CA2782330A1 - Improved methods and compositions for detecting and treating cea-expressing cancers - Google Patents

Improved methods and compositions for detecting and treating cea-expressing cancers Download PDF

Info

Publication number
CA2782330A1
CA2782330A1 CA2782330A CA2782330A CA2782330A1 CA 2782330 A1 CA2782330 A1 CA 2782330A1 CA 2782330 A CA2782330 A CA 2782330A CA 2782330 A CA2782330 A CA 2782330A CA 2782330 A1 CA2782330 A1 CA 2782330A1
Authority
CA
Canada
Prior art keywords
cea
protein
sample
antibody
concentration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2782330A
Other languages
English (en)
French (fr)
Inventor
Scott Hammond
Michael David Oberst
Li Peng
Jiaqi Huang
Melissa Damschroder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MedImmune LLC
Original Assignee
MedImmune LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MedImmune LLC filed Critical MedImmune LLC
Publication of CA2782330A1 publication Critical patent/CA2782330A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57565—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving carcinoembryonic antigen [CEA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/54—Determining the risk of relapse

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA2782330A 2009-12-01 2010-11-29 Improved methods and compositions for detecting and treating cea-expressing cancers Abandoned CA2782330A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26558009P 2009-12-01 2009-12-01
US61/265,580 2009-12-01
PCT/US2010/058206 WO2011068758A1 (en) 2009-12-01 2010-11-29 Improved methods and compositions for detecting and treating cea-expressing cancers

Publications (1)

Publication Number Publication Date
CA2782330A1 true CA2782330A1 (en) 2011-06-09

Family

ID=44115238

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2782330A Abandoned CA2782330A1 (en) 2009-12-01 2010-11-29 Improved methods and compositions for detecting and treating cea-expressing cancers

Country Status (6)

Country Link
US (1) US20130035249A1 (https=)
EP (1) EP2507628A4 (https=)
JP (1) JP2013512454A (https=)
AU (1) AU2010326174A1 (https=)
CA (1) CA2782330A1 (https=)
WO (1) WO2011068758A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140242081A1 (en) * 2011-07-18 2014-08-28 Micromet Ag Dosing regimens for treatment of cea-expressing cancers
JP2014161283A (ja) * 2013-02-26 2014-09-08 Shizuoka Prefecture Ｃｅａｃａｍ５遺伝子のスプライシングバリアント
EP3145531A4 (en) * 2014-05-02 2018-03-21 Icahn School of Medicine at Mount Sinai Ceacam5 peptides for crohn's disease
WO2016036678A1 (en) * 2014-09-02 2016-03-10 Medimmune, Llc Formulations of bispecific antibodies

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9324807D0 (en) * 1993-12-03 1994-01-19 Cancer Res Campaign Tech Tumour antibody
JP2001002700A (ja) * 1999-06-18 2001-01-09 Wako Pure Chem Ind Ltd 癌の判定方法
AU3655301A (en) * 2000-01-25 2001-08-07 Nuvelo, Inc. Methods and materials relating to carcinoembryonic antigen-like (cea-like) polypeptides and polynucleotides
WO2002040059A2 (en) * 2000-11-01 2002-05-23 American Foundation For Biological Research, Inc. Methods and compositions for inducing cell-mediated immune responses
US20040142325A1 (en) * 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
ATE520979T1 (de) * 2005-08-24 2011-09-15 Bristol Myers Squibb Co Biomarker und verfahren zur bestimmung der empfindlichkeit gegenüber modulatoren des egf(epidermal growth factor)-rezeptors
LT1976880T (lt) * 2005-12-21 2016-10-10 Amgen Research (Munich) Gmbh Farmacinės kompozicijos, pasižyminčios atsparumu tirpiam cea

Also Published As

Publication number Publication date
WO2011068758A1 (en) 2011-06-09
AU2010326174A1 (en) 2012-07-12
EP2507628A4 (en) 2013-04-24
JP2013512454A (ja) 2013-04-11
US20130035249A1 (en) 2013-02-07
EP2507628A1 (en) 2012-10-10

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20151130

FZDE Discontinued

Effective date: 20161130