CA2757744C - Combination of decitabine with cytidine deaminase inhibitor and use thereof in the treatment of cancer - Google Patents

Combination of decitabine with cytidine deaminase inhibitor and use thereof in the treatment of cancer Download PDF

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Publication number
CA2757744C
CA2757744C CA2757744A CA2757744A CA2757744C CA 2757744 C CA2757744 C CA 2757744C CA 2757744 A CA2757744 A CA 2757744A CA 2757744 A CA2757744 A CA 2757744A CA 2757744 C CA2757744 C CA 2757744C
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Prior art keywords
compound
formula
ester
cancer
pharmaceutically acceptable
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CA2757744A
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English (en)
French (fr)
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CA2757744A1 (en
Inventor
Sergei Belyakov
Bridget Duvall
Dana Ferraris
Gregory Hamilton
Mark Vaal
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Otsuka Pharmaceutical Co Ltd
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Otsuka Pharmaceutical Co Ltd
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Publication of CA2757744A1 publication Critical patent/CA2757744A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2757744A 2009-04-06 2010-04-06 Combination of decitabine with cytidine deaminase inhibitor and use thereof in the treatment of cancer Active CA2757744C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16711909P 2009-04-06 2009-04-06
US61/167,119 2009-04-06
PCT/US2010/030078 WO2010118010A1 (en) 2009-04-06 2010-04-06 Combination of decitabine with cytidine deaminase inhibitor and use thereof in the treatment of cancer

Publications (2)

Publication Number Publication Date
CA2757744A1 CA2757744A1 (en) 2010-10-14
CA2757744C true CA2757744C (en) 2018-02-13

Family

ID=42357480

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2757744A Active CA2757744C (en) 2009-04-06 2010-04-06 Combination of decitabine with cytidine deaminase inhibitor and use thereof in the treatment of cancer

Country Status (11)

Country Link
US (1) US8329666B2 (https=)
EP (1) EP2416780B1 (https=)
JP (1) JP5730854B2 (https=)
AR (1) AR076263A1 (https=)
AU (1) AU2010234641B2 (https=)
CA (1) CA2757744C (https=)
ES (1) ES2628580T3 (https=)
JO (1) JO3262B1 (https=)
TW (1) TWI503121B (https=)
UY (1) UY32546A (https=)
WO (1) WO2010118010A1 (https=)

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US8609631B2 (en) 2009-04-06 2013-12-17 Eisai Inc. Compositions and methods for treating cancer
AU2010234637B2 (en) * 2009-04-06 2016-05-12 Taiho Pharmaceutical Co., Ltd. (2 ' -deoxy-ribofuranosyl) -1,3,4, 7-tetrahydro- (1,3) iazepin-2-0ne derivatives for treating cancer
WO2017096357A1 (en) 2015-12-03 2017-06-08 Epidestiny, Inc. Compositions containing decitabine, 5azacytidine and tetrahydrouridine and uses thereof
CN110168092A (zh) 2016-12-28 2019-08-23 特朗斯吉有限公司 溶瘤病毒和治疗分子
US11224610B2 (en) 2018-09-19 2022-01-18 Otsuka Pharmaceutical Co., Ltd. Low dose combination CDA substrate drug/cedazuridine with extended administration
EP3988099B1 (en) * 2019-03-29 2023-06-07 Novocure GmbH Methods for restoring sensitivity to ttfields in ttfields-resistant cancer cells with ptger3 inhibitors
US11938143B2 (en) 2021-10-19 2024-03-26 Akirabio, Inc. Compositions comprising 2′-deoxycytidine analogs and use thereof for the treatment of sickle cell disease, thalassemia, and cancers

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Also Published As

Publication number Publication date
JP5730854B2 (ja) 2015-06-10
EP2416780A1 (en) 2012-02-15
JP2012522841A (ja) 2012-09-27
TW201102072A (en) 2011-01-16
TWI503121B (zh) 2015-10-11
CA2757744A1 (en) 2010-10-14
JO3262B1 (ar) 2018-09-16
US8329666B2 (en) 2012-12-11
UY32546A (es) 2010-10-29
AU2010234641B2 (en) 2016-04-21
AR076263A1 (es) 2011-06-01
WO2010118010A1 (en) 2010-10-14
EP2416780B1 (en) 2017-03-08
US20100279967A1 (en) 2010-11-04
ES2628580T3 (es) 2017-08-03
AU2010234641A1 (en) 2011-11-10

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KR20100091978A (ko) 시티딘 탈아미노효소 억제제로서 2'-플루오로-2'-데옥시테트라하이드로우리딘
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