AU2009300357B2 - Fused diimidazodiazepine compounds and methods of use and manufacture thereof - Google Patents

Fused diimidazodiazepine compounds and methods of use and manufacture thereof Download PDF

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Publication number
AU2009300357B2
AU2009300357B2 AU2009300357A AU2009300357A AU2009300357B2 AU 2009300357 B2 AU2009300357 B2 AU 2009300357B2 AU 2009300357 A AU2009300357 A AU 2009300357A AU 2009300357 A AU2009300357 A AU 2009300357A AU 2009300357 B2 AU2009300357 B2 AU 2009300357B2
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Australia
Prior art keywords
illustrative embodiments
groups
certain illustrative
benzyl group
group substituted
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AU2009300357A
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English (en)
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AU2009300357A1 (en
Inventor
Ramachandra S. Hosmane
Raj Kumar
Venu Raman
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Johns Hopkins University
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Johns Hopkins University
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Publication of AU2009300357A1 publication Critical patent/AU2009300357A1/en
Assigned to THE JOHNS HOPKINS UNIVERSITY reassignment THE JOHNS HOPKINS UNIVERSITY Amend patent request/document other than specification (104) Assignors: UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
Application granted granted Critical
Publication of AU2009300357B2 publication Critical patent/AU2009300357B2/en
Priority to AU2014240289A priority Critical patent/AU2014240289B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2009300357A 2008-09-23 2009-09-23 Fused diimidazodiazepine compounds and methods of use and manufacture thereof Active AU2009300357B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2014240289A AU2014240289B2 (en) 2008-09-23 2014-10-03 Fused diimidazodiazepine compounds and methods of use and manufacture thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9932408P 2008-09-23 2008-09-23
US61/099,324 2008-09-23
PCT/US2009/005273 WO2010039187A2 (en) 2008-09-23 2009-09-23 Fused diimidazodiazepine compounds and methods of use and manufacture thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2014240289A Division AU2014240289B2 (en) 2008-09-23 2014-10-03 Fused diimidazodiazepine compounds and methods of use and manufacture thereof

Publications (2)

Publication Number Publication Date
AU2009300357A1 AU2009300357A1 (en) 2010-04-08
AU2009300357B2 true AU2009300357B2 (en) 2014-07-03

Family

ID=42074054

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009300357A Active AU2009300357B2 (en) 2008-09-23 2009-09-23 Fused diimidazodiazepine compounds and methods of use and manufacture thereof

Country Status (6)

Country Link
US (1) US8518901B2 (OSRAM)
EP (1) EP2350086B1 (OSRAM)
JP (1) JP5802872B2 (OSRAM)
AU (1) AU2009300357B2 (OSRAM)
CA (1) CA2738650C (OSRAM)
WO (1) WO2010039187A2 (OSRAM)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9322831B2 (en) 2008-09-23 2016-04-26 The Johns Hopkins University DDX3 as a biomarker for cancer and methods related thereto
JP2014511396A (ja) * 2011-03-09 2014-05-15 ザ・ジョンズ・ホプキンス・ユニバーシティ 除去的放射線治療に使用される組成物およびその使用方法
KR20150046787A (ko) * 2012-09-04 2015-04-30 고쿠리츠다이가쿠호진 니이가타 다이가쿠 암 줄기세포에서 발현하는 분자를 타깃으로 하는 암 진단 및 치료 방법
WO2015200779A2 (en) * 2014-06-26 2015-12-30 The Johns Hopkins University Methods of prevention and treatment of viral disease by use of ddx3 inhibitors
AU2020345000A1 (en) * 2019-09-13 2022-03-31 Origenis Gmbh 1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as LRRK2, NUAK1 and/or TYK2 kinase modulators for the treatment of e.g. autoimmune disease
RS65045B1 (sr) * 2019-09-13 2024-02-29 Origenis Gmbh Derivati 1,4-dihidrobenzo[d]pirazolo[3,4-f][1,3]diazepina i srodna jedinjenja kao modulatori kinaze lrrk2, nuak1 i/ili tyk2 za lečenje npr. autoimunih bolesti
US20230077636A1 (en) * 2021-08-31 2023-03-16 Natsar Pharmaceuticals, Inc. Intravenous formulations of rk-33

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5387585A (en) * 1991-06-17 1995-02-07 Hoffmann-La Roche Inc. Imidazodiazepine derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698155A (en) 1991-05-31 1997-12-16 Gs Technologies, Inc. Method for the manufacture of pharmaceutical cellulose capsules
EP1968581A4 (en) * 2005-12-16 2009-05-27 Genentech Inc TETRACYCLIC KINASE INHIBITORS

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5387585A (en) * 1991-06-17 1995-02-07 Hoffmann-La Roche Inc. Imidazodiazepine derivatives

Also Published As

Publication number Publication date
AU2009300357A1 (en) 2010-04-08
JP5802872B2 (ja) 2015-11-04
WO2010039187A2 (en) 2010-04-08
EP2350086A2 (en) 2011-08-03
US8518901B2 (en) 2013-08-27
US20110275588A1 (en) 2011-11-10
CA2738650A1 (en) 2010-04-08
EP2350086B1 (en) 2021-04-21
CA2738650C (en) 2017-07-04
WO2010039187A3 (en) 2010-06-17
EP2350086A4 (en) 2012-06-27
JP2012503653A (ja) 2012-02-09

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