CA2735192C - Polymorphs of acyl sulfonamides - Google Patents

Polymorphs of acyl sulfonamides Download PDF

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Publication number
CA2735192C
CA2735192C CA2735192A CA2735192A CA2735192C CA 2735192 C CA2735192 C CA 2735192C CA 2735192 A CA2735192 A CA 2735192A CA 2735192 A CA2735192 A CA 2735192A CA 2735192 C CA2735192 C CA 2735192C
Authority
CA
Canada
Prior art keywords
compound
acid
hiv
polymorphic
administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2735192A
Other languages
English (en)
French (fr)
Other versions
CA2735192A1 (en
Inventor
James Prentice Davidson
Michael Martin
Fei PANG
Margaret Wong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Priority to CA2949912A priority Critical patent/CA2949912C/en
Publication of CA2735192A1 publication Critical patent/CA2735192A1/en
Application granted granted Critical
Publication of CA2735192C publication Critical patent/CA2735192C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/51—Y being a hydrogen or a carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/42—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
CA2735192A 2008-09-09 2009-08-31 Polymorphs of acyl sulfonamides Active CA2735192C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2949912A CA2949912C (en) 2008-09-09 2009-08-31 Polymorphs of acyl sulfonamides

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9536408P 2008-09-09 2008-09-09
US61/095,364 2008-09-09
PCT/EP2009/061185 WO2010028968A2 (en) 2008-09-09 2009-08-31 Polymorphs of acyl sulfonamides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2949912A Division CA2949912C (en) 2008-09-09 2009-08-31 Polymorphs of acyl sulfonamides

Publications (2)

Publication Number Publication Date
CA2735192A1 CA2735192A1 (en) 2010-03-18
CA2735192C true CA2735192C (en) 2017-02-28

Family

ID=41664548

Family Applications (5)

Application Number Title Priority Date Filing Date
CA3086566A Active CA3086566C (en) 2008-09-09 2009-08-31 ACYLATE SULFONAMIDE POLYMORPHS
CA2735192A Active CA2735192C (en) 2008-09-09 2009-08-31 Polymorphs of acyl sulfonamides
CA2949912A Active CA2949912C (en) 2008-09-09 2009-08-31 Polymorphs of acyl sulfonamides
CA3003213A Active CA3003213C (en) 2008-09-09 2009-08-31 Polymorphs of acyl sulfonamides
CA3059552A Active CA3059552C (en) 2008-09-09 2009-08-31 Polymorphs of acyl sulfonamides

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA3086566A Active CA3086566C (en) 2008-09-09 2009-08-31 ACYLATE SULFONAMIDE POLYMORPHS

Family Applications After (3)

Application Number Title Priority Date Filing Date
CA2949912A Active CA2949912C (en) 2008-09-09 2009-08-31 Polymorphs of acyl sulfonamides
CA3003213A Active CA3003213C (en) 2008-09-09 2009-08-31 Polymorphs of acyl sulfonamides
CA3059552A Active CA3059552C (en) 2008-09-09 2009-08-31 Polymorphs of acyl sulfonamides

Country Status (16)

Country Link
US (1) US8063103B2 (enExample)
EP (1) EP2334638B1 (enExample)
JP (6) JP5989339B2 (enExample)
KR (7) KR20180001582A (enExample)
CN (1) CN102143943B (enExample)
AU (1) AU2009290988B2 (enExample)
BR (3) BR122021020474B1 (enExample)
CA (5) CA3086566C (enExample)
EA (1) EA019340B1 (enExample)
ES (1) ES2706875T3 (enExample)
IL (4) IL299322B2 (enExample)
MX (1) MX2011002319A (enExample)
PL (1) PL2334638T3 (enExample)
TR (1) TR201818979T4 (enExample)
UA (1) UA107561C2 (enExample)
WO (1) WO2010028968A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2644156C1 (ru) 2017-02-28 2018-02-08 Александр Васильевич Иващенко Пролекарство ингибитора NS5B HCV полимеразы, способ его получения и применения
RU2665383C9 (ru) * 2017-06-22 2019-07-23 Общество с ограниченной ответственностью "Вириом" Фармацевтическая наносуспензия для терапии ВИЧ-инфекции
RU2662160C9 (ru) 2017-07-03 2018-10-22 Александрович Иващенко Андрей Комбинированный лекарственный препарат для терапии вирусных инфекций
RU2716257C1 (ru) * 2019-04-30 2020-03-11 Андрей Александрович Иващенко Активный компонент, фармацевтическая композиция и лекарственный препарат для терапии ВИЧ и СПИДа
RU2717101C1 (ru) 2019-06-03 2020-03-18 Андрей Александрович Иващенко Анелированные 9-гидрокси-1,8-диоксо-1,3,4,8-тетрагидро-2Н-пиридо[1,2-a]пиразин-7-карбоксамиды - ингибиторы интегразы ВИЧ, способы их получения и применения

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2272285C (en) * 1997-01-23 2006-11-21 Yamanouchi Pharmaceutical Co., Ltd. Amide derivatives and medicinal compositions thereof
US7625949B2 (en) * 2004-04-23 2009-12-01 Roche Palo Alto Llc Methods for treating retroviral infections
US7166738B2 (en) * 2004-04-23 2007-01-23 Roche Palo Alto Llc Non-nucleoside reverse transcriptase inhibitors
WO2005102989A1 (en) * 2004-04-23 2005-11-03 F. Hoffmann-La Roche Ag Non-nucleoside reverse transcriptase inhibitors
US7618981B2 (en) * 2004-05-06 2009-11-17 Cytokinetics, Inc. Imidazopyridinyl-benzamide anti-cancer agents
CN101166524B (zh) * 2005-04-28 2010-12-22 辉瑞有限公司 氨基酸衍生物
KR20080056220A (ko) * 2005-10-19 2008-06-20 에프. 호프만-라 로슈 아게 페닐-아세트아마이드 ｎｎｒｔ 저해제
KR20100092424A (ko) * 2007-07-30 2010-08-20 아디아 바이오사이언스즈 인크. 다형체를 포함하는, ｍｅｋ의 억제제로서의 ｎ-(아릴아미노) 술폰아미드의 유도체 및 조성물, 사용 방법 및 이의 제조 방법
JP2011514897A (ja) * 2008-03-04 2011-05-12 エフ．ホフマン−ラ ロシュ アーゲー 高濃度のミセル水溶液を調製する方法

Also Published As

Publication number Publication date
JP2021176894A (ja) 2021-11-11
BR122021020475B1 (pt) 2022-06-07
IL299322B1 (en) 2024-06-01
BR122021020474B1 (pt) 2022-06-07
US20100063154A1 (en) 2010-03-11
KR20110053234A (ko) 2011-05-19
KR20220120723A (ko) 2022-08-30
KR20180110237A (ko) 2018-10-08
KR102560207B1 (ko) 2023-07-27
CA3086566A1 (en) 2010-03-18
IL211353A0 (en) 2011-05-31
JP2019194229A (ja) 2019-11-07
IL299322B2 (en) 2024-10-01
EP2334638B1 (en) 2018-11-21
IL299322A (en) 2023-02-01
JP2012502075A (ja) 2012-01-26
JP2016172741A (ja) 2016-09-29
CA2949912C (en) 2019-12-03
CA3059552A1 (en) 2010-03-18
MX2011002319A (es) 2011-04-05
KR20230113420A (ko) 2023-07-28
KR101822319B1 (ko) 2018-01-25
KR102437499B1 (ko) 2022-08-29
JP2018058862A (ja) 2018-04-12
KR20210108499A (ko) 2021-09-02
KR20160092049A (ko) 2016-08-03
AU2009290988B2 (en) 2016-01-28
IL211353A (en) 2016-04-21
JP5989339B2 (ja) 2016-09-07
UA107561C2 (xx) 2015-01-26
CA3059552C (en) 2021-03-16
KR101678700B1 (ko) 2016-11-22
EA019340B1 (ru) 2014-02-28
AU2009290988A1 (en) 2010-03-18
WO2010028968A3 (en) 2010-06-10
KR20180001582A (ko) 2018-01-04
EA201100451A1 (ru) 2011-10-31
BRPI0918526B1 (pt) 2022-02-15
CA3003213A1 (en) 2010-03-18
US8063103B2 (en) 2011-11-22
BRPI0918526A2 (pt) 2015-12-01
WO2010028968A2 (en) 2010-03-18
ES2706875T3 (es) 2019-04-01
CA3003213C (en) 2021-07-20
EP2334638A2 (en) 2011-06-22
JP2023082131A (ja) 2023-06-13
CA2735192A1 (en) 2010-03-18
TR201818979T4 (tr) 2019-01-21
JP6450340B2 (ja) 2019-01-09
IL264118A (en) 2019-02-28
IL244350A0 (en) 2016-05-01
CN102143943B (zh) 2014-03-12
PL2334638T3 (pl) 2019-04-30
CA2949912A1 (en) 2010-03-18
CN102143943A (zh) 2011-08-03
CA3086566C (en) 2025-09-02

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Effective date: 20140613