CA2743610C - Fibroblast growth factor-9 promotes hair follicle regeneration after wounding - Google Patents

Fibroblast growth factor-9 promotes hair follicle regeneration after wounding Download PDF

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Publication number
CA2743610C
CA2743610C CA2743610A CA2743610A CA2743610C CA 2743610 C CA2743610 C CA 2743610C CA 2743610 A CA2743610 A CA 2743610A CA 2743610 A CA2743610 A CA 2743610A CA 2743610 C CA2743610 C CA 2743610C
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subject
administering
another embodiment
disrupting
hair
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CA2743610A
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English (en)
French (fr)
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CA2743610A1 (en
Inventor
George Cotsarelis
Ohsang Kwon
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University of Pennsylvania Penn
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University of Pennsylvania Penn
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Publication of CA2743610A1 publication Critical patent/CA2743610A1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1092—Details
    • A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Birds (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
CA2743610A 2008-11-12 2009-11-11 Fibroblast growth factor-9 promotes hair follicle regeneration after wounding Active CA2743610C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11402808P 2008-11-12 2008-11-12
US61/114,028 2008-11-12
PCT/US2009/064049 WO2010056759A1 (en) 2008-11-12 2009-11-11 Fibroblast growth factor-9 promotes hair follicle regeneration after wounding

Publications (2)

Publication Number Publication Date
CA2743610A1 CA2743610A1 (en) 2010-05-20
CA2743610C true CA2743610C (en) 2021-04-27

Family

ID=42170304

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2743610A Active CA2743610C (en) 2008-11-12 2009-11-11 Fibroblast growth factor-9 promotes hair follicle regeneration after wounding

Country Status (9)

Country Link
US (4) US8871711B2 (https=)
EP (2) EP2361119B1 (https=)
JP (1) JP5723780B2 (https=)
KR (2) KR101711995B1 (https=)
AU (2) AU2009314147B2 (https=)
BR (1) BRPI0915262B1 (https=)
CA (1) CA2743610C (https=)
IL (2) IL212858A (https=)
WO (1) WO2010056759A1 (https=)

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Publication number Priority date Publication date Assignee Title
CA2964111A1 (en) 2005-03-29 2006-10-05 The Trustees Of The University Of Pennsylvania Methods for generating new hair folicles, treating baldness, and hair removal
AU2009314147B2 (en) * 2008-11-12 2015-12-24 The Trustees Of The University Of Pennsylvania Fibroblast growth factor-9 promotes hair follicle regeneration after wounding
PT3213738T (pt) 2010-08-27 2020-03-31 Sebacia Inc Composições e métodos para modulação térmica direcionada
US9572880B2 (en) 2010-08-27 2017-02-21 Sienna Biopharmaceuticals, Inc. Ultrasound delivery of nanoparticles
GB2485475A (en) * 2010-11-10 2012-05-16 Pangaea Lab Ltd Topical growth factor application using controlled and multiple wounding of the skin
AU2011338530B2 (en) 2010-12-06 2017-06-15 Follica, Inc. Methods for treating baldness and promoting hair growth
AU2013329450B2 (en) 2012-10-11 2017-06-22 Coronado Aesthetics, Llc Silver nanoplate compositions and methods
EP2735303A1 (en) * 2012-11-23 2014-05-28 Pilosciences Hair growth compositions and methods
KR101578901B1 (ko) 2013-09-11 2015-12-28 (주)셀아이콘랩 발모 촉진 펩타이드, 이의 제조방법, 및, 이를 함유하는 탈모방지 또는 발모촉진용 조성물
WO2015164800A2 (en) * 2014-04-24 2015-10-29 University Of Central Florida Research Foundation, Inc. Compositions and methods for modulating polarization of monocytes
KR101841482B1 (ko) * 2016-02-25 2018-03-23 (주)피앤피바이오팜 안정성이 증가된 인간 섬유아세포 성장인자-9 변이체 및 이의 용도
KR102535575B1 (ko) * 2016-02-26 2023-05-23 (주)피앤피바이오팜 고안정성 섬유아세포 성장인자-9 변이체를 유효성분으로 포함하는 헤어케어 화장품 조성물
CA3082896A1 (en) * 2017-11-16 2019-05-23 Aivita Biomedical, Inc. Use of cell membrane-bound signaling factors
CN110551692B (zh) * 2019-07-09 2021-06-25 吕贯廷 hFGF9基因修饰型间充质干细胞及其制备方法和用途
CA3189833A1 (en) * 2020-05-12 2021-11-18 Chemistry Rx Methods for treating hair loss and compositions for same
EP4274546A4 (en) * 2021-01-06 2024-12-11 The Penn State Research Foundation METHODS AND MATERIALS FOR TREATING HAIR LOSS
WO2022165313A1 (en) 2021-02-01 2022-08-04 Regenxbio Inc. Gene therapy for neuronal ceroid lipofuscinoses
US12268677B2 (en) 2022-04-27 2025-04-08 The Penn State Research Foundation 4-aminopyridine (4-AP) and bone morphogenetic protein 2 (BMP-2)
AU2024255051A1 (en) * 2023-04-12 2025-08-07 Estetra Srl Topical compositions for promoting hair growth
CN118286487B (zh) * 2024-04-01 2024-09-17 吉林农业大学 一种促进复杂感染伤口愈合的多功能纳米纤维膜的制备方法
CN118161418B (zh) * 2024-05-14 2024-07-23 美归(成都)生物材料合伙企业(有限合伙) 保湿美白脂质体精华液及其制备方法

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JPH04224522A (ja) 1990-04-27 1992-08-13 Merck & Co Inc 繊維芽細胞増殖因子含有組成物による禿頭症の治療又は予防方法
JPH10279501A (ja) 1997-02-10 1998-10-20 Rohto Pharmaceut Co Ltd 育毛剤
US20070009544A1 (en) * 1999-06-17 2007-01-11 Ronit Eisenberg Anti-allergic complex molecules
ATE369144T1 (de) * 2000-03-31 2007-08-15 Gen Hospital Corp Verfahren zur steigerung des haarwuchses durch wnt polypeptid
US7588937B2 (en) * 2001-10-03 2009-09-15 Wisconsin Alumni Research Foundation Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
JP2003192541A (ja) * 2001-12-26 2003-07-09 Pola Chem Ind Inc 育毛促進剤及び育毛用の皮膚外用剤
KR20060123256A (ko) 2003-11-11 2006-12-01 가부시키가이샤 시세이도 모발의 태모화 방법 및 조성물
CA2964111A1 (en) * 2005-03-29 2006-10-05 The Trustees Of The University Of Pennsylvania Methods for generating new hair folicles, treating baldness, and hair removal
JP5153638B2 (ja) * 2005-10-17 2013-02-27 アデランス リサーチ インスティテュート インコーポレイテッド 毛包前駆細胞を皮膚に送達する方法
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US7714014B2 (en) * 2005-12-09 2010-05-11 The Regents Of The University Of California Targeting GLI proteins in human cancer by small molecules
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AU2009314147B2 (en) * 2008-11-12 2015-12-24 The Trustees Of The University Of Pennsylvania Fibroblast growth factor-9 promotes hair follicle regeneration after wounding

Also Published As

Publication number Publication date
BRPI0915262B1 (pt) 2018-06-05
EP2361119B1 (en) 2018-09-19
US20200197488A1 (en) 2020-06-25
EP2361119A1 (en) 2011-08-31
AU2009314147B2 (en) 2015-12-24
IL212858A (en) 2016-12-29
CA2743610A1 (en) 2010-05-20
KR101711995B1 (ko) 2017-03-06
US8871711B2 (en) 2014-10-28
EP2361119A4 (en) 2014-01-08
JP5723780B2 (ja) 2015-05-27
IL249309A0 (en) 2017-01-31
WO2010056759A1 (en) 2010-05-20
EP3144034A1 (en) 2017-03-22
US20110282267A1 (en) 2011-11-17
US20180280475A1 (en) 2018-10-04
AU2016201796A1 (en) 2016-05-05
BRPI0915262A2 (pt) 2016-02-16
KR20110092301A (ko) 2011-08-17
AU2009314147A1 (en) 2010-05-20
KR20170024148A (ko) 2017-03-06
IL212858A0 (en) 2011-07-31
US20150216934A1 (en) 2015-08-06
JP2012508750A (ja) 2012-04-12

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