CA2769618A1 - Combination of a chemotherapeutic agent and an inhibitor of the tgf-beta system - Google Patents
Combination of a chemotherapeutic agent and an inhibitor of the tgf-beta system Download PDFInfo
- Publication number
- CA2769618A1 CA2769618A1 CA2769618A CA2769618A CA2769618A1 CA 2769618 A1 CA2769618 A1 CA 2769618A1 CA 2769618 A CA2769618 A CA 2769618A CA 2769618 A CA2769618 A CA 2769618A CA 2769618 A1 CA2769618 A1 CA 2769618A1
- Authority
- CA
- Canada
- Prior art keywords
- tgf
- beta
- carcinoma
- cancer
- antisense oligonucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/31—Combination therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Biomedical Technology (AREA)
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- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
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| EP09166893 | 2009-07-30 | ||
| EP09166893.9 | 2009-07-30 | ||
| PCT/EP2010/061152 WO2011012713A1 (en) | 2009-07-30 | 2010-07-30 | Combination of a chemotherapeutic agent and an inhibitor of the tgf-beta system |
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| CA2769618A1 true CA2769618A1 (en) | 2011-02-03 |
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| CA2769618A Abandoned CA2769618A1 (en) | 2009-07-30 | 2010-07-30 | Combination of a chemotherapeutic agent and an inhibitor of the tgf-beta system |
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| KR101265180B1 (ko) * | 2002-01-17 | 2013-05-29 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 아이지에프비피-2 및 아이지에프비피-5를 억제하는 양특이성 안티센스 올리고뉴클레오티드, 이를 이용하여 약학적 조성물을 제조하는 방법 및 그 약학적 조성물 |
| US20140031250A1 (en) | 2010-10-07 | 2014-01-30 | David Tsai Ting | Biomarkers of Cancer |
| TWI454281B (zh) * | 2011-10-06 | 2014-10-01 | Nat Univ Tsing Hua | 硼酸於硼中子捕獲治療肝癌之用途 |
| WO2013124869A2 (en) * | 2012-02-21 | 2013-08-29 | Amrita Vishwa Vidyapeetham University | The art, method,manner process and system of fibrous bio-degradable polymeric wafers for the local delivery of therapeutic agents in combinations |
| US20140275214A1 (en) * | 2013-03-14 | 2014-09-18 | Teva Pharmaceutical Industries, Ltd. | Custirsen treatment with reduced toxicity |
| CA2949574C (en) * | 2014-05-23 | 2022-06-07 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods for determining whether a patient will achieve a response after radiation therapy |
| WO2015200697A1 (en) | 2014-06-25 | 2015-12-30 | The General Hospital Corporation | Targeting human satellite ii (hsatii) |
| US11759530B2 (en) * | 2014-11-17 | 2023-09-19 | City Of Hope | TKI permeability enhancers |
| CN108139375A (zh) | 2015-06-26 | 2018-06-08 | 贝斯以色列女执事医疗中心股份有限公司 | 靶向髓样衍生的抑制细胞中的四跨膜蛋白33(tspan33)的癌症疗法 |
| WO2017138924A1 (en) | 2016-02-09 | 2017-08-17 | Autotelic Llc | Compositions and methods for treating pancreatic cancer |
| US9758786B2 (en) | 2016-02-09 | 2017-09-12 | Autotelic, Llc | Compositions and methods for treating pancreatic cancer |
| KR20180103817A (ko) | 2016-02-09 | 2018-09-19 | 오토텔릭 엘엘씨 | 암을 치료하기 위한 조성물과 방법 |
| US11459568B2 (en) | 2016-10-31 | 2022-10-04 | University Of Massachusetts | Targeting microRNA-101-3p in cancer therapy |
| WO2018089688A1 (en) | 2016-11-09 | 2018-05-17 | Jinjun Shi | Restoration of tumor suppression using mrna-based delivery system |
| JP2021512956A (ja) | 2018-02-06 | 2021-05-20 | ザ ジェネラル ホスピタル コーポレイション | 腫瘍免疫応答のバイオマーカーとしてのリピートｒｎａ |
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| GB201908012D0 (en) * | 2019-06-05 | 2019-07-17 | Io Biotech Aps | TGF-Beta vaccine |
| CN112933238A (zh) * | 2021-02-02 | 2021-06-11 | 石河子大学 | 抑制TGF-βR1基因表达的物质与顺铂在治疗和/或预防食管癌中的应用 |
| CN113425855B (zh) * | 2021-06-28 | 2023-11-07 | 深圳瑞吉生物科技有限公司 | 一种mRNA剂型的骨关节炎药物制剂及其制备方法和应用 |
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| US4675189A (en) | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
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| US6809118B2 (en) * | 2002-07-25 | 2004-10-26 | Yih-Lin Chung | Methods for therapy of radiation cutaneous syndrome |
| JP4682312B2 (ja) * | 2003-09-04 | 2011-05-11 | 学校法人日本大学 | ＴＧＦ−β遺伝子発現抑制剤 |
| KR20060127409A (ko) * | 2003-11-13 | 2006-12-12 | 제넨테크, 인크. | 종양 치료 방법 및 스크리닝 검정 |
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| CA2558667A1 (en) * | 2004-02-27 | 2005-09-15 | Antisense Pharma Gmbh | Antisense oligonucleotides for inhibiting the formation of metastases in cancer |
| US20090186076A1 (en) * | 2006-02-01 | 2009-07-23 | Kazunori Kataoka | Combined Use of TGF-Beta Signaling Inhibitor and Antitumor Agent |
| JP5322476B2 (ja) * | 2008-03-31 | 2013-10-23 | テルモ株式会社 | リポソームの製造装置およびリポソームの製造方法 |
-
2010
- 2010-07-30 PE PE2012000130A patent/PE20121495A1/es not_active Application Discontinuation
- 2010-07-30 IN IN969DEN2012 patent/IN2012DN00969A/en unknown
- 2010-07-30 RU RU2012107535/15A patent/RU2012107535A/ru not_active Application Discontinuation
- 2010-07-30 KR KR1020127005337A patent/KR20120107456A/ko not_active Withdrawn
- 2010-07-30 US US13/059,623 patent/US8476246B2/en active Active
- 2010-07-30 MX MX2012001244A patent/MX2012001244A/es active IP Right Grant
- 2010-07-30 CA CA2769618A patent/CA2769618A1/en not_active Abandoned
- 2010-07-30 BR BR112012002102A patent/BR112012002102A2/pt not_active IP Right Cessation
- 2010-07-30 AU AU2010277554A patent/AU2010277554B2/en not_active Ceased
- 2010-07-30 EP EP10737580.0A patent/EP2340308B1/en not_active Not-in-force
- 2010-07-30 JP JP2012522185A patent/JP2013500313A/ja active Pending
- 2010-07-30 CN CN2010800436805A patent/CN102712924A/zh active Pending
- 2010-07-30 WO PCT/EP2010/061152 patent/WO2011012713A1/en not_active Ceased
-
2012
- 2012-01-29 IL IL217821A patent/IL217821A0/en unknown
- 2012-01-30 CL CL2012000247A patent/CL2012000247A1/es unknown
- 2012-02-23 EC ECSP12011689 patent/ECSP12011689A/es unknown
- 2012-02-29 CO CO12035227A patent/CO6511199A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2340308A1 (en) | 2011-07-06 |
| WO2011012713A1 (en) | 2011-02-03 |
| US20120027873A1 (en) | 2012-02-02 |
| RU2012107535A (ru) | 2013-09-10 |
| JP2013500313A (ja) | 2013-01-07 |
| CL2012000247A1 (es) | 2013-07-05 |
| IL217821A0 (en) | 2012-03-29 |
| US8476246B2 (en) | 2013-07-02 |
| BR112012002102A2 (pt) | 2017-05-02 |
| AU2010277554B2 (en) | 2015-02-19 |
| CO6511199A2 (es) | 2012-08-31 |
| CN102712924A (zh) | 2012-10-03 |
| IN2012DN00969A (enExample) | 2015-04-10 |
| EP2340308B1 (en) | 2014-12-24 |
| MX2012001244A (es) | 2012-03-26 |
| AU2010277554A1 (en) | 2012-03-01 |
| PE20121495A1 (es) | 2012-11-19 |
| KR20120107456A (ko) | 2012-10-02 |
| ECSP12011689A (es) | 2012-06-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20160427 |
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| FZDE | Discontinued |
Effective date: 20190606 |