JP5723780B2 - 創傷形成後の毛包再生を促進する繊維芽細胞増殖因子‐9 - Google Patents
創傷形成後の毛包再生を促進する繊維芽細胞増殖因子‐9 Download PDFInfo
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Description
本発明の全体または一部は、米国国立衛生研究所(National Institutes of Health)により認可された認可番号NIH/NIAMS AR46837の下で、米国政府の支援を受けてなされたものである。米国政府は、本発明に対する一定の権利を有し得る。
本出願は、2008年11月12日付で出願された米国仮出願第61/114,028号の優先権を主張する。該米国仮出願の全体は、この引用により本明細書に組み込まれるものとする。
本発明は、脱毛の治療あるいは毛包の再生のための医薬組成物及び方法に関する。具体的には、本発明は、繊維芽細胞増殖因子‐9ポリペプチド、及び脱毛の治療あるいは毛包の再生のための繊維芽細胞増殖因子‐9ポリペプチドの投与に関する。
Claims (15)
- 対象における脱毛を治療するための組成物であって、
該組成物が繊維芽細胞増殖因子‐9ポリペプチドを含み、前記対象は、脱毛領域の表皮を破壊する処置を受けており、かつ該組成物が、前記対象の脱毛領域における表皮が破壊された後、新たな毛包が形成する直前及び/または最中に前記対象に投与されることを特徴とする組成物。
- 対象における脱毛を治療するための組成物であって、
繊維芽細胞増殖因子‐9ポリペプチド及びWntポリペプチドを含み、前記対象は、脱毛領域の表皮を破壊する処置を受けており、かつ該組成物が、前記対象の脱毛領域における表皮が破壊された後、新たな毛包が形成する直前及び/または最中に前記対象に投与されることを特徴とする組成物。 - 請求項1または2に記載の組成物であって、
前記脱毛がアンドロゲン性脱毛症(AGA)に起因することを特徴とする組成物。 - 請求項3に記載の組成物であって、
前記AGAが男性型脱毛症であることを特徴とする組成物。 - 請求項3に記載の組成物であって、
前記AGAが女性型脱毛症であることを特徴とする組成物。 - 請求項1または2に記載の組成物であって、
前記脱毛が皮膚損傷に起因することを特徴とする組成物。 - 請求項1または2に記載の組成物であって、
前記脱毛が前記対象の頭皮または眉に存在することを特徴とする組成物。 - 請求項1または2に記載の組成物であって、
前記脱毛が前記対象の瘢痕化皮膚組織に存在することを特徴とする組成物。 - 請求項1ないし8のいずれか一項に記載の組成物であって、
該組成物の投与が、表皮破壊の3〜12日後に行われることを特徴とする組成物。 - 請求項1ないし9のいずれか一項に記載の組成物であって、
表皮破壊が、前記脱毛領域または変性皮膚疾患領域を物理的若しくは化学的刺激に曝すことにより行われることを特徴とする組成物。 - 請求項1ないし9のいずれか一項に記載の組成物であって、
表皮破壊が、前記脱毛領域または変性皮膚疾患領域を放射線に曝すことにより行われることを特徴とする組成物。 - 請求項1ないし11のいずれか一項に記載の組成物であって、
該組成物の投与が、局所投与により行われることを特徴とする組成物。 - 請求項1ないし11のいずれか一項に記載の組成物であって、
該組成物の投与が、表皮下投与により行われることを特徴とする組成物。 - 請求項2に記載の組成物であって、
前記WntポリペプチドがWnt7ポリペプチドであることを特徴とする組成物。 - 対象における脱毛を治療するための組成物であって、
該組成物がソニック・ヘッジホッグ(SHH)を上方制御する繊維芽細胞増殖因子‐9ポリペプチドを含み、かつ該組成物が、前記対象の脱毛領域における表皮が破壊された後、新たな毛包が形成する直前及び/または最中に前記対象に投与されることを特徴とする組成物。
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PCT/US2009/064049 WO2010056759A1 (en) | 2008-11-12 | 2009-11-11 | Fibroblast growth factor-9 promotes hair follicle regeneration after wounding |
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ES2931949T3 (es) | 2005-03-29 | 2023-01-05 | Univ Pennsylvania | Minoxidilo para generar nuevos folículos pilosos y tratar la calvicie |
WO2010056759A1 (en) | 2008-11-12 | 2010-05-20 | The Trustees Of The University Of Pennsylvania | Fibroblast growth factor-9 promotes hair follicle regeneration after wounding |
US9572880B2 (en) | 2010-08-27 | 2017-02-21 | Sienna Biopharmaceuticals, Inc. | Ultrasound delivery of nanoparticles |
EP2608762B2 (en) | 2010-08-27 | 2020-05-13 | Sienna Biopharmaceuticals, Inc. | Compositions and methods for targeted thermomodulation |
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AU2011338530B2 (en) | 2010-12-06 | 2017-06-15 | Follica, Inc. | Methods for treating baldness and promoting hair growth |
JP6325552B2 (ja) | 2012-10-11 | 2018-05-16 | ナノコンポジックス,インコーポレイテッド | 銀ナノプレート組成物および方法 |
EP2735303A1 (en) * | 2012-11-23 | 2014-05-28 | Pilosciences | Hair growth compositions and methods |
KR101578901B1 (ko) | 2013-09-11 | 2015-12-28 | (주)셀아이콘랩 | 발모 촉진 펩타이드, 이의 제조방법, 및, 이를 함유하는 탈모방지 또는 발모촉진용 조성물 |
WO2015164800A2 (en) * | 2014-04-24 | 2015-10-29 | University Of Central Florida Research Foundation, Inc. | Compositions and methods for modulating polarization of monocytes |
KR101841482B1 (ko) * | 2016-02-25 | 2018-03-23 | (주)피앤피바이오팜 | 안정성이 증가된 인간 섬유아세포 성장인자-9 변이체 및 이의 용도 |
KR102535575B1 (ko) * | 2016-02-26 | 2023-05-23 | (주)피앤피바이오팜 | 고안정성 섬유아세포 성장인자-9 변이체를 유효성분으로 포함하는 헤어케어 화장품 조성물 |
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WO2021232055A1 (en) * | 2020-05-12 | 2021-11-18 | Chemistryrx | Methods for treating hair loss and compositions for same |
CA3207296A1 (en) * | 2021-01-06 | 2022-07-14 | The Penn State Research Foundation | Methods and materials for treating hair loss |
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CN118161418A (zh) * | 2024-05-14 | 2024-06-11 | 美归(成都)生物材料合伙企业(有限合伙) | 保湿美白脂质体精华液及其制备方法 |
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BRPI0915262A2 (pt) | 2016-02-16 |
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KR20170024148A (ko) | 2017-03-06 |
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