CA2740793A1 - Method for the treatment of hemophilia - Google Patents
Method for the treatment of hemophilia Download PDFInfo
- Publication number
- CA2740793A1 CA2740793A1 CA2740793A CA2740793A CA2740793A1 CA 2740793 A1 CA2740793 A1 CA 2740793A1 CA 2740793 A CA2740793 A CA 2740793A CA 2740793 A CA2740793 A CA 2740793A CA 2740793 A1 CA2740793 A1 CA 2740793A1
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- fviii
- mutein
- amino acid
- biocompatible polymer
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C07—ORGANIC CHEMISTRY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/745—Blood coagulation or fibrinolysis factors
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- C—CHEMISTRY; METALLURGY
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- C12N9/6424—Serine endopeptidases (3.4.21)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/6424—Serine endopeptidases (3.4.21)
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| US11197916B2 (en) | 2007-12-28 | 2021-12-14 | Takeda Pharmaceutical Company Limited | Lyophilized recombinant VWF formulations |
| SG187410A1 (en) | 2007-12-28 | 2013-02-28 | Baxter Int | Recombinant vwf formulations |
| TWI593421B (zh) | 2008-10-21 | 2017-08-01 | 巴克斯歐塔公司 | 凍乾的重組ｖｗｆ調配物 |
| NZ606427A (en) | 2009-02-03 | 2014-10-31 | Amunix Operating Inc | Extended recombinant polypeptides and compositions comprising same |
| NZ623810A (en) | 2009-07-27 | 2015-10-30 | Lipoxen Technologies Ltd | Glycopolysialylation of non-blood coagulation proteins |
| WO2011012850A2 (en) | 2009-07-27 | 2011-02-03 | Lipoxen Technologies Limited | Glycopolysialylation of non-blood coagulation proteins |
| US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| CN102497884A (zh) | 2009-07-27 | 2012-06-13 | 巴克斯特国际公司 | 凝血蛋白缀合物 |
| WO2011028228A1 (en) | 2009-08-24 | 2011-03-10 | Amunix Operating Inc. | Coagulation factor vii compositions and methods of making and using same |
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| PT2654794T (pt) | 2010-12-22 | 2020-06-11 | Baxalta Inc | Materiais e métodos para conjugação de um derivado de ácido gordo solúvel em água a uma proteína |
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| JP2015519313A (ja) | 2012-04-24 | 2015-07-09 | ノヴォ ノルディスク アー／エス | 血友病の治療に適する医薬組成物 |
| WO2013083858A1 (en) | 2012-04-24 | 2013-06-13 | Novo Nordisk A/S | Compounds suitable for treatment of haemophilia |
| US10548953B2 (en) | 2013-08-14 | 2020-02-04 | Bioverativ Therapeutics Inc. | Factor VIII-XTEN fusions and uses thereof |
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|---|---|---|---|---|
| US5766897A (en) * | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
| FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| IL113010A0 (en) * | 1994-03-31 | 1995-10-31 | Pharmacia Ab | Pharmaceutical formulation comprising factor VIII or factor ix with an activity of at least 200 IU/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration |
| SE9503380D0 (sv) * | 1995-09-29 | 1995-09-29 | Pharmacia Ab | Protein derivatives |
| US8465468B1 (en) * | 2000-06-29 | 2013-06-18 | Becton, Dickinson And Company | Intradermal delivery of substances |
| SI1596887T1 (sl) * | 2003-02-26 | 2022-05-31 | Nektar Therapeutics | Konjugati polimer-del faktorja VIII |
| PT2371856T (pt) * | 2004-11-12 | 2022-08-12 | Bayer Healthcare Llc | Modificação de fviii direcionada a sítio |
| JP2008534559A (ja) * | 2005-04-01 | 2008-08-28 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 血液凝固ｆｖｉｉｉ類似体 |
| EP2099475B1 (en) * | 2007-01-03 | 2016-08-24 | Novo Nordisk Health Care AG | Subcutaneous administration of coagulation factor viia-related polypeptides |
| WO2008119815A1 (en) * | 2007-04-02 | 2008-10-09 | Novo Nordisk A/S | Subcutaneous administration of coagulation factor ix |
-
2009
- 2009-11-03 KR KR1020117010062A patent/KR20110093775A/ko not_active Withdrawn
- 2009-11-03 US US13/127,461 patent/US20120027743A1/en not_active Abandoned
- 2009-11-03 WO PCT/US2009/063151 patent/WO2010062768A1/en not_active Ceased
- 2009-11-03 CA CA2740793A patent/CA2740793A1/en not_active Abandoned
- 2009-11-03 EP EP09829685A patent/EP2352515A4/en not_active Withdrawn
- 2009-11-03 JP JP2011534887A patent/JP2012508172A/ja active Pending
- 2009-11-03 CN CN2009801426047A patent/CN102202684A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010062768A1 (en) | 2010-06-03 |
| EP2352515A1 (en) | 2011-08-10 |
| KR20110093775A (ko) | 2011-08-18 |
| EP2352515A4 (en) | 2012-04-25 |
| CN102202684A (zh) | 2011-09-28 |
| JP2012508172A (ja) | 2012-04-05 |
| US20120027743A1 (en) | 2012-02-02 |
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| Date | Code | Title | Description |
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| FZDE | Discontinued |
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