CA2748490C - Analogues substitues de dicetopiperazine pour une utilisation en tant qu'agents d'administration de medicaments - Google Patents
Analogues substitues de dicetopiperazine pour une utilisation en tant qu'agents d'administration de medicaments Download PDFInfo
- Publication number
- CA2748490C CA2748490C CA2748490A CA2748490A CA2748490C CA 2748490 C CA2748490 C CA 2748490C CA 2748490 A CA2748490 A CA 2748490A CA 2748490 A CA2748490 A CA 2748490A CA 2748490 C CA2748490 C CA 2748490C
- Authority
- CA
- Canada
- Prior art keywords
- active agent
- composition
- cooh
- insulin
- nhc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Abstract
L'invention porte sur des systèmes d'administration de médicaments pour l'administration de médicaments à petites molécules et macromoléculaires. Plus particulièrement, l'invention porte sur des analogues substitués de 3,6-di(alkyl-4 aminobutyl)-2,5-dicétopipérazine (qui peut également être appelée DCP), sur leur utilisation pour la formulation de médicaments à la fois à petites molécules et macromoléculaires comprenant des agents thérapeutiques, prophylactiques et diagnostiques, des agents stabilisants, et sur des systèmes permettant leur administration.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14120708P | 2008-12-29 | 2008-12-29 | |
US61/141,207 | 2008-12-29 | ||
PCT/US2009/069745 WO2010078373A1 (fr) | 2008-12-29 | 2009-12-29 | Analogues substitués de dicétopipérazine pour une utilisation en tant qu'agents d'administration de médicaments |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2748490A1 CA2748490A1 (fr) | 2010-07-08 |
CA2748490C true CA2748490C (fr) | 2016-10-04 |
Family
ID=41694085
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2748490A Active CA2748490C (fr) | 2008-12-29 | 2009-12-29 | Analogues substitues de dicetopiperazine pour une utilisation en tant qu'agents d'administration de medicaments |
Country Status (9)
Country | Link |
---|---|
EP (2) | EP2379511B1 (fr) |
JP (2) | JP5788806B2 (fr) |
CA (1) | CA2748490C (fr) |
DK (1) | DK2379511T3 (fr) |
ES (1) | ES2531009T3 (fr) |
MX (1) | MX2011007065A (fr) |
PT (1) | PT2379511E (fr) |
SI (1) | SI2379511T1 (fr) |
WO (1) | WO2010078373A1 (fr) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
ES2425392T3 (es) | 2002-03-20 | 2013-10-15 | Mannkind Corporation | Cartucho para un aparato de inhalación |
ATE486064T1 (de) | 2004-08-20 | 2010-11-15 | Mannkind Corp | Katalyse der diketopiperazinsynthese |
PL1791542T3 (pl) | 2004-08-23 | 2015-11-30 | Mannkind Corp | Sole diketopiperazyny do dostarczania leków |
AU2006290870B2 (en) | 2005-09-14 | 2013-02-28 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces |
EP2497484A3 (fr) | 2006-02-22 | 2012-11-07 | MannKind Corporation | Procédé pour améliorer les propriétés pharmaceutiques de microparticules comprenant de la dicétopipérazine et un agent actif |
DK2570147T3 (da) | 2008-06-13 | 2018-01-29 | Mannkind Corp | Tørpulverinhalator og system til lægemiddelindgivelse |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
KR101628410B1 (ko) | 2008-06-20 | 2016-06-08 | 맨카인드 코포레이션 | 흡입 활동에 관한 실시간 프로파일링을 위한 대화형 장치 및 방법 |
TWI532497B (zh) | 2008-08-11 | 2016-05-11 | 曼凱公司 | 超快起作用胰島素之用途 |
MX2011004859A (es) | 2008-11-07 | 2011-08-03 | Massachusetts Inst Technology | Lipidoides de aminoalcohol y usos de los mismos. |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
ES2531009T3 (es) * | 2008-12-29 | 2015-03-09 | Mannkind Corp | Análogos sustituidos de dicetopiperazina para su uso como agentes para la administración de fármacos |
CA2754595C (fr) | 2009-03-11 | 2017-06-27 | Mannkind Corporation | Appareil, systeme et procede de mesure de resistance d'un inhalateur |
US8734845B2 (en) | 2009-06-12 | 2014-05-27 | Mannkind Corporation | Diketopiperazine microparticles with defined specific surface areas |
CA2778698A1 (fr) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | Appareil et methode de simulation d'efforts d'inhalation |
RU2531455C2 (ru) | 2010-06-21 | 2014-10-20 | Маннкайнд Корпорейшн | Системы и способы доставки сухих порошковых лекарств |
EP2691443B1 (fr) | 2011-03-28 | 2021-02-17 | Massachusetts Institute of Technology | Lipomères conjugués et utilisations associées |
MY180552A (en) | 2011-04-01 | 2020-12-02 | Mannkind Corp | Blister package for pharmaceutical cartridges |
WO2012174472A1 (fr) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | Microparticules de dicétopipérazine de capacité élevée |
WO2013063160A1 (fr) | 2011-10-24 | 2013-05-02 | Mannkind Corporation | Procédés et compositions pour traiter la douleur |
EP4074694A1 (fr) | 2011-10-27 | 2022-10-19 | Massachusetts Institute Of Technology | Lipides d'acides aminés, de peptides et polypeptides, isomères, compositions, et leurs utilisations |
WO2013142969A1 (fr) * | 2012-03-28 | 2013-10-03 | Jian Ping Gao | Uréthanes et urées, et procédés associés |
WO2013162764A1 (fr) * | 2012-04-27 | 2013-10-31 | Mannkind Corp | Procédés de synthèse de fumarates d'éthyle et leur utilisation en tant qu'intermédiaires |
CA2878457C (fr) * | 2012-07-12 | 2021-01-19 | Mannkind Corporation | Systemes et procedes de liberation de medicament en poudre seche |
WO2014066856A1 (fr) | 2012-10-26 | 2014-05-01 | Mannkind Corporation | Compositions et procédés de vaccin antigrippal inhalable |
BR112015023168B1 (pt) | 2013-03-15 | 2021-08-10 | Mannkind Corporation | Composição de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina cristalina, método de produção de partículas de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina e uso de uma composição de dicetopiperazina cristalina |
CN114848614A (zh) | 2013-07-18 | 2022-08-05 | 曼金德公司 | 热稳定性干粉药物组合物和方法 |
CA2920488C (fr) | 2013-08-05 | 2022-04-26 | Mannkind Corporation | Appareil d'insufflation et procedes |
US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
WO2016004202A1 (fr) | 2014-07-02 | 2016-01-07 | Massachusetts Institute Of Technology | Lipidoïdes dérivés de polyamine-acide gras et leurs utilisations |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
SI3310764T1 (sl) | 2015-06-19 | 2023-06-30 | Massachusetts Institute Of Technology | Z alkenilom substituirani 2,5-piperazindioni in njihova uporaba v sestavkih za dostavo sredstva subjektu ali celici |
EP4031111A2 (fr) * | 2019-09-17 | 2022-07-27 | Cass Pharmaceuticals, Inc. | Formulations d'insuline et de glucagon injectables par voie sous-cutanée et procédés d'administration |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6331318B1 (en) | 1994-09-30 | 2001-12-18 | Emisphere Technologies Inc. | Carbon-substituted diketopiperazine delivery systems |
US5352461A (en) | 1992-03-11 | 1994-10-04 | Pharmaceutical Discovery Corporation | Self assembling diketopiperazine drug delivery system |
US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
US6509006B1 (en) | 1992-07-08 | 2003-01-21 | Inhale Therapeutic Systems, Inc. | Devices compositions and methods for the pulmonary delivery of aerosolized medicaments |
US6051256A (en) | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
AU696387B2 (en) | 1994-05-18 | 1998-09-10 | Inhale Therapeutic Systems, Inc. | Methods and compositions for the dry powder formulation of interferons |
US6428771B1 (en) | 1995-05-15 | 2002-08-06 | Pharmaceutical Discovery Corporation | Method for drug delivery to the pulmonary system |
AU5719798A (en) | 1996-12-31 | 1998-07-31 | Inhale Therapeutic Systems, Inc. | Processes for spray drying aqueous suspensions of hydrophobic drugs with hydrophilic excipients and compositions prepared by such processes |
US7464706B2 (en) | 1999-07-23 | 2008-12-16 | Mannkind Corporation | Unit dose cartridge and dry powder inhaler |
US7305986B1 (en) | 1999-07-23 | 2007-12-11 | Mannkind Corporation | Unit dose capsules for use in a dry powder inhaler |
AU2001284697A1 (en) * | 2000-08-04 | 2002-02-18 | Dmi Biosciences, Inc. | Method of synthesizing diketopiperazines |
EP1309312A2 (fr) | 2000-08-07 | 2003-05-14 | Inhale Therapeutic Systems, Inc. | Poudres a inhaler de proteines en faisceau a quatre helices sechees par atomisation presentant une agregation reduite au minimum |
ATE355849T1 (de) | 2000-12-21 | 2007-03-15 | Nektar Therapeutics | Lagerstabile pulverzusammensetzungen mit interleukin-4 rezeptor |
JP4663906B2 (ja) * | 2001-04-26 | 2011-04-06 | 富士フイルム株式会社 | セルロースアシレートフイルム |
BR0209896A (pt) | 2001-05-21 | 2004-08-17 | Nektar Therapeutics | Composição de insulina para administração pulmonar, e, métodos para suprir insulina a um indivìduo mamìfero, para prover uma composição de insulina não-imunogênica e uma composição de insulina de efeito prolongado para administração ao pulmão de um indivìduo |
JP2008510825A (ja) | 2004-08-23 | 2008-04-10 | マンカインド コーポレイション | ホスホジエステラーゼ5型の阻害剤の肺送達 |
PL1791542T3 (pl) | 2004-08-23 | 2015-11-30 | Mannkind Corp | Sole diketopiperazyny do dostarczania leków |
AU2006290870B2 (en) | 2005-09-14 | 2013-02-28 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces |
EP2497484A3 (fr) | 2006-02-22 | 2012-11-07 | MannKind Corporation | Procédé pour améliorer les propriétés pharmaceutiques de microparticules comprenant de la dicétopipérazine et un agent actif |
BRPI0714616A2 (pt) * | 2006-08-04 | 2013-06-11 | Manus Pharmaceuticals Canada Ltd | composto bioativo multifuncional, composiÇço farmacÊutica, e, uso de um composto |
ES2531009T3 (es) * | 2008-12-29 | 2015-03-09 | Mannkind Corp | Análogos sustituidos de dicetopiperazina para su uso como agentes para la administración de fármacos |
-
2009
- 2009-12-29 ES ES09803976T patent/ES2531009T3/es active Active
- 2009-12-29 CA CA2748490A patent/CA2748490C/fr active Active
- 2009-12-29 PT PT98039761T patent/PT2379511E/pt unknown
- 2009-12-29 SI SI200931126T patent/SI2379511T1/sl unknown
- 2009-12-29 MX MX2011007065A patent/MX2011007065A/es active IP Right Grant
- 2009-12-29 DK DK09803976.1T patent/DK2379511T3/en active
- 2009-12-29 JP JP2011543723A patent/JP5788806B2/ja active Active
- 2009-12-29 EP EP09803976.1A patent/EP2379511B1/fr active Active
- 2009-12-29 WO PCT/US2009/069745 patent/WO2010078373A1/fr active Application Filing
- 2009-12-29 EP EP20140192154 patent/EP2862854A1/fr not_active Withdrawn
-
2015
- 2015-07-30 JP JP2015150379A patent/JP2016006082A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DK2379511T3 (en) | 2015-01-12 |
SI2379511T1 (sl) | 2015-03-31 |
MX2011007065A (es) | 2011-08-03 |
CA2748490A1 (fr) | 2010-07-08 |
EP2862854A1 (fr) | 2015-04-22 |
JP2016006082A (ja) | 2016-01-14 |
JP5788806B2 (ja) | 2015-10-07 |
EP2379511A1 (fr) | 2011-10-26 |
PT2379511E (pt) | 2015-02-27 |
ES2531009T3 (es) | 2015-03-09 |
JP2012514008A (ja) | 2012-06-21 |
WO2010078373A1 (fr) | 2010-07-08 |
EP2379511B1 (fr) | 2014-12-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request |
Effective date: 20140829 |