CA2739794A1 - Use of il-20 antagonists for treating rheumatoid arthritis and osteoporosis - Google Patents

Use of il-20 antagonists for treating rheumatoid arthritis and osteoporosis Download PDF

Info

Publication number
CA2739794A1
CA2739794A1 CA2739794A CA2739794A CA2739794A1 CA 2739794 A1 CA2739794 A1 CA 2739794A1 CA 2739794 A CA2739794 A CA 2739794A CA 2739794 A CA2739794 A CA 2739794A CA 2739794 A1 CA2739794 A1 CA 2739794A1
Authority
CA
Canada
Prior art keywords
antibody
antagonist
mab
osteoporosis
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2739794A
Other languages
English (en)
French (fr)
Inventor
Ming-Shi Chang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Cheng Kung University
Original Assignee
National Cheng Kung University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/246,715 external-priority patent/US7837994B2/en
Application filed by National Cheng Kung University filed Critical National Cheng Kung University
Publication of CA2739794A1 publication Critical patent/CA2739794A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA2739794A 2008-10-07 2009-10-07 Use of il-20 antagonists for treating rheumatoid arthritis and osteoporosis Abandoned CA2739794A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12/246,715 US7837994B2 (en) 2008-10-07 2008-10-07 Use of anti-IL-20 antibody for treating osteoporosis
US12/246,715 2008-10-07
US23866109P 2009-08-31 2009-08-31
US61/238,661 2009-08-31
PCT/US2009/059865 WO2010042634A1 (en) 2008-10-07 2009-10-07 Use of il-20 antagonists for treating rheumatoid arthritis and osteoporosis

Publications (1)

Publication Number Publication Date
CA2739794A1 true CA2739794A1 (en) 2010-04-15

Family

ID=42100943

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2739794A Abandoned CA2739794A1 (en) 2008-10-07 2009-10-07 Use of il-20 antagonists for treating rheumatoid arthritis and osteoporosis

Country Status (7)

Country Link
EP (1) EP2340039B1 (enExample)
JP (2) JP5860699B2 (enExample)
KR (1) KR101691534B1 (enExample)
CN (1) CN102281898B (enExample)
CA (1) CA2739794A1 (enExample)
DK (1) DK2340039T3 (enExample)
WO (1) WO2010042634A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011239520A1 (en) * 2010-04-16 2012-11-08 National Cheng Kung University Treating disorders associated with IL-20 receptor-mediated signaling pathway by blocking IL-20 receptor activity
WO2014006230A1 (en) 2012-07-06 2014-01-09 Novo Nordisk A/S Il-20 epitopes and il-20 ligands
CA2878825A1 (en) * 2012-07-10 2014-01-16 The Uab Research Foundation Compositions and methods for modulation of il-20 family cytokine activity
US8603470B1 (en) * 2012-08-07 2013-12-10 National Cheng Kung University Use of IL-20 antagonists for treating liver diseases
US9376490B2 (en) * 2014-04-01 2016-06-28 National Cheng Kung University Treatment of inflammatory pain using IL-20 antagonists
CN107249630A (zh) * 2014-11-24 2017-10-13 国家健康与医学研究院 通过il‑20r的拮抗作用治疗慢性阻塞性肺疾病的急性加重
US9982043B2 (en) 2016-06-03 2018-05-29 National Cheng Kung University Use of IL-20 antagonists for treating pancreatic cancer
KR101796025B1 (ko) 2017-04-25 2017-11-10 가톨릭대학교 산학협력단 사포그릴레이트, 프라바스타틴 및 tnf-억제제를 유효성분으로 포함하는 죽상동맥경화증 예방 또는 치료용 약학조성물
CN121800920B (zh) * 2026-03-06 2026-07-31 遵义北科融汇生命科技有限公司 脐带间充质干细胞与外周血prp联合在治疗膝关节炎中的应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE239041T1 (de) * 1996-02-09 2003-05-15 Basf Ag Humane antikörper welche an humanen tnfalpha binden
US6649779B2 (en) * 1997-05-02 2003-11-18 Wyeth Estrenes
ES2218872T3 (es) * 1997-11-26 2004-11-16 Zymogenetics Inc Polipeptido 10 de tipo citoquina de mamifero.
US20030148955A1 (en) * 1999-04-19 2003-08-07 Pluenneke John D. Soluble tumor necrosis factor receptor treatment of medical disorders
US7122632B2 (en) * 1999-12-23 2006-10-17 Zymogenetics, Inc. Soluble Interleukin-20 receptor
RU2279441C2 (ru) * 1999-12-23 2006-07-10 Займодженетикс, Инк. Выделенный растворимый il-20 рецептор (варианты)
US6610286B2 (en) * 1999-12-23 2003-08-26 Zymogenetics, Inc. Method for treating inflammation using soluble receptors to interleukin-20
ES2387394T3 (es) * 1999-12-23 2012-09-21 Zymogenetics, Inc. Procedimiento de tratamiento de la inflamación
US20050143333A1 (en) * 2001-05-18 2005-06-30 Sirna Therapeutics, Inc. RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (SINA)
EP1429779A2 (en) * 2001-09-21 2004-06-23 Merck & Co., Inc. Androstanes as androgen receptor modulators
CA2465499A1 (en) * 2001-11-08 2003-05-15 Merck & Co., Inc. Compositions and methods for treating osteoporosis
US7435800B2 (en) * 2003-05-23 2008-10-14 Chi-Mei Medical Center Antibodies to interleukin-20 and method for inhibiting interleukin-20 induced cell proliferation
EP1697418A2 (en) * 2003-11-21 2006-09-06 ZymoGenetics, Inc. Anti-il-20 receptor antibodies and binding partners and methods of using in inflammation
WO2007116818A1 (ja) * 2006-03-30 2007-10-18 Toray Industries, Inc. 樹状ポリエステル、その製造方法および熱可塑性樹脂組成物
JP5330829B2 (ja) * 2006-08-04 2013-10-30 憲弘 西本 関節リウマチ患者の治療予後予測方法

Also Published As

Publication number Publication date
EP2340039B1 (en) 2015-11-25
AU2009302383A1 (en) 2010-04-15
KR20110094272A (ko) 2011-08-23
JP2016041730A (ja) 2016-03-31
AU2009302383B2 (en) 2016-05-12
DK2340039T3 (en) 2016-02-29
WO2010042634A1 (en) 2010-04-15
JP2012505227A (ja) 2012-03-01
EP2340039A1 (en) 2011-07-06
CN102281898A (zh) 2011-12-14
EP2340039A4 (en) 2012-10-24
JP5860699B2 (ja) 2016-02-16
CN102281898B (zh) 2015-06-03
KR101691534B1 (ko) 2017-01-09

Similar Documents

Publication Publication Date Title
US8454956B2 (en) Methods for treating rheumatoid arthritis and osteoporosis with anti-IL-20 antibodies
US10059772B2 (en) Antagonist anti-IL-7 receptor antibodies and methods
EP2340039B1 (en) Use of il-20 antagonists for treating osteoporosis
WO2004073653A2 (en) Methods for treating pain by administering a nerve growth factor antagonist and an nsaid and compositions containing the same
US9365652B2 (en) Use of IL-20 antagonists for treating liver diseases
US9982043B2 (en) Use of IL-20 antagonists for treating pancreatic cancer
US9221904B2 (en) Treatment of osteoarthritis using IL-20 antagonists
AU2013203707B2 (en) Use of il-20 antagonists for treating rheumatoid arthritis and osteoporosis
AU2009302383B9 (en) Use of IL-20 antagonists for treating rheumatoid arthritis and osteoporosis
US20140065144A1 (en) Use of il-20 antagonists for promoting bone fracture healing
US9751949B2 (en) Method of inhibiting adipogenesis with an IL-20 antibody
US12409208B2 (en) Treating tissue fibrosis with interleukin 24
US9512218B2 (en) Use of IL-20 antagonists for alleviating spinal cord injury
TW201210613A (en) Use of IL-20 antagonists for preventing rheumatoid arthritis and osteoporosis

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20141003

FZDE Discontinued

Effective date: 20161007