CA2772190A1 - Systems and methods for producing hyperpolarized materials and mixtures thereof - Google Patents

Systems and methods for producing hyperpolarized materials and mixtures thereof Download PDF

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Publication number
CA2772190A1
CA2772190A1 CA2772190A CA2772190A CA2772190A1 CA 2772190 A1 CA2772190 A1 CA 2772190A1 CA 2772190 A CA2772190 A CA 2772190A CA 2772190 A CA2772190 A CA 2772190A CA 2772190 A1 CA2772190 A1 CA 2772190A1
Authority
CA
Canada
Prior art keywords
nuclei
polarization
hyperpolarized
temperature
magnetic field
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2772190A
Other languages
English (en)
French (fr)
Inventor
Neal Kalechofsky
Avrum Belzer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MILLIKELVIN TECHNOLOGIES LLC
Original Assignee
MILLIKELVIN TECHNOLOGIES LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MILLIKELVIN TECHNOLOGIES LLC filed Critical MILLIKELVIN TECHNOLOGIES LLC
Publication of CA2772190A1 publication Critical patent/CA2772190A1/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CA2772190A 2009-08-31 2010-08-31 Systems and methods for producing hyperpolarized materials and mixtures thereof Abandoned CA2772190A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23864709P 2009-08-31 2009-08-31
US61/238,647 2009-08-31
PCT/US2010/047310 WO2011026103A2 (en) 2009-08-31 2010-08-31 Systems and methods for producing hyperpolarized materials and mixtures thereof

Publications (1)

Publication Number Publication Date
CA2772190A1 true CA2772190A1 (en) 2011-03-03

Family

ID=43628703

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2772190A Abandoned CA2772190A1 (en) 2009-08-31 2010-08-31 Systems and methods for producing hyperpolarized materials and mixtures thereof

Country Status (9)

Country Link
EP (1) EP2473198A4 (https=)
JP (1) JP5792726B2 (https=)
KR (1) KR20120101339A (https=)
CN (1) CN102753201A (https=)
AU (1) AU2010286413B2 (https=)
CA (1) CA2772190A1 (https=)
IN (1) IN2012DN02418A (https=)
SG (1) SG178927A1 (https=)
WO (1) WO2011026103A2 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1986702A4 (en) 2006-02-21 2012-12-12 Avrum Belzer HYPERPOLARIZATION PROCEDURES, SYSTEMS AND COMPOSITIONS
US8703102B2 (en) 2008-04-04 2014-04-22 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
GB2498181A (en) * 2011-12-29 2013-07-10 Bruker Biospin Gmbh Device and method for rapid dynamic nuclear polarisation
US9329246B2 (en) 2012-10-03 2016-05-03 Bruker Biospin Ag Method for hyperpolarization transfer in the liquid state
US9404984B2 (en) 2012-11-06 2016-08-02 Bruker Uk Limited Method of hyperpolarization applying brute force using particulate acceleration agents

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545396A (en) * 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases
US5617859A (en) 1995-10-02 1997-04-08 General Electric Company Apparatus and methods for magnetic resonance (MR) imaging of cavities using fluids polarized at low temperatures
US5809801A (en) * 1996-03-29 1998-09-22 The Trustees Of Princeton University Cryogenic accumulator for spin-polarized xenon-129
CN1224502A (zh) * 1996-03-29 1999-07-28 劳伦斯·伯克利国家实验室 利用超极化惰性气体对于核磁共振和磁共振成象质量的提高
FI982069A7 (fi) 1996-03-29 1998-11-10 Lawrence Berkeley Nat Laboratory NMR:n ja MRI:n tehostaminen hyperpolaroitujen jalokaasujen läsnä olles sa
GB9614139D0 (en) 1996-07-05 1996-09-04 Nycomed Imaging As Method
EP0951650B1 (en) * 1997-01-08 2003-12-10 Amersham Health AS Method of magnetic resonance imaging
CN1269015A (zh) * 1997-06-19 2000-10-04 耐克麦德英梅金公司 使用体外极化磁共振成像剂的奥氏磁共振成像方法
KR100600670B1 (ko) 1997-11-12 2006-07-13 지이 헬스케어 에이에스 파라수소 표지된 작용물질 및 자기공명영상에서의 그의 용도
US6278893B1 (en) * 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
GB0001727D0 (en) 2000-01-25 2000-03-15 Oxford Instr Uk Ltd Hyperpolarization of a noble gas
JP4061192B2 (ja) * 2000-11-03 2008-03-12 ジーイー・ヘルスケア・アクスイェ・セルスカプ 分極ｎｍｒ試料用のデバイス及び方法
BR0115124B1 (pt) 2000-11-03 2012-12-25 dispositivo para fundir uma amostra hiperpolarizada sàlida, mÉtodo para produzir uma amostra hiperpolarizada fundida, e, uso de um dispositivo ou mÉtodo.
NO20025738D0 (no) * 2002-11-29 2002-11-29 Amersham Health As Metode
DE102004002639A1 (de) * 2004-01-19 2005-09-15 Forschungszentrum Jülich GmbH Verfahren zur Anreicherung von hyperpolarisierten Atomkernen und Vorrichtung zur Durchführung des Verfahrens
GB0501346D0 (en) * 2005-01-21 2005-03-02 Oxford Instr Molecular Biotool Method of carrying out dynamic nuclear polarization
FR2881226B1 (fr) * 2005-01-27 2007-04-27 Commissariat Energie Atomique Accroissement de la polarisation des spins nucleaires d'une molecule via un transfert de polarisation de type hartmann-hahn utilisant le champ dipolaire moyen cree par une source
GB0514303D0 (en) * 2005-07-12 2005-08-17 Oxford Instr Molecular Biotool Magnet assembly
EP1986702A4 (en) * 2006-02-21 2012-12-12 Avrum Belzer HYPERPOLARIZATION PROCEDURES, SYSTEMS AND COMPOSITIONS
NL2000122C2 (nl) * 2006-07-03 2008-01-07 Vialle Alternative Fuel System Bufferhouder.
US7631507B2 (en) * 2006-11-02 2009-12-15 General Electric Company Methods and devices for polarized samples for use in MRI
US20080242974A1 (en) * 2007-04-02 2008-10-02 Urbahn John A Method and apparatus to hyperpolarize materials for enhanced mr techniques
US7519492B2 (en) * 2007-05-02 2009-04-14 General Electric Company Apparatus and method for fully automated closed system quality control of a substance

Also Published As

Publication number Publication date
WO2011026103A2 (en) 2011-03-03
IN2012DN02418A (https=) 2015-08-21
CN102753201A (zh) 2012-10-24
KR20120101339A (ko) 2012-09-13
SG178927A1 (en) 2012-04-27
EP2473198A2 (en) 2012-07-11
WO2011026103A3 (en) 2011-07-21
JP5792726B2 (ja) 2015-10-14
AU2010286413B2 (en) 2014-11-20
EP2473198A4 (en) 2015-06-24
AU2010286413A1 (en) 2012-04-05
JP2013503021A (ja) 2013-01-31

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20150731

FZDE Discontinued

Effective date: 20180228