JP5802872B2 - 縮合ジイミダゾジアゼピン化合物並びにその使用及び製造方法 - Google Patents
縮合ジイミダゾジアゼピン化合物並びにその使用及び製造方法 Download PDFInfo
- Publication number
- JP5802872B2 JP5802872B2 JP2011529012A JP2011529012A JP5802872B2 JP 5802872 B2 JP5802872 B2 JP 5802872B2 JP 2011529012 A JP2011529012 A JP 2011529012A JP 2011529012 A JP2011529012 A JP 2011529012A JP 5802872 B2 JP5802872 B2 JP 5802872B2
- Authority
- JP
- Japan
- Prior art keywords
- exemplary embodiments
- certain exemplary
- groups
- benzyl group
- group substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9932408P | 2008-09-23 | 2008-09-23 | |
| US61/099,324 | 2008-09-23 | ||
| PCT/US2009/005273 WO2010039187A2 (en) | 2008-09-23 | 2009-09-23 | Fused diimidazodiazepine compounds and methods of use and manufacture thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012503653A JP2012503653A (ja) | 2012-02-09 |
| JP2012503653A5 JP2012503653A5 (OSRAM) | 2015-04-30 |
| JP5802872B2 true JP5802872B2 (ja) | 2015-11-04 |
Family
ID=42074054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011529012A Active JP5802872B2 (ja) | 2008-09-23 | 2009-09-23 | 縮合ジイミダゾジアゼピン化合物並びにその使用及び製造方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8518901B2 (OSRAM) |
| EP (1) | EP2350086B1 (OSRAM) |
| JP (1) | JP5802872B2 (OSRAM) |
| AU (1) | AU2009300357B2 (OSRAM) |
| CA (1) | CA2738650C (OSRAM) |
| WO (1) | WO2010039187A2 (OSRAM) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9322831B2 (en) | 2008-09-23 | 2016-04-26 | The Johns Hopkins University | DDX3 as a biomarker for cancer and methods related thereto |
| JP2014511396A (ja) * | 2011-03-09 | 2014-05-15 | ザ・ジョンズ・ホプキンス・ユニバーシティ | 除去的放射線治療に使用される組成物およびその使用方法 |
| KR20150046787A (ko) * | 2012-09-04 | 2015-04-30 | 고쿠리츠다이가쿠호진 니이가타 다이가쿠 | 암 줄기세포에서 발현하는 분자를 타깃으로 하는 암 진단 및 치료 방법 |
| WO2015200779A2 (en) * | 2014-06-26 | 2015-12-30 | The Johns Hopkins University | Methods of prevention and treatment of viral disease by use of ddx3 inhibitors |
| AU2020345000A1 (en) * | 2019-09-13 | 2022-03-31 | Origenis Gmbh | 1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as LRRK2, NUAK1 and/or TYK2 kinase modulators for the treatment of e.g. autoimmune disease |
| RS65045B1 (sr) * | 2019-09-13 | 2024-02-29 | Origenis Gmbh | Derivati 1,4-dihidrobenzo[d]pirazolo[3,4-f][1,3]diazepina i srodna jedinjenja kao modulatori kinaze lrrk2, nuak1 i/ili tyk2 za lečenje npr. autoimunih bolesti |
| US20230077636A1 (en) * | 2021-08-31 | 2023-03-16 | Natsar Pharmaceuticals, Inc. | Intravenous formulations of rk-33 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5698155A (en) | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
| TW201311B (OSRAM) * | 1991-06-17 | 1993-03-01 | Hoffmann La Roche | |
| EP1968581A4 (en) * | 2005-12-16 | 2009-05-27 | Genentech Inc | TETRACYCLIC KINASE INHIBITORS |
-
2009
- 2009-09-23 AU AU2009300357A patent/AU2009300357B2/en active Active
- 2009-09-23 CA CA2738650A patent/CA2738650C/en active Active
- 2009-09-23 US US13/061,612 patent/US8518901B2/en active Active
- 2009-09-23 WO PCT/US2009/005273 patent/WO2010039187A2/en not_active Ceased
- 2009-09-23 JP JP2011529012A patent/JP5802872B2/ja active Active
- 2009-09-23 EP EP09818080.5A patent/EP2350086B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009300357A1 (en) | 2010-04-08 |
| WO2010039187A2 (en) | 2010-04-08 |
| EP2350086A2 (en) | 2011-08-03 |
| US8518901B2 (en) | 2013-08-27 |
| US20110275588A1 (en) | 2011-11-10 |
| CA2738650A1 (en) | 2010-04-08 |
| EP2350086B1 (en) | 2021-04-21 |
| CA2738650C (en) | 2017-07-04 |
| WO2010039187A3 (en) | 2010-06-17 |
| EP2350086A4 (en) | 2012-06-27 |
| JP2012503653A (ja) | 2012-02-09 |
| AU2009300357B2 (en) | 2014-07-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5802872B2 (ja) | 縮合ジイミダゾジアゼピン化合物並びにその使用及び製造方法 | |
| EP3277380B1 (en) | Dna alkylating agents | |
| JP6141568B1 (ja) | 新規なピラゾロ［３，４−ｄ］ピリミジン化合物又はその塩 | |
| EP1636228B1 (de) | Neue pyridopyrazine und deren verwendung als modulatoren von kinasen | |
| US20110281908A1 (en) | Aminoquinoline Derived Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use | |
| WO2012046030A2 (en) | Phosphodiesterase inhibitors | |
| CN113271939B (zh) | 咪唑四嗪化合物 | |
| JP2013530951A (ja) | ヤヌスキナーゼ阻害剤としてのヘテロ環式化合物 | |
| JP6838045B2 (ja) | 化合物 | |
| JPWO2018159613A1 (ja) | ピラゾロ［３，４−ｄ］ピリミジン化合物を用いた抗腫瘍効果増強剤 | |
| US9322831B2 (en) | DDX3 as a biomarker for cancer and methods related thereto | |
| CN114478561B (zh) | 一种依帕司他石蒜碱偶联物及其制备方法和用途 | |
| US20250011292A1 (en) | Novel rhodanine derivatives and uses thereof | |
| EP0850224B1 (en) | Radiation-activated cytotoxin therapy | |
| AU2014240289B2 (en) | Fused diimidazodiazepine compounds and methods of use and manufacture thereof | |
| KR102640385B1 (ko) | 고혈압 및/또는 폐 섬유증 치료용 조성물 | |
| US11098043B2 (en) | Certain imidazopyridines as cyclic AMP response element binding (CREB) binding protein (CBP) inhibitors and uses thereof | |
| KR20180020119A (ko) | 새로운 5형포스포디에스테라아제 억제제 및 그 용도 | |
| US8383631B2 (en) | 1,6-disubstituted-3-amino-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-C]pyridin-7-one compounds and preparation thereof | |
| KR20170016705A (ko) | 트리아졸로-아릴아크릴로나이트라일 유도체 및 이의 용도 | |
| RU2793918C2 (ru) | Ингибитор некроза клеток, способ его получения и применения | |
| US20090143375A1 (en) | Tricyclic Lactam Derivatives, Their Manufacture and Use as Pharmaceutical Agents | |
| US10449186B2 (en) | Phenylethynyl-substituted benzenes and heterocycles for the treatment of cancer | |
| HUP0202929A2 (hu) | Kardiális aritmiák kezelésében alkalmazható új biszpidinvegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| KR101589632B1 (ko) | 항암활성을 가지는 6-벤질옥시퀴나졸린-7-일유레아 유도체 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20120924 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20140226 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140526 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20140908 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20141208 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20141215 |
|
| A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20150309 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20150413 |
|
| A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20150513 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20150513 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150807 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5802872 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |