CA2748490C - Analogues substitues de dicetopiperazine pour une utilisation en tant qu'agents d'administration de medicaments - Google Patents
Analogues substitues de dicetopiperazine pour une utilisation en tant qu'agents d'administration de medicaments Download PDFInfo
- Publication number
- CA2748490C CA2748490C CA2748490A CA2748490A CA2748490C CA 2748490 C CA2748490 C CA 2748490C CA 2748490 A CA2748490 A CA 2748490A CA 2748490 A CA2748490 A CA 2748490A CA 2748490 C CA2748490 C CA 2748490C
- Authority
- CA
- Canada
- Prior art keywords
- active agent
- composition
- cooh
- insulin
- nhc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
L'invention porte sur des systèmes d'administration de médicaments pour l'administration de médicaments à petites molécules et macromoléculaires. Plus particulièrement, l'invention porte sur des analogues substitués de 3,6-di(alkyl-4 aminobutyl)-2,5-dicétopipérazine (qui peut également être appelée DCP), sur leur utilisation pour la formulation de médicaments à la fois à petites molécules et macromoléculaires comprenant des agents thérapeutiques, prophylactiques et diagnostiques, des agents stabilisants, et sur des systèmes permettant leur administration.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14120708P | 2008-12-29 | 2008-12-29 | |
US61/141,207 | 2008-12-29 | ||
PCT/US2009/069745 WO2010078373A1 (fr) | 2008-12-29 | 2009-12-29 | Analogues substitués de dicétopipérazine pour une utilisation en tant qu'agents d'administration de médicaments |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2748490A1 CA2748490A1 (fr) | 2010-07-08 |
CA2748490C true CA2748490C (fr) | 2016-10-04 |
Family
ID=41694085
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2748490A Active CA2748490C (fr) | 2008-12-29 | 2009-12-29 | Analogues substitues de dicetopiperazine pour une utilisation en tant qu'agents d'administration de medicaments |
Country Status (9)
Country | Link |
---|---|
EP (2) | EP2379511B1 (fr) |
JP (2) | JP5788806B2 (fr) |
CA (1) | CA2748490C (fr) |
DK (1) | DK2379511T3 (fr) |
ES (1) | ES2531009T3 (fr) |
MX (1) | MX2011007065A (fr) |
PT (1) | PT2379511E (fr) |
SI (1) | SI2379511T1 (fr) |
WO (1) | WO2010078373A1 (fr) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
ES2300568T3 (es) | 2002-03-20 | 2008-06-16 | Mannkind Corporation | Aparato de inhalacion. |
JP5078014B2 (ja) | 2004-08-20 | 2012-11-21 | マンカインド コーポレイション | ジケトピペラジン合成の触媒反応 |
ES2543007T3 (es) | 2004-08-23 | 2015-08-13 | Mannkind Corporation | Micropartículas que comprenden sales de dicetopiperazina para la administración de fármacos |
JP5465878B2 (ja) | 2005-09-14 | 2014-04-09 | マンカインド コーポレイション | 活性薬剤に対する結晶性微粒子表面の親和性を増大させることに基づく薬物処方の方法 |
MX360812B (es) | 2006-02-22 | 2018-11-16 | Mannkind Corp | Un método para mejorar las propiedades farmacéuticas de micropartículas que contienen dicetopiperazina y un agente activo. |
KR101629154B1 (ko) | 2008-06-13 | 2016-06-21 | 맨카인드 코포레이션 | 건조 분말 흡입기 및 약물 투여 시스템 |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
AU2009259883B2 (en) | 2008-06-20 | 2015-02-05 | Mannkind Corporation | An interactive apparatus and method for real-time profiling of inhalation efforts |
TWI494123B (zh) | 2008-08-11 | 2015-08-01 | Mannkind Corp | 超快起作用胰島素之用途 |
AU2009311667B2 (en) | 2008-11-07 | 2016-04-14 | Massachusetts Institute Of Technology | Aminoalcohol lipidoids and uses thereof |
EP2379511B1 (fr) * | 2008-12-29 | 2014-12-17 | MannKind Corporation | Analogues substitués de dicétopipérazine pour une utilisation en tant qu'agents d'administration de médicaments |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
CA2754595C (fr) | 2009-03-11 | 2017-06-27 | Mannkind Corporation | Appareil, systeme et procede de mesure de resistance d'un inhalateur |
KR20210027546A (ko) | 2009-06-12 | 2021-03-10 | 맨카인드 코포레이션 | 한정된 비표면적을 갖는 디케토피페라진 마이크로입자 |
WO2011056889A1 (fr) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | Appareil et méthode de simulation d'efforts d'inhalation |
CN102985125A (zh) | 2010-06-21 | 2013-03-20 | 曼金德公司 | 干粉药物输送系统和方法 |
WO2012135025A2 (fr) | 2011-03-28 | 2012-10-04 | Massachusetts Institute Of Technology | Lipomères conjugués et utilisations associées |
BR112013025395B1 (pt) | 2011-04-01 | 2022-02-01 | Mannkind Corporation | Embalagem de bolha e método de fabricação de uma embalagem de bolhas |
WO2012174472A1 (fr) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | Microparticules de dicétopipérazine de capacité élevée |
US9233159B2 (en) | 2011-10-24 | 2016-01-12 | Mannkind Corporation | Methods and compositions for treating pain |
KR102451116B1 (ko) | 2011-10-27 | 2022-10-06 | 메사추세츠 인스티튜트 오브 테크놀로지 | 약물 캡슐화 마이크로스피어를 형성할 수 있는, n-말단 상에 관능화된 아미노산 유도체 |
CN104284918B (zh) * | 2012-03-28 | 2017-03-29 | 高剑萍 | 氨酯型和脲酯型化合物及其制备方法 |
KR20150023315A (ko) | 2012-04-27 | 2015-03-05 | 맨카인드 코포레이션 | 에틸푸마레이트의 합성방법 및 중간체로서의 이들의 용도 |
EP2872205B1 (fr) | 2012-07-12 | 2017-02-08 | MannKind Corporation | Systèmes de libération de médicament en poudre sèche |
US10159644B2 (en) | 2012-10-26 | 2018-12-25 | Mannkind Corporation | Inhalable vaccine compositions and methods |
ES2928365T3 (es) | 2013-03-15 | 2022-11-17 | Mannkind Corp | Composiciones de dicetopiperazina microcristalina, métodos de preparación y uso del mismo |
US9925144B2 (en) | 2013-07-18 | 2018-03-27 | Mannkind Corporation | Heat-stable dry powder pharmaceutical compositions and methods |
CN105517607A (zh) | 2013-08-05 | 2016-04-20 | 曼金德公司 | 吹入设备和方法 |
WO2015148905A1 (fr) | 2014-03-28 | 2015-10-01 | Mannkind Corporation | Utilisation d'insuline à action ultrarapide |
EP3164379A1 (fr) | 2014-07-02 | 2017-05-10 | Massachusetts Institute of Technology | Lipidoïdes dérivés de polyamine-acide gras et leurs utilisations |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
AU2016278970B2 (en) | 2015-06-19 | 2020-10-29 | Massachusetts Institute Of Technology | Alkenyl substituted 2,5-piperazinediones and their use in compositions for delivering an agent to a subject or cell |
US20220354782A1 (en) * | 2019-09-17 | 2022-11-10 | Cass Pharmaceuticals, Inc. | Subcutaneously injectable insulin and glucagon formulations and methods of administration |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6331318B1 (en) | 1994-09-30 | 2001-12-18 | Emisphere Technologies Inc. | Carbon-substituted diketopiperazine delivery systems |
US5352461A (en) | 1992-03-11 | 1994-10-04 | Pharmaceutical Discovery Corporation | Self assembling diketopiperazine drug delivery system |
US6509006B1 (en) | 1992-07-08 | 2003-01-21 | Inhale Therapeutic Systems, Inc. | Devices compositions and methods for the pulmonary delivery of aerosolized medicaments |
US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
US6051256A (en) | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
JPH10500672A (ja) | 1994-05-18 | 1998-01-20 | インヘイル セラピューティック システムズ,インコーポレイティド | インターフェロンの乾燥粉末製剤に関する方法及び組成物 |
US6428771B1 (en) | 1995-05-15 | 2002-08-06 | Pharmaceutical Discovery Corporation | Method for drug delivery to the pulmonary system |
AU5806898A (en) | 1996-12-31 | 1998-07-31 | Inhale Therapeutic Systems | Processes and compositions for spray drying hydrophobic drugs in organic solventsuspensions of hydrophilic excipients |
US7464706B2 (en) | 1999-07-23 | 2008-12-16 | Mannkind Corporation | Unit dose cartridge and dry powder inhaler |
US7305986B1 (en) | 1999-07-23 | 2007-12-11 | Mannkind Corporation | Unit dose capsules for use in a dry powder inhaler |
US6967202B2 (en) * | 2000-08-04 | 2005-11-22 | Dmi Biosciences, Inc. | Method of synthesizing diketopiperazines |
TWI283182B (en) | 2000-08-07 | 2007-07-01 | Nektar Therapeutics | Inhalable spray dried 4-helix bundle protein powders having minimized aggregation |
CA2432175C (fr) | 2000-12-21 | 2010-08-10 | Jayne E. Hastedt | Compositions de recepteur de l'interleukine 4 en poudre stables au stockage |
JP4663906B2 (ja) * | 2001-04-26 | 2011-04-06 | 富士フイルム株式会社 | セルロースアシレートフイルム |
CZ20033182A3 (cs) | 2001-05-21 | 2004-09-15 | Nektar Therapeutics | Inzulínový prostředek a způsob podávání inzulínu |
CA2575684A1 (fr) | 2004-08-23 | 2006-03-02 | Mannkind Corporation | Administration pulmonaire d'inhibiteurs de phosphodiesterase de type 5 |
ES2543007T3 (es) | 2004-08-23 | 2015-08-13 | Mannkind Corporation | Micropartículas que comprenden sales de dicetopiperazina para la administración de fármacos |
JP5465878B2 (ja) | 2005-09-14 | 2014-04-09 | マンカインド コーポレイション | 活性薬剤に対する結晶性微粒子表面の親和性を増大させることに基づく薬物処方の方法 |
MX360812B (es) | 2006-02-22 | 2018-11-16 | Mannkind Corp | Un método para mejorar las propiedades farmacéuticas de micropartículas que contienen dicetopiperazina y un agente activo. |
EP2046778B1 (fr) * | 2006-08-04 | 2013-12-04 | Manus Pharmaceuticals (Canada) Ltd. | Composés bioactifs multifonctionnels |
EP2379511B1 (fr) * | 2008-12-29 | 2014-12-17 | MannKind Corporation | Analogues substitués de dicétopipérazine pour une utilisation en tant qu'agents d'administration de médicaments |
-
2009
- 2009-12-29 EP EP09803976.1A patent/EP2379511B1/fr active Active
- 2009-12-29 CA CA2748490A patent/CA2748490C/fr active Active
- 2009-12-29 EP EP20140192154 patent/EP2862854A1/fr not_active Withdrawn
- 2009-12-29 SI SI200931126T patent/SI2379511T1/sl unknown
- 2009-12-29 PT PT98039761T patent/PT2379511E/pt unknown
- 2009-12-29 JP JP2011543723A patent/JP5788806B2/ja active Active
- 2009-12-29 ES ES09803976T patent/ES2531009T3/es active Active
- 2009-12-29 DK DK09803976.1T patent/DK2379511T3/en active
- 2009-12-29 WO PCT/US2009/069745 patent/WO2010078373A1/fr active Application Filing
- 2009-12-29 MX MX2011007065A patent/MX2011007065A/es active IP Right Grant
-
2015
- 2015-07-30 JP JP2015150379A patent/JP2016006082A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP2379511A1 (fr) | 2011-10-26 |
DK2379511T3 (en) | 2015-01-12 |
WO2010078373A1 (fr) | 2010-07-08 |
MX2011007065A (es) | 2011-08-03 |
EP2379511B1 (fr) | 2014-12-17 |
PT2379511E (pt) | 2015-02-27 |
CA2748490A1 (fr) | 2010-07-08 |
JP2012514008A (ja) | 2012-06-21 |
EP2862854A1 (fr) | 2015-04-22 |
ES2531009T3 (es) | 2015-03-09 |
JP2016006082A (ja) | 2016-01-14 |
SI2379511T1 (sl) | 2015-03-31 |
JP5788806B2 (ja) | 2015-10-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request |
Effective date: 20140829 |