CA2759085C - Use of allopurinol for the treatment of hand foot skin reaction - Google Patents
Use of allopurinol for the treatment of hand foot skin reaction Download PDFInfo
- Publication number
- CA2759085C CA2759085C CA2759085A CA2759085A CA2759085C CA 2759085 C CA2759085 C CA 2759085C CA 2759085 A CA2759085 A CA 2759085A CA 2759085 A CA2759085 A CA 2759085A CA 2759085 C CA2759085 C CA 2759085C
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- Prior art keywords
- allopurinol
- treatment
- hfsr
- medicament
- skin reaction
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Toxicology (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21489409P | 2009-04-29 | 2009-04-29 | |
| EP09382058A EP2246057A1 (en) | 2009-04-29 | 2009-04-29 | Use of allopurinol for the treatment of hand foot skin reaction |
| US61/214,894 | 2009-04-29 | ||
| EP09382058.7 | 2009-04-29 | ||
| PCT/EP2010/055806 WO2010125143A1 (en) | 2009-04-29 | 2010-04-29 | Use of allopurinol for the treatment of hand foot skin reaction |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2759085A1 CA2759085A1 (en) | 2010-11-04 |
| CA2759085C true CA2759085C (en) | 2016-08-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2759085A Expired - Fee Related CA2759085C (en) | 2009-04-29 | 2010-04-29 | Use of allopurinol for the treatment of hand foot skin reaction |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US8623878B2 (enExample) |
| EP (2) | EP2246057A1 (enExample) |
| JP (1) | JP6007101B2 (enExample) |
| KR (1) | KR20120049848A (enExample) |
| CN (1) | CN102421436B (enExample) |
| AR (1) | AR076505A1 (enExample) |
| AU (2) | AU2010243594A1 (enExample) |
| BR (1) | BRPI1011971A2 (enExample) |
| CA (1) | CA2759085C (enExample) |
| DK (1) | DK2424538T3 (enExample) |
| ES (1) | ES2434366T3 (enExample) |
| HR (1) | HRP20131070T1 (enExample) |
| IL (1) | IL215831A (enExample) |
| ME (1) | ME01567B (enExample) |
| MX (1) | MX2011011529A (enExample) |
| NZ (1) | NZ595901A (enExample) |
| PL (1) | PL2424538T3 (enExample) |
| PT (1) | PT2424538E (enExample) |
| RS (1) | RS53005B (enExample) |
| RU (1) | RU2543325C2 (enExample) |
| SI (1) | SI2424538T1 (enExample) |
| WO (1) | WO2010125143A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2488642B1 (en) | 2009-10-16 | 2015-03-11 | Duke University | Compositions and methods for the treatment of drug-induced hand-foot syndrome |
| CA2824933A1 (en) * | 2011-01-18 | 2012-07-26 | Vicus Therapeutics, Llc | Pharmaceutical compositions and methods for making and using them |
| WO2019114705A1 (zh) | 2017-12-13 | 2019-06-20 | 上海小午医药科技有限公司 | 一种用于预防或治疗与egfr被抑制相关疾病的方法 |
| TW201943428A (zh) * | 2018-04-16 | 2019-11-16 | 大陸商上海岸闊醫藥科技有限公司 | 預防或治療腫瘤療法副作用的方法 |
| US20200046703A1 (en) * | 2018-08-09 | 2020-02-13 | Asymmetric Therapeutics, Llc | Compositions and methods for treatment of the side-effects associated with administration of therapeutic agents |
| KR20240159565A (ko) | 2022-01-05 | 2024-11-05 | 아시메트릭 테라퓨틱스, 엘엘씨 | 피부 증식성 장애 및 다른 피부 병태 치료를 위한 방법 및 조성물 |
| KR20250056445A (ko) * | 2023-10-19 | 2025-04-28 | (주) 수파드엘릭사 | 수족증후군 또는 수족피부반응의 예방 또는 치료용 약학 조성물 |
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| ES2037672T3 (es) * | 1987-02-13 | 1993-07-01 | Pharm-Allergan Gmbh | Utilizacion de pteridinas y/o purinas o de un inhibidor de xantinoxidasa para la fabricacion de un medicamento para el tratamiento de enfermedades degenerativas de la retina condicionadas geneticamente. |
| GB9218711D0 (en) | 1992-09-04 | 1992-10-21 | Salim Aws S M | Skin cancer treatment |
| AU4974893A (en) | 1992-09-04 | 1994-03-29 | Aws Shakir Mustafa Salim | Skin treatment compositions containing dimethylsulphone and allopurinol or oxypurinol |
| JP3106817B2 (ja) | 1993-11-02 | 2000-11-06 | 富士電機株式会社 | 漏電遮断器 |
| US6284234B1 (en) * | 1998-08-04 | 2001-09-04 | Johnson & Johnson Consumer Companies, Inc. | Topical delivery systems for active agents |
| US6060083A (en) * | 1999-04-01 | 2000-05-09 | Topical Technologies, Inc. | Topical DMSO treatment for palmar-plantar erythrodysethesia |
| GB0013346D0 (en) * | 2000-06-01 | 2000-07-26 | Glaxo Group Ltd | Therapeutic benzamide derivatives |
| BRPI0115531B1 (pt) * | 2000-11-22 | 2015-10-13 | Rxkinetix Inc | composição terapêutica útil para o tratamento de mucosite em um local de mucosa como efeito colateral de terapia de câncer |
| US7544348B2 (en) * | 2001-02-15 | 2009-06-09 | Access Pharmaceuticals, Inc. | Liquid formulations for the prevention and treatment of mucosal diseases and disorders |
| SE0100873D0 (sv) * | 2001-03-13 | 2001-03-13 | Astrazeneca Ab | Method of treatment |
| WO2003018102A2 (en) | 2001-08-29 | 2003-03-06 | Vectura Limited | Topical administration device |
| AU2002352982B2 (en) * | 2001-11-29 | 2008-03-06 | Sound Pharmaceuticals Incorporated | Methods and compositions for ameliorating the undesirable effects of chemotherapy |
| DE10200578A1 (de) | 2002-01-09 | 2003-07-10 | Roehm Gmbh | Haft- und Bindemittel für dermale oder transdermale Therapiesysteme |
| US6979688B2 (en) * | 2002-02-12 | 2005-12-27 | Ford John P | Treatment method against side-effects of chemotherapy |
| US20040214215A1 (en) | 2003-03-07 | 2004-10-28 | Yu Ruey J. | Bioavailability and improved delivery of alkaline pharmaceutical drugs |
| CA2528378A1 (en) * | 2003-06-11 | 2004-12-23 | Novacea, Inc. | Treatment of immune-mediated disorders with active vitamin d compounds alone or in combination with other therapeutic agents |
| WO2004110151A1 (en) * | 2003-06-11 | 2004-12-23 | Novacea, Inc. | Treatment of cancer with active vitamin d compounds in combination with radiotherapeutic agents and treatments |
| US20050142093A1 (en) * | 2003-12-24 | 2005-06-30 | Gregory Skover | Treatment of skin with an apparatus and a benefit agent |
| JP4405326B2 (ja) | 2004-06-28 | 2010-01-27 | 株式会社東芝 | ランドリー機器 |
| EP1796660B1 (en) | 2004-09-17 | 2016-11-23 | BioMAS Ltd. | Use of ammonium trichloro(dioxyethylene-o,o')tellurate (as101) for the inhibition of interleukin-1beta-converting enzyme |
| JP5028480B2 (ja) | 2006-06-01 | 2012-09-19 | ノベラ ファルマ ソシエダッド リミターダ | 手足症候群の治療のためのアロプリノールの使用 |
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2009
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2010
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- 2010-04-29 PL PL10719314T patent/PL2424538T3/pl unknown
- 2010-04-29 DK DK10719314.6T patent/DK2424538T3/da active
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- 2010-04-29 SI SI201030402T patent/SI2424538T1/sl unknown
- 2010-04-29 CN CN201080019054.2A patent/CN102421436B/zh not_active Expired - Fee Related
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- 2010-04-29 EP EP10719314.6A patent/EP2424538B1/en active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2010125143A1 (en) | 2010-11-04 |
| US20100280051A1 (en) | 2010-11-04 |
| CN102421436B (zh) | 2014-05-07 |
| RU2011148355A (ru) | 2013-06-10 |
| HRP20131070T1 (hr) | 2013-12-20 |
| AU2010243594A1 (en) | 2011-11-10 |
| US8623878B2 (en) | 2014-01-07 |
| BRPI1011971A2 (pt) | 2016-04-26 |
| NZ595901A (en) | 2013-11-29 |
| CN102421436A (zh) | 2012-04-18 |
| US20140080845A1 (en) | 2014-03-20 |
| CA2759085A1 (en) | 2010-11-04 |
| HK1168042A1 (en) | 2012-12-21 |
| EP2424538B1 (en) | 2013-08-14 |
| ES2434366T3 (es) | 2013-12-16 |
| RU2543325C2 (ru) | 2015-02-27 |
| SI2424538T1 (sl) | 2013-12-31 |
| AU2016228193A1 (en) | 2016-11-03 |
| JP6007101B2 (ja) | 2016-10-12 |
| MX2011011529A (es) | 2012-02-08 |
| IL215831A0 (en) | 2012-01-31 |
| DK2424538T3 (da) | 2013-11-04 |
| AR076505A1 (es) | 2011-06-15 |
| EP2424538A1 (en) | 2012-03-07 |
| KR20120049848A (ko) | 2012-05-17 |
| JP2012525358A (ja) | 2012-10-22 |
| RS53005B (sr) | 2014-04-30 |
| PL2424538T3 (pl) | 2014-05-30 |
| ME01567B (me) | 2014-04-20 |
| PT2424538E (pt) | 2013-11-07 |
| IL215831A (en) | 2016-02-29 |
| EP2246057A1 (en) | 2010-11-03 |
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