CA2738650C - Fused diimidazodiazepine compounds and methods of use and manufacture thereof - Google Patents

Fused diimidazodiazepine compounds and methods of use and manufacture thereof Download PDF

Info

Publication number
CA2738650C
CA2738650C CA2738650A CA2738650A CA2738650C CA 2738650 C CA2738650 C CA 2738650C CA 2738650 A CA2738650 A CA 2738650A CA 2738650 A CA2738650 A CA 2738650A CA 2738650 C CA2738650 C CA 2738650C
Authority
CA
Canada
Prior art keywords
illustrative embodiments
groups
compound
certain illustrative
benzyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2738650A
Other languages
English (en)
French (fr)
Other versions
CA2738650A1 (en
Inventor
Ramachandra S. Hosmane
Venu Raman
Raj Kumar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Publication of CA2738650A1 publication Critical patent/CA2738650A1/en
Application granted granted Critical
Publication of CA2738650C publication Critical patent/CA2738650C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2738650A 2008-09-23 2009-09-23 Fused diimidazodiazepine compounds and methods of use and manufacture thereof Active CA2738650C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9932408P 2008-09-23 2008-09-23
US61/099,324 2008-09-23
PCT/US2009/005273 WO2010039187A2 (en) 2008-09-23 2009-09-23 Fused diimidazodiazepine compounds and methods of use and manufacture thereof

Publications (2)

Publication Number Publication Date
CA2738650A1 CA2738650A1 (en) 2010-04-08
CA2738650C true CA2738650C (en) 2017-07-04

Family

ID=42074054

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2738650A Active CA2738650C (en) 2008-09-23 2009-09-23 Fused diimidazodiazepine compounds and methods of use and manufacture thereof

Country Status (6)

Country Link
US (1) US8518901B2 (OSRAM)
EP (1) EP2350086B1 (OSRAM)
JP (1) JP5802872B2 (OSRAM)
AU (1) AU2009300357B2 (OSRAM)
CA (1) CA2738650C (OSRAM)
WO (1) WO2010039187A2 (OSRAM)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9322831B2 (en) 2008-09-23 2016-04-26 The Johns Hopkins University DDX3 as a biomarker for cancer and methods related thereto
JP2014511396A (ja) * 2011-03-09 2014-05-15 ザ・ジョンズ・ホプキンス・ユニバーシティ 除去的放射線治療に使用される組成物およびその使用方法
KR20150046787A (ko) * 2012-09-04 2015-04-30 고쿠리츠다이가쿠호진 니이가타 다이가쿠 암 줄기세포에서 발현하는 분자를 타깃으로 하는 암 진단 및 치료 방법
WO2015200779A2 (en) * 2014-06-26 2015-12-30 The Johns Hopkins University Methods of prevention and treatment of viral disease by use of ddx3 inhibitors
AU2020345000A1 (en) * 2019-09-13 2022-03-31 Origenis Gmbh 1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as LRRK2, NUAK1 and/or TYK2 kinase modulators for the treatment of e.g. autoimmune disease
RS65045B1 (sr) * 2019-09-13 2024-02-29 Origenis Gmbh Derivati 1,4-dihidrobenzo[d]pirazolo[3,4-f][1,3]diazepina i srodna jedinjenja kao modulatori kinaze lrrk2, nuak1 i/ili tyk2 za lečenje npr. autoimunih bolesti
US20230077636A1 (en) * 2021-08-31 2023-03-16 Natsar Pharmaceuticals, Inc. Intravenous formulations of rk-33

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698155A (en) 1991-05-31 1997-12-16 Gs Technologies, Inc. Method for the manufacture of pharmaceutical cellulose capsules
TW201311B (OSRAM) * 1991-06-17 1993-03-01 Hoffmann La Roche
EP1968581A4 (en) * 2005-12-16 2009-05-27 Genentech Inc TETRACYCLIC KINASE INHIBITORS

Also Published As

Publication number Publication date
AU2009300357A1 (en) 2010-04-08
JP5802872B2 (ja) 2015-11-04
WO2010039187A2 (en) 2010-04-08
EP2350086A2 (en) 2011-08-03
US8518901B2 (en) 2013-08-27
US20110275588A1 (en) 2011-11-10
CA2738650A1 (en) 2010-04-08
EP2350086B1 (en) 2021-04-21
WO2010039187A3 (en) 2010-06-17
EP2350086A4 (en) 2012-06-27
JP2012503653A (ja) 2012-02-09
AU2009300357B2 (en) 2014-07-03

Similar Documents

Publication Publication Date Title
CA2738650C (en) Fused diimidazodiazepine compounds and methods of use and manufacture thereof
EP3675839B1 (en) Novel compounds having estrogen receptor alpha degradation activity and uses thereof
EP3277380B1 (en) Dna alkylating agents
TWI458723B (zh) １，２－雙取代雜環化合物
EP1636228B1 (de) Neue pyridopyrazine und deren verwendung als modulatoren von kinasen
EP2617420B1 (en) Phenoxymethyl heterocyclic compounds
EP1628976A1 (de) Neue pyridopyrazine und deren verwendung als kinase-inhibitoren
CA3109191A1 (en) Imidazotetrazine compounds
WO2017083756A1 (en) Heterocyclic compounds for the treatment of disease
EP1902054B1 (fr) Derives de pyrido[2,3-d]pyrimidine, leur preparation, leur application en therapeutique
EP3242881B1 (en) Furoquinolinediones as inhibitors of tdp2
EP3369740B1 (en) New cytidine derivative dimers and applications thereof
AU2014240289B2 (en) Fused diimidazodiazepine compounds and methods of use and manufacture thereof
US20250011292A1 (en) Novel rhodanine derivatives and uses thereof
EP0431799A2 (en) Use of nucleoside derivatives as cytotoxic agents
US8383631B2 (en) 1,6-disubstituted-3-amino-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-C]pyridin-7-one compounds and preparation thereof
DE69124392T2 (de) Tri(c1-c6 alkoxy)benzolderivat
US20090143375A1 (en) Tricyclic Lactam Derivatives, Their Manufacture and Use as Pharmaceutical Agents
CA2989161C (en) Ethynylxanthines, preparation and use for cancer treatment
KR101812128B1 (ko) 단백질 키나아제 저해제인 신규 5-아미노-3-(이속사졸-3-일)-1h-피라졸-4-카보아마이드 유도체들의 제조방법 및 약학적 활용
KR101589632B1 (ko) 항암활성을 가지는 6-벤질옥시퀴나졸린-7-일유레아 유도체
KR101178495B1 (ko) 3,6-이치환-4,5,6,7-테트라하이드로-1Ｈ-피라졸로［3,4-ｃ］피리딘-7-온 화합물과 이 화합물의 제조방법
HK1174032A (en) 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy
HK1174032B (en) 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20140923