CA2739046A1 - Process and compositions for liposomal and effective delivery of nucleic acids - Google Patents
Process and compositions for liposomal and effective delivery of nucleic acids Download PDFInfo
- Publication number
- CA2739046A1 CA2739046A1 CA2739046A CA2739046A CA2739046A1 CA 2739046 A1 CA2739046 A1 CA 2739046A1 CA 2739046 A CA2739046 A CA 2739046A CA 2739046 A CA2739046 A CA 2739046A CA 2739046 A1 CA2739046 A1 CA 2739046A1
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- agent
- nucleic acid
- peptide
- disease
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| PCT/US2009/060930 WO2010045512A2 (en) | 2008-10-16 | 2009-10-16 | Processes and compositions for liposomal and efficient delivery of gene silencing therapeutics |
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| SI2494993T1 (sl) | 2007-05-04 | 2019-01-31 | Marina Biotech, Inc. | Aminokislinski lipidi in njihove uporabe |
| CA3006395C (en) | 2008-11-07 | 2022-05-31 | Massachusetts Institute Of Technology | Aminoalcohol lipidoids and uses thereof |
| WO2010059829A2 (en) * | 2008-11-19 | 2010-05-27 | Mdrna, Inc. | Compositions and methods for triggered release rna therapeutics |
| CN102665761A (zh) | 2009-11-04 | 2012-09-12 | 玛瑞纳生物技术有限公司 | 活性产生递送分子 |
| US20110244026A1 (en) | 2009-12-01 | 2011-10-06 | Braydon Charles Guild | Delivery of mrna for the augmentation of proteins and enzymes in human genetic diseases |
| EP2609135A4 (en) | 2010-08-26 | 2015-05-20 | Massachusetts Inst Technology | POLY (BETA AMINO ALCOHOLS), THEIR PREPARATION AND USES THEREOF |
| JP6054308B2 (ja) * | 2011-02-15 | 2016-12-27 | メリマック ファーマシューティカルズ， インコーポレイテッドＭｅｒｒｉｍａｃｋ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 核酸を細胞へ送達する組成物及び方法 |
| PL2691443T3 (pl) | 2011-03-28 | 2021-08-30 | Massachusetts Institute Of Technology | Sprzężone lipomery i ich zastosowania |
| LT2717893T (lt) | 2011-06-08 | 2019-08-12 | Translate Bio, Inc. | Lipidų nanodalelių kompozicijos ir mrnr pristatymo būdai |
| AU2012308320C1 (en) * | 2011-09-14 | 2018-08-23 | Translate Bio Ma, Inc. | Multimeric oligonucleotide compounds |
| EP4074694A1 (en) | 2011-10-27 | 2022-10-19 | Massachusetts Institute Of Technology | Amino acid-, peptide- an polypeptide-lipids, isomers, compositions, an uses thereof |
| SI2773326T1 (sl) * | 2011-11-04 | 2019-04-30 | Nitto Denko Corporation | Metoda za sterilno proizvodnjo delcev lipidno-nukleinske kisline |
| AU2013262700A1 (en) | 2012-05-16 | 2015-01-22 | Rana Therapeutics, Inc. | Compositions and methods for modulating hemoglobin gene family expression |
| CA2873794A1 (en) | 2012-05-16 | 2013-11-21 | Rana Therapeutics Inc. | Compositions and methods for modulating smn gene family expression |
| WO2013173598A1 (en) | 2012-05-16 | 2013-11-21 | Rana Therapeutics, Inc. | Compositions and methods for modulating atp2a2 expression |
| US10837014B2 (en) | 2012-05-16 | 2020-11-17 | Translate Bio Ma, Inc. | Compositions and methods for modulating SMN gene family expression |
| EP2850185A4 (en) | 2012-05-16 | 2015-12-30 | Rana Therapeutics Inc | COMPOSITIONS AND METHOD FOR MODULATING UTRN GENE EXPRESSION |
| US20150152410A1 (en) | 2012-05-16 | 2015-06-04 | Rana Therapeutics, Inc. | Compositions and methods for modulating mecp2 expression |
| US20150267192A1 (en) | 2012-06-08 | 2015-09-24 | Shire Human Genetic Therapies, Inc. | Nuclease resistant polynucleotides and uses thereof |
| WO2014028487A1 (en) | 2012-08-13 | 2014-02-20 | Massachusetts Institute Of Technology | Amine-containing lipidoids and uses thereof |
| US20150247141A1 (en) | 2012-09-14 | 2015-09-03 | Rana Therapeutics, Inc. | Multimeric oligonucleotide compounds |
| AU2014236305B2 (en) | 2013-03-14 | 2019-01-17 | Ethris Gmbh | CFTR mRNA compositions and related methods and uses |
| MX2015012865A (es) | 2013-03-14 | 2016-07-21 | Shire Human Genetic Therapies | Metodos para purificacion de arn mensajero. |
| CN103172701B (zh) * | 2013-03-18 | 2015-09-30 | 中国科学院过程工程研究所 | 一种新型穿膜肽及其应用 |
| US9745583B2 (en) | 2013-04-30 | 2017-08-29 | Delta-Fly Pharma, Inc. | Liposome for topical administration and application thereof |
| WO2014179562A1 (en) | 2013-05-01 | 2014-11-06 | Massachusetts Institute Of Technology | 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof |
| CA2921161A1 (en) * | 2013-09-24 | 2015-04-02 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for the manufacture of lipid nanoparticles |
| EP3574923A1 (en) | 2013-10-22 | 2019-12-04 | Translate Bio, Inc. | Mrna therapy for phenylketonuria |
| EP3871696B1 (en) | 2013-10-22 | 2025-03-19 | Translate Bio, Inc. | Lipid formulations for delivery of messenger rna |
| ES2954366T3 (es) | 2013-10-22 | 2023-11-21 | Translate Bio Inc | Terapia de ácido ribonucleico mensajero para la deficiencia de argininosuccinato sintetasa |
| RS66380B1 (sr) | 2014-04-23 | 2025-02-28 | Modernatx Inc | Vakcine nukleinske kiseline |
| MX373952B (es) | 2014-04-25 | 2020-07-13 | Shire Human Genetic Therapies | Métodos de purificación de arn mensajero. |
| CN106659731A (zh) | 2014-05-30 | 2017-05-10 | 夏尔人类遗传性治疗公司 | 用于递送核酸的可生物降解脂质 |
| JP6599373B2 (ja) | 2014-06-24 | 2019-10-30 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | 核酸の送達のための立体化学的に濃縮した組成物 |
| EP3164379A1 (en) | 2014-07-02 | 2017-05-10 | Massachusetts Institute of Technology | Polyamine-fatty acid derived lipidoids and uses thereof |
| JP5934848B1 (ja) * | 2014-10-30 | 2016-06-15 | Ｄｅｌｔａ−Ｆｌｙ Ｐｈａｒｍａ株式会社 | 局所投与用リポプレックスの新規製造方法及び該リポプレックスを使用する抗腫瘍剤 |
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2009
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- 2009-10-16 EP EP15153333.8A patent/EP2902013A1/en not_active Withdrawn
- 2009-10-16 JP JP2011532268A patent/JP2012505913A/ja active Pending
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- 2009-10-16 CN CN201410524574.9A patent/CN104382853A/zh active Pending
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2012
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2015
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| JP2012505913A (ja) | 2012-03-08 |
| BRPI0920171A2 (pt) | 2016-07-12 |
| SG196818A1 (en) | 2014-02-13 |
| CN102231979B (zh) | 2014-10-29 |
| CN102231979A (zh) | 2011-11-02 |
| AU2009305639B2 (en) | 2016-06-23 |
| EP2349210A2 (en) | 2011-08-03 |
| AU2009305639A1 (en) | 2010-04-22 |
| ZA201102319B (en) | 2012-09-26 |
| JP2015096529A (ja) | 2015-05-21 |
| US20130039970A1 (en) | 2013-02-14 |
| AU2018204605A1 (en) | 2018-07-12 |
| EP2349210B1 (en) | 2015-03-18 |
| US20100112042A1 (en) | 2010-05-06 |
| WO2010045512A3 (en) | 2011-01-27 |
| WO2010045512A2 (en) | 2010-04-22 |
| CN104382853A (zh) | 2015-03-04 |
| AU2016222371A1 (en) | 2016-09-15 |
| KR20110071017A (ko) | 2011-06-27 |
| JP6126072B2 (ja) | 2017-05-10 |
| US20150209283A1 (en) | 2015-07-30 |
| EP2902013A1 (en) | 2015-08-05 |
| IL212329A0 (en) | 2011-06-30 |
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