CA2780908A1 - Novel compounds as receptor modulators with therapeutic utility - Google Patents

Novel compounds as receptor modulators with therapeutic utility Download PDF

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Publication number
CA2780908A1
CA2780908A1 CA2780908A CA2780908A CA2780908A1 CA 2780908 A1 CA2780908 A1 CA 2780908A1 CA 2780908 A CA2780908 A CA 2780908A CA 2780908 A CA2780908 A CA 2780908A CA 2780908 A1 CA2780908 A1 CA 2780908A1
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Canada
Prior art keywords
alkyl
carboxylic acid
azetidine
benzyl
phenylpentyl
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Abandoned
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CA2780908A
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English (en)
French (fr)
Inventor
Todd M. Heidelbaugh
Phong X. Nguyen
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Allergan Inc
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Allergan Inc
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Publication of CA2780908A1 publication Critical patent/CA2780908A1/en
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    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
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Families Citing this family (12)

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Publication number Priority date Publication date Assignee Title
CN103619828A (zh) * 2011-04-14 2014-03-05 阿勒根公司 作为1-磷酸鞘氨醇受体调节剂的苯基双环甲基胺衍生物
CA2865215A1 (en) 2012-02-21 2013-08-29 Allergan, Inc. Phenoxy-azetidine derivatives as sphingosine 1-phosphate (s1p) receptor modulators
WO2014093253A1 (en) * 2012-12-13 2014-06-19 Allergan, Inc. Novel aromatic thio compounds as receptor modulators
SI2958913T1 (sl) 2013-02-20 2018-12-31 Lg Chem, Ltd. Sfingozin-1-fosfat receptor agonisti, postopki za njegovo pripravo in farmacevtski sestavki, ki ga vsebujejo kot aktivno sredstvo
US20140256945A1 (en) * 2013-03-07 2014-09-11 Allergan, Inc. Phosphonic acid compounds as sphingosine-1-phosphate receptor modulators
WO2015021112A1 (en) * 2013-08-08 2015-02-12 Allergan, Inc. Disubstituted aryl oxy derivatives as sphingosine-1- phosphate receptors modulators
US20150045341A1 (en) * 2013-08-08 2015-02-12 Allergan, Inc. Disubstituted aryl azetidine derivatives as sphingosine-1 phosphate receptors modulators
WO2015073547A1 (en) * 2013-11-13 2015-05-21 Allergan, Inc. Disubstituted phenoxy azetidine derivatives as sphingosine-1-phosphate (s1p) receptor modulators
KR20200116953A (ko) 2018-02-02 2020-10-13 고쿠리츠 다이가쿠 호진 교토 다이가쿠 안내 혈관 신생 및/또는 안내 혈관 투과성 항진을 수반하는 안과 질환의 예방 또는 치료를 위한 의약
US20240217935A1 (en) * 2021-04-14 2024-07-04 Lg Chem, Ltd. Method for preparing intermediate for synthesis of sphingosine-1-phosphate receptor agonist
KR102802371B1 (ko) * 2021-04-14 2025-05-07 주식회사 엘지화학 스핑고신-1-인산 수용체 효능제의 신규한 제조방법
EP4306516A4 (en) * 2021-04-14 2024-09-11 Lg Chem, Ltd. NEW METHOD FOR THE PRODUCTION OF A SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONIST

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0146810A3 (de) * 1983-12-05 1987-05-13 Solco Basel AG Verfahren zur Herstellung von Sphingosinderivaten
US5110987A (en) * 1988-06-17 1992-05-05 Emory University Method of preparing sphingosine derivatives
ZA902794B (en) * 1989-04-18 1991-04-24 Duphar Int Res New 3-n substituted carbamoyl-indole derivatives
US5294722A (en) * 1992-04-16 1994-03-15 E. R. Squibb & Sons, Inc. Process for the preparation of imidazoles useful in angiotensin II antagonism
US5403851A (en) * 1994-04-05 1995-04-04 Interneuron Pharmaceuticals, Inc. Substituted tryptamines, phenalkylamines and related compounds
US6235912B1 (en) * 1997-03-12 2001-05-22 Takara Shuzo Co., Ltd. Sphingosine analogues
JP4091250B2 (ja) * 1997-09-11 2008-05-28 タカラバイオ株式会社 スフィンゴシン類誘導体及び医薬組成物
DE10010067A1 (de) * 2000-03-02 2001-09-06 Bayer Ag Neue Imidazotriazinone und ihre Verwendung
DE60221391T2 (de) * 2001-06-20 2008-04-17 Wyeth Substituierte indolsäurederivate als inhibitoren von plasminogen-aktivator-inhibitor-1 (pai-1)
US20050070506A1 (en) * 2002-01-18 2005-03-31 Doherty George A. Selective s1p1/edg1 receptor agonists
ATE441654T1 (de) * 2002-01-18 2009-09-15 Merck & Co Inc Edg-rezeptoragonisten
AU2003202994B2 (en) * 2002-01-18 2007-11-22 Merck Sharp & Dohme Corp. N-(benzyl)aminoalkylcarboxylates, phosphinates, phosphonates and tetrazoles as Edg receptor agonists
CN1787817B (zh) * 2003-05-19 2011-09-07 Irm责任有限公司 免疫抑制剂化合物及组合物
US7825109B2 (en) * 2003-08-29 2010-11-02 Ono Pharmaceutical Co., Ltd. Compound capable of binding S1P receptor and pharmaceutical use thereof
RU2007109778A (ru) * 2004-08-17 2008-09-27 Галдерма Ресерч Энд Девелопмент, С.Н.С. (Fr) Новые биароматические соединения, которые активируют рецепторы типа ppar, и их применение в косметических и фармацевтических композициях
GB0612721D0 (en) * 2006-06-27 2006-08-09 Novartis Ag Organic compounds
AU2007292436A1 (en) * 2006-09-07 2008-03-13 Allergan, Inc. Heteroaromatic compounds having sphingosine-1-phosphate (S1P) receptor agonist biological activity
CA2662852A1 (en) * 2006-09-07 2008-03-13 Allergan, Inc. Heteroaromatic compounds having sphingosine-1-phosphate (s1p) receptor agonist and/or antagonist biological activity
CA2667706A1 (en) * 2006-10-27 2008-05-08 Lpath, Inc. Compositions and methods for treating ocular diseases and conditions
TW200827346A (en) * 2006-11-03 2008-07-01 Astrazeneca Ab Chemical compounds
US8633245B2 (en) 2008-04-11 2014-01-21 Institute Of Medicinal Molecular Design, Inc. PAI-1 inhibitor

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JP5939158B2 (ja) 2016-06-22
RU2012122615A (ru) 2013-12-27
AU2010324988A1 (en) 2012-06-07
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US8703745B1 (en) 2014-04-22
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