comprenant les efficacités préférentielles de certaines de telles compositions pour traiter certaines infections par des bactéries gram-positives, et les efficacités préférentielles distinctes de certaines de telles compositions pour traiter certaines infections par des bactéries gram-négatives.
CA2788669A 2010-02-03 2011-02-03 Bismuth-thiols comme antiseptiques destines a des utilisations biomedicales, comprenant le traitement de biofilms bacteriens et d'autres utilisations Active CA2788669C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
USPCT/US2010/023108 2010-02-03
PCT/US2010/023108 WO2010091124A2 (fr) 2009-02-03 2010-02-03 Bismuth-thiols comme antiseptiques pour tissus épithéliaux, plaies aiguës et chroniques, biofilms bactériens et autres indications
US37318810P 2010-08-12 2010-08-12
US61/373,188 2010-08-12
PCT/US2011/023549 WO2011097347A2 (fr) 2010-02-03 2011-02-03 Bismuth-thiols comme antiseptiques destinés à des utilisations biomédicales, comprenant le traitement de biofilms bactériens et d'autres utilisations

Publications (2)

Publication Number Publication Date
CA2788669A1 CA2788669A1 (fr) 2011-08-11
CA2788669C true CA2788669C (fr) 2021-05-25

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CA2788669A Active CA2788669C (fr) 2010-02-03 2011-02-03 Bismuth-thiols comme antiseptiques destines a des utilisations biomedicales, comprenant le traitement de biofilms bacteriens et d'autres utilisations

Country Status (7)

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EP (1) EP2536406A4 (fr)
JP (1) JP2013518895A (fr)
CN (2) CN103079557A (fr)
AU (1) AU2011212941B2 (fr)
CA (1) CA2788669C (fr)
MX (1) MX346409B (fr)
WO (1) WO2011097347A2 (fr)

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US11596599B2 (en) 2012-05-03 2023-03-07 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
EP2844295A1 (fr) 2012-05-03 2015-03-11 Kala Pharmaceuticals, Inc. Nanoparticules pharmaceutiques permettant un transport muqueux amélioré
WO2013166408A1 (fr) 2012-05-03 2013-11-07 Kala Pharmaceuticals, Inc. Nanoparticules pharmaceutiques présentant un transport muqueux amélioré
US9827191B2 (en) 2012-05-03 2017-11-28 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
WO2014052973A1 (fr) * 2012-09-28 2014-04-03 Stelo Technologies Procédés de fabrication de nanoparticules d'argent et leurs applications
CN103667119B (zh) * 2013-11-26 2015-07-29 浙江大学 用于降解乙硫醇的菌株及其培养方法和应用
US11039621B2 (en) 2014-02-19 2021-06-22 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US9622483B2 (en) 2014-02-19 2017-04-18 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US11039620B2 (en) 2014-02-19 2021-06-22 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
AU2014385792B2 (en) 2014-03-07 2021-01-21 Tuffley, Mark DR Composition and method for enhancing wound healing
CN105572126B (zh) * 2015-04-07 2018-10-23 湖南华纳大药厂股份有限公司 一种胶体果胶铋药物组合物
US10045950B2 (en) * 2015-04-08 2018-08-14 BioMendics, LLC Formulation and process for modulating wound healing
WO2017145142A1 (fr) 2016-02-25 2017-08-31 Nobio Ltd. Compositions de microparticules et de nanoparticules comprenant des groupes à activité antimicrobienne
BR112019011660A2 (pt) * 2016-12-05 2019-10-22 Technophage Investig E Desenvolvimento Em Biotecnologia Sa composições de bacteriófagos que compreendem fagos antibacterianos respiratórios e métodos de uso das mesmas
WO2018112511A1 (fr) * 2016-12-22 2018-06-28 Whiteley Corporation Pty Ltd Composition de rupture de biofilm
WO2019043714A1 (fr) 2017-08-30 2019-03-07 Nobio Ltd. Particules antimicrobiennes et procédés d'utilisation de celles-ci
EP3485869B1 (fr) * 2017-11-16 2021-07-21 DSM IP Assets B.V. Utilisation de phytantriol comme agent antimicrobien dans la conservation d'une composition
CN110387416B (zh) * 2018-04-16 2022-06-17 华东理工大学 可控聚合调控功能的纳米金双探针体系及其应用
CN112788950A (zh) * 2018-07-31 2021-05-11 微生物公司 用于治疗伤口的铋-硫醇组合物和方法
US11464749B2 (en) * 2018-07-31 2022-10-11 Microbion Corporation Bismuth-thiol compositions and methods of use
CN110870874A (zh) * 2018-08-13 2020-03-10 中山大学 具有抗菌效果的药物及其应用
KR102054341B1 (ko) * 2019-06-20 2019-12-10 한국지질자원연구원 비흡수성 항생물질 및 점토광물의 복합체를 포함하는 항생제 내성인 헬리코박터 파일로리 제균을 위한 경구투여용 약학적 조성물
SG11202108262VA (en) * 2019-01-31 2021-08-30 Pulsethera Corp Bacterialcidal methods and compositions
WO2020191076A1 (fr) * 2019-03-18 2020-09-24 Cedars-Sinai Medical Center Compositions et méthodes pour traiter des maladies et des troubles gastro-intestinaux
CN112425608B (zh) * 2019-08-23 2023-07-21 香港科技大学 弹性蛋白酶抑制剂、具有抗生物膜活性的抑菌剂
CN111034711B (zh) * 2019-12-19 2022-04-05 海南一龄医疗产业发展有限公司 高效清除细胞培养过程中微生物污染的组合物及方法
CN111175103B (zh) * 2020-01-16 2023-07-04 江西业力医疗器械有限公司 一种真菌性阴道炎荧光检测的白带样本前处理液及其制备方法
US20230124862A1 (en) * 2020-03-24 2023-04-20 Jeffrey W. MILLARD Bismuth thiol compounds and compositions and methods of treating microbial co-infections
CN113712842B (zh) * 2020-05-25 2023-06-13 基元美业生物科技(上海)有限公司 一种组合物及其在制备化妆品及医疗器械中的应用
CN112618716B (zh) * 2021-01-11 2022-04-08 福州大学 一种光动力联合溶菌酶抗菌方法
CN113930462A (zh) * 2021-10-19 2022-01-14 江南大学 高丝氨酸内酯信号分子促进碳链延长微生物合成己酸的方法
CN114984746B (zh) * 2022-08-05 2022-11-01 山东建筑大学 一种消杀剂及养殖废水池VOCs废气处理系统方法和装置
CN115532295B (zh) * 2022-09-27 2023-07-25 苏州大学 含有Zn-N-C活性中心的纳米材料在去除细菌生物膜中的应用

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Publication number Publication date
MX2012009054A (es) 2012-12-17
CA2788669A1 (fr) 2011-08-11
WO2011097347A3 (fr) 2011-12-22
EP2536406A4 (fr) 2014-04-09
MX346409B (es) 2017-03-17
AU2011212941B2 (en) 2016-03-03
CN107308186A (zh) 2017-11-03
WO2011097347A2 (fr) 2011-08-11
EP2536406A2 (fr) 2012-12-26
JP2013518895A (ja) 2013-05-23
AU2011212941A1 (en) 2012-09-27
CN103079557A (zh) 2013-05-01

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