CA2759196A1 - Nouveau polymorphe cristallin du dihydrogenophosphate de sitagliptine - Google Patents

Nouveau polymorphe cristallin du dihydrogenophosphate de sitagliptine Download PDF

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Publication number
CA2759196A1
CA2759196A1 CA2759196A CA2759196A CA2759196A1 CA 2759196 A1 CA2759196 A1 CA 2759196A1 CA 2759196 A CA2759196 A CA 2759196A CA 2759196 A CA2759196 A CA 2759196A CA 2759196 A1 CA2759196 A1 CA 2759196A1
Authority
CA
Canada
Prior art keywords
sitagliptin
dihydrogenphosphate
sitagliptin dihydrogenphosphate
polymorphic forms
organic solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2759196A
Other languages
English (en)
Inventor
Vinayak Govind Gore
Maheshkumar Gadakar
Priyanka Bhosle
Suresh Shinde
Prashant Yadav
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Generics UK Ltd
Original Assignee
Generics UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Generics UK Ltd filed Critical Generics UK Ltd
Publication of CA2759196A1 publication Critical patent/CA2759196A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention a pour objet une nouvelle forme cristalline anhydre du dihydrogénophosphate de sitagliptine (I), ses procédés de préparation et son utilisation dans des compositions pharmaceutiques. Formule (I).
CA2759196A 2009-05-11 2010-05-11 Nouveau polymorphe cristallin du dihydrogenophosphate de sitagliptine Abandoned CA2759196A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN723KO2009 2009-05-11
IN723/KOL/2009 2009-05-11
PCT/GB2010/050772 WO2010131035A1 (fr) 2009-05-11 2010-05-11 Nouveau polymorphe cristallin du dihydrogénophosphate de sitagliptine

Publications (1)

Publication Number Publication Date
CA2759196A1 true CA2759196A1 (fr) 2010-11-18

Family

ID=42288585

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2759196A Abandoned CA2759196A1 (fr) 2009-05-11 2010-05-11 Nouveau polymorphe cristallin du dihydrogenophosphate de sitagliptine

Country Status (2)

Country Link
CA (1) CA2759196A1 (fr)
WO (1) WO2010131035A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8846916B2 (en) 2009-05-11 2014-09-30 Generics [Uk] Limited Sitagliptin synthesis
SI2691083T1 (sl) 2011-03-29 2017-12-29 Krka, D.D., Novo Mesto Farmacevtski sestavek sitagliptina
SI2736909T1 (sl) 2011-07-27 2017-08-31 Farma Grs, D.O.O. Proces za pripravo sitagliptina in njegovih farmacevtsko sprejemljivih soli
CN105530941A (zh) * 2013-09-20 2016-04-27 荷兰联合利华有限公司 抗糖尿病组合物
CZ27898U1 (cs) 2015-01-13 2015-03-02 Zentiva, K.S. Krystalická modifikace 2 L-vínanu (3R)-3-amino-1-[3-(trifluormethyl)-6,8-dihydro-5H-[1,2,4,]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorfenyl)butan-1-onu
CZ27930U1 (cs) 2015-01-13 2015-03-10 Zentiva, K.S. Krystalická modifikace 3 L-vínanu (3R)-3-amino-1-[3-(trifluormethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorfenyl)butan-1-onu

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2625B1 (en) * 2003-06-24 2011-11-01 ميرك شارب اند دوم كوربوريشن Phosphoric acid salts of dipeptidyl betidase inhibitor 4
CN100457108C (zh) * 2003-09-02 2009-02-04 默克公司 一种二肽基肽酶iv抑制剂的磷酸盐新晶体
WO2005030127A2 (fr) * 2003-09-23 2005-04-07 Merck & Co., Inc. Nouvelle forme cristalline d'un sel d'acide phosphorique d'un inhibiteur de dipeptidyle peptase-iv
US20090247532A1 (en) * 2008-03-28 2009-10-01 Mae De Ltd. Crystalline polymorph of sitagliptin phosphate and its preparation
EP2331545B1 (fr) * 2008-08-27 2013-10-02 Cadila Healthcare Limited Procédé de préparation de (2r)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro [1,2,4]-triazolo[4,3-a]pyrazin-7(8h)-yl]-1-(2,4,5-trifluorophenyl) butan-2-amine & nouveaux impurities dans sa préparation

Also Published As

Publication number Publication date
WO2010131035A1 (fr) 2010-11-18
WO2010131035A8 (fr) 2011-10-06

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20130513

FZDE Discontinued

Effective date: 20130513