CA2736243A1 - Multi-stage, regression-based pcr analysis system - Google Patents

Multi-stage, regression-based pcr analysis system Download PDF

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Publication number
CA2736243A1
CA2736243A1 CA2736243A CA2736243A CA2736243A1 CA 2736243 A1 CA2736243 A1 CA 2736243A1 CA 2736243 A CA2736243 A CA 2736243A CA 2736243 A CA2736243 A CA 2736243A CA 2736243 A1 CA2736243 A1 CA 2736243A1
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Prior art keywords
function
derivative
amplification
data
baseline
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Abandoned
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CA2736243A
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English (en)
French (fr)
Inventor
Jeffrey Lerner
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Bio Rad Laboratories Inc
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Bio Rad Laboratories Inc
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Publication of CA2736243A1 publication Critical patent/CA2736243A1/en
Abandoned legal-status Critical Current

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    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
    • G06F17/10—Complex mathematical operations
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Data Mining & Analysis (AREA)
  • Theoretical Computer Science (AREA)
  • Mathematical Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Mathematical Analysis (AREA)
  • Mathematical Optimization (AREA)
  • Computational Mathematics (AREA)
  • Pure & Applied Mathematics (AREA)
  • Databases & Information Systems (AREA)
  • Software Systems (AREA)
  • Algebra (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CA2736243A 2008-09-09 2009-09-09 Multi-stage, regression-based pcr analysis system Abandoned CA2736243A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9541008P 2008-09-09 2008-09-09
US61/095,410 2008-09-09
PCT/US2009/056384 WO2010030686A1 (en) 2008-09-09 2009-09-09 Multi-stage, regression-based pcr analysis system

Publications (1)

Publication Number Publication Date
CA2736243A1 true CA2736243A1 (en) 2010-03-18

Family

ID=42005454

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2736243A Abandoned CA2736243A1 (en) 2008-09-09 2009-09-09 Multi-stage, regression-based pcr analysis system

Country Status (6)

Country Link
US (3) US8285489B2 (enExample)
EP (1) EP2326949A1 (enExample)
JP (1) JP5166608B2 (enExample)
CN (1) CN102187215A (enExample)
CA (1) CA2736243A1 (enExample)
WO (1) WO2010030686A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3926636A2 (de) 2020-06-18 2021-12-22 Analytik Jena GmbH Verfahren zum erkennen einer amplifikationsphase in einer amplifikation
US20220082550A1 (en) * 2017-10-12 2022-03-17 Carrot, Inc. Breath sensor apparatus and methods of use
US11957451B2 (en) 2019-12-31 2024-04-16 Pivot Health Technologies Inc. Breath sensor calibration methods and apparatus

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JP5166608B2 (ja) * 2008-09-09 2013-03-21 バイオ−ラッド ラボラトリーズ，インコーポレイティド 多段階回帰ベースｐｃｒ解析システム
AU2009352527B2 (en) 2009-09-12 2014-04-03 Azure Vault Ltd. Identifying transition points in chemical reactions
WO2011130184A2 (en) * 2010-04-11 2011-10-20 Life Technologies Corporation SYSTEMS AND METHODS FOR MODEL-BASED qPCR
US8666673B2 (en) 2010-05-14 2014-03-04 Biomerieux, Inc Identification and/or characterization of a microbial agent using taxonomic hierarchical classification
WO2012123895A1 (en) 2011-03-15 2012-09-20 Azure Vault Ltd Rate based identification of reaction points
EP2809767B1 (en) * 2012-02-03 2017-11-08 Axxin Pty Ltd Nucleic acid amplification and detection apparatus
US10475527B2 (en) 2012-03-22 2019-11-12 Biomerieux, Inc. Method and system for detection of microbial growth in a specimen container
EP2864503B1 (en) 2012-06-26 2019-10-09 Axxin Pty Ltd Nucleic acid amplification and detection kit
US9607128B2 (en) * 2013-12-30 2017-03-28 Roche Molecular Systems, Inc. Detection and correction of jumps in real-time PCR signals
KR20160039529A (ko) * 2014-10-01 2016-04-11 주식회사 씨젠 증폭곡선을 보정하는 방법 및 시료 분석을 위한 정보를 획득하는 방법, 그 기록매체, 그 컴퓨터 프로그램, 컴퓨터 장치
ES2809600T3 (es) 2014-11-14 2021-03-04 Axxin Pty Ltd Conjunto de recogida y almacenamiento de muestras biológicas
US10470090B2 (en) * 2014-11-14 2019-11-05 Qualcomm Incorporated Data compression techniques for handover and radio link failure recovery
WO2017011862A1 (en) 2015-07-17 2017-01-26 Axxin Pty Ltd Diagnostic test assembly, apparatus, method
KR102165931B1 (ko) * 2015-09-24 2020-10-14 주식회사 씨젠 타겟 분석물질의 존재 또는 부존재를 결정하기 위한 다중 데이터 세트 분석법
US10978173B2 (en) 2016-02-05 2021-04-13 Seegene, Inc. Method for reducing noise level of data set for a target analyte
CN105755159A (zh) * 2016-05-13 2016-07-13 苏州国科闻普生物科技有限公司 自动快速判别荧光定量pcr结果的方法
CN106908655B (zh) * 2017-03-06 2019-06-14 广东顺德工业设计研究院(广东顺德创新设计研究院) 光电信号峰值检测方法与系统
KR102651024B1 (ko) 2017-09-27 2024-03-26 액신 피티와이 엘티디 진단 테스트 시스템 및 방법
EP4513499A3 (en) * 2017-09-28 2025-04-16 Seegene, Inc. Method and device for analyzing target analyte in sample
US11072820B2 (en) * 2017-10-19 2021-07-27 Bio-Rad Laboratories, Inc. Digital amplification assays with unconventional and/or inverse changes in photoluminescence
WO2020251306A1 (en) 2019-06-14 2020-12-17 Seegene, Inc. Computer-implemented method for collaborative development of reagents for detection of target nucleic acids
CN111931118A (zh) * 2020-08-25 2020-11-13 杭州博日科技股份有限公司 荧光定量熔解实验中熔解曲线测量方法
CN112257754B (zh) * 2020-09-24 2023-07-28 北京航天测控技术有限公司 航天器运行状态的分析方法和装置
US20240418649A1 (en) 2021-10-21 2024-12-19 Seegene, Inc. Device and method for reading positive/negative with respect to target assay substance in sample
CN114058683B (zh) * 2021-11-17 2022-09-30 杭州优思达生物技术有限公司 一种核酸扩增结果判定方法
CN114065120B (zh) * 2022-01-14 2022-04-19 深圳市刚竹医疗科技有限公司 测定pcr的直线-s形生长曲线的循环阈值的方法
WO2024010351A1 (ko) 2022-07-05 2024-01-11 주식회사 씨젠 복수의 표적 분석물 각각에 대한 근사 신호의 획득 방법 및 이를 수행하는 컴퓨터 장치
IL320357A (en) 2022-10-20 2025-06-01 Seegene Inc Method of guiding multiple detailed performance experiments required for developing reagent for detecting target nucleic acid molecule, and organizing experiment result record sheets
KR20250124154A (ko) 2023-01-05 2025-08-19 주식회사 씨젠 분자진단 분석 결과의 획득 방법, 분자진단 분석 결과를 추정하는 모델의 획득 방법 및 이를 수행하는 컴퓨터 장치
CN117106862A (zh) * 2023-01-19 2023-11-24 江苏普瑞悉恩生物科技有限公司 核酸样本检测定量方法及装置、存储介质及电子设备
CN116564411B (zh) * 2023-07-12 2023-09-29 广州普世君安生物科技有限公司 等温扩增核酸的结果判定方法、系统、设备及存储介质
WO2026005528A1 (ko) * 2024-06-28 2026-01-02 주식회사 씨젠 시료 내 타겟 분석물에 대한 데이터 세트의 보정 방법 및 장치

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US5766889A (en) * 1994-06-08 1998-06-16 The Perkin-Elmer Corporation Method for determining the characteristics of the concentration growth of target nucleic acid molecules in polymerase chain reaction sample
ATE428801T1 (de) * 1996-06-04 2009-05-15 Univ Utah Res Found Überwachung der hybridisierung während pcr
US6783934B1 (en) * 2000-05-01 2004-08-31 Cepheid, Inc. Methods for quantitative analysis of nucleic acid amplification reaction
US7228237B2 (en) 2002-02-07 2007-06-05 Applera Corporation Automatic threshold setting and baseline determination for real-time PCR
ES2301754T3 (es) 2002-02-12 2008-07-01 University Of Utah Research Foundation Analisis de pruebas multiples de amplificaciones de acidos nucleicos en tiempo real.
JP5313663B2 (ja) * 2005-05-13 2013-10-09 バイオ−ラッド ラボラトリーズ，インコーポレイティド 増幅データのベースライン化
US7720611B2 (en) * 2005-05-13 2010-05-18 Bio-Rad Laboratories, Inc. Baselining amplification data
US7647187B2 (en) * 2005-05-13 2010-01-12 Bio-Rad Laboratories, Inc. Identifying statistically linear data
WO2006124673A2 (en) * 2005-05-13 2006-11-23 Bio-Rad Laboratories, Inc. Identifying statistically linear data
EP1798650A1 (en) * 2005-12-19 2007-06-20 Roche Diagnostics GmbH Analytical method and instrument
US7668663B2 (en) 2005-12-20 2010-02-23 Roche Molecular Systems, Inc. Levenberg-Marquardt outlier spike removal method
JP5166608B2 (ja) * 2008-09-09 2013-03-21 バイオ−ラッド ラボラトリーズ，インコーポレイティド 多段階回帰ベースｐｃｒ解析システム

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220082550A1 (en) * 2017-10-12 2022-03-17 Carrot, Inc. Breath sensor apparatus and methods of use
US11796532B2 (en) * 2017-10-12 2023-10-24 Pivot Health Technologies Inc. Breath sensor apparatus and methods of use
US11957451B2 (en) 2019-12-31 2024-04-16 Pivot Health Technologies Inc. Breath sensor calibration methods and apparatus
EP3926636A2 (de) 2020-06-18 2021-12-22 Analytik Jena GmbH Verfahren zum erkennen einer amplifikationsphase in einer amplifikation
DE102020116178A1 (de) 2020-06-18 2021-12-23 Analytik Jena Gmbh Verfahren zum Erkennen einer Amplifikationsphase in einer Amplifikation

Also Published As

Publication number Publication date
US20100070190A1 (en) 2010-03-18
JP5166608B2 (ja) 2013-03-21
US20140032126A1 (en) 2014-01-30
US8285489B2 (en) 2012-10-09
CN102187215A (zh) 2011-09-14
US9442891B2 (en) 2016-09-13
JP2012502378A (ja) 2012-01-26
US20130018593A1 (en) 2013-01-17
WO2010030686A1 (en) 2010-03-18
EP2326949A1 (en) 2011-06-01
US8560247B2 (en) 2013-10-15

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