CA2769251C - 5-fluoro-2-oxopyrimidine- 1(2h)-carboxylate derivatives - Google Patents

5-fluoro-2-oxopyrimidine- 1(2h)-carboxylate derivatives Download PDF

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Publication number
CA2769251C
CA2769251C CA2769251A CA2769251A CA2769251C CA 2769251 C CA2769251 C CA 2769251C CA 2769251 A CA2769251 A CA 2769251A CA 2769251 A CA2769251 A CA 2769251A CA 2769251 C CA2769251 C CA 2769251C
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CA
Canada
Prior art keywords
optionally substituted
compound
ring system
benzyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2769251A
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English (en)
French (fr)
Other versions
CA2769251A1 (en
Inventor
Timothy A. Boebel
Kristy Bryan
Beth Lorsbach
Timothy P. Martin
W. John Owen
Mark A. Pobanz
Scott Thornburgh
Jeffery D. Webster
Chenglin Yao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adama Makhteshim Ltd
Original Assignee
Adama Makhteshim Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43535293&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2769251(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Adama Makhteshim Ltd filed Critical Adama Makhteshim Ltd
Publication of CA2769251A1 publication Critical patent/CA2769251A1/en
Application granted granted Critical
Publication of CA2769251C publication Critical patent/CA2769251C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/541,3-Diazines; Hydrogenated 1,3-diazines
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/16Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof the nitrogen atom being part of a heterocyclic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms

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  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2769251A 2009-08-07 2010-08-05 5-fluoro-2-oxopyrimidine- 1(2h)-carboxylate derivatives Expired - Fee Related CA2769251C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23223209P 2009-08-07 2009-08-07
US61/232,232 2009-08-07
PCT/US2010/044585 WO2011017544A1 (en) 2009-08-07 2010-08-05 5-fluoro-2-oxopyrimidine- 1(2h)-carboxylate derivatives

Publications (2)

Publication Number Publication Date
CA2769251A1 CA2769251A1 (en) 2011-02-10
CA2769251C true CA2769251C (en) 2018-05-15

Family

ID=43535293

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2769251A Expired - Fee Related CA2769251C (en) 2009-08-07 2010-08-05 5-fluoro-2-oxopyrimidine- 1(2h)-carboxylate derivatives

Country Status (28)

Country Link
US (1) US8318758B2 (enEXAMPLES)
EP (1) EP2462133B1 (enEXAMPLES)
JP (1) JP5818791B2 (enEXAMPLES)
KR (1) KR101792286B1 (enEXAMPLES)
CN (1) CN102548979B (enEXAMPLES)
AU (1) AU2010279408B2 (enEXAMPLES)
BR (1) BR112012002807B1 (enEXAMPLES)
CA (1) CA2769251C (enEXAMPLES)
CL (1) CL2012000314A1 (enEXAMPLES)
CO (1) CO6491089A2 (enEXAMPLES)
CR (1) CR20120033A (enEXAMPLES)
DK (1) DK2462133T3 (enEXAMPLES)
EA (1) EA022930B1 (enEXAMPLES)
EC (1) ECSP12011651A (enEXAMPLES)
ES (1) ES2506169T3 (enEXAMPLES)
HN (1) HN2012000261A (enEXAMPLES)
IL (1) IL217954A (enEXAMPLES)
IN (1) IN2012DN00695A (enEXAMPLES)
MX (1) MX2012001623A (enEXAMPLES)
NI (1) NI201200019A (enEXAMPLES)
NZ (1) NZ597638A (enEXAMPLES)
PE (1) PE20120689A1 (enEXAMPLES)
PL (1) PL2462133T3 (enEXAMPLES)
PT (1) PT2462133E (enEXAMPLES)
RS (1) RS53658B1 (enEXAMPLES)
UA (1) UA106086C2 (enEXAMPLES)
WO (1) WO2011017544A1 (enEXAMPLES)
ZA (1) ZA201305992B (enEXAMPLES)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010279411B2 (en) * 2009-08-07 2014-10-23 Adama Makhteshim Ltd. N1-sulfonyl-5-fluoropyrimidinone derivatives
EP2945634A4 (en) 2012-12-28 2016-05-25 Dow Agrosciences Llc N- (SUBSTITUTED) 5-FLUORO-4-IMINO-3-METHYL-2-OXO-3,4-DIHYDROPYRIMIDIN-1 (2H) CARBOXYLATE DERIVATIVES
DK2938194T3 (da) 2012-12-28 2020-01-02 Adama Makhteshim Ltd N-(substituerede)-5-fluor-4-imino-3-methyl-2-oxo-3,4-dihydropyrimidin-1 (2h)-carboxylatderivater
WO2014105821A1 (en) * 2012-12-28 2014-07-03 Dow Agrosciences Llc 1-(substituted-benzoyl)-5-fluoro-4-imino-3-methyl-3,4-dihydropyrimidin-2(1h)-one derivatives
NZ708981A (en) 2012-12-31 2020-01-31 Adama Makhteshim Ltd 3-alkyl-5-fluoro-4-substituted-imino-3,4-dihydropyrimidin-2(1h)-one derivatives as fungicides
UA129860C2 (uk) 2013-12-31 2025-08-27 Адама Махтешім Лтд. 5-фтор-4-іміно-3-(алкіл/заміщений алкіл)-1-(арилсульфоніл)-3,4-дигідропіримідин-2(1h)-он і способи його одержання
CN106028816A (zh) 2013-12-31 2016-10-12 阿达玛马克西姆股份有限公司 用防治谷类中真菌的协同杀真菌混合物
WO2016040193A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
EP3370721A4 (en) 2015-11-06 2019-05-22 Samumed, LLC TREATMENT OF OSTEOARTHRITIS
CN109476660B (zh) 2016-06-01 2023-04-04 拜斯丽治疗有限公司 N-(5-(3-(7-(3-氟苯基)-3h-咪唑并[4,5-c]吡啶-2-基)-1h-吲唑-5-基)吡啶-3-基)-3-甲基丁酰胺的制备方法
IL309708A (en) 2017-07-17 2024-02-01 Adama Makhteshim Ltd Polymorphs of 5-fluoro-4-imino-3-methyl-1-tosyl-4,3-dihydropyrimidin-2-one

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3368938A (en) * 1966-01-13 1968-02-13 Hoffmann La Roche Controlling fungi with 5-fluorocytosine
DK0888359T3 (da) 1996-03-11 2002-08-12 Syngenta Participations Ag Pyrimidin-4-on-derivat som pesticid
WO2004037159A2 (en) * 2002-10-23 2004-05-06 Obetherapy Biotechnology Compounds, compositions and methods for modulating fat metabolism
ES2566327T3 (es) * 2007-04-27 2016-04-12 Daiichi Sankyo Company, Limited Derivados de anillo aromático de 6 miembros que contiene nitrógeno y productos farmacéuticos que contienen los mismos
US20100029482A1 (en) 2008-08-01 2010-02-04 Benko Zoltan L Use of 5-fluorocytosine as a fungicide

Also Published As

Publication number Publication date
EA022930B1 (ru) 2016-03-31
EP2462133B1 (en) 2014-09-24
EP2462133A4 (en) 2013-01-16
ZA201305992B (en) 2014-10-29
IN2012DN00695A (enEXAMPLES) 2015-06-19
BR112012002807B1 (pt) 2018-07-10
PE20120689A1 (es) 2012-06-06
MX2012001623A (es) 2012-04-11
US20110034491A1 (en) 2011-02-10
CL2012000314A1 (es) 2012-10-05
ECSP12011651A (es) 2012-03-30
IL217954A0 (en) 2012-03-29
ES2506169T3 (es) 2014-10-13
CO6491089A2 (es) 2012-07-31
AU2010279408B2 (en) 2015-09-10
WO2011017544A1 (en) 2011-02-10
NI201200019A (es) 2012-05-22
EA201270255A1 (ru) 2012-07-30
BR112012002807A2 (pt) 2015-10-13
RS53658B1 (en) 2015-04-30
CA2769251A1 (en) 2011-02-10
PL2462133T3 (pl) 2015-03-31
BR112012002807A8 (pt) 2017-07-11
CN102548979A (zh) 2012-07-04
KR101792286B1 (ko) 2017-10-31
CN102548979B (zh) 2015-05-13
NZ597638A (en) 2014-06-27
AU2010279408A1 (en) 2012-02-09
UA106086C2 (uk) 2014-07-25
EP2462133A1 (en) 2012-06-13
HN2012000261A (es) 2015-01-05
JP2013501726A (ja) 2013-01-17
PT2462133E (pt) 2014-12-26
IL217954A (en) 2016-02-29
US8318758B2 (en) 2012-11-27
JP5818791B2 (ja) 2015-11-18
HK1172892A1 (en) 2013-05-03
KR20120043069A (ko) 2012-05-03
DK2462133T3 (en) 2015-01-05
CR20120033A (es) 2012-03-22

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Effective date: 20150731

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Effective date: 20190806