CL2012000247A1 - Composicion farmaceutica que comprende un agente quimioterapeutico y un oligonucleotido antisentido contra tgf beta. - Google Patents

Composicion farmaceutica que comprende un agente quimioterapeutico y un oligonucleotido antisentido contra tgf beta.

Info

Publication number
CL2012000247A1
CL2012000247A1 CL2012000247A CL2012000247A CL2012000247A1 CL 2012000247 A1 CL2012000247 A1 CL 2012000247A1 CL 2012000247 A CL2012000247 A CL 2012000247A CL 2012000247 A CL2012000247 A CL 2012000247A CL 2012000247 A1 CL2012000247 A1 CL 2012000247A1
Authority
CL
Chile
Prior art keywords
pharmaceutical composition
chemotherapeutic agent
antisense oligonucleotide
tgf beta
oligonucleotide against
Prior art date
Application number
CL2012000247A
Other languages
English (en)
Inventor
Karl Hermann Schlingensiepen
Frank Jaschinski
Tanja Rothammer
Anneliese Schneider
Original Assignee
Antisense Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41278403&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2012000247(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Antisense Pharma Gmbh filed Critical Antisense Pharma Gmbh
Publication of CL2012000247A1 publication Critical patent/CL2012000247A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/31—Combination therapy

Abstract

Composición farmacéutica que comprende un agente quimioterapéutico y un oligonucleótido antisentido contra TGF beta.
CL2012000247A 2009-07-30 2012-01-30 Composicion farmaceutica que comprende un agente quimioterapeutico y un oligonucleotido antisentido contra tgf beta. CL2012000247A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09166893 2009-07-30

Publications (1)

Publication Number Publication Date
CL2012000247A1 true CL2012000247A1 (es) 2013-07-05

Family

ID=41278403

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012000247A CL2012000247A1 (es) 2009-07-30 2012-01-30 Composicion farmaceutica que comprende un agente quimioterapeutico y un oligonucleotido antisentido contra tgf beta.

Country Status (17)

Country Link
US (1) US8476246B2 (es)
EP (1) EP2340308B1 (es)
JP (1) JP2013500313A (es)
KR (1) KR20120107456A (es)
CN (1) CN102712924A (es)
AU (1) AU2010277554B2 (es)
BR (1) BR112012002102A2 (es)
CA (1) CA2769618A1 (es)
CL (1) CL2012000247A1 (es)
CO (1) CO6511199A2 (es)
EC (1) ECSP12011689A (es)
IL (1) IL217821A0 (es)
IN (1) IN2012DN00969A (es)
MX (1) MX2012001244A (es)
PE (1) PE20121495A1 (es)
RU (1) RU2012107535A (es)
WO (1) WO2011012713A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030158143A1 (en) * 2002-01-17 2003-08-21 Martin Gleave Bispecific antisense olignucleotides that inhibit IGFBP-2 and IGFBP-5 and methods of using same
WO2012048113A2 (en) 2010-10-07 2012-04-12 The General Hospital Corporation Biomarkers of cancer
TWI454281B (zh) * 2011-10-06 2014-10-01 Nat Univ Tsing Hua 硼酸於硼中子捕獲治療肝癌之用途
WO2013124869A2 (en) * 2012-02-21 2013-08-29 Amrita Vishwa Vidyapeetham University The art, method,manner process and system of fibrous bio-degradable polymeric wafers for the local delivery of therapeutic agents in combinations
US20140275214A1 (en) * 2013-03-14 2014-09-18 Teva Pharmaceutical Industries, Ltd. Custirsen treatment with reduced toxicity
EP3146334B1 (en) * 2014-05-23 2019-08-14 Institut National de la Sante et de la Recherche Medicale (INSERM) Methods for determining whether a patient will achieve a response after radiation therapy
WO2016081503A1 (en) * 2014-11-17 2016-05-26 City Of Hope Tki permeability enhancers
EP3314250A4 (en) 2015-06-26 2018-12-05 Beth Israel Deaconess Medical Center, Inc. Cancer therapy targeting tetraspanin 33 (tspan33) in myeloid derived suppressor cells
KR101843985B1 (ko) 2016-02-09 2018-03-30 오토텔릭 엘엘씨 암을 치료하기 위한 조성물과 방법
WO2017138924A1 (en) 2016-02-09 2017-08-17 Autotelic Llc Compositions and methods for treating pancreatic cancer
US9758786B2 (en) 2016-02-09 2017-09-12 Autotelic, Llc Compositions and methods for treating pancreatic cancer
EP3532638A4 (en) 2016-10-31 2020-07-29 University of Massachusetts TARGETING MICROARN-101-3 P IN CARCINOTHERAPY
WO2018089688A1 (en) 2016-11-09 2018-05-17 Jinjun Shi Restoration of tumor suppression using mrna-based delivery system
CA3090652A1 (en) 2018-02-06 2019-08-15 The General Hospital Corporation Repeat rna as biomarkers of tumor immune response
AU2020237255A1 (en) * 2019-03-14 2021-09-09 The Research Foundation For The State University Of New York Modified micrornas and their use in the treatment of cancer
GB201908012D0 (en) * 2019-06-05 2019-07-17 Io Biotech Aps TGF-Beta vaccine
CN112933238A (zh) * 2021-02-02 2021-06-11 石河子大学 抑制TGF-βR1基因表达的物质与顺铂在治疗和/或预防食管癌中的应用
CN113425855B (zh) * 2021-06-28 2023-11-07 深圳瑞吉生物科技有限公司 一种mRNA剂型的骨关节炎药物制剂及其制备方法和应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3854480A (en) 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
US4469863A (en) 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US4675189A (en) 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
US5023243A (en) 1981-10-23 1991-06-11 Molecular Biosystems, Inc. Oligonucleotide therapeutic agent and method of making same
WO1983001451A1 (en) 1981-10-23 1983-04-28 Molecular Biosystems Inc Oligonucleotide therapeutic agent and methods of making same
US4452775A (en) 1982-12-03 1984-06-05 Syntex (U.S.A.) Inc. Cholesterol matrix delivery system for sustained release of macromolecules
US5075109A (en) 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
US5133974A (en) 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US5714331A (en) 1991-05-24 1998-02-03 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US5719262A (en) 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
US5407686A (en) 1991-11-27 1995-04-18 Sidmak Laboratories, Inc. Sustained release composition for oral administration of active ingredient
US5736152A (en) 1995-10-27 1998-04-07 Atrix Laboratories, Inc. Non-polymeric sustained release delivery system
EP0856579A1 (en) * 1997-01-31 1998-08-05 BIOGNOSTIK GESELLSCHAFT FÜR BIOMOLEKULARE DIAGNOSTIK mbH An antisense oligonucleotide preparation method
US7795232B1 (en) 2000-08-25 2010-09-14 Genta Incorporated Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers
US6809118B2 (en) * 2002-07-25 2004-10-26 Yih-Lin Chung Methods for therapy of radiation cutaneous syndrome
CN1845733A (zh) * 2003-09-04 2006-10-11 学校法人日本大学 TGF－β基因表达抑制剂
CA2542215A1 (en) * 2003-11-13 2005-06-02 Genentech, Inc. Screening assays and methods of tumor treatment
CN1902488A (zh) * 2003-11-13 2007-01-24 健泰科生物技术公司 肿瘤治疗的筛选实验和方法
AU2004299670B2 (en) * 2003-12-19 2010-04-22 Antisense Pharma Gmbh Combination therapy associating a TGF-beta antagonist with a chemotherapeutic agent
US20070155685A1 (en) * 2004-02-27 2007-07-05 Karl-Hermann Schlingensiepen Pharmaceutical composition
JPWO2007088651A1 (ja) * 2006-02-01 2009-06-25 国立大学法人 東京大学 ＴＧＦ−βシグナル阻害剤と抗腫瘍剤の組み合せ使用
JP5322476B2 (ja) * 2008-03-31 2013-10-23 テルモ株式会社 リポソームの製造装置およびリポソームの製造方法

Also Published As

Publication number Publication date
IL217821A0 (en) 2012-03-29
PE20121495A1 (es) 2012-11-19
US8476246B2 (en) 2013-07-02
CN102712924A (zh) 2012-10-03
IN2012DN00969A (es) 2015-04-10
RU2012107535A (ru) 2013-09-10
AU2010277554A1 (en) 2012-03-01
KR20120107456A (ko) 2012-10-02
AU2010277554B2 (en) 2015-02-19
BR112012002102A2 (pt) 2017-05-02
JP2013500313A (ja) 2013-01-07
MX2012001244A (es) 2012-03-26
US20120027873A1 (en) 2012-02-02
EP2340308B1 (en) 2014-12-24
CO6511199A2 (es) 2012-08-31
CA2769618A1 (en) 2011-02-03
WO2011012713A1 (en) 2011-02-03
ECSP12011689A (es) 2012-06-29
EP2340308A1 (en) 2011-07-06

Similar Documents

Publication Publication Date Title
CL2012000247A1 (es) Composicion farmaceutica que comprende un agente quimioterapeutico y un oligonucleotido antisentido contra tgf beta.
BRPI0923823A2 (pt) Agente de colaboração.
GB0823716D0 (en) Stent delivery device with rolling stent retaining sheath
MX2011013421A (es) Arnds formulado con lipido de direccionamiento del gen pcsk9.
BR112012010676A2 (pt) partícula de alta eficiência que compreende um agente de benefício.
IN2012DN01869A (es)
EP2366785A4 (en) OLIGONUCLEOTIDE DERIVATIVES, MARKING AGENTS AND THE MARKETING AGENT
CO6910187A2 (es) Composiciones parasiticidas que comprenden un agente activo isoxazolina, sus métodos y usos
NZ797319A (en) Modified rnai agents
BRPI1014139A2 (pt) sistema de liberação de fármacos compreendendo polioxazolina e um agente biotivo.
HK1156071A1 (en) Buttiauxella sp. phytase variants
GEP20156329B (en) CHEMICAL MODIFICATIONS OF miRNA INHIBITORS AND MIMETICS
IL206932A0 (en) Devices, formulations, and methods for delivery of multiple beneficial agents
CL2011001811A1 (es) Un metodo para tratar un paciente que ha sufrido un infarto agudo al miocardio que comprende el uso de un agente antifibrotico.
CL2011002595A1 (es) Uso de una combinacion de un agente anticancerigeno y un antioxidante para tratar el cancer; y compicicion farmaceutica que comprende dicha combinacion.
BR112012000530A2 (pt) uso de uma população de nanopartículas metálicas, e, composição farmacêutica.
CR20110002S (es) Barra de chocolate
MX2009009468A (es) Ensamble de tampon que tiene una almohadilla moldeada.
BRPI1016194A2 (pt) Composição inseticida que compreende uma espinosina e um óxido de metal.
CL2013000762A1 (es) Composicion que comprende a) una particula de entrega de agente benefico que comprende poli-xiloglucano o poli-galactomanana y b) una mananasa.
BR112012008504A2 (pt) composição para entrega de agente ativo com carboidrato aprisionado e artigos usando a mesma
PH12010000212A1 (en) Absorbent article including absorbent core having a plurality of first regions and a second region surrounding each of the first regions
BR112012004967A2 (pt) forma de dosagem oral, compreendendo pelo menos um agente biologicamente ativo, substâncias auxiliares da formulação e partículas magnetizáveis
BRPI0910912A2 (pt) Composto, prodroga, ativador de glicocinase, agente farmacêutico, e, uso do composto
PH12014502858A1 (en) Racecadotril lipid compositions