CA2746316C - Tris(hydroxymethyl)aminomethane salt of 8-chloro-3-pentyl-3,7-dihydro-1h-purine-2,6 dione and its use in therapy - Google Patents
Tris(hydroxymethyl)aminomethane salt of 8-chloro-3-pentyl-3,7-dihydro-1h-purine-2,6 dione and its use in therapy Download PDFInfo
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- CA2746316C CA2746316C CA2746316A CA2746316A CA2746316C CA 2746316 C CA2746316 C CA 2746316C CA 2746316 A CA2746316 A CA 2746316A CA 2746316 A CA2746316 A CA 2746316A CA 2746316 C CA2746316 C CA 2746316C
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- dyslipidaemia
- chloro
- purine
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Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/133—Amines having hydroxy groups, e.g. sphingosine
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
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- Epidemiology (AREA)
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- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Nutrition Science (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12059608P | 2008-12-08 | 2008-12-08 | |
| US61/120,596 | 2008-12-08 | ||
| PCT/US2009/066941 WO2010068581A1 (en) | 2008-12-08 | 2009-12-07 | Novel compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2746316A1 CA2746316A1 (en) | 2010-06-17 |
| CA2746316C true CA2746316C (en) | 2017-01-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2746316A Expired - Fee Related CA2746316C (en) | 2008-12-08 | 2009-12-07 | Tris(hydroxymethyl)aminomethane salt of 8-chloro-3-pentyl-3,7-dihydro-1h-purine-2,6 dione and its use in therapy |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US9163024B2 (enExample) |
| EP (1) | EP2370440B1 (enExample) |
| JP (1) | JP5666464B2 (enExample) |
| KR (1) | KR101743783B1 (enExample) |
| CN (1) | CN102245606B (enExample) |
| AU (1) | AU2009324811B2 (enExample) |
| BR (1) | BRPI0922134A2 (enExample) |
| CA (1) | CA2746316C (enExample) |
| CY (1) | CY1116032T1 (enExample) |
| DK (1) | DK2370440T3 (enExample) |
| EA (1) | EA020037B1 (enExample) |
| ES (1) | ES2527354T3 (enExample) |
| HR (1) | HRP20150026T1 (enExample) |
| IL (1) | IL213032A (enExample) |
| MX (1) | MX2011006022A (enExample) |
| PL (1) | PL2370440T3 (enExample) |
| PT (1) | PT2370440E (enExample) |
| RS (1) | RS53777B1 (enExample) |
| SI (1) | SI2370440T1 (enExample) |
| SM (1) | SMT201500012B (enExample) |
| WO (1) | WO2010068581A1 (enExample) |
| ZA (1) | ZA201103397B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1781657E (pt) * | 2004-02-14 | 2013-05-23 | Glaxosmithkline Ip Dev Ltd | Medicamentos com actividade no receptor hm74a |
| WO2007017262A1 (en) | 2005-08-10 | 2007-02-15 | Smithkline Beecham Corporation | Xanthine derivatives as selective hm74a agonists |
| CN104202977A (zh) * | 2012-03-22 | 2014-12-10 | 转化技术制药有限责任公司 | 小分子glp1r激动剂的三(羟甲基)氨基甲烷盐及其药物组合物和用途 |
| CN121219290A (zh) | 2023-02-27 | 2025-12-26 | 珊顿医药科技新加坡公司 | 化合物8-氯-3-戊基-3,7-二氢-1h-嘌呤-2,6-二酮的晶型及其制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3657327A (en) * | 1970-06-01 | 1972-04-18 | Upjohn Co | Prostaglandin salts of tris(hydroxymethyl)aminomethane |
| US4647585A (en) | 1984-11-08 | 1987-03-03 | E. R. Squibb & Sons, Inc. | Bicycloheptane substituted ethers |
| JP2003534238A (ja) * | 1999-12-15 | 2003-11-18 | スミスクライン・ビーチャム・コーポレイション | シス−４−シアノ−４−［３−（シクロペンチルオキシ）−４−メトキシフェニル］シクロヘキサン−１−カルボン酸の塩。 |
| US20030013905A1 (en) | 2002-06-10 | 2003-01-16 | Huang Guishu Kris | Salts of cis-4-cyano-4[3(cyclopentyloxy)-4-methoxyphenyl]cyclohexane-1-carboxylic acid |
| PT1781657E (pt) | 2004-02-14 | 2013-05-23 | Glaxosmithkline Ip Dev Ltd | Medicamentos com actividade no receptor hm74a |
| US20090209561A1 (en) | 2004-10-22 | 2009-08-20 | Richard Jonathan Daniel Hatley | Xanthine Derivatives with HM74A Receptor Activity |
| GB0423568D0 (en) * | 2004-10-22 | 2004-11-24 | Smithkline Beecham Corp | Novel compounds |
| WO2007017262A1 (en) | 2005-08-10 | 2007-02-15 | Smithkline Beecham Corporation | Xanthine derivatives as selective hm74a agonists |
| GB0516464D0 (en) * | 2005-08-10 | 2005-09-14 | Smithkline Beecham Corp | Novel compounds |
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2009
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- 2009-12-07 PT PT98324213T patent/PT2370440E/pt unknown
- 2009-12-07 KR KR1020117012975A patent/KR101743783B1/ko not_active Expired - Fee Related
- 2009-12-07 DK DK09832421.3T patent/DK2370440T3/en active
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- 2009-12-07 HR HRP20150026AT patent/HRP20150026T1/hr unknown
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- 2009-12-07 CA CA2746316A patent/CA2746316C/en not_active Expired - Fee Related
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- 2009-12-07 US US13/133,486 patent/US9163024B2/en not_active Expired - Fee Related
- 2009-12-07 ES ES09832421.3T patent/ES2527354T3/es active Active
- 2009-12-07 PL PL09832421T patent/PL2370440T3/pl unknown
-
2011
- 2011-05-10 ZA ZA2011/03397A patent/ZA201103397B/en unknown
- 2011-05-19 IL IL213032A patent/IL213032A/en not_active IP Right Cessation
-
2014
- 2014-12-16 CY CY20141101047T patent/CY1116032T1/el unknown
-
2015
- 2015-01-16 SM SM201500012T patent/SMT201500012B/xx unknown
- 2015-08-31 US US14/840,549 patent/US20150366870A1/en not_active Abandoned
-
2016
- 2016-10-11 US US15/289,996 patent/US20170027945A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PT2370440E (pt) | 2015-01-14 |
| ZA201103397B (en) | 2012-01-25 |
| EA020037B1 (ru) | 2014-08-29 |
| BRPI0922134A2 (pt) | 2015-08-18 |
| CY1116032T1 (el) | 2017-01-25 |
| EP2370440A4 (en) | 2012-05-30 |
| IL213032A (en) | 2015-02-26 |
| JP2012511028A (ja) | 2012-05-17 |
| MX2011006022A (es) | 2011-06-28 |
| EP2370440B1 (en) | 2014-11-12 |
| PL2370440T3 (pl) | 2015-05-29 |
| RS53777B1 (sr) | 2015-06-30 |
| ES2527354T3 (es) | 2015-01-22 |
| SMT201500012B (it) | 2015-05-03 |
| US20150366870A1 (en) | 2015-12-24 |
| AU2009324811A1 (en) | 2011-06-23 |
| CN102245606B (zh) | 2014-08-20 |
| IL213032A0 (en) | 2011-07-31 |
| KR101743783B1 (ko) | 2017-06-05 |
| CA2746316A1 (en) | 2010-06-17 |
| EA201170783A1 (ru) | 2011-12-30 |
| CN102245606A (zh) | 2011-11-16 |
| DK2370440T3 (en) | 2014-12-08 |
| US9163024B2 (en) | 2015-10-20 |
| EP2370440A1 (en) | 2011-10-05 |
| HRP20150026T1 (hr) | 2015-02-13 |
| KR20110097816A (ko) | 2011-08-31 |
| US20110251218A1 (en) | 2011-10-13 |
| US20170027945A1 (en) | 2017-02-02 |
| AU2009324811B2 (en) | 2013-01-24 |
| WO2010068581A1 (en) | 2010-06-17 |
| SI2370440T1 (sl) | 2015-02-27 |
| JP5666464B2 (ja) | 2015-02-12 |
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