CA2769251C - 5-fluoro-2-oxopyrimidine- 1(2h)-carboxylate derivatives - Google Patents

5-fluoro-2-oxopyrimidine- 1(2h)-carboxylate derivatives Download PDF

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Publication number
CA2769251C
CA2769251C CA2769251A CA2769251A CA2769251C CA 2769251 C CA2769251 C CA 2769251C CA 2769251 A CA2769251 A CA 2769251A CA 2769251 A CA2769251 A CA 2769251A CA 2769251 C CA2769251 C CA 2769251C
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CA
Canada
Prior art keywords
optionally substituted
compound
ring system
benzyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2769251A
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English (en)
French (fr)
Other versions
CA2769251A1 (en
Inventor
Timothy A. Boebel
Kristy Bryan
Beth Lorsbach
Timothy P. Martin
W. John Owen
Mark A. Pobanz
Scott Thornburgh
Jeffery D. Webster
Chenglin Yao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adama Makhteshim Ltd
Original Assignee
Adama Makhteshim Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43535293&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2769251(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Adama Makhteshim Ltd filed Critical Adama Makhteshim Ltd
Publication of CA2769251A1 publication Critical patent/CA2769251A1/en
Application granted granted Critical
Publication of CA2769251C publication Critical patent/CA2769251C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/541,3-Diazines; Hydrogenated 1,3-diazines
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/16Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof the nitrogen atom being part of a heterocyclic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms

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  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2769251A 2009-08-07 2010-08-05 5-fluoro-2-oxopyrimidine- 1(2h)-carboxylate derivatives Expired - Fee Related CA2769251C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23223209P 2009-08-07 2009-08-07
US61/232,232 2009-08-07
PCT/US2010/044585 WO2011017544A1 (en) 2009-08-07 2010-08-05 5-fluoro-2-oxopyrimidine- 1(2h)-carboxylate derivatives

Publications (2)

Publication Number Publication Date
CA2769251A1 CA2769251A1 (en) 2011-02-10
CA2769251C true CA2769251C (en) 2018-05-15

Family

ID=43535293

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2769251A Expired - Fee Related CA2769251C (en) 2009-08-07 2010-08-05 5-fluoro-2-oxopyrimidine- 1(2h)-carboxylate derivatives

Country Status (28)

Country Link
US (1) US8318758B2 (enEXAMPLES)
EP (1) EP2462133B1 (enEXAMPLES)
JP (1) JP5818791B2 (enEXAMPLES)
KR (1) KR101792286B1 (enEXAMPLES)
CN (1) CN102548979B (enEXAMPLES)
AU (1) AU2010279408B2 (enEXAMPLES)
BR (1) BR112012002807B1 (enEXAMPLES)
CA (1) CA2769251C (enEXAMPLES)
CL (1) CL2012000314A1 (enEXAMPLES)
CO (1) CO6491089A2 (enEXAMPLES)
CR (1) CR20120033A (enEXAMPLES)
DK (1) DK2462133T3 (enEXAMPLES)
EA (1) EA022930B1 (enEXAMPLES)
EC (1) ECSP12011651A (enEXAMPLES)
ES (1) ES2506169T3 (enEXAMPLES)
HN (1) HN2012000261A (enEXAMPLES)
IL (1) IL217954A (enEXAMPLES)
IN (1) IN2012DN00695A (enEXAMPLES)
MX (1) MX2012001623A (enEXAMPLES)
NI (1) NI201200019A (enEXAMPLES)
NZ (1) NZ597638A (enEXAMPLES)
PE (1) PE20120689A1 (enEXAMPLES)
PL (1) PL2462133T3 (enEXAMPLES)
PT (1) PT2462133E (enEXAMPLES)
RS (1) RS53658B1 (enEXAMPLES)
UA (1) UA106086C2 (enEXAMPLES)
WO (1) WO2011017544A1 (enEXAMPLES)
ZA (1) ZA201305992B (enEXAMPLES)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA106764C2 (uk) * 2009-08-07 2014-10-10 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Похідні n1-сульфоніл-5-фторпіримідинону
US9271497B2 (en) * 2012-12-28 2016-03-01 Dow Agrosciences Llc 1-(substituted-benzoyl)-5-fluoro-4-imino-3-methyl-3,4-dihydropyrimidin-2(1H)-one derivatives
US9321734B2 (en) 2012-12-28 2016-04-26 Dow Agrosciences Llc N-(substituted)-5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydropyrimidine-1(2H)-carboxamide derivatives
CA2893778A1 (en) * 2012-12-28 2014-07-03 Dow Agrosciences Llc N-(substituted)-5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydropyrimidine-1(2h)-carboxylate derivatives
PL2953463T3 (pl) 2012-12-31 2022-01-03 Adama Makhteshim Ltd. Pochodne 3-alkilo-5-fluoro-4-podstawione-imino-3,4-dihydropirymidyn-2(1h)-onu jako środki grzybobójcze
EA030030B1 (ru) 2013-12-31 2018-06-29 Адама Мактешим Лтд. Синергетические фунгицидные смеси и синергетические фунгицидные композиции для борьбы с грибами
EA036389B1 (ru) 2013-12-31 2020-11-03 Адама Мактешим Лтд. 5-фтор-4-имино-3-(алкил/замещенный алкил)-1-(арилсульфонил)-3,4-дигидропиримидин-2(1h)-он и способы их получения
WO2016040193A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
CN108473491A (zh) 2015-11-06 2018-08-31 萨穆梅德有限公司 2-(1h-吲唑-3-基)-3h-咪唑并[4,5-c]吡啶以及其抗炎用途
SMT202200486T1 (it) 2016-06-01 2023-01-13 Biosplice Therapeutics Inc Processo per la preparazione di n-(5-(3-(7-(3- fluorofen il)-3h-imidaz0[4,5-c]piridin-2-il)-1h-indazol-5- il)piridin-3-il)-3-metilbutanammide
CN118515619A (zh) 2017-07-17 2024-08-20 阿达玛克西姆股份有限公司 5-氟-4-亚氨基-3-甲基-1-甲苯磺酰基-3,4-二氢嘧啶-2-酮的多晶型物
AU2019374510A1 (en) 2018-11-05 2021-06-17 Adama Makhteshim Ltd. Mixtures and compositions comprising 5-fluoro-4-imino-3- methyl-1-tosyl-3,4-dihydropyrimidin-2-one, and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3368938A (en) * 1966-01-13 1968-02-13 Hoffmann La Roche Controlling fungi with 5-fluorocytosine
ATE216999T1 (de) * 1996-03-11 2002-05-15 Syngenta Participations Ag Pyrimidin-4-on derivate als pestizidesmittel
AU2003274652A1 (en) * 2002-10-23 2004-05-13 Obetherapy Biotechnology Compounds, compositions and methods for modulating fat metabolism
PL2151439T3 (pl) * 2007-04-27 2014-08-29 Daiichi Sankyo Co Ltd Pochodna z wprowadzonym atomem azotu i 6-członowym pierścieniem aromatycznym oraz zawierający ją środek farmaceutyczny
US20100029482A1 (en) 2008-08-01 2010-02-04 Benko Zoltan L Use of 5-fluorocytosine as a fungicide

Also Published As

Publication number Publication date
KR101792286B1 (ko) 2017-10-31
BR112012002807A8 (pt) 2017-07-11
PT2462133E (pt) 2014-12-26
CN102548979A (zh) 2012-07-04
CO6491089A2 (es) 2012-07-31
EA022930B1 (ru) 2016-03-31
JP5818791B2 (ja) 2015-11-18
MX2012001623A (es) 2012-04-11
HN2012000261A (es) 2015-01-05
RS53658B1 (en) 2015-04-30
UA106086C2 (uk) 2014-07-25
ZA201305992B (en) 2014-10-29
NI201200019A (es) 2012-05-22
NZ597638A (en) 2014-06-27
CA2769251A1 (en) 2011-02-10
EP2462133A4 (en) 2013-01-16
WO2011017544A1 (en) 2011-02-10
US8318758B2 (en) 2012-11-27
BR112012002807B1 (pt) 2018-07-10
ES2506169T3 (es) 2014-10-13
EP2462133A1 (en) 2012-06-13
KR20120043069A (ko) 2012-05-03
HK1172892A1 (en) 2013-05-03
BR112012002807A2 (pt) 2015-10-13
JP2013501726A (ja) 2013-01-17
CN102548979B (zh) 2015-05-13
IL217954A0 (en) 2012-03-29
US20110034491A1 (en) 2011-02-10
IN2012DN00695A (enEXAMPLES) 2015-06-19
IL217954A (en) 2016-02-29
CR20120033A (es) 2012-03-22
CL2012000314A1 (es) 2012-10-05
DK2462133T3 (en) 2015-01-05
ECSP12011651A (es) 2012-03-30
PE20120689A1 (es) 2012-06-06
EP2462133B1 (en) 2014-09-24
AU2010279408B2 (en) 2015-09-10
PL2462133T3 (pl) 2015-03-31
EA201270255A1 (ru) 2012-07-30
AU2010279408A1 (en) 2012-02-09

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