CA2777978A1 - Dac hyp compositions and methods - Google Patents
Dac hyp compositions and methods Download PDFInfo
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- CA2777978A1 CA2777978A1 CA2777978A CA2777978A CA2777978A1 CA 2777978 A1 CA2777978 A1 CA 2777978A1 CA 2777978 A CA2777978 A CA 2777978A CA 2777978 A CA2777978 A CA 2777978A CA 2777978 A1 CA2777978 A1 CA 2777978A1
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- Prior art keywords
- daclizumab
- composition
- dac hyp
- cell
- dac
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K—PEPTIDES
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- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
- C12N2500/95—Protein-free medium and culture conditions
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/04—Immortalised cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
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| US201161490998P | 2011-05-27 | 2011-05-27 | |
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Publications (1)
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| CA2777978A1 true CA2777978A1 (en) | 2012-11-27 |
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| US9809652B2 (en) | 2011-08-08 | 2017-11-07 | Abbvie Biotherapeutics Inc. | Methods of treating progressive forms of multiple sclerosis comprising subcutaneously administering daclizumab |
| CA2857298A1 (en) * | 2011-11-30 | 2013-06-06 | Abbvie Biotherapeutics Inc. | Vectors and host cells comprising a modified sv40 promoter for protein expression |
| US9217168B2 (en) | 2013-03-14 | 2015-12-22 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
| EP3041857B1 (en) | 2013-09-04 | 2019-05-08 | EMD Millipore Corporation | Protein a chromatography |
| GB201503578D0 (en) * | 2015-03-03 | 2015-04-15 | Ge Healthcare Bio Sciences Ab | Sanitization method for affinity chromatography matrices |
| WO2016154290A1 (en) * | 2015-03-23 | 2016-09-29 | Alexion Pharmaceuticals, Inc. | Virus filtration |
| CA2938333A1 (en) * | 2015-08-12 | 2017-02-12 | Pfizer Inc. | Capped and uncapped antibody cysteines, and their use in antibody-drug conjugation |
| EP3408397B1 (en) | 2016-01-27 | 2020-07-15 | Just-Evotec Biologics, Inc. | Hybrid promoter and uses thereof |
| US11261462B2 (en) | 2016-01-27 | 2022-03-01 | Just-Evotec Biologics, Inc. | Inducible expression from transposon-based vectors and uses |
| US11098310B2 (en) | 2016-01-27 | 2021-08-24 | Just-Evotec Biologics, Inc. | Expression from transposon-based vectors and uses |
| WO2018027195A1 (en) | 2016-08-05 | 2018-02-08 | Abbvie Biotherapeutics Inc. | Compositions containing reduced amounts of daclizumab acidic isoforms and methods for preparing the same |
| CN110267721B (zh) * | 2017-01-30 | 2022-03-01 | 瑞泽恩制药公司 | 用于降低色谱中生物负载的组合物和方法 |
| AU2018392697B2 (en) * | 2017-12-21 | 2025-08-14 | Genzyme Corporation | Methods for enhanced removal of impurities during protein a chromatography |
| KR20210148349A (ko) * | 2019-04-17 | 2021-12-07 | 브리스톨-마이어스 스큅 컴퍼니 | 크로마토그래피 수지의 재생 방법 |
| KR102731889B1 (ko) * | 2019-07-18 | 2024-11-19 | 에이비온 주식회사 | 2당화된 인터페론-베타 단백질의 정제 방법 |
| MX2022001166A (es) * | 2019-08-01 | 2022-02-23 | Regeneron Pharma | Metodo para inactivacion viral. |
| JP2022548197A (ja) | 2019-12-06 | 2022-11-17 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗ｖｅｇｆタンパク質組成物及びその製造方法 |
| CN115803009A (zh) | 2020-05-08 | 2023-03-14 | 瑞泽恩制药公司 | 用于治疗眼病和癌症的vegf阱和微阱及方法 |
| JP7631742B2 (ja) * | 2020-11-10 | 2025-02-19 | 東ソー株式会社 | ペプチド性リガンド固定化カラムの洗浄方法 |
| CN114181300A (zh) * | 2021-12-20 | 2022-03-15 | 方坦思(上海)生物医药有限公司 | 一种高纯度单克隆抗体的制备方法 |
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| US7442777B2 (en) * | 2000-11-29 | 2008-10-28 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD63 |
| RU2318537C2 (ru) * | 2001-04-06 | 2008-03-10 | Юниверсити Оф Бристоль | Применение cd25-связывающих молекул для лечения пациентов, устойчивых к стероидам |
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| US7365168B2 (en) * | 2002-10-15 | 2008-04-29 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| JPWO2004087761A1 (ja) * | 2003-03-31 | 2006-07-27 | 麒麟麦酒株式会社 | ヒトモノクローナル抗体およびヒトポリクローナル抗体の精製 |
| US20070190057A1 (en) * | 2006-01-23 | 2007-08-16 | Jian Wu | Methods for modulating mannose content of recombinant proteins |
| US20100173323A1 (en) * | 2006-06-09 | 2010-07-08 | University Of Maryland, Baltimore | Glycosylation engineered antibody therapy |
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| WO2009114641A1 (en) * | 2008-03-11 | 2009-09-17 | Genentech, Inc. | Antibodies with enhanced adcc function |
| US20100055098A1 (en) * | 2008-08-28 | 2010-03-04 | Facet Biotech Corporation | Method for treating multiple sclerosis patients with anti-il2r antibodies |
| AU2010254215A1 (en) * | 2009-05-26 | 2011-12-01 | Momenta Pharmaceuticals, Inc. | Production of glycoproteins |
| WO2010141855A1 (en) | 2009-06-05 | 2010-12-09 | Momenta Pharmaceuticals, Inc. | Methods of modulating fucosylation of glycoproteins |
| CN102574911B (zh) * | 2009-08-07 | 2017-06-06 | Emd密理博公司 | 从样品的一或多种杂质中纯化靶蛋白的方法 |
| WO2011019622A1 (en) | 2009-08-14 | 2011-02-17 | Genentech, Inc. | Cell culture methods to make antibodies with enhanced adcc function |
| US10087236B2 (en) * | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| IL300733B1 (en) | 2010-03-05 | 2025-10-01 | Univ Johns Hopkins | Compositions and methods for antibodies and fusion proteins targeted for immune modulation |
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- 2012-05-25 CN CN2012102472614A patent/CN102796705A/zh active Pending
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