CA2724523A1 - Novel macrocyclic peptides - Google Patents

Info

Publication number

CA2724523A1

CA2724523A1 CA2724523A CA2724523A CA2724523A1 CA 2724523 A1 CA2724523 A1 CA 2724523A1 CA 2724523 A CA2724523 A CA 2724523A CA 2724523 A CA2724523 A CA 2724523A CA 2724523 A1 CA2724523 A1 CA 2724523A1

Authority

CA

Canada

Prior art keywords

group

carbon atoms

optionally substituted

groups

cyclosporine

Prior art date

2008-06-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 108090000765 processed proteins & peptides Proteins 0.000 title description 4
• 102000004196 processed proteins & peptides Human genes 0.000 title description 3
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims abstract description 51
• 238000011282 treatment Methods 0.000 claims abstract description 45
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 40
• 239000003814 drug Substances 0.000 claims abstract description 35
• 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 31
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 10
• 229910052799 carbon Inorganic materials 0.000 claims abstract description 10
• 150000001875 compounds Chemical class 0.000 claims description 204
• 125000000217 alkyl group Chemical group 0.000 claims description 128
• 125000004432 carbon atom Chemical group C* 0.000 claims description 109
• 239000000203 mixture Substances 0.000 claims description 106
• 229910052736 halogen Inorganic materials 0.000 claims description 79
• 150000002367 halogens Chemical class 0.000 claims description 77
• -1 amino, carboxyl Chemical group 0.000 claims description 74
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 73
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 67
• 238000000034 method Methods 0.000 claims description 63
• 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 52
• 125000003545 alkoxy group Chemical group 0.000 claims description 47
• 150000003839 salts Chemical class 0.000 claims description 47
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 45
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• 239000001301 oxygen Substances 0.000 claims description 29
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• 125000000753 cycloalkyl group Chemical group 0.000 claims description 24
• 125000001188 haloalkyl group Chemical group 0.000 claims description 24
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• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 22
• 125000000623 heterocyclic group Chemical group 0.000 claims description 22
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• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 21
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