CA2760253A1 - Phosphotetrahydropyran compounds for the treatment of wounds and fibrotic disorders - Google Patents

Phosphotetrahydropyran compounds for the treatment of wounds and fibrotic disorders Download PDF

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Publication number
CA2760253A1
CA2760253A1 CA2760253A CA2760253A CA2760253A1 CA 2760253 A1 CA2760253 A1 CA 2760253A1 CA 2760253 A CA2760253 A CA 2760253A CA 2760253 A CA2760253 A CA 2760253A CA 2760253 A1 CA2760253 A1 CA 2760253A1
Authority
CA
Canada
Prior art keywords
group
compound
formula
alkyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2760253A
Other languages
English (en)
French (fr)
Inventor
Alan D. Robertson
Diego Silva
Ian Alexander Mcdonald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmaxis Ltd
Original Assignee
Pharmaxis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmaxis Ltd filed Critical Pharmaxis Ltd
Publication of CA2760253A1 publication Critical patent/CA2760253A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/665Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2760253A 2009-04-28 2010-04-28 Phosphotetrahydropyran compounds for the treatment of wounds and fibrotic disorders Abandoned CA2760253A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17341609P 2009-04-28 2009-04-28
US61/173,416 2009-04-28
PCT/IB2010/000960 WO2010125445A1 (en) 2009-04-28 2010-04-28 Phosphotetrahydropyran compounds for the treatment of wounds and fibrotic disorders

Publications (1)

Publication Number Publication Date
CA2760253A1 true CA2760253A1 (en) 2010-11-04

Family

ID=43031758

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2760253A Abandoned CA2760253A1 (en) 2009-04-28 2010-04-28 Phosphotetrahydropyran compounds for the treatment of wounds and fibrotic disorders

Country Status (10)

Country Link
US (1) US8557783B2 (enExample)
EP (1) EP2424542A4 (enExample)
JP (1) JP2012525369A (enExample)
KR (1) KR20120049183A (enExample)
AU (1) AU2010243314C1 (enExample)
CA (1) CA2760253A1 (enExample)
IL (1) IL215990A0 (enExample)
NZ (1) NZ596419A (enExample)
SG (1) SG175816A1 (enExample)
WO (1) WO2010125445A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6366598B2 (ja) * 2012-11-15 2018-08-01 タフツ ユニバーシティー ガレクチンタンパク質阻害剤を用いて被験体の眼の血管新生または繊維症を処置し、調節し、または、予防する方法、組成物、およびキット
CA3109137A1 (en) * 2018-08-10 2020-02-13 New York Univeristy Use of igf-2 receptor agonist ligands for treatment of angelman syndrome and autism
US12491203B2 (en) 2018-08-10 2025-12-09 New York University Use of mannose 6 phosphate and modifications thereof for memory enhancement and reducing memory impairment
MX2021007376A (es) 2018-12-19 2021-09-21 Univ Leland Stanford Junior Moléculas bifuncionales para el direccionamiento lisosómico y composiciones y métodos relacionados.
CN113368106B (zh) * 2020-02-25 2023-09-29 渐宽(苏州)生物科技有限公司 艾托莫德用于防治特发性肺纤维化的药物中的用途
CN113288890B (zh) * 2021-06-21 2022-02-22 南方医科大学南方医院 N-乙酰-l-半胱氨酸在制备预防和/或治疗运动损伤的药物中的应用
WO2023288033A1 (en) 2021-07-14 2023-01-19 Lycia Therapeutics, Inc. Asgpr cell surface receptor binding compounds and conjugates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPQ872300A0 (en) 2000-07-11 2000-08-03 Praxis Pharmaceuticals Pty Ltd Compounds and methods
DK1628987T3 (da) * 2003-05-20 2009-12-21 Pharmaxis Pty Ltd Mannose-6-phosphonat-forbindelser til behandling af inflammatoriske sygdomme
FR2930943B1 (fr) 2008-05-07 2011-03-18 Centre Nat Rech Scient Nouvelles utilisations de derives de d-mannopyranose inhibiteurs de l'angiogenese
FR2930942B1 (fr) 2008-05-07 2011-03-04 Centre Nat Rech Scient Nouvelles utilisations de derives de d-mannopyranose activateurs de l'angiogenese

Also Published As

Publication number Publication date
AU2010243314C1 (en) 2015-11-12
IL215990A0 (en) 2012-01-31
EP2424542A1 (en) 2012-03-07
JP2012525369A (ja) 2012-10-22
AU2010243314B2 (en) 2015-07-02
WO2010125445A1 (en) 2010-11-04
US8557783B2 (en) 2013-10-15
NZ596419A (en) 2014-01-31
SG175816A1 (en) 2011-12-29
KR20120049183A (ko) 2012-05-16
AU2010243314A1 (en) 2011-12-01
US20120045455A1 (en) 2012-02-23
EP2424542A4 (en) 2012-12-19

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20160428