CA2745071C - C-ring modified tricyclic benzonaphthiridinone protein kinase inhibitors and use thereof - Google Patents
C-ring modified tricyclic benzonaphthiridinone protein kinase inhibitors and use thereof Download PDFInfo
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- CA2745071C CA2745071C CA2745071A CA2745071A CA2745071C CA 2745071 C CA2745071 C CA 2745071C CA 2745071 A CA2745071 A CA 2745071A CA 2745071 A CA2745071 A CA 2745071A CA 2745071 C CA2745071 C CA 2745071C
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- oxo
- benzamide
- ylamino
- phenyl
- hexahydrobenzo
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
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- C07—ORGANIC CHEMISTRY
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
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- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
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- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
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Applications Claiming Priority (3)
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| US20196108P | 2008-12-17 | 2008-12-17 | |
| US61/201,961 | 2008-12-17 | ||
| PCT/US2009/066319 WO2010077530A1 (en) | 2008-12-17 | 2009-12-02 | C-ring modified tricyclic benzonaphthiridinone protein kinase inhibitors and use thereof |
Publications (2)
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| CA2745071A1 CA2745071A1 (en) | 2010-07-08 |
| CA2745071C true CA2745071C (en) | 2018-08-28 |
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| CA2745071A Expired - Fee Related CA2745071C (en) | 2008-12-17 | 2009-12-02 | C-ring modified tricyclic benzonaphthiridinone protein kinase inhibitors and use thereof |
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| US (1) | US9938268B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2367821B1 (cg-RX-API-DMAC10.html) |
| JP (2) | JP2012512246A (cg-RX-API-DMAC10.html) |
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| IL (1) | IL213588A0 (cg-RX-API-DMAC10.html) |
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| CN103889986B (zh) * | 2011-09-30 | 2017-07-21 | C&C新药研究所 | 新杂环衍生物及其应用 |
| EA030003B1 (ru) | 2012-12-21 | 2018-06-29 | Джилид Сайэнс, Инк. | Полициклическое карбамоилпиридоновое соединение и его фармацевтическое применение для лечения вич-инфекции |
| TWI695003B (zh) | 2014-12-23 | 2020-06-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
| CN116490507A (zh) | 2020-09-10 | 2023-07-25 | 薛定谔公司 | 用于治疗癌症的杂环包缩合cdc7激酶抑制剂 |
| CN115611896A (zh) * | 2021-07-16 | 2023-01-17 | 中国药科大学 | 含四氢萘啶酮或四氢吡啶并嘧啶酮骨架的化合物及其制备方法与制药用途 |
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| JPS4961198A (cg-RX-API-DMAC10.html) * | 1972-10-14 | 1974-06-13 | ||
| US4680298A (en) * | 1983-05-31 | 1987-07-14 | Schering Corporation | Tricyclic anti-allergy and use as anti-inflammatory agents |
| US4596809A (en) * | 1985-03-25 | 1986-06-24 | Schering Corporation | Substituted 1,8-naphthyridinones, useful as anti-allergic agents |
| ATE90096T1 (de) * | 1986-04-11 | 1993-06-15 | Schering Corp | Arylsubstituierte naphthyridin- und pyridopyrazin-derivate. |
| CA1309658C (en) * | 1986-12-05 | 1992-11-03 | David J. Blythin | Pharmaceutical compositions for treatment of hyperproliferate skin disease |
| DE69122427T2 (de) * | 1990-06-01 | 1997-03-06 | Kyowa Hakko Kogyo Kk | Imidazonaphthyridinderivate |
| JPH0961198A (ja) * | 1995-08-25 | 1997-03-07 | Nippon Seiki Co Ltd | 計器装置 |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| CA2242425C (en) | 1996-02-13 | 2006-07-18 | Zeneca Limited | Quinazoline derivatives as vegf inhibitors |
| NZ331191A (en) | 1996-03-05 | 2000-03-27 | Zeneca Ltd | 4-anilinoquinazoline derivatives and pharmaceutical compositions thereof |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
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| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| BR0111230A (pt) | 2000-05-31 | 2003-06-10 | Astrazeneca Ab | Composto, e, uso e processo para a preparação do mesmo |
| KR20030014425A (ko) | 2000-07-07 | 2003-02-17 | 앤지오젠 파마슈티칼스 리미티드 | 혈관 손상제인 콜치놀 유도체 |
| EE200300015A (et) | 2000-07-07 | 2004-10-15 | Angiogene Pharmaceuticals Limited | Kolhinooli derivaadid kui angiogeneesi inhibiitorid |
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| EP1910365A4 (en) | 2005-07-22 | 2009-07-15 | Merck & Co Inc | INHIBITORS OF CHECKPOINT KINASES |
| JP2010500961A (ja) | 2006-08-02 | 2010-01-14 | 武田薬品工業株式会社 | α−カルボリン誘導体およびその製造方法 |
| DK2061765T3 (en) * | 2006-09-01 | 2015-01-26 | Senhwa Biosciences Inc | Serine-threonine protein kinase AND PARP-MODULATOR |
| CA2712990C (en) * | 2008-02-28 | 2016-09-27 | Bayard R. Huck | Benzonaphthyridinyl compounds as protein kinase inhibitors and use thereof |
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| IL213588A0 (en) | 2011-07-31 |
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| EP2367821A1 (en) | 2011-09-28 |
| WO2010077530A1 (en) | 2010-07-08 |
| JP2015163653A (ja) | 2015-09-10 |
| JP2012512246A (ja) | 2012-05-31 |
| AU2009333653A1 (en) | 2011-06-30 |
| US20110312951A1 (en) | 2011-12-22 |
| EP2367821B1 (en) | 2015-09-16 |
| JP6378138B2 (ja) | 2018-08-22 |
| CA2745071A1 (en) | 2010-07-08 |
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| MKLA | Lapsed |
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