CA2732440C - Cystamine analogues for the treatment of parkinson`s disease - Google Patents
Cystamine analogues for the treatment of parkinson`s disease Download PDFInfo
- Publication number
- CA2732440C CA2732440C CA2732440A CA2732440A CA2732440C CA 2732440 C CA2732440 C CA 2732440C CA 2732440 A CA2732440 A CA 2732440A CA 2732440 A CA2732440 A CA 2732440A CA 2732440 C CA2732440 C CA 2732440C
- Authority
- CA
- Canada
- Prior art keywords
- cystamine
- pharmaceutically acceptable
- cysteine
- acceptable salt
- analogue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
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- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2732440A CA2732440C (en) | 2011-02-23 | 2011-02-23 | Cystamine analogues for the treatment of parkinson`s disease |
| RU2013137645A RU2630583C2 (ru) | 2011-02-23 | 2012-02-23 | Аналоги цистамина, применяемые для лечения болезни паркинсона |
| BR112013021616-6A BR112013021616A2 (pt) | 2011-02-23 | 2012-02-23 | análogos de cistamina para o tratamento de doença de parkinson |
| US14/000,234 US20140073694A1 (en) | 2011-02-23 | 2012-02-23 | Cystamine analogues for the treatment of parkinson's disease |
| EP12750124.5A EP2678009B1 (en) | 2011-02-23 | 2012-02-23 | Cystamine analogues for the treatment of parkinson's disease |
| KR1020137024680A KR20140115239A (ko) | 2011-02-23 | 2012-02-23 | 파킨슨병 치료용 시스타민 유사체 |
| AU2012220314A AU2012220314B2 (en) | 2011-02-23 | 2012-02-23 | Cystamine analogues for the treatment of Parkinson's disease |
| MX2013009608A MX350195B (es) | 2011-02-23 | 2012-02-23 | Analogos de cistamina para el tratamiento de la enfermedad de parkinson. |
| JP2013554768A JP6000985B2 (ja) | 2011-02-23 | 2012-02-23 | パーキンソン病を治療するためのシスタミン類似体 |
| CN2012800099995A CN103442704A (zh) | 2011-02-23 | 2012-02-23 | 用于治疗帕金森病的胱胺类似物 |
| PCT/CA2012/050106 WO2012113079A1 (en) | 2011-02-23 | 2012-02-23 | Cystamine analogues for the treatment of parkinson's disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2732440A CA2732440C (en) | 2011-02-23 | 2011-02-23 | Cystamine analogues for the treatment of parkinson`s disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2732440A1 CA2732440A1 (en) | 2012-08-23 |
| CA2732440C true CA2732440C (en) | 2017-10-31 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2732440A Expired - Fee Related CA2732440C (en) | 2011-02-23 | 2011-02-23 | Cystamine analogues for the treatment of parkinson`s disease |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20140073694A1 (OSRAM) |
| EP (1) | EP2678009B1 (OSRAM) |
| JP (1) | JP6000985B2 (OSRAM) |
| KR (1) | KR20140115239A (OSRAM) |
| CN (1) | CN103442704A (OSRAM) |
| AU (1) | AU2012220314B2 (OSRAM) |
| BR (1) | BR112013021616A2 (OSRAM) |
| CA (1) | CA2732440C (OSRAM) |
| MX (1) | MX350195B (OSRAM) |
| RU (1) | RU2630583C2 (OSRAM) |
| WO (1) | WO2012113079A1 (OSRAM) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI659209B (zh) * | 2013-06-17 | 2019-05-11 | 地平線罕見醫學製藥有限責任公司 | 分析半胱胺組合物的方法 |
| TW201618760A (zh) * | 2014-11-05 | 2016-06-01 | 雷普特製藥有限公司 | 使用半胱胺組合物治療亨廷頓氏病之方法 |
| KR20180004756A (ko) | 2015-05-06 | 2018-01-12 | 신애질 코포레이션 | 약물 입자를 함유하는 제약 현탁액, 그의 투여를 위한 장치, 및 그의 사용 방법 |
| TW202247838A (zh) | 2015-07-02 | 2022-12-16 | 美商地平線罕見醫學製藥有限責任公司 | Ado抗性半胱胺類似物及其用途 |
| EP3393099B1 (en) | 2016-03-30 | 2021-07-07 | Guangdong Oppo Mobile Telecommunications Corp., Ltd. | Relay transmission method and device |
| EP3946298A4 (en) * | 2019-03-26 | 2023-01-25 | The Regents of the University of California | Substituted amino-thiol and amino-disulfide compounds, and uses thereof |
| US20220265583A1 (en) * | 2019-07-30 | 2022-08-25 | The Regents Of The University Of California | Methods and composition for treating respiratory obstructive diseases |
| CN119909064B (zh) * | 2025-04-07 | 2025-08-15 | 北京大学深圳研究生院 | 胱胺衍生物或其盐以及其在制备具有抗氧化功效的药物中的应用 |
| CN120437102B (zh) * | 2025-07-09 | 2025-09-16 | 中南大学湘雅医院 | 胱胺在制备治疗脓毒症脑病药物中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004069175A2 (en) * | 2003-02-02 | 2004-08-19 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PARKINSON’S DISEASE AND OTHER α-SYNUCLEINOPATHIES |
| RU2255775C1 (ru) * | 2003-12-25 | 2005-07-10 | Государственное учреждение научно-исследовательский институт неврологии Российской академии медицинских наук | Способ лечения болезни паркинсона |
| EA201600089A1 (ru) * | 2006-01-27 | 2017-01-30 | Те Риджентс Оф Те Юниверсити Оф Калифорния | Покрытые энтеросолюбильной оболочкой цистеамин и цистамин и их производные |
| WO2008143876A2 (en) * | 2007-05-14 | 2008-11-27 | The Trustees Of Columia University In The City Of New York | Agents and assays for modulating neurodegeneration |
| JP2011522892A (ja) * | 2008-06-13 | 2011-08-04 | テバ ファーマシューティカル インダストリーズ リミティド | パーキンソン病緩和のためのラサギリン |
-
2011
- 2011-02-23 CA CA2732440A patent/CA2732440C/en not_active Expired - Fee Related
-
2012
- 2012-02-23 US US14/000,234 patent/US20140073694A1/en not_active Abandoned
- 2012-02-23 WO PCT/CA2012/050106 patent/WO2012113079A1/en not_active Ceased
- 2012-02-23 RU RU2013137645A patent/RU2630583C2/ru not_active IP Right Cessation
- 2012-02-23 AU AU2012220314A patent/AU2012220314B2/en not_active Ceased
- 2012-02-23 EP EP12750124.5A patent/EP2678009B1/en not_active Not-in-force
- 2012-02-23 KR KR1020137024680A patent/KR20140115239A/ko not_active Ceased
- 2012-02-23 CN CN2012800099995A patent/CN103442704A/zh active Pending
- 2012-02-23 JP JP2013554768A patent/JP6000985B2/ja not_active Expired - Fee Related
- 2012-02-23 MX MX2013009608A patent/MX350195B/es active IP Right Grant
- 2012-02-23 BR BR112013021616-6A patent/BR112013021616A2/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2012220314A1 (en) | 2013-08-22 |
| MX2013009608A (es) | 2013-09-16 |
| EP2678009B1 (en) | 2017-11-01 |
| AU2012220314B2 (en) | 2017-04-06 |
| BR112013021616A2 (pt) | 2020-09-29 |
| US20140073694A1 (en) | 2014-03-13 |
| RU2013137645A (ru) | 2015-02-20 |
| KR20140115239A (ko) | 2014-09-30 |
| MX350195B (es) | 2017-08-30 |
| WO2012113079A1 (en) | 2012-08-30 |
| RU2630583C2 (ru) | 2017-09-11 |
| JP2014508758A (ja) | 2014-04-10 |
| CA2732440A1 (en) | 2012-08-23 |
| EP2678009A4 (en) | 2014-08-06 |
| EP2678009A1 (en) | 2014-01-01 |
| JP6000985B2 (ja) | 2016-10-05 |
| CN103442704A (zh) | 2013-12-11 |
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