CA2787010C - Combined sensor and infusion sets - Google Patents
Combined sensor and infusion sets Download PDFInfo
- Publication number
- CA2787010C CA2787010C CA2787010A CA2787010A CA2787010C CA 2787010 C CA2787010 C CA 2787010C CA 2787010 A CA2787010 A CA 2787010A CA 2787010 A CA2787010 A CA 2787010A CA 2787010 C CA2787010 C CA 2787010C
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- sensor
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0031—Implanted circuitry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
- A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Optics & Photonics (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29642810P | 2010-01-19 | 2010-01-19 | |
| US61/296,428 | 2010-01-19 | ||
| US13/008,723 | 2011-01-18 | ||
| US13/008,723 US20120046533A1 (en) | 2007-08-29 | 2011-01-18 | Combined sensor and infusion sets |
| PCT/US2011/021749 WO2011091061A1 (en) | 2010-01-19 | 2011-01-19 | Insertion device for a combined sensor and infusion sets |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2787010A1 CA2787010A1 (en) | 2011-07-28 |
| CA2787010C true CA2787010C (en) | 2018-03-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2787010A Active CA2787010C (en) | 2010-01-19 | 2011-01-19 | Combined sensor and infusion sets |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20120046533A1 (enExample) |
| EP (1) | EP2525847A1 (enExample) |
| JP (1) | JP5777639B2 (enExample) |
| CN (1) | CN102802697B (enExample) |
| CA (1) | CA2787010C (enExample) |
| WO (1) | WO2011091061A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9044178B2 (en) | 2007-08-30 | 2015-06-02 | Pepex Biomedical, Llc | Electrochemical sensor and method for manufacturing |
| WO2009032760A2 (en) | 2007-08-30 | 2009-03-12 | Pepex Biomedical Llc | Electrochmical sensor and method for manufacturing |
| US9008744B2 (en) | 2011-05-06 | 2015-04-14 | Medtronic Minimed, Inc. | Method and apparatus for continuous analyte monitoring |
| GB201117539D0 (en) * | 2011-10-11 | 2011-11-23 | Univ Graz Med | Medical apparatus having infusion and detection capabilities |
| US9645111B2 (en) | 2012-06-08 | 2017-05-09 | Medtronic Minimed, Inc. | Application of electrochemical impedance spectroscopy in sensor systems, devices, and related methods |
| CN104918551B (zh) * | 2012-12-03 | 2019-07-26 | Pepex生物医药有限公司 | 传感器模块以及使用传感器模块的方法 |
| WO2014152717A2 (en) * | 2013-03-14 | 2014-09-25 | Sano Intelligence, Inc. | On-body microsensor for biomonitoring |
| US10820860B2 (en) | 2013-03-14 | 2020-11-03 | One Drop Biosensor Technologies, Llc | On-body microsensor for biomonitoring |
| EP3116397A4 (en) | 2014-03-13 | 2017-11-01 | Sano Intelligence, Inc. | System for monitoring body chemistry |
| US10595754B2 (en) | 2014-03-13 | 2020-03-24 | Sano Intelligence, Inc. | System for monitoring body chemistry |
| CN107003264B (zh) | 2014-06-04 | 2020-02-21 | 普佩克斯生物医药有限公司 | 电化学传感器和使用先进印刷技术制造电化学传感器的方法 |
| US10772556B2 (en) | 2014-11-05 | 2020-09-15 | Cláudio Afonso Ambrósio | Method and system for monitoring and treating hypoglycemia |
| US9399117B2 (en) | 2014-11-13 | 2016-07-26 | George Hsu | Systems and methods for providing securement and position verification for medical catheters |
| US20220062621A1 (en) | 2015-02-24 | 2022-03-03 | Elira, Inc. | Electrical Stimulation-Based Weight Management System |
| US9956393B2 (en) | 2015-02-24 | 2018-05-01 | Elira, Inc. | Systems for increasing a delay in the gastric emptying time for a patient using a transcutaneous electro-dermal patch |
| US10864367B2 (en) | 2015-02-24 | 2020-12-15 | Elira, Inc. | Methods for using an electrical dermal patch in a manner that reduces adverse patient reactions |
| EP3261712B1 (en) | 2015-02-24 | 2024-04-03 | Elira, Inc. | System for enabling appetite modulation and/or improving dietary compliance using an electro-dermal patch |
| US10765863B2 (en) | 2015-02-24 | 2020-09-08 | Elira, Inc. | Systems and methods for using a transcutaneous electrical stimulation device to deliver titrated therapy |
| US10335302B2 (en) | 2015-02-24 | 2019-07-02 | Elira, Inc. | Systems and methods for using transcutaneous electrical stimulation to enable dietary interventions |
| US10376145B2 (en) | 2015-02-24 | 2019-08-13 | Elira, Inc. | Systems and methods for enabling a patient to achieve a weight loss objective using an electrical dermal patch |
| WO2016196516A1 (en) * | 2015-06-03 | 2016-12-08 | William Kenneth Ward | Measurement of glucose in an insulin delivery catheter by minimizing the adverse effects of insulin preservatives |
| JP2017118911A (ja) * | 2015-12-28 | 2017-07-06 | セイコーエプソン株式会社 | センサー基板、分析素子、グルコース測定装置およびインスリン供給装置 |
| US11413092B2 (en) | 2016-01-13 | 2022-08-16 | The General Hospital Corporation | Systems and methods to facilitate delivery of a therapeutic agent into the skin of a subject |
| US10709834B2 (en) * | 2016-12-21 | 2020-07-14 | Medtronic Minimed, Inc. | Medication fluid infusion set component with integrated physiological analyte sensor, and corresponding fluid infusion device |
| US11457870B2 (en) | 2017-01-18 | 2022-10-04 | Dexcom, Inc. | Sensors for continuous analyte monitoring |
| EP4154802B1 (en) * | 2017-06-19 | 2024-02-14 | Dexcom, Inc. | Applicators for applying transcutaneous analyte sensors |
| WO2019010119A1 (en) | 2017-07-03 | 2019-01-10 | George Hsu | OPEN CUTTING DESIGN DEVICE FOR POSITION FIXING AND CHECKING OF MEDICAL CATHETERS |
| GB201809007D0 (en) * | 2018-06-01 | 2018-07-18 | Smith & Nephew | Restriction of sensor-monitored region for sensor-enabled wound dressings |
| WO2019067684A1 (en) * | 2017-09-28 | 2019-04-04 | California Institute Of Technology | SWITCHABLE LOW VOLTAGE ELECTROCHEMICAL DETECTION FOR REJECTION OF INTERFERING SPECIES |
| CN111836582A (zh) * | 2018-03-16 | 2020-10-27 | 国立大学法人东京大学 | 检测芯片以及检测装置 |
| CN113727747A (zh) * | 2019-03-25 | 2021-11-30 | 比奥林公司 | 用于将微针阵列分析物选择性传感器结合到输液器、贴片泵或自动治疗递送系统中的设备和方法 |
| AU2020244743A1 (en) * | 2019-03-25 | 2021-10-14 | Biolinq Incorporated | Devices and methods for the incorporation of a microneedle array analyte-selective sensor |
| US11317867B2 (en) * | 2019-04-23 | 2022-05-03 | Medtronic Minimed, Inc. | Flexible physiological characteristic sensor assembly |
| CN114144113A (zh) * | 2019-06-17 | 2022-03-04 | 比奥林公司 | 分析物选择性传感器和输注系统的机械耦合 |
| US20220211941A1 (en) * | 2019-07-19 | 2022-07-07 | Medtrum Technologies Inc. | Integrated drug infusion device |
| USD1086030S1 (en) | 2021-04-21 | 2025-07-29 | One Health Biosensing Inc. | Charging station |
| USD988882S1 (en) | 2021-04-21 | 2023-06-13 | Informed Data Systems Inc. | Sensor assembly |
| USD1076079S1 (en) | 2021-04-21 | 2025-05-20 | One Health Biosensing Inc. | Applicator assembly |
| US20220346677A1 (en) * | 2021-04-28 | 2022-11-03 | Pacific Diabetes Technologies Inc | Systems and methods for blood glucose management using concentrated insulin |
| USD1013864S1 (en) | 2021-08-26 | 2024-02-06 | Deka Products Limited Partnership | Fluid administration apparatus assembly |
| EP4404997A4 (en) * | 2021-09-22 | 2025-04-30 | Embecta Corp. | INJECTION PORT FOR GLUCOSE MONITOR |
| US20230414866A1 (en) * | 2022-06-24 | 2023-12-28 | Medtronic Minimed, Inc. | Integrated subcutaneous sensor and infusion device, system and method |
| USD1057941S1 (en) | 2022-08-26 | 2025-01-14 | Deka Products Limited Partnership | Patient care assembly component |
| USD1043976S1 (en) | 2022-08-26 | 2024-09-24 | Deka Products Limited Partnership | Fluid transfer connector |
| USD1090862S1 (en) | 2022-08-26 | 2025-08-26 | Deka Products Limited Partnership | Adhering assembly for medical devices and the like |
| WO2024081099A1 (en) * | 2022-10-12 | 2024-04-18 | Aita Bio Inc. | Cartridge assembly and hub for infusion catheter and cgm sensor insertion and introducer needle removal |
| TW202448544A (zh) * | 2023-02-15 | 2024-12-16 | 瑞士商赫孚孟拉羅股份公司 | 用於插入醫療裝置之插入系統及方法 |
Family Cites Families (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4573994A (en) | 1979-04-27 | 1986-03-04 | The Johns Hopkins University | Refillable medication infusion apparatus |
| US4678868A (en) | 1979-06-25 | 1987-07-07 | Medtronic, Inc. | Hermetic electrical feedthrough assembly |
| US4402819A (en) | 1980-03-17 | 1983-09-06 | University Of Delaware | Antibody-selective membrane electrodes |
| US4431004A (en) | 1981-10-27 | 1984-02-14 | Bessman Samuel P | Implantable glucose sensor |
| US4571292A (en) | 1982-08-12 | 1986-02-18 | Case Western Reserve University | Apparatus for electrochemical measurements |
| US4536274A (en) | 1983-04-18 | 1985-08-20 | Diamond Shamrock Chemicals Company | pH and CO2 sensing device and method of making the same |
| US4678408A (en) | 1984-01-06 | 1987-07-07 | Pacesetter Infusion, Ltd. | Solenoid drive apparatus for an external infusion pump |
| US4685903A (en) | 1984-01-06 | 1987-08-11 | Pacesetter Infusion, Ltd. | External infusion pump apparatus |
| US4562751A (en) | 1984-01-06 | 1986-01-07 | Nason Clyde K | Solenoid drive apparatus for an external infusion pump |
| GB8402058D0 (en) | 1984-01-26 | 1984-02-29 | Serono Diagnostics Ltd | Methods of assay |
| US4890620A (en) | 1985-09-20 | 1990-01-02 | The Regents Of The University Of California | Two-dimensional diffusion glucose substrate sensing electrode |
| IL78034A (en) | 1986-03-04 | 1991-08-16 | Univ Ramot | Biosensors comprising antibodies bonded to glassy carbon electrode for immunoassays |
| US4703756A (en) | 1986-05-06 | 1987-11-03 | The Regents Of The University Of California | Complete glucose monitoring system with an implantable, telemetered sensor module |
| US4894253A (en) | 1986-08-12 | 1990-01-16 | University Of Cincinnati | Method for production of coated electrode |
| US5362307A (en) | 1989-01-24 | 1994-11-08 | The Regents Of The University Of California | Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance |
| US6306594B1 (en) | 1988-11-14 | 2001-10-23 | I-Stat Corporation | Methods for microdispensing patterened layers |
| US5212050A (en) | 1988-11-14 | 1993-05-18 | Mier Randall M | Method of forming a permselective layer |
| US4940858A (en) | 1989-08-18 | 1990-07-10 | Medtronic, Inc. | Implantable pulse generator feedthrough |
| US5985129A (en) | 1989-12-14 | 1999-11-16 | The Regents Of The University Of California | Method for increasing the service life of an implantable sensor |
| US5165407A (en) | 1990-04-19 | 1992-11-24 | The University Of Kansas | Implantable glucose sensor |
| US5593852A (en) | 1993-12-02 | 1997-01-14 | Heller; Adam | Subcutaneous glucose electrode |
| DE69211010T2 (de) | 1991-10-21 | 1997-01-23 | Cornell Res Foundation Inc | Chromographiesäule mit makroporöser Polymerfüllung |
| US5720719A (en) * | 1992-08-12 | 1998-02-24 | Vidamed, Inc. | Ablative catheter with conformable body |
| US5299571A (en) | 1993-01-22 | 1994-04-05 | Eli Lilly And Company | Apparatus and method for implantation of sensors |
| US5427912A (en) | 1993-08-27 | 1995-06-27 | Boehringer Mannheim Corporation | Electrochemical enzymatic complementation immunoassay |
| US5390691A (en) | 1994-01-27 | 1995-02-21 | Sproule; Ronald | Bleed valve for water supply for camping vehicle |
| US5391250A (en) | 1994-03-15 | 1995-02-21 | Minimed Inc. | Method of fabricating thin film sensors |
| US5390671A (en) | 1994-03-15 | 1995-02-21 | Minimed Inc. | Transcutaneous sensor insertion set |
| US5505713A (en) | 1994-04-01 | 1996-04-09 | Minimed Inc. | Indwelling catheter with stable enzyme coating |
| AU2365895A (en) | 1994-04-26 | 1995-11-16 | Regents Of The University Of Michigan, The | Unitary sandwich enzyme immunoassay cassette, device and method of use |
| US5482473A (en) | 1994-05-09 | 1996-01-09 | Minimed Inc. | Flex circuit connector |
| US5705399A (en) | 1994-05-20 | 1998-01-06 | The Cooper Union For Advancement Of Science And Art | Sensor and method for detecting predetermined chemical species in solution |
| US5494562A (en) | 1994-06-27 | 1996-02-27 | Ciba Corning Diagnostics Corp. | Electrochemical sensors |
| US5605152A (en) | 1994-07-18 | 1997-02-25 | Minimed Inc. | Optical glucose sensor |
| IE72524B1 (en) * | 1994-11-04 | 1997-04-23 | Elan Med Tech | Analyte-controlled liquid delivery device and analyte monitor |
| US5568806A (en) | 1995-02-16 | 1996-10-29 | Minimed Inc. | Transcutaneous sensor insertion set |
| US5586553A (en) | 1995-02-16 | 1996-12-24 | Minimed Inc. | Transcutaneous sensor insertion set |
| US5786439A (en) | 1996-10-24 | 1998-07-28 | Minimed Inc. | Hydrophilic, swellable coatings for biosensors |
| US5882494A (en) | 1995-03-27 | 1999-03-16 | Minimed, Inc. | Polyurethane/polyurea compositions containing silicone for biosensor membranes |
| US5995860A (en) | 1995-07-06 | 1999-11-30 | Thomas Jefferson University | Implantable sensor and system for measurement and control of blood constituent levels |
| US5735273A (en) | 1995-09-12 | 1998-04-07 | Cygnus, Inc. | Chemical signal-impermeable mask |
| US5711861A (en) | 1995-11-22 | 1998-01-27 | Ward; W. Kenneth | Device for monitoring changes in analyte concentration |
| DE69633573T2 (de) | 1995-11-22 | 2005-10-06 | Medtronic MiniMed, Inc., Northridge | Detektion von biologischen molekülen unter verwendung von chemischer amplifikation und optischem sensor |
| US6043437A (en) | 1996-12-20 | 2000-03-28 | Alfred E. Mann Foundation | Alumina insulation for coating implantable components and other microminiature devices |
| US5851197A (en) | 1997-02-05 | 1998-12-22 | Minimed Inc. | Injector for a subcutaneous infusion set |
| US6093172A (en) * | 1997-02-05 | 2000-07-25 | Minimed Inc. | Injector for a subcutaneous insertion set |
| US6607509B2 (en) | 1997-12-31 | 2003-08-19 | Medtronic Minimed, Inc. | Insertion device for an insertion set and method of using the same |
| ATE227844T1 (de) | 1997-02-06 | 2002-11-15 | Therasense Inc | Kleinvolumiger sensor zur in-vitro bestimmung |
| US6001067A (en) | 1997-03-04 | 1999-12-14 | Shults; Mark C. | Device and method for determining analyte levels |
| US6558351B1 (en) | 1999-06-03 | 2003-05-06 | Medtronic Minimed, Inc. | Closed loop system for controlling insulin infusion |
| US5771868A (en) | 1997-07-03 | 1998-06-30 | Turbodyne Systems, Inc. | Turbocharging systems for internal combustion engines |
| US6119028A (en) | 1997-10-20 | 2000-09-12 | Alfred E. Mann Foundation | Implantable enzyme-based monitoring systems having improved longevity due to improved exterior surfaces |
| US6081736A (en) | 1997-10-20 | 2000-06-27 | Alfred E. Mann Foundation | Implantable enzyme-based monitoring systems adapted for long term use |
| US6155992A (en) | 1997-12-02 | 2000-12-05 | Abbott Laboratories | Method and apparatus for obtaining interstitial fluid for diagnostic tests |
| CA2575064C (en) * | 1997-12-31 | 2010-02-02 | Medtronic Minimed, Inc. | Insertion device for an insertion set and method of using the same |
| US6134461A (en) | 1998-03-04 | 2000-10-17 | E. Heller & Company | Electrochemical analyte |
| CA2311487C (en) | 1998-05-13 | 2004-02-10 | Cygnus, Inc. | Signal processing for measurement of physiological analytes |
| US6554798B1 (en) | 1998-08-18 | 2003-04-29 | Medtronic Minimed, Inc. | External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities |
| EP1413245B1 (en) | 1998-10-08 | 2011-06-29 | Medtronic MiniMed, Inc. | Telemetered characteristic monitor system |
| JP3395673B2 (ja) | 1998-11-18 | 2003-04-14 | 株式会社豊田中央研究所 | 微小酸素電極を利用した特異的結合対測定方法 |
| US6368274B1 (en) | 1999-07-01 | 2002-04-09 | Medtronic Minimed, Inc. | Reusable analyte sensor site and method of using the same |
| US6413393B1 (en) | 1999-07-07 | 2002-07-02 | Minimed, Inc. | Sensor including UV-absorbing polymer and method of manufacture |
| EP1253852B1 (en) | 2000-02-10 | 2007-09-19 | Medtronic MiniMed, Inc. | Analyte sensor |
| US6706159B2 (en) | 2000-03-02 | 2004-03-16 | Diabetes Diagnostics | Combined lancet and electrochemical analyte-testing apparatus |
| IT1314759B1 (it) | 2000-05-08 | 2003-01-03 | Menarini Farma Ind | Strumentazione per la misura ed il controllo del contenuto di glucosiolattato o altri metaboliti in fluidi biologici |
| US6400974B1 (en) | 2000-06-29 | 2002-06-04 | Sensors For Medicine And Science, Inc. | Implanted sensor processing system and method for processing implanted sensor output |
| US6475196B1 (en) | 2000-08-18 | 2002-11-05 | Minimed Inc. | Subcutaneous infusion cannula |
| US6703210B2 (en) | 2000-11-02 | 2004-03-09 | Satake Corporation | Method and device for determining concentration of dioxins |
| US6702857B2 (en) | 2001-07-27 | 2004-03-09 | Dexcom, Inc. | Membrane for use with implantable devices |
| US6740072B2 (en) | 2001-09-07 | 2004-05-25 | Medtronic Minimed, Inc. | System and method for providing closed loop infusion formulation delivery |
| US6915147B2 (en) | 2001-09-07 | 2005-07-05 | Medtronic Minimed, Inc. | Sensing apparatus and process |
| US6671554B2 (en) | 2001-09-07 | 2003-12-30 | Medtronic Minimed, Inc. | Electronic lead for a medical implant device, method of making same, and method and apparatus for inserting same |
| US7323142B2 (en) | 2001-09-07 | 2008-01-29 | Medtronic Minimed, Inc. | Sensor substrate and method of fabricating same |
| US7192766B2 (en) | 2001-10-23 | 2007-03-20 | Medtronic Minimed, Inc. | Sensor containing molded solidified protein |
| US6923936B2 (en) | 2001-10-23 | 2005-08-02 | Medtronic Minimed, Inc. | Sterile device and method for producing same |
| WO2003034902A2 (en) | 2001-10-23 | 2003-05-01 | Medtronic Minimed Inc. | Method and system for non-vascular sensor implantation |
| US6809507B2 (en) | 2001-10-23 | 2004-10-26 | Medtronic Minimed, Inc. | Implantable sensor electrodes and electronic circuitry |
| US20030077702A1 (en) | 2001-10-23 | 2003-04-24 | Rajiv Shah | Method for formulating a glucose oxidase enzyme with a desired property or properties and a glucose oxidase enzyme with the desired property |
| US7500949B2 (en) | 2002-03-01 | 2009-03-10 | Medtronic Minimed, Inc. | Multilumen catheter |
| US7813780B2 (en) * | 2005-12-13 | 2010-10-12 | Medtronic Minimed, Inc. | Biosensors and methods for making and using them |
| US7153265B2 (en) | 2002-04-22 | 2006-12-26 | Medtronic Minimed, Inc. | Anti-inflammatory biosensor for reduced biofouling and enhanced sensor performance |
| US20040068230A1 (en) | 2002-07-24 | 2004-04-08 | Medtronic Minimed, Inc. | System for providing blood glucose measurements to an infusion device |
| US7278983B2 (en) | 2002-07-24 | 2007-10-09 | Medtronic Minimed, Inc. | Physiological monitoring device for controlling a medication infusion device |
| AU2002326098A1 (en) | 2002-09-04 | 2004-03-29 | Pendragon Medical Ltd. | Method and device for measuring glucose |
| US6770729B2 (en) | 2002-09-30 | 2004-08-03 | Medtronic Minimed, Inc. | Polymer compositions containing bioactive agents and methods for their use |
| AU2003269844A1 (en) * | 2002-10-07 | 2004-04-23 | Novo Nordisk A/S | Needle device comprising a plurality of needles |
| EP1649260A4 (en) | 2003-07-25 | 2010-07-07 | Dexcom Inc | ELECTRODE SYSTEMS FOR ELECTROCHEMICAL DETECTORS |
| US9636450B2 (en) * | 2007-02-19 | 2017-05-02 | Udo Hoss | Pump system modular components for delivering medication and analyte sensing at seperate insertion sites |
| US7641649B2 (en) * | 2005-05-06 | 2010-01-05 | Medtronic Minimed, Inc. | Reservoir support and method for infusion device |
| US20060253085A1 (en) * | 2005-05-06 | 2006-11-09 | Medtronic Minimed, Inc. | Dual insertion set |
| ATE480278T1 (de) * | 2005-09-12 | 2010-09-15 | Unomedical As | Einfürungssystem für ein infusionsset mit einem ersten und zweiten federeinheit |
| WO2008133702A1 (en) * | 2007-04-30 | 2008-11-06 | Medtronic Minimed, Inc. | Needle inserting and fluid flow connection for infusion medium delivery system |
| US9968742B2 (en) * | 2007-08-29 | 2018-05-15 | Medtronic Minimed, Inc. | Combined sensor and infusion set using separated sites |
| US9921703B2 (en) | 2012-11-27 | 2018-03-20 | Guardian Glass, LLC | Transparent conductive coating for capacitive touch panel with additional functional film(s) |
| US9496283B1 (en) | 2015-08-10 | 2016-11-15 | Stmicroelectronics, Inc. | Transistor with self-aligned source and drain contacts and method of making same |
-
2011
- 2011-01-18 US US13/008,723 patent/US20120046533A1/en not_active Abandoned
- 2011-01-19 CN CN201180014556.0A patent/CN102802697B/zh active Active
- 2011-01-19 WO PCT/US2011/021749 patent/WO2011091061A1/en not_active Ceased
- 2011-01-19 JP JP2012550092A patent/JP5777639B2/ja active Active
- 2011-01-19 EP EP11703947A patent/EP2525847A1/en not_active Withdrawn
- 2011-01-19 CA CA2787010A patent/CA2787010C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2787010A1 (en) | 2011-07-28 |
| JP5777639B2 (ja) | 2015-09-09 |
| JP2013517102A (ja) | 2013-05-16 |
| CN102802697A (zh) | 2012-11-28 |
| CN102802697B (zh) | 2015-11-25 |
| US20120046533A1 (en) | 2012-02-23 |
| EP2525847A1 (en) | 2012-11-28 |
| WO2011091061A1 (en) | 2011-07-28 |
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