CA2743861A1 - Methods and compositions related to targeting monoacylglycerol lipase - Google Patents
Methods and compositions related to targeting monoacylglycerol lipase Download PDFInfo
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- CA2743861A1 CA2743861A1 CA2743861A CA2743861A CA2743861A1 CA 2743861 A1 CA2743861 A1 CA 2743861A1 CA 2743861 A CA2743861 A CA 2743861A CA 2743861 A CA2743861 A CA 2743861A CA 2743861 A1 CA2743861 A1 CA 2743861A1
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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| US61/199,286 | 2008-11-14 | ||
| PCT/US2009/006045 WO2010056309A2 (en) | 2008-11-14 | 2009-11-10 | Methods and compositions related to targeting monoacylglycerol lipase |
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| CA2743861A1 true CA2743861A1 (en) | 2010-05-20 |
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| EP (1) | EP2373315A4 (https=) |
| JP (1) | JP5576874B2 (https=) |
| AU (1) | AU2009314629B2 (https=) |
| CA (1) | CA2743861A1 (https=) |
| WO (1) | WO2010056309A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210069230A1 (en) * | 2018-04-13 | 2021-03-11 | The Broad Institute, Inc. | Synergistic drug combinations predicted from genomic features and single-agent response profiles |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US9487495B2 (en) | 2012-01-06 | 2016-11-08 | The Scripts Research Institute | Carbamate compounds and of making and using same |
| EP2828253A1 (en) * | 2012-03-19 | 2015-01-28 | Abide Therapeutics, Inc. | Carbamate compounds and of making and using same |
| ES2753386T3 (es) | 2013-03-13 | 2020-04-08 | Forma Therapeutics Inc | Derivados de 2-hidroxi-1-{4-[(4-fenil)fenil]carbonil}piperazin-1-il}etano-1-ona y compuestos relacionados como inhibidores de sintasa de ácido graso (FASN) para el tratamiento del cáncer |
| WO2015179563A2 (en) | 2014-05-22 | 2015-11-26 | Abide Therapeutics, Inc. | N-hydroxy bicyclic hydantoin carbamates as tools for identification of serine hydrolase targets |
| ES2878041T3 (es) | 2015-03-18 | 2021-11-18 | H Lundbeck As | Carbamatos de piperazina y métodos para prepararlos y usarlos |
| SG10202012002TA (en) | 2015-05-11 | 2021-01-28 | Lundbeck La Jolla Research Center Inc | Methods of treating inflammation or neuropathic pain |
| UA121775C2 (uk) | 2015-07-31 | 2020-07-27 | Пфайзер Інк. | 1,1,1-трифтор-3-гідроксипропан-2-ілкарбаматні похідні та 1,1,1-трифтор-4-гідроксибутан-2-ілкарбаматні похідні як інгібітори magl |
| EP3331536A4 (en) * | 2015-08-03 | 2019-03-27 | The Regents of The University of California | COMPOSITIONS AND METHODS OF MODULATING THE ABHD2 ACTIVITY |
| US10336709B2 (en) | 2015-10-02 | 2019-07-02 | Abide Therapeutics, Inc | Lp-PLA2 inhibitors |
| WO2017143283A1 (en) | 2016-02-19 | 2017-08-24 | Abide Therapeutics, Inc. | Radiolabeled monoacylglycerol lipase occupancy probe |
| WO2017222713A1 (en) * | 2016-06-24 | 2017-12-28 | Indiana University Research & Technology Corporation | A gpr119-based signaling system in the murine eye regulates intraocular pressure in a sex-dependent manner |
| JP7042804B2 (ja) | 2016-09-19 | 2022-03-28 | ルンドベック ラ ホーヤ リサーチ センター，インク． | ピペラジンカルバメート、及びその製造と使用の方法 |
| JOP20190105A1 (ar) | 2016-11-16 | 2019-05-09 | Lundbeck La Jolla Research Center Inc | مثبطات أحادي أسيل جليسرول ليباز (magl) |
| JOP20190106A1 (ar) | 2016-11-16 | 2019-05-09 | Lundbeck La Jolla Research Center Inc | مثبطات أحادي أسيل جليسرول ليباز (magl) |
| EP3571191A1 (en) | 2017-01-20 | 2019-11-27 | Pfizer Inc | 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives as magl inhibitors |
| EP3571202B1 (en) | 2017-01-23 | 2021-06-30 | Pfizer Inc. | Heterocyclic spiro compounds as magl inhibitors |
| EP4335848A3 (en) | 2017-03-13 | 2024-06-19 | Lundbeck La Jolla Research Center, Inc. | Dual magl and faah inhibitors |
| US10927105B1 (en) | 2017-05-23 | 2021-02-23 | Lundbeck La Jolla Research Center, Inc. | Pyrazole MAGL inhibitors |
| EA201992409A1 (ru) | 2017-05-23 | 2020-03-23 | Лундбекк Ла-Хойя Рисерч Сентер, Инк. | Ингибиторы magl на основе пиразола |
| KR20210010475A (ko) | 2018-05-15 | 2021-01-27 | 룬드벡 라 졸라 리서치 센터 인코포레이티드 | Magl 저해제 |
| AU2019304198A1 (en) | 2018-07-19 | 2021-02-04 | Pfizer Inc. | Heterocyclic spiro compounds as MAGL inhibitors |
| TWI767148B (zh) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
| US10793554B2 (en) | 2018-10-29 | 2020-10-06 | Forma Therapeutics, Inc. | Solid forms of 4-(2-fluoro-4-(1-methyl-1H-benzo[d]imidazol-5-yl)benzoyl)piperazin-1-yl)(1-hydroxycyclopropyl)methanone |
| US11147805B2 (en) * | 2019-02-07 | 2021-10-19 | Medipure Pharmaceuticals Inc. | Cannabinoid receptor agonists and serine hydrolase enzyme inhibitor based anxiolytic therapeutic product |
| CN109750104A (zh) * | 2019-03-18 | 2019-05-14 | 南通大学附属医院 | Abhd6在非小细胞肺癌诊断、预后、治疗产品中的应用 |
| WO2021062232A1 (en) * | 2019-09-26 | 2021-04-01 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for reducing rewarding effects of morphine without affecting its analgesic effects |
| IL297470A (en) | 2020-04-21 | 2022-12-01 | H Lundbeck As | Synthesis of a monoacylglycerol lipase inhibitor |
| TW202304932A (zh) * | 2021-04-01 | 2023-02-01 | 日商小野藥品工業股份有限公司 | Abhd6拮抗劑 |
| CN113527270B (zh) * | 2021-07-16 | 2024-03-01 | 河南大学 | 一种靶向单酰基甘油脂肪酶的protac分子的医药中间体、制备方法及应用 |
| CA3242372A1 (en) | 2021-12-29 | 2023-07-06 | Psy Therapeutics, Inc. | Inhibiting monoacylglycerol lipase (magl) |
| JP7852604B2 (ja) * | 2022-09-30 | 2026-04-28 | 小野薬品工業株式会社 | Ａｂｈｄ６アンタゴニストを含有する医薬組成物 |
| EP4665718A1 (en) | 2023-02-13 | 2025-12-24 | Apogee Pharmaceuticals, Inc. | Small molecules as monoacylglycerol lipase (magl) inhibitors, compositions and use thereof |
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| AU2003262515A1 (en) | 2002-09-19 | 2004-04-08 | Nieland, John Mr | Inhibitors of the fatty acid oxidation for the prophylaxis and/or the treatment of chronic and/or atopic skin diseases |
| WO2006058088A2 (en) * | 2004-11-23 | 2006-06-01 | Ptc Therapeutics, Inc. | Carbazole, carboline and indole derivatives useful in the inhibition of vegf production |
| WO2006116773A2 (en) * | 2005-04-28 | 2006-11-02 | The Regents Of The University Of California | Methods, compositions, and compounds for modulation of monoacylglycerol lipase, pain, and stress-related disorders |
| WO2008024408A2 (en) * | 2006-08-22 | 2008-02-28 | Theraquest Biosciences, Inc. | Pharmaceutical formulations of cannabinoids for application to the skin and method of use |
| FR2915197B1 (fr) * | 2007-04-18 | 2009-06-12 | Sanofi Aventis Sa | Derives de triazolopyridine-carboxamides, leur preparation et leur application therapeutique. |
| US7989623B2 (en) * | 2007-11-21 | 2011-08-02 | Synthon Bv | Process for making n-(diphenylmethyl)piperazines |
| MX342128B (es) | 2008-12-24 | 2016-09-14 | Bial - Portela & C A S A | Compuestos farmaceuticos. |
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- 2009-11-10 EP EP09826412A patent/EP2373315A4/en not_active Withdrawn
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210069230A1 (en) * | 2018-04-13 | 2021-03-11 | The Broad Institute, Inc. | Synergistic drug combinations predicted from genomic features and single-agent response profiles |
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| US20110275650A1 (en) | 2011-11-10 |
| AU2009314629A1 (en) | 2010-05-20 |
| EP2373315A2 (en) | 2011-10-12 |
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| US8772318B2 (en) | 2014-07-08 |
| AU2009314629B2 (en) | 2014-09-25 |
| JP2012508737A (ja) | 2012-04-12 |
| EP2373315A4 (en) | 2012-06-27 |
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